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The map label for this gene is cah [H]

Identifier: 209694616

GI number: 209694616

Start: 1147951

End: 1148658

Strand: Reverse

Name: cah [H]

Synonym: VSAL_I1056

Alternate gene names: 209694616

Gene position: 1148658-1147951 (Counterclockwise)

Preceding gene: 209694617

Following gene: 209694587

Centisome position: 34.54

GC content: 39.55

Gene sequence:

>708_bases
ATGAAAAAAATCATTACAACGTTAGCGGCTTTAACGGTTCTATCAACCAGCTACACTGTCTCTGCCTCTGAATGGAGTTA
CTCAGGTGAAACCGCACCCACAAATTGGCATGGAACCTGTCAATCAGGAGTAAACCAGTCACCGATAGATATTACTCACG
CTATCGAGAGCACATTAGACCCAATTATTTTCAACTATTCAAAAGCGGGAAAAAATGTCGTCAATAATGGACATACGGTA
CAAGTTAATTTTGACGCAAAGCAATCCATTCAAATTGAAGGGAAAACCTTTACGCTTTTACAACTTCATTTCCATGCCCC
AAGCGAAAACCTCATTGAGGGTCACTCATTCCCATTAGAAATGCACTTAGTCCATGCAGATAAAGATGGCAACCTTGCCG
TTATTGGAGTGATGCTAAAAGAAGGAAAACCTAATTCTGAATTGACAAAAATATGGGCTAAAATGCCACAATCAGGGCAA
GTAGATCTTGAAAATCAATTAGATCTAACGAAGCTTCTTCCTCGTGATCAAGCTTATTACCGTTTCAACGGTTCATTAAC
TACCCCACCTTGTTCGGAAGGGGTTACTTGGCTAGTGATGAAAAACCCTATTGAGATATCATCAGAACAGCTAGCACAAT
TTACAGCGCTTTATAATGGTAATAATTGTCCTACTCAAGCAATAAACGCTCGGCCGATTTTAAAATAA

Upstream 100 bases:

>100_bases
GGAAGTAGGTTGCAAAACTTCATTTAAACTATTATCAACCAAATTGTATTTATATTAGCCTATCGGTGATTATCTAAAAC
AATAAGGTTATATAAATACC

Downstream 100 bases:

>100_bases
GACCACTCAACTCACGTAGCTATCTATTTATTACGAAGAAAAATCACTTAAGAACAAAGTAAACGTTCTGATAAGTAGTT
ATTTTACCATTAAAACTCTT

Product: carbonic anhydrase precursor

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKKIITTLAALTVLSTSYTVSASEWSYSGETAPTNWHGTCQSGVNQSPIDITHAIESTLDPIIFNYSKAGKNVVNNGHTV
QVNFDAKQSIQIEGKTFTLLQLHFHAPSENLIEGHSFPLEMHLVHADKDGNLAVIGVMLKEGKPNSELTKIWAKMPQSGQ
VDLENQLDLTKLLPRDQAYYRFNGSLTTPPCSEGVTWLVMKNPIEISSEQLAQFTALYNGNNCPTQAINARPILK

Sequences:

>Translated_235_residues
MKKIITTLAALTVLSTSYTVSASEWSYSGETAPTNWHGTCQSGVNQSPIDITHAIESTLDPIIFNYSKAGKNVVNNGHTV
QVNFDAKQSIQIEGKTFTLLQLHFHAPSENLIEGHSFPLEMHLVHADKDGNLAVIGVMLKEGKPNSELTKIWAKMPQSGQ
VDLENQLDLTKLLPRDQAYYRFNGSLTTPPCSEGVTWLVMKNPIEISSEQLAQFTALYNGNNCPTQAINARPILK
>Mature_235_residues
MKKIITTLAALTVLSTSYTVSASEWSYSGETAPTNWHGTCQSGVNQSPIDITHAIESTLDPIIFNYSKAGKNVVNNGHTV
QVNFDAKQSIQIEGKTFTLLQLHFHAPSENLIEGHSFPLEMHLVHADKDGNLAVIGVMLKEGKPNSELTKIWAKMPQSGQ
VDLENQLDLTKLLPRDQAYYRFNGSLTTPPCSEGVTWLVMKNPIEISSEQLAQFTALYNGNNCPTQAINARPILK

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI258679498, Length=257, Percent_Identity=31.9066147859922, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI192447434, Length=257, Percent_Identity=31.9066147859922, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI192447432, Length=257, Percent_Identity=31.9066147859922, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI192447430, Length=257, Percent_Identity=31.9066147859922, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI4502517, Length=257, Percent_Identity=31.9066147859922, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI38348436, Length=230, Percent_Identity=33.9130434782609, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4502515, Length=238, Percent_Identity=33.6134453781513, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI45935383, Length=238, Percent_Identity=33.6134453781513, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI4557395, Length=244, Percent_Identity=34.0163934426229, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4885101, Length=225, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI4885099, Length=255, Percent_Identity=31.3725490196078, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI4502521, Length=205, Percent_Identity=33.6585365853659, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI6005723, Length=224, Percent_Identity=34.375, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI169636420, Length=219, Percent_Identity=31.5068493150685, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI62240989, Length=172, Percent_Identity=34.3023255813954, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4502519, Length=251, Percent_Identity=29.4820717131474, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI70167127, Length=230, Percent_Identity=29.1304347826087, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI22027500, Length=212, Percent_Identity=30.188679245283, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI6912284, Length=239, Percent_Identity=29.2887029288703, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI91208428, Length=227, Percent_Identity=30.3964757709251, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI194097398, Length=231, Percent_Identity=31.6017316017316, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI130979954, Length=232, Percent_Identity=25.4310344827586, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI130979679, Length=232, Percent_Identity=25.4310344827586, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI9910366, Length=232, Percent_Identity=25.4310344827586, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568715, Length=241, Percent_Identity=34.4398340248963, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71995280, Length=253, Percent_Identity=33.596837944664, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17737413, Length=247, Percent_Identity=34.0080971659919, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21358169, Length=285, Percent_Identity=30.1754385964912, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24645604, Length=247, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI161079350, Length=262, Percent_Identity=31.2977099236641, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221329761, Length=267, Percent_Identity=26.5917602996255, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI161079354, Length=258, Percent_Identity=28.2945736434109, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI20130189, Length=243, Percent_Identity=30.4526748971193, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18858185, Length=264, Percent_Identity=26.1363636363636, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24650523, Length=255, Percent_Identity=29.8039215686275, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24649809, Length=243, Percent_Identity=27.9835390946502, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI18857983, Length=216, Percent_Identity=28.7037037037037, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 25880; Mature: 25880

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00162 ALPHA_CA_1 ; PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIITTLAALTVLSTSYTVSASEWSYSGETAPTNWHGTCQSGVNQSPIDITHAIESTLD
CHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCC
PIIFNYSKAGKNVVNNGHTVQVNFDAKQSIQIEGKTFTLLQLHFHAPSENLIEGHSFPLE
CEEEECCCCCCHHHCCCCEEEEEECCCCEEEECCCEEEEEEEEEECCCCHHCCCCCCCEE
MHLVHADKDGNLAVIGVMLKEGKPNSELTKIWAKMPQSGQVDLENQLDLTKLLPRDQAYY
EEEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCEEE
RFNGSLTTPPCSEGVTWLVMKNPIEISSEQLAQFTALYNGNNCPTQAINARPILK
EECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKIITTLAALTVLSTSYTVSASEWSYSGETAPTNWHGTCQSGVNQSPIDITHAIESTLD
CHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCC
PIIFNYSKAGKNVVNNGHTVQVNFDAKQSIQIEGKTFTLLQLHFHAPSENLIEGHSFPLE
CEEEECCCCCCHHHCCCCEEEEEECCCCEEEECCCEEEEEEEEEECCCCHHCCCCCCCEE
MHLVHADKDGNLAVIGVMLKEGKPNSELTKIWAKMPQSGQVDLENQLDLTKLLPRDQAYY
EEEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCEEE
RFNGSLTTPPCSEGVTWLVMKNPIEISSEQLAQFTALYNGNNCPTQAINARPILK
EECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9811652 [H]