Click here to switch to the map view.

The map label for this gene is gpt

Identifier: 209694538

GI number: 209694538

Start: 1077908

End: 1078366

Strand: Direct

Name: gpt

Synonym: VSAL_I0975

Alternate gene names: 209694538

Gene position: 1077908-1078366 (Clockwise)

Preceding gene: 209694537

Following gene: 209694539

Centisome position: 32.42

GC content: 40.52

Gene sequence:

>459_bases
ATGGCTAATAAATTTGTAATAACTTGGGATAACATGCAGATGTATACTCGTCAGCTTGCTGAACAGTTACTTCCTGCTGA
ACAATGGAAAGGTATTTTGGCTGTGAGCCGTGGTGGACTTGTCCCTGCGGCAATTCTAGCTCGTGAATTAAATATTCGTT
ATGTTGATACCGTATGTATTTCAAGTTATGACCACGATCATCAGCGTGATATGACGGTTGTTAAAGCGATGGAAGGTGAT
GGTGAAGGTTTCATCATCATTGATGATTTAGTTGATAGTGGTGACACTGCCGTTAAATTGCGCCAGATGTACCCTAAAGG
TAAATTAGTCACTGTATGTGCAAAACCTGCAGGCATTGATTTAGTTGATGCGTATGTTGTCGATATTCCACAAGATACGT
GGATCGAGCAACCATGGGACATGGCTGTAACGTACGTAGATCCTATTTGTAAAAAATAA

Upstream 100 bases:

>100_bases
GTTCATATCAGTGTTTGGGTTCTTGCTGCACTATTCACGCTGAAATTTATTTTTACGGCATAGTTGTTGTTAACTGTGCC
ACTGAGAGGTTTTGTCTATT

Downstream 100 bases:

>100_bases
ACTTACGTTATAACCAATAGAAAATGACTCTTTTAAGGGTCATTTTTTTTGCTTGTCATTTATCGATATTAATTAAATTC
AAGAGTAAGTTGATTACCCT

Product: xanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: Xanthine-guanine phosphoribosyltransferase; XGPRT

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MANKFVITWDNMQMYTRQLAEQLLPAEQWKGILAVSRGGLVPAAILARELNIRYVDTVCISSYDHDHQRDMTVVKAMEGD
GEGFIIIDDLVDSGDTAVKLRQMYPKGKLVTVCAKPAGIDLVDAYVVDIPQDTWIEQPWDMAVTYVDPICKK

Sequences:

>Translated_152_residues
MANKFVITWDNMQMYTRQLAEQLLPAEQWKGILAVSRGGLVPAAILARELNIRYVDTVCISSYDHDHQRDMTVVKAMEGD
GEGFIIIDDLVDSGDTAVKLRQMYPKGKLVTVCAKPAGIDLVDAYVVDIPQDTWIEQPWDMAVTYVDPICKK
>Mature_151_residues
ANKFVITWDNMQMYTRQLAEQLLPAEQWKGILAVSRGGLVPAAILARELNIRYVDTVCISSYDHDHQRDMTVVKAMEGDG
EGFIIIDDLVDSGDTAVKLRQMYPKGKLVTVCAKPAGIDLVDAYVVDIPQDTWIEQPWDMAVTYVDPICKK

Specific function: Acts on guanine, xanthine and to a lesser extent hypoxanthine

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily

Homologues:

Organism=Escherichia coli, GI1786433, Length=152, Percent_Identity=68.4210526315789, Blast_Score=231, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XGPT_ALISL (B6EIE9)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262466.1
- GeneID:   6986758
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0975
- HOGENOM:   HBG503428
- OMA:   LVDTFIT
- ProtClustDB:   PRK09177
- HAMAP:   MF_01903
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.22

Molecular weight: Translated: 17076; Mature: 16945

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 69-69 BINDING 92-92 BINDING 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKFVITWDNMQMYTRQLAEQLLPAEQWKGILAVSRGGLVPAAILARELNIRYVDTVCI
CCCEEEEEECCHHHHHHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHCCEEEEEEEEE
SSYDHDHQRDMTVVKAMEGDGEGFIIIDDLVDSGDTAVKLRQMYPKGKLVTVCAKPAGID
CCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCEEHEEHHCCCCCEEEEEECCCCCE
LVDAYVVDIPQDTWIEQPWDMAVTYVDPICKK
EEEEEEEECCCCCCCCCCHHHEEEECCHHCCC
>Mature Secondary Structure 
ANKFVITWDNMQMYTRQLAEQLLPAEQWKGILAVSRGGLVPAAILARELNIRYVDTVCI
CCEEEEEECCHHHHHHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHCCEEEEEEEEE
SSYDHDHQRDMTVVKAMEGDGEGFIIIDDLVDSGDTAVKLRQMYPKGKLVTVCAKPAGID
CCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCEEHEEHHCCCCCEEEEEECCCCCE
LVDAYVVDIPQDTWIEQPWDMAVTYVDPICKK
EEEEEEEECCCCCCCCCCHHHEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA