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The map label for this gene is fkpA [H]

Identifier: 209693911

GI number: 209693911

Start: 350844

End: 351638

Strand: Direct

Name: fkpA [H]

Synonym: VSAL_I0305

Alternate gene names: 209693911

Gene position: 350844-351638 (Clockwise)

Preceding gene: 209693908

Following gene: 209693912

Centisome position: 10.55

GC content: 40.13

Gene sequence:

>795_bases
ATGAAATCTATCTTTAAAGTATCGCTACTTGCTGCAACTGTTGCATTTGTTGTTGGTTGTCAGAAAGAAGAAGCACCAAA
AACAGAAGCAACTACGCTACCTGCAAAAATTGAAGCATCAGCAGAAGGCGCAACAGCATCAACATTTGCTTCTGAAGATG
AAAAAGCGGGTTATGCAATCGGTGCATCATTGGCTAAATACTTAAACTCTAATTTAGAGAAACAAACAGAACTAGGCTTA
GACCTGAAAAAAGCCGATGTGCTTGCTGGCGTAACGGATGTATTTAACGGTAAAGAACGTCTAACTGATGAGCAAATTCA
AGGCGCTCTACAAGCATTAGATCAACGTGTTGCTGAAATCGGTAAAAAGAAAGCGGCTGCTGAATCTGAAGCAAATATTA
AAGCGGGGGCAGATTATCGTGCTAAGTTTGCAAAAGAAGACGGCGTAATAAAAACGGAATCAGGTCTGTTATACAAAGTA
CTTACACCTGCTGATGGCCCTAAACCAAAAGACACAGATACCGTTGTAGTTCATTACACTGGTACGTTAATTGATGGCAC
TAAGTTTGATAGCTCTTATGATCGTAAGCAACCTGCTACGTTCCCTCTTAATGCTGTAATTCCAGGTTGGACTGAAGGTG
TTCAATTAATGAACGTGGGTTCTAAATACAAGTTCGTTGTTCCTGCTGAATTAGGTTACGGCGCTCAAGGTAACCAAGCG
ATTCCTGCAAATTCAACATTGGTATTTGATGTTGAATTGCTAGAAATTAAAGACGCAGCAAAACCTGCAAAATAA

Upstream 100 bases:

>100_bases
TATAAGTACTAGTATATTGTGATGAGCACTATTTCGCATCTTTATCTAAATAATTGAATAAGAAAATGAGGCAGCACCTC
AAATAATTCGGAGTTTTGAA

Downstream 100 bases:

>100_bases
TCTTAGCGAAGATTAAATAATCTAAACTTTGTTTTAGATCACTGAATTAGCCCCGGCACTTGCTGGGGTTTTTTATTTTC
ATGCAAATATTCTGATAAAC

Product: FKBP-type peptidyl-prolyl cis-trans isomerase FkpA precursor

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKSIFKVSLLAATVAFVVGCQKEEAPKTEATTLPAKIEASAEGATASTFASEDEKAGYAIGASLAKYLNSNLEKQTELGL
DLKKADVLAGVTDVFNGKERLTDEQIQGALQALDQRVAEIGKKKAAAESEANIKAGADYRAKFAKEDGVIKTESGLLYKV
LTPADGPKPKDTDTVVVHYTGTLIDGTKFDSSYDRKQPATFPLNAVIPGWTEGVQLMNVGSKYKFVVPAELGYGAQGNQA
IPANSTLVFDVELLEIKDAAKPAK

Sequences:

>Translated_264_residues
MKSIFKVSLLAATVAFVVGCQKEEAPKTEATTLPAKIEASAEGATASTFASEDEKAGYAIGASLAKYLNSNLEKQTELGL
DLKKADVLAGVTDVFNGKERLTDEQIQGALQALDQRVAEIGKKKAAAESEANIKAGADYRAKFAKEDGVIKTESGLLYKV
LTPADGPKPKDTDTVVVHYTGTLIDGTKFDSSYDRKQPATFPLNAVIPGWTEGVQLMNVGSKYKFVVPAELGYGAQGNQA
IPANSTLVFDVELLEIKDAAKPAK
>Mature_264_residues
MKSIFKVSLLAATVAFVVGCQKEEAPKTEATTLPAKIEASAEGATASTFASEDEKAGYAIGASLAKYLNSNLEKQTELGL
DLKKADVLAGVTDVFNGKERLTDEQIQGALQALDQRVAEIGKKKAAAESEANIKAGADYRAKFAKEDGVIKTESGLLYKV
LTPADGPKPKDTDTVVVHYTGTLIDGTKFDSSYDRKQPATFPLNAVIPGWTEGVQLMNVGSKYKFVVPAELGYGAQGNQA
IPANSTLVFDVELLEIKDAAKPAK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=48.5981308411215, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=48.5981308411215, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI206725530, Length=93, Percent_Identity=49.4623655913978, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI17149844, Length=93, Percent_Identity=49.4623655913978, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI17149842, Length=93, Percent_Identity=49.4623655913978, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=43.9252336448598, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4503729, Length=92, Percent_Identity=47.8260869565217, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI224809329, Length=116, Percent_Identity=40.5172413793103, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI224809327, Length=116, Percent_Identity=40.5172413793103, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4758384, Length=116, Percent_Identity=40.5172413793103, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI8923659, Length=99, Percent_Identity=40.4040404040404, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI33469985, Length=92, Percent_Identity=42.3913043478261, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI224809331, Length=116, Percent_Identity=40.5172413793103, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1789745, Length=261, Percent_Identity=45.2107279693487, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI87082390, Length=215, Percent_Identity=41.8604651162791, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17540882, Length=92, Percent_Identity=47.8260869565217, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71993519, Length=92, Percent_Identity=51.0869565217391, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17561782, Length=91, Percent_Identity=47.2527472527472, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324194, Length=101, Percent_Identity=46.5346534653465, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320727, Length=92, Percent_Identity=51.0869565217391, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323566, Length=108, Percent_Identity=39.8148148148148, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323482, Length=107, Percent_Identity=38.3177570093458, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281363946, Length=96, Percent_Identity=54.1666666666667, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17352457, Length=96, Percent_Identity=54.1666666666667, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24655568, Length=101, Percent_Identity=49.5049504950495, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21356629, Length=94, Percent_Identity=51.063829787234, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=38.6792452830189, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28019; Mature: 28019

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIFKVSLLAATVAFVVGCQKEEAPKTEATTLPAKIEASAEGATASTFASEDEKAGYAI
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHCCCCCCCCHHH
GASLAKYLNSNLEKQTELGLDLKKADVLAGVTDVFNGKERLTDEQIQGALQALDQRVAEI
HHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHH
GKKKAAAESEANIKAGADYRAKFAKEDGVIKTESGLLYKVLTPADGPKPKDTDTVVVHYT
HHHHHCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCEEEEECCCCCCCCCCCCEEEEEEE
GTLIDGTKFDSSYDRKQPATFPLNAVIPGWTEGVQLMNVGSKYKFVVPAELGYGAQGNQA
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCEEEEECCCCEEEEEECCCCCCCCCCCC
IPANSTLVFDVELLEIKDAAKPAK
CCCCCEEEEEEEEEEECCCCCCCC
>Mature Secondary Structure
MKSIFKVSLLAATVAFVVGCQKEEAPKTEATTLPAKIEASAEGATASTFASEDEKAGYAI
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHCCCCCCCCHHH
GASLAKYLNSNLEKQTELGLDLKKADVLAGVTDVFNGKERLTDEQIQGALQALDQRVAEI
HHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHH
GKKKAAAESEANIKAGADYRAKFAKEDGVIKTESGLLYKVLTPADGPKPKDTDTVVVHYT
HHHHHCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCEEEEECCCCCCCCCCCCEEEEEEE
GTLIDGTKFDSSYDRKQPATFPLNAVIPGWTEGVQLMNVGSKYKFVVPAELGYGAQGNQA
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCEEEEECCCCEEEEEECCCCCCCCCCCC
IPANSTLVFDVELLEIKDAAKPAK
CCCCCEEEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]