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The map label for this gene is coaBC [H]

Identifier: 209693808

GI number: 209693808

Start: 232816

End: 234036

Strand: Direct

Name: coaBC [H]

Synonym: VSAL_I0193

Alternate gene names: 209693808

Gene position: 232816-234036 (Clockwise)

Preceding gene: 209693801

Following gene: 209693809

Centisome position: 7.0

GC content: 46.76

Gene sequence:

>1221_bases
ATGGCATCTCTCTCAGGAAAACGTATTCTTCTTGGTATTAGTGGCGGCATTGCTGCTTATAAATGTGCAGAGCTCACTCG
TCGACTTATCGAGCGCGGCGCTGAGGTTCGTGTTGTGATGACAACCGCAGCCAAAGAGTTTATTACCCCCCTGACAATGC
AAGCCGTCTCTGGGCACCCTGTTGCTGACAGTTTATTAGATCCTGCGGCAGAAGCGTCGATGGGACACATTGAATTAGCT
AAGTGGGCCGATATCGTATTACTGGCTCCTGCTACCGCCGATTTAATCGCAAGAATGGCTGCTGGCATGGGTAATGATTT
ATTAAGTACTTTAGTGCTTGCGACGGATTCTCCTATTGCGGTTTCCCCAGCGATGAATCAACAAATGTACGCCAATCTAG
CGACTCAAGAGAACATTGCGACGCTGACTCGTCGTGGTATGCATATTTGGGGTCCCGCTGCGGGTCAACAAGCTTGTGGT
GACGTTGGTATGGGCAGAATGCTTGAGCCAATGGAACTGGTGCATTTGTGTGAAGATTTTTTTCAACCAAAAGCACTAGA
AGGCCAGTCTTTATTAATCACGGCAGGTCCAACTCGTGAAGCACTTGATCCGGTTCGCTACATCTCAAATCACAGCTCAG
GAAAAATGGGGTTTGCGATTGCAGAAGCCGCCGCGCAACTAGGCGCAAAAGTCACCTTGATTAGTGGCCCTGTAAATTTG
GCTACTCCTGCTAATGTTGAGCGTATTGATATTGAAAGCGCAGAACAAATGCATAGTGCAGTGATGAGTAACGCGTCATC
TCATTCACTCTTTATTGCCTGTGCTGCGGTGGCTGATTTCAGACCAAGCCAAGTTGCCACTCAAAAAATGAAGAAAACCG
CCGATAATGACGGTATGACCATCACAATGGTGAAGAACCCTGATATTGTTGCATCCGTTGCTGCAATGACTGAACAACGA
CCATTTACGGTTGGTTTTGCTGCAGAAACGCAAGAGGTAGAAAAGTATGCTCGTGGTAAGTTAGAGCGTAAGAATCTAGA
TATGATCTGCGCTAATGATGTCTCAATTCAAGGACAAGGCTTTAATAGCGACAACAATGCGCTTCATCTGTATTGGAAAG
GCGGCGATAAAGCTTTACCGTTAACGGCGAAGTCAGAGTTGGGTAAGGCGATTATGTTGGAAATAGTTGAGAGACTAGAG
ACTATACGCTGCGCTAACTAG

Upstream 100 bases:

>100_bases
CTCATTTACTTGCATCAAGAGATTGAAGTGCATCACTCTGAAAAAAAATTATGATATGGTTAGCGCATTAATGGTGAATC
ACTTAAAGGTAAGTCGCGTC

Downstream 100 bases:

>100_bases
AGACTAGTAAGAGCAGGATTCAGGACACTTAGGTTTCAGGGTTCAAGAAAAGCACTAGAAACTATACGCTACGCTAACTA
GAAACTATACGCTACGCTAA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MASLSGKRILLGISGGIAAYKCAELTRRLIERGAEVRVVMTTAAKEFITPLTMQAVSGHPVADSLLDPAAEASMGHIELA
KWADIVLLAPATADLIARMAAGMGNDLLSTLVLATDSPIAVSPAMNQQMYANLATQENIATLTRRGMHIWGPAAGQQACG
DVGMGRMLEPMELVHLCEDFFQPKALEGQSLLITAGPTREALDPVRYISNHSSGKMGFAIAEAAAQLGAKVTLISGPVNL
ATPANVERIDIESAEQMHSAVMSNASSHSLFIACAAVADFRPSQVATQKMKKTADNDGMTITMVKNPDIVASVAAMTEQR
PFTVGFAAETQEVEKYARGKLERKNLDMICANDVSIQGQGFNSDNNALHLYWKGGDKALPLTAKSELGKAIMLEIVERLE
TIRCAN

Sequences:

>Translated_406_residues
MASLSGKRILLGISGGIAAYKCAELTRRLIERGAEVRVVMTTAAKEFITPLTMQAVSGHPVADSLLDPAAEASMGHIELA
KWADIVLLAPATADLIARMAAGMGNDLLSTLVLATDSPIAVSPAMNQQMYANLATQENIATLTRRGMHIWGPAAGQQACG
DVGMGRMLEPMELVHLCEDFFQPKALEGQSLLITAGPTREALDPVRYISNHSSGKMGFAIAEAAAQLGAKVTLISGPVNL
ATPANVERIDIESAEQMHSAVMSNASSHSLFIACAAVADFRPSQVATQKMKKTADNDGMTITMVKNPDIVASVAAMTEQR
PFTVGFAAETQEVEKYARGKLERKNLDMICANDVSIQGQGFNSDNNALHLYWKGGDKALPLTAKSELGKAIMLEIVERLE
TIRCAN
>Mature_405_residues
ASLSGKRILLGISGGIAAYKCAELTRRLIERGAEVRVVMTTAAKEFITPLTMQAVSGHPVADSLLDPAAEASMGHIELAK
WADIVLLAPATADLIARMAAGMGNDLLSTLVLATDSPIAVSPAMNQQMYANLATQENIATLTRRGMHIWGPAAGQQACGD
VGMGRMLEPMELVHLCEDFFQPKALEGQSLLITAGPTREALDPVRYISNHSSGKMGFAIAEAAAQLGAKVTLISGPVNLA
TPANVERIDIESAEQMHSAVMSNASSHSLFIACAAVADFRPSQVATQKMKKTADNDGMTITMVKNPDIVASVAAMTEQRP
FTVGFAAETQEVEKYARGKLERKNLDMICANDVSIQGQGFNSDNNALHLYWKGGDKALPLTAKSELGKAIMLEIVERLET
IRCAN

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=166, Percent_Identity=32.5301204819277, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI87082301, Length=400, Percent_Identity=64.5, Blast_Score=512, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17560194, Length=175, Percent_Identity=30.2857142857143, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322762, Length=189, Percent_Identity=30.1587301587302, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=29.9465240641711, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43235; Mature: 43104

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLSGKRILLGISGGIAAYKCAELTRRLIERGAEVRVVMTTAAKEFITPLTMQAVSGHP
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHCHHHHHHCCCCC
VADSLLDPAAEASMGHIELAKWADIVLLAPATADLIARMAAGMGNDLLSTLVLATDSPIA
CHHHHHCCHHHCCCCCEEHHCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
VSPAMNQQMYANLATQENIATLTRRGMHIWGPAAGQQACGDVGMGRMLEPMELVHLCEDF
ECCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHH
FQPKALEGQSLLITAGPTREALDPVRYISNHSSGKMGFAIAEAAAQLGAKVTLISGPVNL
CCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCC
ATPANVERIDIESAEQMHSAVMSNASSHSLFIACAAVADFRPSQVATQKMKKTADNDGMT
CCCCCCEEECCHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCCHHHHHHHHHHCCCCCCEE
ITMVKNPDIVASVAAMTEQRPFTVGFAAETQEVEKYARGKLERKNLDMICANDVSIQGQG
EEEECCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCCCCEEEECCCEEECCC
FNSDNNALHLYWKGGDKALPLTAKSELGKAIMLEIVERLETIRCAN
CCCCCCEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASLSGKRILLGISGGIAAYKCAELTRRLIERGAEVRVVMTTAAKEFITPLTMQAVSGHP
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHCHHHHHHCCCCC
VADSLLDPAAEASMGHIELAKWADIVLLAPATADLIARMAAGMGNDLLSTLVLATDSPIA
CHHHHHCCHHHCCCCCEEHHCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHCCCCCEE
VSPAMNQQMYANLATQENIATLTRRGMHIWGPAAGQQACGDVGMGRMLEPMELVHLCEDF
ECCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHH
FQPKALEGQSLLITAGPTREALDPVRYISNHSSGKMGFAIAEAAAQLGAKVTLISGPVNL
CCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCC
ATPANVERIDIESAEQMHSAVMSNASSHSLFIACAAVADFRPSQVATQKMKKTADNDGMT
CCCCCCEEECCHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCCHHHHHHHHHHCCCCCCEE
ITMVKNPDIVASVAAMTEQRPFTVGFAAETQEVEKYARGKLERKNLDMICANDVSIQGQG
EEEECCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCCCCEEEECCCEEECCC
FNSDNNALHLYWKGGDKALPLTAKSELGKAIMLEIVERLETIRCAN
CCCCCCEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA