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The map label for this gene is trxA [H]

Identifier: 209693768

GI number: 209693768

Start: 186733

End: 187059

Strand: Direct

Name: trxA [H]

Synonym: VSAL_I0147

Alternate gene names: 209693768

Gene position: 186733-187059 (Clockwise)

Preceding gene: 209693766

Following gene: 209693769

Centisome position: 5.62

GC content: 40.67

Gene sequence:

>327_bases
ATGAGCGACAAAATTTTGCAGCTTACAGATGACGGTTTTGAAGAAAGTGTTATCAATGCTTCAGGCCCAGTACTAGTAGA
TTTCTGGGCAGAATGGTGTGGTCCTTGTAAAATGATTGCTCCCATTCTGGATGAGATTGCAGATGAGTACGAAGGCAAAT
TAACGATTGGTAAATTAAATATCGATCAGAATGCAGGAACACCGCCAAAATTCGGTATCCGTGGCATTCCAACGCTGCTT
TTATTTAAAGATGGTGGCGTAGCTGCAACGAAAGTGGGTGCACTTTCTAAAACTCAACTTAAAGAGTTTCTTGATGCAAA
CCTATAA

Upstream 100 bases:

>100_bases
TCAGTTAAAGCTTGCAATACGAAACGGATTCCATTCAAATAGAGCATCAATTTGCTGGTTACCATGAAATCAGCCTTTAA
ATTTAACGTTGGAGTTGACG

Downstream 100 bases:

>100_bases
TATAGGGTGCAATTAAGTCAGATAGAACCGCATGTAATGAAAAATTATGTGCGGTTTTGTTTTTCTGAGCTAAGCTAAGC
TTAGAAATCAGGGCTAAGCC

Product: thioredoxin 1

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDKILQLTDDGFEESVINASGPVLVDFWAEWCGPCKMIAPILDEIADEYEGKLTIGKLNIDQNAGTPPKFGIRGIPTLL
LFKDGGVAATKVGALSKTQLKEFLDANL

Sequences:

>Translated_108_residues
MSDKILQLTDDGFEESVINASGPVLVDFWAEWCGPCKMIAPILDEIADEYEGKLTIGKLNIDQNAGTPPKFGIRGIPTLL
LFKDGGVAATKVGALSKTQLKEFLDANL
>Mature_107_residues
SDKILQLTDDGFEESVINASGPVLVDFWAEWCGPCKMIAPILDEIADEYEGKLTIGKLNIDQNAGTPPKFGIRGIPTLLL
FKDGGVAATKVGALSKTQLKEFLDANL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=36.9565217391304, Blast_Score=80, Evalue=3e-16,
Organism=Homo sapiens, GI21361657, Length=91, Percent_Identity=38.4615384615385, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI5031973, Length=85, Percent_Identity=31.7647058823529, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=81.4814814814815, Blast_Score=184, Evalue=1e-48,
Organism=Escherichia coli, GI1788936, Length=109, Percent_Identity=39.4495412844037, Blast_Score=89, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=38.7096774193548, Blast_Score=81, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=42.5287356321839, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=36.046511627907, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=42.2535211267606, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=88, Percent_Identity=35.2272727272727, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17549970, Length=115, Percent_Identity=32.1739130434783, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=82, Percent_Identity=37.8048780487805, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=79, Percent_Identity=39.2405063291139, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=101, Percent_Identity=37.6237623762376, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=86, Percent_Identity=38.3720930232558, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=86, Percent_Identity=38.3720930232558, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=86, Percent_Identity=38.3720930232558, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=93, Percent_Identity=39.7849462365591, Blast_Score=70, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=85, Percent_Identity=36.4705882352941, Blast_Score=67, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=34.020618556701, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639826, Length=87, Percent_Identity=36.7816091954023, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921434, Length=88, Percent_Identity=35.2272727272727, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=32.183908045977, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24639068, Length=103, Percent_Identity=29.126213592233, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17648013, Length=90, Percent_Identity=34.4444444444444, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583090, Length=90, Percent_Identity=34.4444444444444, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11639; Mature: 11507

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKILQLTDDGFEESVINASGPVLVDFWAEWCGPCKMIAPILDEIADEYEGKLTIGKLN
CCCCEEEECCCCCCHHCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEE
IDQNAGTPPKFGIRGIPTLLLFKDGGVAATKVGALSKTQLKEFLDANL
ECCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SDKILQLTDDGFEESVINASGPVLVDFWAEWCGPCKMIAPILDEIADEYEGKLTIGKLN
CCCEEEECCCCCCHHCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEE
IDQNAGTPPKFGIRGIPTLLLFKDGGVAATKVGALSKTQLKEFLDANL
ECCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]