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The map label for this gene is hmuU [H]

Identifier: 209554612

GI number: 209554612

Start: 491153

End: 492199

Strand: Reverse

Name: hmuU [H]

Synonym: UUR10_0442

Alternate gene names: 209554612

Gene position: 492199-491153 (Counterclockwise)

Preceding gene: 209554591

Following gene: 209554110

Centisome position: 56.28

GC content: 26.27

Gene sequence:

>1047_bases
ATGAAAACAAAATTTAATTTCTTTAAAAATAAACAAAATGTTATTGGACAAAAACAACTTTTAGAACTAAATAAGAAAAG
TTTTGTTCCCTATCGTTTTAAACCTTTGTTAACAACAATGATTTTATTAATTACTTTATTAATAATTATCATTCTCATCT
TTTCAGTTACATTAGCTAATGATTTAAACTTTAGTGAATTAGCAAAAATTATATGACAAGAAGTTGTGCAAATGATTATT
ACTGGGGCAGCATTGGGTGTGAGTAGTTATGTACTACAGCGTATCACACGAAATCGATTTGCTGATGTGTCCATAATGGG
AATTGGAACAATTAATTTAATTCTTTTATGTGCATTAAGTATTCCAATTGATTTTACAAGTGCAAATGAATTAAATATTT
TACAAAAAAAAGAACCATGAATTTTTATGTCCATGAGTTGTTGCTTGATGATTGTTTATTTTATAGTATCACGTCAAAAA
GAAAATTTTAATTATAAAAAACTAATTTTAATTGGTGTAATTTTAACTTTCTTTTTAGTAGCTATTGCACAAAGTATTCG
TGGTTGATTAAATTATCATGCTAATGATTATGTTATTGGTCACATCGTTGGAAGCGTGCAAAAAGCACCTTTAAATACAT
TAATTATTGCATCAAGTTTTGTAATTTTAGGTTTATTGTGATTATTATTTAATTCGTATAAATTAAATATTATTTCAACA
AACCAACAAGTTGCTAAACAATTAGGGATAAAAATTAATTTTCAAATTTTTGTAGCTTTAGTTTTTGTAGGTATAATGGT
TGGGGCAAGCTATTCAGTATCTGGTGATTTTGTTTATGTTGGTTTATTGGCTGGAAATGCAGCCATGCGAAAACGTAATA
ATAGTTTTTCATATGGAATATTAAATTCAGGTTTATATGGAATACTATCAACATTAATTACGTACTGAATTGGAATTTCA
TTGATTGGAATGGATGTTCATCACATTGGGGCAATATTACCTTTATTAATCGGACCATATTTCATTTATAAAGTTTTAAG
ATCATAA

Upstream 100 bases:

>100_bases
ATTTGATATTAACTTCTTTTCAGCGATTGCTGCTTTACCAGTTTTTGCATACATTTTTGTTTCAAAACAATATCGTAAGA
ATGTTGAATAAAAATAAATT

Downstream 100 bases:

>100_bases
TTAAACTTCTCTGTAATGGAGAAGTTTTTATTTTTGTGAATAAAAAACTTTTGATAAAAAGTATCAAAAGTTAATTATCT
AAATTTAATTATATAAAATT

Product: hemin permease

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MKTKFNFFKNKQNVIGQKQLLELNKKSFVPYRFKPLLTTMILLITLLIIIILIFSVTLANDLNFSELAKIIWQEVVQMII
TGAALGVSSYVLQRITRNRFADVSIMGIGTINLILLCALSIPIDFTSANELNILQKKEPWIFMSMSCCLMIVYFIVSRQK
ENFNYKKLILIGVILTFFLVAIAQSIRGWLNYHANDYVIGHIVGSVQKAPLNTLIIASSFVILGLLWLLFNSYKLNIIST
NQQVAKQLGIKINFQIFVALVFVGIMVGASYSVSGDFVYVGLLAGNAAMRKRNNSFSYGILNSGLYGILSTLITYWIGIS
LIGMDVHHIGAILPLLIGPYFIYKVLRS

Sequences:

>Translated_348_residues
MKTKFNFFKNKQNVIGQKQLLELNKKSFVPYRFKPLLTTMILLITLLIIIILIFSVTLANDLNFSELAKII*QEVVQMII
TGAALGVSSYVLQRITRNRFADVSIMGIGTINLILLCALSIPIDFTSANELNILQKKEP*IFMSMSCCLMIVYFIVSRQK
ENFNYKKLILIGVILTFFLVAIAQSIRG*LNYHANDYVIGHIVGSVQKAPLNTLIIASSFVILGLL*LLFNSYKLNIIST
NQQVAKQLGIKINFQIFVALVFVGIMVGASYSVSGDFVYVGLLAGNAAMRKRNNSFSYGILNSGLYGILSTLITY*IGIS
LIGMDVHHIGAILPLLIGPYFIYKVLRS
>Mature_348_residues
MKTKFNFFKNKQNVIGQKQLLELNKKSFVPYRFKPLLTTMILLITLLIIIILIFSVTLANDLNFSELAKII*QEVVQMII
TGAALGVSSYVLQRITRNRFADVSIMGIGTINLILLCALSIPIDFTSANELNILQKKEP*IFMSMSCCLMIVYFIVSRQK
ENFNYKKLILIGVILTFFLVAIAQSIRG*LNYHANDYVIGHIVGSVQKAPLNTLIIASSFVILGLL*LLFNSYKLNIIST
NQQVAKQLGIKINFQIFVALVFVGIMVGASYSVSGDFVYVGLLAGNAAMRKRNNSFSYGILNSGLYGILSTLITY*IGIS
LIGMDVHHIGAILPLLIGPYFIYKVLRS

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 38049; Mature: 38049

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKFNFFKNKQNVIGQKQLLELNKKSFVPYRFKPLLTTMILLITLLIIIILIFSVTLAN
CCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DLNFSELAKIIQEVVQMIITGAALGVSSYVLQRITRNRFADVSIMGIGTINLILLCALSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHC
PIDFTSANELNILQKKEPIFMSMSCCLMIVYFIVSRQKENFNYKKLILIGVILTFFLVAI
CCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AQSIRGLNYHANDYVIGHIVGSVQKAPLNTLIIASSFVILGLLLLFNSYKLNIISTNQQV
HHHHCCCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHH
AKQLGIKINFQIFVALVFVGIMVGASYSVSGDFVYVGLLAGNAAMRKRNNSFSYGILNSG
HHHHCCEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHCCCCCCCHHHHCC
LYGILSTLITYIGISLIGMDVHHIGAILPLLIGPYFIYKVLRS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKTKFNFFKNKQNVIGQKQLLELNKKSFVPYRFKPLLTTMILLITLLIIIILIFSVTLAN
CCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DLNFSELAKIIQEVVQMIITGAALGVSSYVLQRITRNRFADVSIMGIGTINLILLCALSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHC
PIDFTSANELNILQKKEPIFMSMSCCLMIVYFIVSRQKENFNYKKLILIGVILTFFLVAI
CCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AQSIRGLNYHANDYVIGHIVGSVQKAPLNTLIIASSFVILGLLLLFNSYKLNIISTNQQV
HHHHCCCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHH
AKQLGIKINFQIFVALVFVGIMVGASYSVSGDFVYVGLLAGNAAMRKRNNSFSYGILNSG
HHHHCCEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHCCCCCCCHHHHCC
LYGILSTLITYIGISLIGMDVHHIGAILPLLIGPYFIYKVLRS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]