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The map label for this gene is pyrH [H]

Identifier: 209554472

GI number: 209554472

Start: 715493

End: 716200

Strand: Reverse

Name: pyrH [H]

Synonym: UUR10_0596

Alternate gene names: 209554472

Gene position: 716200-715493 (Counterclockwise)

Preceding gene: 209554470

Following gene: 209554340

Centisome position: 81.9

GC content: 27.54

Gene sequence:

>708_bases
ATGTCAAAACAACGAATTGTAATTAAGATTTCTGGTGCTTGTTTAAGACAAGATGATAATTCGATAATTGATGTTAATAA
AATTAATGATTTAGCGAAACAAATTAAAGAAATTTCTAAAAAATATATTGTATCAATTGTTTTAGGTGGTGGCAATATTT
GACGTGGTCATATTGCTAAAGAATTAGGAATGAACCGTAATTTAGCTGATAATATGGGTATGATGGCAACCATTATTAAT
GGATTAGCATTAGAAAATGCCTTAAATAACTATAATGTAGATGCTATTGTTTTATCAGCAATTAAATGTGATAAATTAGT
CTATGAATCATCAGCTAATAATATTAAAAAAGCAATTGAAAAAGAACAAGTAATGATCTTTGTTGGTGGAACAGGTTTTC
CATACTTTACAACTGATTCATGTGCAGCAATTAAAGCAGCTGAAACAGAATCTAGTATAATTTTAATGGGTAAAAATGGT
GTTGATGGAGTTTATGATAGTGATCCAAAAACTAATCCTAATGCGCAATTTTATCAACATATTACATTTAATATGGCCCT
TACTAAAAATCTAAAAGTTATGGATGCAACAGCATTAGCTTTGTGTCAAGAAAACGATATCAACTTATTAGTTTTTAATA
TTGATAAACCAAATGCAATTGTGGATGTTTTAGAAAAAAAGATTAAACACACAATTGTTTCAAAATAA

Upstream 100 bases:

>100_bases
GAAAAAATAATTTCTTTGGACTATAATAATAGAAGGAAACTTAGTTTCTTTCTATTTTTATAGTGTGATTAAATGGTTTA
GTAAAAACGAAAGGAATTAT

Downstream 100 bases:

>100_bases
TTTTTTAAGGAGATTGTATGAATTTTAAAATTTATGAAACTAAAATCAGAGAAGAATTTGAATTAGTTTTAAAATGAATG
CATAATGAATTTATTAAATT

Product: UMP kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MSKQRIVIKISGACLRQDDNSIIDVNKINDLAKQIKEISKKYIVSIVLGGGNIWRGHIAKELGMNRNLADNMGMMATIIN
GLALENALNNYNVDAIVLSAIKCDKLVYESSANNIKKAIEKEQVMIFVGGTGFPYFTTDSCAAIKAAETESSIILMGKNG
VDGVYDSDPKTNPNAQFYQHITFNMALTKNLKVMDATALALCQENDINLLVFNIDKPNAIVDVLEKKIKHTIVSK

Sequences:

>Translated_235_residues
MSKQRIVIKISGACLRQDDNSIIDVNKINDLAKQIKEISKKYIVSIVLGGGNI*RGHIAKELGMNRNLADNMGMMATIIN
GLALENALNNYNVDAIVLSAIKCDKLVYESSANNIKKAIEKEQVMIFVGGTGFPYFTTDSCAAIKAAETESSIILMGKNG
VDGVYDSDPKTNPNAQFYQHITFNMALTKNLKVMDATALALCQENDINLLVFNIDKPNAIVDVLEKKIKHTIVSK
>Mature_234_residues
SKQRIVIKISGACLRQDDNSIIDVNKINDLAKQIKEISKKYIVSIVLGGGNI*RGHIAKELGMNRNLADNMGMMATIING
LALENALNNYNVDAIVLSAIKCDKLVYESSANNIKKAIEKEQVMIFVGGTGFPYFTTDSCAAIKAAETESSIILMGKNGV
DGVYDSDPKTNPNAQFYQHITFNMALTKNLKVMDATALALCQENDINLLVFNIDKPNAIVDVLEKKIKHTIVSK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=36.480686695279, Blast_Score=160, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25593; Mature: 25462

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQRIVIKISGACLRQDDNSIIDVNKINDLAKQIKEISKKYIVSIVLGGGNIRGHIAKE
CCCCEEEEEECCEEEECCCCCEEEHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHH
LGMNRNLADNMGMMATIINGLALENALNNYNVDAIVLSAIKCDKLVYESSANNIKKAIEK
HCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCHHEEEEHHHHHHHHHHCCHHHHHHHHCC
EQVMIFVGGTGFPYFTTDSCAAIKAAETESSIILMGKNGVDGVYDSDPKTNPNAQFYQHI
CEEEEEECCCCCCEEECCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEE
TFNMALTKNLKVMDATALALCQENDINLLVFNIDKPNAIVDVLEKKIKHTIVSK
EEEEEEECCCEEEHHHHHEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKQRIVIKISGACLRQDDNSIIDVNKINDLAKQIKEISKKYIVSIVLGGGNIRGHIAKE
CCCEEEEEECCEEEECCCCCEEEHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHH
LGMNRNLADNMGMMATIINGLALENALNNYNVDAIVLSAIKCDKLVYESSANNIKKAIEK
HCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCHHEEEEHHHHHHHHHHCCHHHHHHHHCC
EQVMIFVGGTGFPYFTTDSCAAIKAAETESSIILMGKNGVDGVYDSDPKTNPNAQFYQHI
CEEEEEECCCCCCEEECCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEE
TFNMALTKNLKVMDATALALCQENDINLLVFNIDKPNAIVDVLEKKIKHTIVSK
EEEEEEECCCEEEHHHHHEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11048724 [H]