Click here to switch to the map view.

The map label for this gene is hutU [H]

Identifier: 209551927

GI number: 209551927

Start: 4525339

End: 4527000

Strand: Reverse

Name: hutU [H]

Synonym: Rleg2_4360

Alternate gene names: 209551927

Gene position: 4527000-4525339 (Counterclockwise)

Preceding gene: 209551928

Following gene: 209551923

Centisome position: 99.76

GC content: 65.34

Gene sequence:

>1662_bases
ATGCCGAAGGCCAATCCACGCCATCCGAAATTTCCCATCCCCGGCGGGCCGGAGTTGCGTGCCAAGGGCTGGCGGCAGGA
GGCGCTGCTGCGCCTGCTCGAAAACGTGCTGTCCGTCGGCGAGGATCCCGACAATTTGATCGTCTATGCCGCGCTCGGCA
AGGCGGCGCGCAACTGGGCAGCGCACAAGGGCATCGTCAAGGCGCTGACCGAGATGGAGGAGGACCAGACCCTGCTCATC
CAGTCCGGCAAGCCGATCGGGCTGGTGCGGACCCACGCCAAAGCGCCGCTCGTCATCATGGCGAACTGCAATATCGTTGG
GCAATGGGCGAAAGCCGAGGTGTTCTACGAGCTGCAGCGCAAAGGACTGATCTGCTGGGGCGGACTGACAGCGGGCGCCT
GGCAATATATCGGCAGCCAGGGCGTCATCCAGGGGACCTACGAGATCTTCATGCGCATTGCCGAACGGCGCTTCGGCGGC
GATCTCGCCGGCCGCTTCGTGCTGACGGCCGGGCTTGGCGGCATGGGCGGGGCGCAGCCGCTCGCCGGTCGTATGGCGGG
GGCTGCCATCCTCTGTGTCGACATCGATCCGGAACGTGCCCGCAAGCGCCAGCAGATCGGTTATCTCCAGGAGATCGCGC
CCGATCTCGATAGCGCCCTTGAGATGATCGATGCGGCGGTGAAGGAGAAGCGGGCGCTGTCCGTCGGCCTCGTCGGCAAT
GCGGCCGAGGTCTATCCCGAGATTGCCCGCCGCGGCATCGTGCCCGATATCGTCACCGACCAGACCTCGGCCCACGACCT
CGTTTACGGCTATGTGCCGAAAGGCATGGACCTCGATCAGGTCAGAGGATTGCGCGACGACGGTCAGGGGCAATTGATGG
CGGCAAGCCGCGCCTCGATCGTCGAGCATGTGACGGCGATGCTGGAGTTCCAGAAGCGCGGCTCGGAGGTTTTCGACAAC
GGCAATCTCATCCGCACGCAGGCGAAAGAGGGTGGCGTCGCCAATGCTTTCGACATCCCGATCTTCACCGAAGCCTATCT
GAGACCGCTGTTTGCCCGGGCGATCGGGCCGTTCCGCTGGATGGCGCTGTCAGGCGAGGAAAGCGATATCGCCCGCATCG
ACGACCTGCTGCTCGAGATGTTTCCCGACAACAAAATCATCACCAACTGGATCCGGCTGGCGCGCGAGCACGTTCCCTTC
GAGGGGCTGCCGGCCCGCATTGCCTGGCTCGGCCACGGCGAGCGCACGATGCTGGCGCGGCGCGTCAACGCGCTGGTTGC
GAGCGGCGAACTGAAGGGCCCGGTCGCCTTCTCCCGCGACCATCTCGACGCCGGCGCCATGGCGCATCCGAATATCATGA
CCGAGCGGATGAAGGACGGTTCCGACGCGATCGCCGACTGGCCGCTGATCGATGCGATGATGCTCTGCTCGTCGATGGCC
GATCTCGTCGTCGTCCATTCCGGCGGCGGCGGCTATGCCGGCTACATGACGAGCTGCGGCGTCACCGTCGTCGCCGACGG
CACCGATGCCGCCGACGAGCGGCTCGACCACGCGCTGACCAACGACACCGCCCTCGGCGTCATGCGGTATGCCGATGCTG
GCTACGAGGAGGCGCTGGACGAGGTGGCGAAGAAGGACGTGCCCTATATCCGGCTGGATTGA

Upstream 100 bases:

>100_bases
TTCGGGGCCACCGACCGGGGTCGAGCCACAGGTCTCGACCCGTCCTTCGGACCCCCGCAGGGGAGAAGGGAAAAACAGAG
AACGAAGCGAGGAATCCACC

Downstream 100 bases:

>100_bases
GTCGGGCGGCCTGTATGGCCAAATCGAGGATCAATCGATCAGATTCGAAACTTCGATGAGATTGCCGTCGGGATCTCTGA
AATAGATCGAGCGCAGGCGC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MPKANPRHPKFPIPGGPELRAKGWRQEALLRLLENVLSVGEDPDNLIVYAALGKAARNWAAHKGIVKALTEMEEDQTLLI
QSGKPIGLVRTHAKAPLVIMANCNIVGQWAKAEVFYELQRKGLICWGGLTAGAWQYIGSQGVIQGTYEIFMRIAERRFGG
DLAGRFVLTAGLGGMGGAQPLAGRMAGAAILCVDIDPERARKRQQIGYLQEIAPDLDSALEMIDAAVKEKRALSVGLVGN
AAEVYPEIARRGIVPDIVTDQTSAHDLVYGYVPKGMDLDQVRGLRDDGQGQLMAASRASIVEHVTAMLEFQKRGSEVFDN
GNLIRTQAKEGGVANAFDIPIFTEAYLRPLFARAIGPFRWMALSGEESDIARIDDLLLEMFPDNKIITNWIRLAREHVPF
EGLPARIAWLGHGERTMLARRVNALVASGELKGPVAFSRDHLDAGAMAHPNIMTERMKDGSDAIADWPLIDAMMLCSSMA
DLVVVHSGGGGYAGYMTSCGVTVVADGTDAADERLDHALTNDTALGVMRYADAGYEEALDEVAKKDVPYIRLD

Sequences:

>Translated_553_residues
MPKANPRHPKFPIPGGPELRAKGWRQEALLRLLENVLSVGEDPDNLIVYAALGKAARNWAAHKGIVKALTEMEEDQTLLI
QSGKPIGLVRTHAKAPLVIMANCNIVGQWAKAEVFYELQRKGLICWGGLTAGAWQYIGSQGVIQGTYEIFMRIAERRFGG
DLAGRFVLTAGLGGMGGAQPLAGRMAGAAILCVDIDPERARKRQQIGYLQEIAPDLDSALEMIDAAVKEKRALSVGLVGN
AAEVYPEIARRGIVPDIVTDQTSAHDLVYGYVPKGMDLDQVRGLRDDGQGQLMAASRASIVEHVTAMLEFQKRGSEVFDN
GNLIRTQAKEGGVANAFDIPIFTEAYLRPLFARAIGPFRWMALSGEESDIARIDDLLLEMFPDNKIITNWIRLAREHVPF
EGLPARIAWLGHGERTMLARRVNALVASGELKGPVAFSRDHLDAGAMAHPNIMTERMKDGSDAIADWPLIDAMMLCSSMA
DLVVVHSGGGGYAGYMTSCGVTVVADGTDAADERLDHALTNDTALGVMRYADAGYEEALDEVAKKDVPYIRLD
>Mature_552_residues
PKANPRHPKFPIPGGPELRAKGWRQEALLRLLENVLSVGEDPDNLIVYAALGKAARNWAAHKGIVKALTEMEEDQTLLIQ
SGKPIGLVRTHAKAPLVIMANCNIVGQWAKAEVFYELQRKGLICWGGLTAGAWQYIGSQGVIQGTYEIFMRIAERRFGGD
LAGRFVLTAGLGGMGGAQPLAGRMAGAAILCVDIDPERARKRQQIGYLQEIAPDLDSALEMIDAAVKEKRALSVGLVGNA
AEVYPEIARRGIVPDIVTDQTSAHDLVYGYVPKGMDLDQVRGLRDDGQGQLMAASRASIVEHVTAMLEFQKRGSEVFDNG
NLIRTQAKEGGVANAFDIPIFTEAYLRPLFARAIGPFRWMALSGEESDIARIDDLLLEMFPDNKIITNWIRLAREHVPFE
GLPARIAWLGHGERTMLARRVNALVASGELKGPVAFSRDHLDAGAMAHPNIMTERMKDGSDAIADWPLIDAMMLCSSMAD
LVVVHSGGGGYAGYMTSCGVTVVADGTDAADERLDHALTNDTALGVMRYADAGYEEALDEVAKKDVPYIRLD

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=547, Percent_Identity=28.7020109689214, Blast_Score=225, Evalue=1e-58,
Organism=Homo sapiens, GI260306182, Length=213, Percent_Identity=31.924882629108, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71997891, Length=578, Percent_Identity=27.8546712802768, Blast_Score=223, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60068; Mature: 59937

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKANPRHPKFPIPGGPELRAKGWRQEALLRLLENVLSVGEDPDNLIVYAALGKAARNWA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHH
AHKGIVKALTEMEEDQTLLIQSGKPIGLVRTHAKAPLVIMANCNIVGQWAKAEVFYELQR
HHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCEEECHHHHHHHHHHHH
KGLICWGGLTAGAWQYIGSQGVIQGTYEIFMRIAERRFGGDLAGRFVLTAGLGGMGGAQP
CCEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHCCEEEEECCCCCCCCCC
LAGRMAGAAILCVDIDPERARKRQQIGYLQEIAPDLDSALEMIDAAVKEKRALSVGLVGN
HHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEECCC
AAEVYPEIARRGIVPDIVTDQTSAHDLVYGYVPKGMDLDQVRGLRDDGQGQLMAASRASI
HHHHHHHHHHCCCCCCHHCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCEEHHHHHHH
VEHVTAMLEFQKRGSEVFDNGNLIRTQAKEGGVANAFDIPIFTEAYLRPLFARAIGPFRW
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHCCCEEE
MALSGEESDIARIDDLLLEMFPDNKIITNWIRLAREHVPFEGLPARIAWLGHGERTMLAR
EEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHH
RVNALVASGELKGPVAFSRDHLDAGAMAHPNIMTERMKDGSDAIADWPLIDAMMLCSSMA
HHHHHHHCCCCCCCCEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCC
DLVVVHSGGGGYAGYMTSCGVTVVADGTDAADERLDHALTNDTALGVMRYADAGYEEALD
CEEEEECCCCCCCHHHHHCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHH
EVAKKDVPYIRLD
HHHHCCCCEEEEC
>Mature Secondary Structure 
PKANPRHPKFPIPGGPELRAKGWRQEALLRLLENVLSVGEDPDNLIVYAALGKAARNWA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHH
AHKGIVKALTEMEEDQTLLIQSGKPIGLVRTHAKAPLVIMANCNIVGQWAKAEVFYELQR
HHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCEEECHHHHHHHHHHHH
KGLICWGGLTAGAWQYIGSQGVIQGTYEIFMRIAERRFGGDLAGRFVLTAGLGGMGGAQP
CCEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHCCEEEEECCCCCCCCCC
LAGRMAGAAILCVDIDPERARKRQQIGYLQEIAPDLDSALEMIDAAVKEKRALSVGLVGN
HHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEECCC
AAEVYPEIARRGIVPDIVTDQTSAHDLVYGYVPKGMDLDQVRGLRDDGQGQLMAASRASI
HHHHHHHHHHCCCCCCHHCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCEEHHHHHHH
VEHVTAMLEFQKRGSEVFDNGNLIRTQAKEGGVANAFDIPIFTEAYLRPLFARAIGPFRW
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHCCCEEE
MALSGEESDIARIDDLLLEMFPDNKIITNWIRLAREHVPFEGLPARIAWLGHGERTMLAR
EEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHH
RVNALVASGELKGPVAFSRDHLDAGAMAHPNIMTERMKDGSDAIADWPLIDAMMLCSSMA
HHHHHHHCCCCCCCCEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCC
DLVVVHSGGGGYAGYMTSCGVTVVADGTDAADERLDHALTNDTALGVMRYADAGYEEALD
CEEEEECCCCCCCHHHHHCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHH
EVAKKDVPYIRLD
HHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]