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The map label for this gene is guaA [H]

Identifier: 209551875

GI number: 209551875

Start: 4473630

End: 4475192

Strand: Reverse

Name: guaA [H]

Synonym: Rleg2_4308

Alternate gene names: 209551875

Gene position: 4475192-4473630 (Counterclockwise)

Preceding gene: 209551876

Following gene: 209551871

Centisome position: 98.62

GC content: 64.24

Gene sequence:

>1563_bases
ATGACCCAGACAGCACATCCCGACTCCGTTCTCATCGTCGATTTCGGCAGCCAGGTGACCCAGCTCATCGCACGACGCGT
GCGCGAGGCCGGCGTCTATTGCGAGATCGTTCCCTTCCAATCGGCCGAAGAGGGCTTCAACCGCCTCCAGCCGAAAGCCG
TGATCCTGTCCGGCAGCCCGGCCTCCACGGTCGACGAGGGATCGCCGCGAGCGCCGCAGATCGTCTTCGACAGCGGCCTG
CCGGTCTTCGGCATCTGCTATGGCCAGCAGACGATGTGCATGCAGCTCGGCGGCAAGGTCGAGAGCGGCCATCACCGCGA
ATTCGGCCGCGCCTTTCTCGACGTCGACAAGGACTGCCAGCTGTTCGAGGGCCTCTGGTCCTCCGGCTCGCGCCATCAGG
TATGGATGAGCCATGGCGACCGCGTCACCGCGCTGCCTGACGGTTTCGAGGTGGTCGCCACCTCCTCCAACGCGCCCTAC
GCCTTCATCGCCGACGAGAAGCGCAAATATTACGGCGTGCAGTTCCACCCCGAGGTCGTGCACACGCCCGACGGCGCCAA
GCTGATCGGCAACTTCATTCATAACATCGCCGGCATCAAGGGCGACTGGTCGATGTCGGCCTATCGCCAGAAGGCGGTCG
ACGAAATCCGCAAGCAGGTGGGCGACAAGCGCGTCATCTGCGCGCTTTCGGGCGGCGTCGACAGTTCGGTCGCCGCGCTG
CTGATCCATGAGGCGGTCGGCGACCAGCTGACCTGCATCCTCGTCGACCACGGCCTCATGCGCAAGGACGAAGCGGCCAA
CGTCGTCGCTATGTTCCGCGAGCATTACAATCTGCATCTCTTGCATGTCGACGCTTCCGACCGTTTCATCGGCGAGCTCG
AAGGCGTCAGCGATCCGGAAACCAAGCGCAAGATCATCGGCCGGCTGTTCATCGAAACCTTCGAGGAAGAGGCAAAGAAA
CTCGGCGGCGCCGATTTCCTCGGCCAGGGCACGCTCTATCCCGACGTGATCGAGAGCGTTTCCTTCACCGGCGGCCCGTC
GGTGACGATCAAGTCGCACCACAATGTCGGCGGCCTGCCGGAGCGCATGAAGATGCAGCTCGTCGAGCCGCTGCGCGAAC
TCTTCAAGGACGAGGTGCGCGCGCTCGGCCGCGAACTCGGCCTGCCCGACAGCTTCATCGGCCGCCACCCCTTCCCCGGC
CCGGGCCTTGCGATCCGCTGCCCCGGCGGCATCAGCCGCGAAAAGCTGGAAATCCTGCGCGAAGCCGATGCGATCTATCT
CGACGAAATCCGCAAGGCCGGCCTCTACGATGCCATCTGGCAAGCCTTCGCCGTGCTGCTGCCCGTCCAGACCGTCGGCG
TCATGGGCGACGGACGCACCTACGAATTCGTCTGCGCACTGCGCGCCGTCACCTCCGTCGACGGCATGACCGCGGATTTC
TACCATTACGACATGGAATTCCTCGGCCGCGCCGCCACCCGCATCATCAACGAAGTGCGTGGTATCAACCGCGTAGTCTA
CGACGTCACCTCGAAGCCGCCCGGCACGATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
CGCGTCTTTCAGACGCGCGAGGGACAATCGGAACAATAAAAACCCGACGCCGCCGATTTCCCGGATTGCAAGGCGGAGCG
CTTTTCATTAAAGCCTCGCC

Downstream 100 bases:

>100_bases
TTTTGGCCTATCCGAACGCCGCCGATATCGCGCCAAAAACTAATAACGCACTGAAAGAACAATAAATCATCTGCCGTCTA
TCGCGGGGCAAGGCTCGGGA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MTQTAHPDSVLIVDFGSQVTQLIARRVREAGVYCEIVPFQSAEEGFNRLQPKAVILSGSPASTVDEGSPRAPQIVFDSGL
PVFGICYGQQTMCMQLGGKVESGHHREFGRAFLDVDKDCQLFEGLWSSGSRHQVWMSHGDRVTALPDGFEVVATSSNAPY
AFIADEKRKYYGVQFHPEVVHTPDGAKLIGNFIHNIAGIKGDWSMSAYRQKAVDEIRKQVGDKRVICALSGGVDSSVAAL
LIHEAVGDQLTCILVDHGLMRKDEAANVVAMFREHYNLHLLHVDASDRFIGELEGVSDPETKRKIIGRLFIETFEEEAKK
LGGADFLGQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMKMQLVEPLRELFKDEVRALGRELGLPDSFIGRHPFPG
PGLAIRCPGGISREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
YHYDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE

Sequences:

>Translated_520_residues
MTQTAHPDSVLIVDFGSQVTQLIARRVREAGVYCEIVPFQSAEEGFNRLQPKAVILSGSPASTVDEGSPRAPQIVFDSGL
PVFGICYGQQTMCMQLGGKVESGHHREFGRAFLDVDKDCQLFEGLWSSGSRHQVWMSHGDRVTALPDGFEVVATSSNAPY
AFIADEKRKYYGVQFHPEVVHTPDGAKLIGNFIHNIAGIKGDWSMSAYRQKAVDEIRKQVGDKRVICALSGGVDSSVAAL
LIHEAVGDQLTCILVDHGLMRKDEAANVVAMFREHYNLHLLHVDASDRFIGELEGVSDPETKRKIIGRLFIETFEEEAKK
LGGADFLGQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMKMQLVEPLRELFKDEVRALGRELGLPDSFIGRHPFPG
PGLAIRCPGGISREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
YHYDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
>Mature_519_residues
TQTAHPDSVLIVDFGSQVTQLIARRVREAGVYCEIVPFQSAEEGFNRLQPKAVILSGSPASTVDEGSPRAPQIVFDSGLP
VFGICYGQQTMCMQLGGKVESGHHREFGRAFLDVDKDCQLFEGLWSSGSRHQVWMSHGDRVTALPDGFEVVATSSNAPYA
FIADEKRKYYGVQFHPEVVHTPDGAKLIGNFIHNIAGIKGDWSMSAYRQKAVDEIRKQVGDKRVICALSGGVDSSVAALL
IHEAVGDQLTCILVDHGLMRKDEAANVVAMFREHYNLHLLHVDASDRFIGELEGVSDPETKRKIIGRLFIETFEEEAKKL
GGADFLGQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMKMQLVEPLRELFKDEVRALGRELGLPDSFIGRHPFPGP
GLAIRCPGGISREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADFY
HYDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=555, Percent_Identity=35.4954954954955, Blast_Score=294, Evalue=2e-79,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=54.8571428571429, Blast_Score=604, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI71992717, Length=571, Percent_Identity=36.077057793345, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71992710, Length=571, Percent_Identity=36.077057793345, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI133901714, Length=571, Percent_Identity=36.077057793345, Blast_Score=284, Evalue=8e-77,
Organism=Saccharomyces cerevisiae, GI6323873, Length=522, Percent_Identity=51.9157088122605, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI281365319, Length=549, Percent_Identity=32.2404371584699, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57323; Mature: 57192

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTAHPDSVLIVDFGSQVTQLIARRVREAGVYCEIVPFQSAEEGFNRLQPKAVILSGSP
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEECCC
ASTVDEGSPRAPQIVFDSGLPVFGICYGQQTMCMQLGGKVESGHHREFGRAFLDVDKDCQ
CCCCCCCCCCCCEEEEECCCCEEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHH
LFEGLWSSGSRHQVWMSHGDRVTALPDGFEVVATSSNAPYAFIADEKRKYYGVQFHPEVV
HHHHHHCCCCCEEEEECCCCEEEECCCCCEEEEECCCCCEEEEECCCCCEECEEECCCEE
HTPDGAKLIGNFIHNIAGIKGDWSMSAYRQKAVDEIRKQVGDKRVICALSGGVDSSVAAL
ECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHH
LIHEAVGDQLTCILVDHGLMRKDEAANVVAMFREHYNLHLLHVDASDRFIGELEGVSDPE
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCH
TKRKIIGRLFIETFEEEAKKLGGADFLGQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCH
ERMKMQLVEPLRELFKDEVRALGRELGLPDSFIGRHPFPGPGLAIRCPGGISREKLEILR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
EADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
HCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCEEHH
YHYDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TQTAHPDSVLIVDFGSQVTQLIARRVREAGVYCEIVPFQSAEEGFNRLQPKAVILSGSP
CCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCEEEEECCC
ASTVDEGSPRAPQIVFDSGLPVFGICYGQQTMCMQLGGKVESGHHREFGRAFLDVDKDCQ
CCCCCCCCCCCCEEEEECCCCEEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHH
LFEGLWSSGSRHQVWMSHGDRVTALPDGFEVVATSSNAPYAFIADEKRKYYGVQFHPEVV
HHHHHHCCCCCEEEEECCCCEEEECCCCCEEEEECCCCCEEEEECCCCCEECEEECCCEE
HTPDGAKLIGNFIHNIAGIKGDWSMSAYRQKAVDEIRKQVGDKRVICALSGGVDSSVAAL
ECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHH
LIHEAVGDQLTCILVDHGLMRKDEAANVVAMFREHYNLHLLHVDASDRFIGELEGVSDPE
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCH
TKRKIIGRLFIETFEEEAKKLGGADFLGQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCH
ERMKMQLVEPLRELFKDEVRALGRELGLPDSFIGRHPFPGPGLAIRCPGGISREKLEILR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
EADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
HCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCEEHH
YHYDMEFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA