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The map label for this gene is ghrA [H]

Identifier: 209551707

GI number: 209551707

Start: 4317904

End: 4318863

Strand: Direct

Name: ghrA [H]

Synonym: Rleg2_4136

Alternate gene names: 209551707

Gene position: 4317904-4318863 (Clockwise)

Preceding gene: 209551706

Following gene: 209551708

Centisome position: 95.15

GC content: 62.71

Gene sequence:

>960_bases
ATGCCGACACTTCCTCCCGTTCTCGTCGATATCAAGTTCAATCCCGAAGGCGTTGCCCGCGCGCTGGAGACGGCCTTTTC
CGATCGCGGCAGCATCAATCTCGCAAACCCTGCCGATCGGGGGCGTGATCTCAGCGAAGCAGAATATGCGCTGCTCTGGA
AGCCTGATGCCGACCTTTTCGCTCGGGCGCCGAAGCTCAAGGTGATCTTCTCGGGCGGCGCCGGCGTCGACCACATCATC
GGCATGAACGGCCTGCCCGAGATCCCGATCGTCCGTTTCGTCGACCGCAGCCTGACGACCCGCATGAGCGAATGGGTGGT
CATGCAATGCCTGATGCATCTGCGCGGGCAGTACGCCCATGACAGCCACCAGCGGCAGCGCCAATGGGCCAAGCTGATCG
CGCCTGAGGCGGCGGAGGTCACGGTCGGCGTCATGGGCCTCGGCATTCTCGGGCTGGATGCGGTCGCCAAGCTGAAGGTC
ATGGGGTTTAACGTTATCGGCTGGTCGCGCACTCGCAAGGAGATCGACGGCGTCGAAACCTTCGATGCCGGCGCCTTGGA
TAGCTTCCTCGGGAAGACCGACATCCTGGTCGGCCTCCTGCCGCTGACCCCTGAGACGACAGGCTTTTATGATAGCGGGC
TATTTAAGAAGCTGCGTCGCAACGGCGCGCTCGGGCGCCCAGTCTTCATCAATGCCGGCCGCGGCAAAAGCCAGGTCGAA
GCCGATATCGTTTCTTCAATCCGCGACGGCACCCTCGGCGGCGCTTCCCTCGATGTCTTCGAGGCGGAGCCGCTTGGTTC
AGACAACCCGCTGTGGGAACTGGAAAACGTCTTCATCACGCCGCACGACGCGGCGGTTTCGGAAGAAAACGCGCTGTTCC
GTCACGTCGAGACGCAAATCGCCCGTTTCGAGCGCGGCGAGCCGCTGCAATTCCTGGTCGACCGCGCCGTCGGCTATTAG

Upstream 100 bases:

>100_bases
TCTTCCGCGCTCCGAAGGACGAATACACCAGGGCGCTGATGGCGGCCGCCTTCAACATCGAGGCGGTGCCGACATCCGCC
GTGCAGCAGTAAAGATCATC

Downstream 100 bases:

>100_bases
AGCATGTCAGGCAAAACTGTGCCGCGGGTATGCGACAACGACATGCGTACAAACAAAGGGCTGAAGCGCTAAGAGCGAAT
CTGAACGATCGCGACGCGCT

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding subunit

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MPTLPPVLVDIKFNPEGVARALETAFSDRGSINLANPADRGRDLSEAEYALLWKPDADLFARAPKLKVIFSGGAGVDHII
GMNGLPEIPIVRFVDRSLTTRMSEWVVMQCLMHLRGQYAHDSHQRQRQWAKLIAPEAAEVTVGVMGLGILGLDAVAKLKV
MGFNVIGWSRTRKEIDGVETFDAGALDSFLGKTDILVGLLPLTPETTGFYDSGLFKKLRRNGALGRPVFINAGRGKSQVE
ADIVSSIRDGTLGGASLDVFEAEPLGSDNPLWELENVFITPHDAAVSEENALFRHVETQIARFERGEPLQFLVDRAVGY

Sequences:

>Translated_319_residues
MPTLPPVLVDIKFNPEGVARALETAFSDRGSINLANPADRGRDLSEAEYALLWKPDADLFARAPKLKVIFSGGAGVDHII
GMNGLPEIPIVRFVDRSLTTRMSEWVVMQCLMHLRGQYAHDSHQRQRQWAKLIAPEAAEVTVGVMGLGILGLDAVAKLKV
MGFNVIGWSRTRKEIDGVETFDAGALDSFLGKTDILVGLLPLTPETTGFYDSGLFKKLRRNGALGRPVFINAGRGKSQVE
ADIVSSIRDGTLGGASLDVFEAEPLGSDNPLWELENVFITPHDAAVSEENALFRHVETQIARFERGEPLQFLVDRAVGY
>Mature_318_residues
PTLPPVLVDIKFNPEGVARALETAFSDRGSINLANPADRGRDLSEAEYALLWKPDADLFARAPKLKVIFSGGAGVDHIIG
MNGLPEIPIVRFVDRSLTTRMSEWVVMQCLMHLRGQYAHDSHQRQRQWAKLIAPEAAEVTVGVMGLGILGLDAVAKLKVM
GFNVIGWSRTRKEIDGVETFDAGALDSFLGKTDILVGLLPLTPETTGFYDSGLFKKLRRNGALGRPVFINAGRGKSQVEA
DIVSSIRDGTLGGASLDVFEAEPLGSDNPLWELENVFITPHDAAVSEENALFRHVETQIARFERGEPLQFLVDRAVGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=264, Percent_Identity=26.5151515151515, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI23308577, Length=266, Percent_Identity=23.6842105263158, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081824, Length=285, Percent_Identity=36.140350877193, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI87082289, Length=170, Percent_Identity=32.9411764705882, Blast_Score=92, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17532191, Length=269, Percent_Identity=26.3940520446097, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI28574286, Length=257, Percent_Identity=29.1828793774319, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45551003, Length=240, Percent_Identity=27.0833333333333, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45552429, Length=240, Percent_Identity=27.0833333333333, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574284, Length=240, Percent_Identity=27.0833333333333, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585514, Length=240, Percent_Identity=27.0833333333333, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574282, Length=240, Percent_Identity=27.0833333333333, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585516, Length=158, Percent_Identity=29.746835443038, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34892; Mature: 34761

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLPPVLVDIKFNPEGVARALETAFSDRGSINLANPADRGRDLSEAEYALLWKPDADLF
CCCCCCEEEEEEECHHHHHHHHHHHHCCCCCEEECCCHHHCCCCCCCCEEEEECCCHHHH
ARAPKLKVIFSGGAGVDHIIGMNGLPEIPIVRFVDRSLTTRMSEWVVMQCLMHLRGQYAH
HCCCCEEEEEECCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DSHQRQRQWAKLIAPEAAEVTVGVMGLGILGLDAVAKLKVMGFNVIGWSRTRKEIDGVET
CHHHHHHHHHHHHCCCHHHEEEHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHCCCCC
FDAGALDSFLGKTDILVGLLPLTPETTGFYDSGLFKKLRRNGALGRPVFINAGRGKSQVE
CCCCHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHHH
ADIVSSIRDGTLGGASLDVFEAEPLGSDNPLWELENVFITPHDAAVSEENALFRHVETQI
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEECEEEECCCCCCCCCHHHHHHHHHHHH
ARFERGEPLQFLVDRAVGY
HHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PTLPPVLVDIKFNPEGVARALETAFSDRGSINLANPADRGRDLSEAEYALLWKPDADLF
CCCCCEEEEEEECHHHHHHHHHHHHCCCCCEEECCCHHHCCCCCCCCEEEEECCCHHHH
ARAPKLKVIFSGGAGVDHIIGMNGLPEIPIVRFVDRSLTTRMSEWVVMQCLMHLRGQYAH
HCCCCEEEEEECCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DSHQRQRQWAKLIAPEAAEVTVGVMGLGILGLDAVAKLKVMGFNVIGWSRTRKEIDGVET
CHHHHHHHHHHHHCCCHHHEEEHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHCCCCC
FDAGALDSFLGKTDILVGLLPLTPETTGFYDSGLFKKLRRNGALGRPVFINAGRGKSQVE
CCCCHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHHH
ADIVSSIRDGTLGGASLDVFEAEPLGSDNPLWELENVFITPHDAAVSEENALFRHVETQI
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEECEEEECCCCCCCCCHHHHHHHHHHHH
ARFERGEPLQFLVDRAVGY
HHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA