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The map label for this gene is gyaR [H]

Identifier: 209551660

GI number: 209551660

Start: 4263406

End: 4264407

Strand: Direct

Name: gyaR [H]

Synonym: Rleg2_4089

Alternate gene names: 209551660

Gene position: 4263406-4264407 (Clockwise)

Preceding gene: 209551658

Following gene: 209551664

Centisome position: 93.95

GC content: 64.67

Gene sequence:

>1002_bases
ATGACAGCGAAGAAAAAACCGAAGGTCTATATCACCCGCAAGCTGCCCGATGCCGTCGAAACGCGCATGCGCGAGCTGTT
CGACGCCGAGCTGAACATCGACGACGCGCCGCGCTCCGTGCCCGAGCTGATCGCCGCCGTCAGGACCGCCGACGTGCTGG
TGCCGACCGTCACCGATCGCATCGATGCGGCGCTGATCGATGAGGCGGGGCCGCAGATGAAGCTGATTGCGAGCTTCTCC
AACGGCACCGACCATATCGACGTCGAGGCGGCGGCGCGCAAGGGCATCACCGTCACCAACACGCCGAACGTCCTAACCGA
GGATACCGCCGATATGACCATGGCGCTCATTCTCGCGGTTCCGAGACGGCTCGGCGAAGGCGCGCGCGTGCTCACCGACA
AGCCCGGCGAATGGGCCGGCTGGTCTCCGACCTGGATGCTCGGCCGGCGTATTCACGGCAAACGCATCGGCATCGTCGGC
ATGGGCCGCATCGGCACTGCGGTCGCCCGCCGCGCCAAGGCTTTCGGCCTGTCGATCCACTACCACAACCGCAAGCGCGT
CAATCCGGCCGTCGAGGACGAGTTGGAAGCGACCTATTGGGAAAGCCTCGACCAGATGCTCGCCCGCGTCGACATCGTTT
CGGTCAATTGCCCGTCGACGCCGGCAACCTTCCACCTGATTTCGGCGCGCCGGCTGGCGCTGCTGCAGCCGACGGCCTAT
CTCGTCAATACCGCGCGCGGCGACGTCGTCGATGAAGCTGCGCTGATCAAGGCTCTGAGGGAGGGTCGGATCGCCGGCGC
CGGCCTCGACGTCTTCGAAAACGAGCCTGCCGTCAATCCGAAGCTCGTCAAGCTCGCCAATGAGGGCAAGGTCGTGCTGT
TGCCGCATATGAGTTCGGCGACGATCGAGGGCCGCATCGACATGGGTGATAAGGTCATCATCAATATCCGCACCTTCATC
GACGGTCACAGGCCGCCGAACCGGGTGCTGCCCGGCCGCTAA

Upstream 100 bases:

>100_bases
TTTGTTTGTCTTCGCGTGCGGGTCTGGTAGAAAATGCCCGGATGGGAAAATTATCACCCCTCTTGGTTAAAGACCTCTGA
ACAAGGCACCACAGCCAGCC

Downstream 100 bases:

>100_bases
AGCCGAACTGGAGTCAGGCGACCTCGATCTGAGGCGCAAGGGTCTTGCGCATCTCGACGAAGGTCGTCCTGGCAAAGCCC
GGATGCGCCTTCTCGGCGGT

Product: glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MTAKKKPKVYITRKLPDAVETRMRELFDAELNIDDAPRSVPELIAAVRTADVLVPTVTDRIDAALIDEAGPQMKLIASFS
NGTDHIDVEAAARKGITVTNTPNVLTEDTADMTMALILAVPRRLGEGARVLTDKPGEWAGWSPTWMLGRRIHGKRIGIVG
MGRIGTAVARRAKAFGLSIHYHNRKRVNPAVEDELEATYWESLDQMLARVDIVSVNCPSTPATFHLISARRLALLQPTAY
LVNTARGDVVDEAALIKALREGRIAGAGLDVFENEPAVNPKLVKLANEGKVVLLPHMSSATIEGRIDMGDKVIINIRTFI
DGHRPPNRVLPGR

Sequences:

>Translated_333_residues
MTAKKKPKVYITRKLPDAVETRMRELFDAELNIDDAPRSVPELIAAVRTADVLVPTVTDRIDAALIDEAGPQMKLIASFS
NGTDHIDVEAAARKGITVTNTPNVLTEDTADMTMALILAVPRRLGEGARVLTDKPGEWAGWSPTWMLGRRIHGKRIGIVG
MGRIGTAVARRAKAFGLSIHYHNRKRVNPAVEDELEATYWESLDQMLARVDIVSVNCPSTPATFHLISARRLALLQPTAY
LVNTARGDVVDEAALIKALREGRIAGAGLDVFENEPAVNPKLVKLANEGKVVLLPHMSSATIEGRIDMGDKVIINIRTFI
DGHRPPNRVLPGR
>Mature_332_residues
TAKKKPKVYITRKLPDAVETRMRELFDAELNIDDAPRSVPELIAAVRTADVLVPTVTDRIDAALIDEAGPQMKLIASFSN
GTDHIDVEAAARKGITVTNTPNVLTEDTADMTMALILAVPRRLGEGARVLTDKPGEWAGWSPTWMLGRRIHGKRIGIVGM
GRIGTAVARRAKAFGLSIHYHNRKRVNPAVEDELEATYWESLDQMLARVDIVSVNCPSTPATFHLISARRLALLQPTAYL
VNTARGDVVDEAALIKALREGRIAGAGLDVFENEPAVNPKLVKLANEGKVVLLPHMSSATIEGRIDMGDKVIINIRTFID
GHRPPNRVLPGR

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=325, Percent_Identity=34.4615384615385, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI23308577, Length=288, Percent_Identity=30.9027777777778, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI61743967, Length=261, Percent_Identity=35.632183908046, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI4557497, Length=261, Percent_Identity=35.632183908046, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI145580578, Length=264, Percent_Identity=35.2272727272727, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI4557499, Length=264, Percent_Identity=35.2272727272727, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI145580575, Length=264, Percent_Identity=35.2272727272727, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI87082289, Length=329, Percent_Identity=38.9057750759878, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1789279, Length=249, Percent_Identity=30.9236947791165, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787645, Length=336, Percent_Identity=24.1071428571429, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788660, Length=321, Percent_Identity=25.8566978193146, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87081824, Length=289, Percent_Identity=26.643598615917, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=284, Percent_Identity=30.6338028169014, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25147481, Length=268, Percent_Identity=31.7164179104478, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=304, Percent_Identity=35.1973684210526, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6322116, Length=323, Percent_Identity=28.4829721362229, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320925, Length=294, Percent_Identity=29.2517006802721, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6324964, Length=279, Percent_Identity=30.1075268817204, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=259, Percent_Identity=29.3436293436293, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=176, Percent_Identity=31.8181818181818, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=153, Percent_Identity=30.718954248366, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28571528, Length=324, Percent_Identity=38.8888888888889, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28574284, Length=311, Percent_Identity=34.4051446945338, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24585514, Length=310, Percent_Identity=34.1935483870968, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28574282, Length=310, Percent_Identity=34.1935483870968, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45551003, Length=310, Percent_Identity=34.1935483870968, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45552429, Length=310, Percent_Identity=34.1935483870968, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28574286, Length=312, Percent_Identity=34.6153846153846, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24646446, Length=260, Percent_Identity=35, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24646448, Length=260, Percent_Identity=35, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24646452, Length=260, Percent_Identity=35, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24646450, Length=260, Percent_Identity=35, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI62472511, Length=260, Percent_Identity=35, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24585516, Length=287, Percent_Identity=30.6620209059233, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19921140, Length=273, Percent_Identity=29.3040293040293, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36403; Mature: 36271

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKKKPKVYITRKLPDAVETRMRELFDAELNIDDAPRSVPELIAAVRTADVLVPTVTDR
CCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEECCHHHH
IDAALIDEAGPQMKLIASFSNGTDHIDVEAAARKGITVTNTPNVLTEDTADMTMALILAV
HHHHHHHCCCCCEEEEEEECCCCCEEEEEHHHHCCEEEECCCCCCCCCHHHHHHHHHHHH
PRRLGEGARVLTDKPGEWAGWSPTWMLGRRIHGKRIGIVGMGRIGTAVARRAKAFGLSIH
HHHHCCCCEEEECCCCCCCCCCHHHHHCCEECCCEEEEEECCHHHHHHHHHHHHHEEEEE
YHNRKRVNPAVEDELEATYWESLDQMLARVDIVSVNCPSTPATFHLISARRLALLQPTAY
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEHHHHHEEECCHHH
LVNTARGDVVDEAALIKALREGRIAGAGLDVFENEPAVNPKLVKLANEGKVVLLPHMSSA
HHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCEEEEEECCCCEEEEECCCCC
TIEGRIDMGDKVIINIRTFIDGHRPPNRVLPGR
EEEEEECCCCEEEEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TAKKKPKVYITRKLPDAVETRMRELFDAELNIDDAPRSVPELIAAVRTADVLVPTVTDR
CCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEECCHHHH
IDAALIDEAGPQMKLIASFSNGTDHIDVEAAARKGITVTNTPNVLTEDTADMTMALILAV
HHHHHHHCCCCCEEEEEEECCCCCEEEEEHHHHCCEEEECCCCCCCCCHHHHHHHHHHHH
PRRLGEGARVLTDKPGEWAGWSPTWMLGRRIHGKRIGIVGMGRIGTAVARRAKAFGLSIH
HHHHCCCCEEEECCCCCCCCCCHHHHHCCEECCCEEEEEECCHHHHHHHHHHHHHEEEEE
YHNRKRVNPAVEDELEATYWESLDQMLARVDIVSVNCPSTPATFHLISARRLALLQPTAY
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEHHHHHEEECCHHH
LVNTARGDVVDEAALIKALREGRIAGAGLDVFENEPAVNPKLVKLANEGKVVLLPHMSSA
HHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCEEEEEECCCCEEEEECCCCC
TIEGRIDMGDKVIINIRTFIDGHRPPNRVLPGR
EEEEEECCCCEEEEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA