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The map label for this gene is serA [H]

Identifier: 209551580

GI number: 209551580

Start: 4178372

End: 4179382

Strand: Direct

Name: serA [H]

Synonym: Rleg2_4009

Alternate gene names: 209551580

Gene position: 4178372-4179382 (Clockwise)

Preceding gene: 209551579

Following gene: 209551586

Centisome position: 92.08

GC content: 65.68

Gene sequence:

>1011_bases
ATGAGCCGACCCGCCATCGTCCTTGCCATGCAGCCCTCGCGCACCGAGCATGTCCTGCCGGATGAGATCCTGCGCCGGCT
GAATGGCATCGGCCGTCTGCTGGATGCCGAGCCGCTGCAGCATTTCGACGATGCGCGGGCGAGGCGTCTGCTGGCCGAAG
CCGAAATCCTGATGACCGGCTGGGGCGCGCCCTATGTCGGGCCTGACTTCCTCACAGCCGCGCCGCGGCTTCGCCTCATC
GTCCATGCGGCGGGCACGGTGAAGGGCATCATCGACGACGCCATCTTCGAAGCCGGCATAGCGGTCAGCCACGCGGCCGA
GGCCAATGCCGTGCCGGTCGCCGAATTCACGCTGGCCGCGATCCTCTTCGCCGGCAAACGCGCCTTCCAGTTCCGCGATC
TCTACGTTGCCGACCGCAACCGCGATCGAACCTATCCGATGCAGCGCGAGGCCATCGGCAATTACGGCCGCACCCTCGGC
ATCGTCGGCGCCTCACGCATCGGCCGGCGGGTAATCGAGCTGTTGAAACCCTTCGGCTACAGGCTGCTGCTGTTCGACCC
CATGCTCGATGCCGCCGAGGCGGCCGGCCTCGGCGCCGAGAAGGTCGAGCTCGACGAATTGATGCGCCGCTCCGATATCG
TTTCCCTGCACGCGCCGTCGCTGCCGTCGACCCGGCATATGATCGACGCGCGAGAACTGTCGTTGATGAAGGACGGCGCG
ACGCTGATCAACACCGCGCGCGGCATTCTCATCGATGAGGCGGCGCTGCTTTCGGAGCTGAAGACCGGCCGCATCGATGC
GGTCATCGATGTCACCGATCCGGAAATTCCGGAGGCGAGTTCGATGTTCTACGATCTGCCGAACGTTTTCCTGACGCCGC
ATATCGCTGGCGCCATCGGGCTGGAACGGGCGCGTCTCGGCGAGATGGCGGCGGATGAGGTCGAGCGTTTTACGGCCGGC
CGGCCGCTGCTCTACCAGATCCGCCGGCAGGATCTCGAAAACATCGCCTGA

Upstream 100 bases:

>100_bases
GGACGAAGCCGCCGAAGGCGCCCGACATCGCAGCGCTGGAGGCCCTGATGCGGGAAAAGGGCGTGACCGTCAGCGCCATC
GAAGCCCCGGGACAGATGCC

Downstream 100 bases:

>100_bases
CGCTGCCGCGTCAGCGCGCTGTTTTCAGCGAATTCGGCGACCCGTCATCGGCAAGCTCCGGCATCAGATCGGCAATATTG
ACCACCTTGCCGGTGCGCGA

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding subunit

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSRPAIVLAMQPSRTEHVLPDEILRRLNGIGRLLDAEPLQHFDDARARRLLAEAEILMTGWGAPYVGPDFLTAAPRLRLI
VHAAGTVKGIIDDAIFEAGIAVSHAAEANAVPVAEFTLAAILFAGKRAFQFRDLYVADRNRDRTYPMQREAIGNYGRTLG
IVGASRIGRRVIELLKPFGYRLLLFDPMLDAAEAAGLGAEKVELDELMRRSDIVSLHAPSLPSTRHMIDARELSLMKDGA
TLINTARGILIDEAALLSELKTGRIDAVIDVTDPEIPEASSMFYDLPNVFLTPHIAGAIGLERARLGEMAADEVERFTAG
RPLLYQIRRQDLENIA

Sequences:

>Translated_336_residues
MSRPAIVLAMQPSRTEHVLPDEILRRLNGIGRLLDAEPLQHFDDARARRLLAEAEILMTGWGAPYVGPDFLTAAPRLRLI
VHAAGTVKGIIDDAIFEAGIAVSHAAEANAVPVAEFTLAAILFAGKRAFQFRDLYVADRNRDRTYPMQREAIGNYGRTLG
IVGASRIGRRVIELLKPFGYRLLLFDPMLDAAEAAGLGAEKVELDELMRRSDIVSLHAPSLPSTRHMIDARELSLMKDGA
TLINTARGILIDEAALLSELKTGRIDAVIDVTDPEIPEASSMFYDLPNVFLTPHIAGAIGLERARLGEMAADEVERFTAG
RPLLYQIRRQDLENIA
>Mature_335_residues
SRPAIVLAMQPSRTEHVLPDEILRRLNGIGRLLDAEPLQHFDDARARRLLAEAEILMTGWGAPYVGPDFLTAAPRLRLIV
HAAGTVKGIIDDAIFEAGIAVSHAAEANAVPVAEFTLAAILFAGKRAFQFRDLYVADRNRDRTYPMQREAIGNYGRTLGI
VGASRIGRRVIELLKPFGYRLLLFDPMLDAAEAAGLGAEKVELDELMRRSDIVSLHAPSLPSTRHMIDARELSLMKDGAT
LINTARGILIDEAALLSELKTGRIDAVIDVTDPEIPEASSMFYDLPNVFLTPHIAGAIGLERARLGEMAADEVERFTAGR
PLLYQIRRQDLENIA

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=273, Percent_Identity=28.9377289377289, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI61743967, Length=254, Percent_Identity=34.6456692913386, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI4557497, Length=254, Percent_Identity=34.6456692913386, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI145580578, Length=254, Percent_Identity=34.251968503937, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI4557499, Length=254, Percent_Identity=34.251968503937, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI145580575, Length=254, Percent_Identity=34.251968503937, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI6912396, Length=260, Percent_Identity=26.5384615384615, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1787645, Length=188, Percent_Identity=34.5744680851064, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1789279, Length=299, Percent_Identity=29.4314381270903, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI87082289, Length=317, Percent_Identity=28.7066246056782, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788660, Length=260, Percent_Identity=29.2307692307692, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI87081824, Length=185, Percent_Identity=25.9459459459459, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25147481, Length=252, Percent_Identity=31.3492063492063, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17532191, Length=252, Percent_Identity=28.968253968254, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324055, Length=158, Percent_Identity=36.0759493670886, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=235, Percent_Identity=30.2127659574468, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322116, Length=235, Percent_Identity=29.7872340425532, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=252, Percent_Identity=28.968253968254, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19921140, Length=169, Percent_Identity=37.2781065088757, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24646446, Length=269, Percent_Identity=33.457249070632, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24646448, Length=269, Percent_Identity=33.457249070632, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24646452, Length=269, Percent_Identity=33.457249070632, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24646450, Length=269, Percent_Identity=33.457249070632, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI62472511, Length=253, Percent_Identity=34.7826086956522, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28571528, Length=184, Percent_Identity=32.0652173913043, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI45552429, Length=271, Percent_Identity=27.3062730627306, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585514, Length=271, Percent_Identity=27.3062730627306, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574282, Length=271, Percent_Identity=27.3062730627306, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45551003, Length=271, Percent_Identity=27.3062730627306, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574284, Length=271, Percent_Identity=27.3062730627306, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574286, Length=274, Percent_Identity=25.9124087591241, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24585516, Length=167, Percent_Identity=25.748502994012, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36920; Mature: 36789

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPAIVLAMQPSRTEHVLPDEILRRLNGIGRLLDAEPLQHFDDARARRLLAEAEILMTG
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEC
WGAPYVGPDFLTAAPRLRLIVHAAGTVKGIIDDAIFEAGIAVSHAAEANAVPVAEFTLAA
CCCCCCCCHHHHHCCHHEEEEEECCHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHH
ILFAGKRAFQFRDLYVADRNRDRTYPMQREAIGNYGRTLGIVGASRIGRRVIELLKPFGY
HHHHCCHHHEEEEEEEECCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCC
RLLLFDPMLDAAEAAGLGAEKVELDELMRRSDIVSLHAPSLPSTRHMIDARELSLMKDGA
EEEEECCHHHHHHHCCCCCHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHCCH
TLINTARGILIDEAALLSELKTGRIDAVIDVTDPEIPEASSMFYDLPNVFLTPHIAGAIG
HHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHCCCHHCCCHHHHHHH
LERARLGEMAADEVERFTAGRPLLYQIRRQDLENIA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRPAIVLAMQPSRTEHVLPDEILRRLNGIGRLLDAEPLQHFDDARARRLLAEAEILMTG
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEC
WGAPYVGPDFLTAAPRLRLIVHAAGTVKGIIDDAIFEAGIAVSHAAEANAVPVAEFTLAA
CCCCCCCCHHHHHCCHHEEEEEECCHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHH
ILFAGKRAFQFRDLYVADRNRDRTYPMQREAIGNYGRTLGIVGASRIGRRVIELLKPFGY
HHHHCCHHHEEEEEEEECCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCC
RLLLFDPMLDAAEAAGLGAEKVELDELMRRSDIVSLHAPSLPSTRHMIDARELSLMKDGA
EEEEECCHHHHHHHCCCCCHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHCCH
TLINTARGILIDEAALLSELKTGRIDAVIDVTDPEIPEASSMFYDLPNVFLTPHIAGAIG
HHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHCCCHHCCCHHHHHHH
LERARLGEMAADEVERFTAGRPLLYQIRRQDLENIA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]