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The map label for this gene is hisB [H]

Identifier: 209551552

GI number: 209551552

Start: 4132521

End: 4133129

Strand: Reverse

Name: hisB [H]

Synonym: Rleg2_3981

Alternate gene names: 209551552

Gene position: 4133129-4132521 (Counterclockwise)

Preceding gene: 209551558

Following gene: 209551551

Centisome position: 91.08

GC content: 60.76

Gene sequence:

>609_bases
ATGGCCGAGACCGCAGCAAGCCGCACGGGCAGCGTTTCCCGCAAGACCAACGAAACCTCGATTTCCGTCTCCGTCAATCT
CGACGGCACCGGCAAATCGAAGATTTCGACCGGCGTCGGCTTCTTCGATCATATGCTCGACCAGCTTTCGCGGCATTCCC
TGATCGACATGGAGATCGAATCCCAGGGCGACCTGCACATCGACGACCACCACACGGTCGAGGATACGGGCATCGCCATC
GGCCAGGCGATCTCTAAGGCGCTCGGCGACCGGCGCGGCATCACGCGGTATGCCTCGATCGATCTTGCCATGGACGAGAC
GATGACCAAGGCCGCGGTCGATCTTTCCGGCCGGCCGTTCCTCGTCTGGAACGTCGCCTTCAGCGCGCCGAAGATCGGCA
CGTTCGATACCGAACTCGTTCGCGAATTCTTCCAGGCGCTCGCCCAGAATGCCGGCATCACCTTGCATATTCTCAACCAT
TATGGCGCCAACAATCACCATATTGCCGAGACATGCTTCAAGGCCGTCGCCCGCGCATTGCGCACGGCGACTGAGATCGA
TCCGAGACAGGTGGGCCGTGTACCTTCGACGAAGGGCACGCTCGTCTGA

Upstream 100 bases:

>100_bases
CCGGCGCCGTTTGCAAATGGGCGGGCTTTTCTCTTGCCCGGCTTCTGGATATTTGCCGATCCGCCTGATAAGGAACGGCC
TTATTCCGATGGAGGGCCAT

Downstream 100 bases:

>100_bases
GCCCCTCAAGGGAGCGGCGACAATGACATCCAGCTATATTTTCCTGACGCCGCCCGGCGGCACGAGCGCCACGGTCGAAG
AGACGCGGACCATCCGCGAC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MAETAASRTGSVSRKTNETSISVSVNLDGTGKSKISTGVGFFDHMLDQLSRHSLIDMEIESQGDLHIDDHHTVEDTGIAI
GQAISKALGDRRGITRYASIDLAMDETMTKAAVDLSGRPFLVWNVAFSAPKIGTFDTELVREFFQALAQNAGITLHILNH
YGANNHHIAETCFKAVARALRTATEIDPRQVGRVPSTKGTLV

Sequences:

>Translated_202_residues
MAETAASRTGSVSRKTNETSISVSVNLDGTGKSKISTGVGFFDHMLDQLSRHSLIDMEIESQGDLHIDDHHTVEDTGIAI
GQAISKALGDRRGITRYASIDLAMDETMTKAAVDLSGRPFLVWNVAFSAPKIGTFDTELVREFFQALAQNAGITLHILNH
YGANNHHIAETCFKAVARALRTATEIDPRQVGRVPSTKGTLV
>Mature_201_residues
AETAASRTGSVSRKTNETSISVSVNLDGTGKSKISTGVGFFDHMLDQLSRHSLIDMEIESQGDLHIDDHHTVEDTGIAIG
QAISKALGDRRGITRYASIDLAMDETMTKAAVDLSGRPFLVWNVAFSAPKIGTFDTELVREFFQALAQNAGITLHILNHY
GANNHHIAETCFKAVARALRTATEIDPRQVGRVPSTKGTLV

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=198, Percent_Identity=48.989898989899, Blast_Score=192, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324776, Length=215, Percent_Identity=39.5348837209302, Blast_Score=159, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21863; Mature: 21732

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETAASRTGSVSRKTNETSISVSVNLDGTGKSKISTGVGFFDHMLDQLSRHSLIDMEIE
CCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEC
SQGDLHIDDHHTVEDTGIAIGQAISKALGDRRGITRYASIDLAMDETMTKAAVDLSGRPF
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCE
LVWNVAFSAPKIGTFDTELVREFFQALAQNAGITLHILNHYGANNHHIAETCFKAVARAL
EEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHH
RTATEIDPRQVGRVPSTKGTLV
HHHHCCCHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AETAASRTGSVSRKTNETSISVSVNLDGTGKSKISTGVGFFDHMLDQLSRHSLIDMEIE
CCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEC
SQGDLHIDDHHTVEDTGIAIGQAISKALGDRRGITRYASIDLAMDETMTKAAVDLSGRPF
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCE
LVWNVAFSAPKIGTFDTELVREFFQALAQNAGITLHILNHYGANNHHIAETCFKAVARAL
EEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHH
RTATEIDPRQVGRVPSTKGTLV
HHHHCCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA