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The map label for this gene is trxA [C]

Identifier: 209551529

GI number: 209551529

Start: 4106823

End: 4107143

Strand: Reverse

Name: trxA [C]

Synonym: Rleg2_3958

Alternate gene names: 209551529

Gene position: 4107143-4106823 (Counterclockwise)

Preceding gene: 209551530

Following gene: 209551519

Centisome position: 90.51

GC content: 56.39

Gene sequence:

>321_bases
ATGGCTACCGTGAAAGTCGATATCAACAATTTCCAGTCGGAAGTTCTGGAATCCGCAGAGCCCGTCGTCGTCGATTTCTG
GGCTGAATGGTGCGGCCCGTGCAAGATGATTGCGCCGAGCCTTGAAGAAATCTCCGTCGAGATGGAAGGCAAGGTCAAGG
TCGCCAAGCTGAATATCGATGAGAACCCGGAACTCGCCGCACAGTTCGGTGTGCGCTCCATTCCGACGCTCGCAATTTTC
AAGGGCGGCGAAGTCGCCGATATTTCTGTCGGCGCCAAGGCGAAGACCGCGCTTTCGAACTGGATTTCCAGCGCCGCCTG
A

Upstream 100 bases:

>100_bases
TGGCGCTTGCAGCGGTCAAGACAAAGTGAAATACCGGACATTGAAAATTTGGCACCGCACCATCACATGTGGTTCAACAC
CCGAGGTAAAGGAGCAGCCC

Downstream 100 bases:

>100_bases
TATCGCCCGATTCACATCGACGAAAAAGCCCGGCTTCGACCGGGCTTTTTTCATTTCGTATTGTTCATTTCACCGATCAC
TTCGGAGGCGTGCCGTTGTC

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MATVKVDINNFQSEVLESAEPVVVDFWAEWCGPCKMIAPSLEEISVEMEGKVKVAKLNIDENPELAAQFGVRSIPTLAIF
KGGEVADISVGAKAKTALSNWISSAA

Sequences:

>Translated_106_residues
MATVKVDINNFQSEVLESAEPVVVDFWAEWCGPCKMIAPSLEEISVEMEGKVKVAKLNIDENPELAAQFGVRSIPTLAIF
KGGEVADISVGAKAKTALSNWISSAA
>Mature_105_residues
ATVKVDINNFQSEVLESAEPVVVDFWAEWCGPCKMIAPSLEEISVEMEGKVKVAKLNIDENPELAAQFGVRSIPTLAIFK
GGEVADISVGAKAKTALSNWISSAA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=42.7083333333333, Blast_Score=91, Evalue=2e-19,
Organism=Homo sapiens, GI5031973, Length=80, Percent_Identity=37.5, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI21361657, Length=100, Percent_Identity=33, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI20070125, Length=100, Percent_Identity=34, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=96, Percent_Identity=54.1666666666667, Blast_Score=118, Evalue=8e-29,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=44.0860215053763, Blast_Score=99, Evalue=8e-23,
Organism=Escherichia coli, GI87081747, Length=98, Percent_Identity=34.6938775510204, Blast_Score=65, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=77, Percent_Identity=45.4545454545455, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115532380, Length=74, Percent_Identity=41.8918918918919, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115532378, Length=74, Percent_Identity=41.8918918918919, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17544108, Length=74, Percent_Identity=41.8918918918919, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17556044, Length=100, Percent_Identity=34, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=79, Percent_Identity=32.9113924050633, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=101, Percent_Identity=36.6336633663366, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=97, Percent_Identity=36.0824742268041, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=76, Percent_Identity=32.8947368421053, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=41.6666666666667, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=72, Percent_Identity=51.3888888888889, Blast_Score=67, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=88, Percent_Identity=34.0909090909091, Blast_Score=65, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=42.7083333333333, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24639826, Length=83, Percent_Identity=42.1686746987952, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=37.5, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=42.3076923076923, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=42.3076923076923, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24664269, Length=79, Percent_Identity=40.5063291139241, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921434, Length=79, Percent_Identity=39.2405063291139, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639068, Length=85, Percent_Identity=34.1176470588235, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17647799, Length=99, Percent_Identity=34.3434343434343, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11338; Mature: 11207

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVKVDINNFQSEVLESAEPVVVDFWAEWCGPCKMIAPSLEEISVEMEGKVKVAKLNID
CEEEEEECCHHHHHHHCCCCCEEEEEHHHHCCCHHHCCCCHHHEEEEECCCEEEEEECCC
ENPELAAQFGVRSIPTLAIFKGGEVADISVGAKAKTALSNWISSAA
CCCCHHHHCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
ATVKVDINNFQSEVLESAEPVVVDFWAEWCGPCKMIAPSLEEISVEMEGKVKVAKLNID
EEEEEECCHHHHHHHCCCCCEEEEEHHHHCCCHHHCCCCHHHEEEEECCCEEEEEECCC
ENPELAAQFGVRSIPTLAIFKGGEVADISVGAKAKTALSNWISSAA
CCCCHHHHCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]