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The map label for this gene is mltA [H]

Identifier: 209551514

GI number: 209551514

Start: 4091902

End: 4093020

Strand: Direct

Name: mltA [H]

Synonym: Rleg2_3943

Alternate gene names: 209551514

Gene position: 4091902-4093020 (Clockwise)

Preceding gene: 209551513

Following gene: 209551515

Centisome position: 90.17

GC content: 63.0

Gene sequence:

>1119_bases
ATGAGTGACCACGCATCGGACTTCGTCCTGCAGGCCATAAGCTTCGACACCCTGGAAGGCTGGAAGGATGACGATCCCTC
CGGCCTTTTTGAAGTCATGCGACGCTGCCGCCGCCAGATCAGCGATGTCAAACCGTACCGCACCGGCTCGCTTGGCCTGA
GCTCGGAAGACCTGCTGCCGCTTCTGCTGGCCGCCGAAGATTTCACGCCGTTATCGCCATCAGCGGCGCGCGCCTTTTTC
GAGACGCATTGTCGGCCCTTCCTGATTCGCCGCAAGGATGGCAATCCCGGTTTCGTCACCGCCTTTTACGAACCTGATAT
CGAGGTGTCGGAGCGGCCGGACGAGGTTTTCCGTTTTCCTTTCTACCGGCGCCCGGACGATCTGATCGATCTCGACGATG
CCAATCGCCCCGCCGAGCTCGACAGTTCCTATGCTTTCGGCCGCCTGCATGATGGCCATATCGCTGCCTATCCGGATCGC
CGCGCCATCGACCAAGGTTTTCTCGAAGGCCGAGGTTTCGAAATCGCCTGGGCGAAGTCGAAGGTCGATGTCTTCTTCGT
GCATGTGCAGGGTGCGGCCCGTTTGCGTTACAGCGACGGCCGCATCGGCCGCATCACCTATGCGGCGAAGGCCGGCCATC
CTTTCTCGGCGGTCGGCAAGCTGCTGATCGACCGAGGCGAGATCGCTCGCGCCGACATTTCGATGCAGTCGATCCGCACC
TGGCTGGCGCGCAATCCCGGGCGCGTCGACGAGGTGTTGTGGCATAATCGCTCCTATATCTTCTTTCGTGAGGCGCTGGT
GGCCGATCCCGAGGCCGGTCCGATCGCCGCCGCCAAGGTGCCGCTTTTGGCCGGACGCTCGCTTGCCGTCGACCGGGTGA
TCCATACCTTCGGCTTTCCCTTTTTCATCCGCTCCGAAAGCCTCACCCATCTCGATGACGGCCGGCCCTTCCGCCGGCTG
ATGCTGGCGCTCGATACCGGCTCGGCGATCGTCGGACCGGCGCGCGGCGATATCTTCACCGGCTCGGGGGATCTGGCGGG
AGAAAGGGCCGGCACCGTTCGCAACGACGCCGATTTCGCCATCCTTATTCCCCAGGGCGCCGCCGGACGGTTCGACTGA

Upstream 100 bases:

>100_bases
GATGCCGAAAACGTCGCCGAGGTCAACGACCTCTGGACCTTCGCCCGCGACACCCGCTCGCGCGATCCGAACTGGAAACT
CGTGGCGACCGAATCGGAAC

Downstream 100 bases:

>100_bases
TGGCCAGGGATCGAAAACTAAGCGCGGACGAGAGGATCCTCTGGGGCAAGGTTGCCCGCAGCACACGGCCGATGCCCGGT
AAGGTGGGTGCGTTGACCGA

Product: MltA domain-containing protein

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MSDHASDFVLQAISFDTLEGWKDDDPSGLFEVMRRCRRQISDVKPYRTGSLGLSSEDLLPLLLAAEDFTPLSPSAARAFF
ETHCRPFLIRRKDGNPGFVTAFYEPDIEVSERPDEVFRFPFYRRPDDLIDLDDANRPAELDSSYAFGRLHDGHIAAYPDR
RAIDQGFLEGRGFEIAWAKSKVDVFFVHVQGAARLRYSDGRIGRITYAAKAGHPFSAVGKLLIDRGEIARADISMQSIRT
WLARNPGRVDEVLWHNRSYIFFREALVADPEAGPIAAAKVPLLAGRSLAVDRVIHTFGFPFFIRSESLTHLDDGRPFRRL
MLALDTGSAIVGPARGDIFTGSGDLAGERAGTVRNDADFAILIPQGAAGRFD

Sequences:

>Translated_372_residues
MSDHASDFVLQAISFDTLEGWKDDDPSGLFEVMRRCRRQISDVKPYRTGSLGLSSEDLLPLLLAAEDFTPLSPSAARAFF
ETHCRPFLIRRKDGNPGFVTAFYEPDIEVSERPDEVFRFPFYRRPDDLIDLDDANRPAELDSSYAFGRLHDGHIAAYPDR
RAIDQGFLEGRGFEIAWAKSKVDVFFVHVQGAARLRYSDGRIGRITYAAKAGHPFSAVGKLLIDRGEIARADISMQSIRT
WLARNPGRVDEVLWHNRSYIFFREALVADPEAGPIAAAKVPLLAGRSLAVDRVIHTFGFPFFIRSESLTHLDDGRPFRRL
MLALDTGSAIVGPARGDIFTGSGDLAGERAGTVRNDADFAILIPQGAAGRFD
>Mature_371_residues
SDHASDFVLQAISFDTLEGWKDDDPSGLFEVMRRCRRQISDVKPYRTGSLGLSSEDLLPLLLAAEDFTPLSPSAARAFFE
THCRPFLIRRKDGNPGFVTAFYEPDIEVSERPDEVFRFPFYRRPDDLIDLDDANRPAELDSSYAFGRLHDGHIAAYPDRR
AIDQGFLEGRGFEIAWAKSKVDVFFVHVQGAARLRYSDGRIGRITYAAKAGHPFSAVGKLLIDRGEIARADISMQSIRTW
LARNPGRVDEVLWHNRSYIFFREALVADPEAGPIAAAKVPLLAGRSLAVDRVIHTFGFPFFIRSESLTHLDDGRPFRRLM
LALDTGSAIVGPARGDIFTGSGDLAGERAGTVRNDADFAILIPQGAAGRFD

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=281, Percent_Identity=33.0960854092527, Blast_Score=109, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 41379; Mature: 41248

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDHASDFVLQAISFDTLEGWKDDDPSGLFEVMRRCRRQISDVKPYRTGSLGLSSEDLLP
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
LLLAAEDFTPLSPSAARAFFETHCRPFLIRRKDGNPGFVTAFYEPDIEVSERPDEVFRFP
EEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHCCC
FYRRPDDLIDLDDANRPAELDSSYAFGRLHDGHIAAYPDRRAIDQGFLEGRGFEIAWAKS
CCCCCCCCEECCCCCCCCCCCCCCCCCEEECCEEEECCCHHHHHHHHHCCCCEEEEEECC
KVDVFFVHVQGAARLRYSDGRIGRITYAAKAGHPFSAVGKLLIDRGEIARADISMQSIRT
CEEEEEEEECCCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHCCCCCEECCCCHHHHHH
WLARNPGRVDEVLWHNRSYIFFREALVADPEAGPIAAAKVPLLAGRSLAVDRVIHTFGFP
HHHCCCCCHHHHHHCCCCEEEEEEHHHCCCCCCCEEHCCCCEECCCHHHHHHHHHHHCCC
FFIRSESLTHLDDGRPFRRLMLALDTGSAIVGPARGDIFTGSGDLAGERAGTVRNDADFA
EEEECCCCCCCCCCCHHHEEEEEECCCCEEECCCCCCEEECCCCCCCCCCCCCCCCCCEE
ILIPQGAAGRFD
EEEECCCCCCCC
>Mature Secondary Structure 
SDHASDFVLQAISFDTLEGWKDDDPSGLFEVMRRCRRQISDVKPYRTGSLGLSSEDLLP
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
LLLAAEDFTPLSPSAARAFFETHCRPFLIRRKDGNPGFVTAFYEPDIEVSERPDEVFRFP
EEEECCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHCCC
FYRRPDDLIDLDDANRPAELDSSYAFGRLHDGHIAAYPDRRAIDQGFLEGRGFEIAWAKS
CCCCCCCCEECCCCCCCCCCCCCCCCCEEECCEEEECCCHHHHHHHHHCCCCEEEEEECC
KVDVFFVHVQGAARLRYSDGRIGRITYAAKAGHPFSAVGKLLIDRGEIARADISMQSIRT
CEEEEEEEECCCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHCCCCCEECCCCHHHHHH
WLARNPGRVDEVLWHNRSYIFFREALVADPEAGPIAAAKVPLLAGRSLAVDRVIHTFGFP
HHHCCCCCHHHHHHCCCCEEEEEEHHHCCCCCCCEEHCCCCEECCCHHHHHHHHHHHCCC
FFIRSESLTHLDDGRPFRRLMLALDTGSAIVGPARGDIFTGSGDLAGERAGTVRNDADFA
EEEECCCCCCCCCCCHHHEEEEEECCCCEEECCCCCCEEECCCCCCCCCCCCCCCCCCEE
ILIPQGAAGRFD
EEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]