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The map label for this gene is hisC2 [H]

Identifier: 209551401

GI number: 209551401

Start: 3962210

End: 3963271

Strand: Reverse

Name: hisC2 [H]

Synonym: Rleg2_3830

Alternate gene names: 209551401

Gene position: 3963271-3962210 (Counterclockwise)

Preceding gene: 209551402

Following gene: 209551399

Centisome position: 87.34

GC content: 61.96

Gene sequence:

>1062_bases
ATGAGCCGCTACTGGTCTGATATCGTCAGCAAGCTCCGACCCTATGTCGCCGGGGAGCAACCCCGTATCCCCGGTCTGGT
CAAGCTCAACACCAACGAGAACCCCTACGGCCCGTCTCCAGCGGCGCTGGAAGCGATCGGCCAAGCGGCGGATGATCGTC
TGCGGCTCTATCCCGATCCGGCGGCGACGGAATTGCGCGAGACGATCGCTGCCCGTCACGGCCTGACGGCGGATGAAGTC
TTCGTCGGCAACGGCTCAGACGAGGTCCTCGCCCATGCGTTTCAGGCGCTGCTGAGACATGAACTGCCGCTTCTCTATCC
CGACATAAGCTACAGCTTCTATCCGACTTATAGCCTGCTATACGACATCGAAGCGATCGAAGCGCCGGTCGATGATACGT
TCCAGATCCGGCTGGCGGATTACGACAGGCCGTGCGGGGCGATCATCATCCCCAATCCGAATGCGCCGACCGGCATCGGC
TTGCCGCTTGCCGACATAGAGGCGCTTGTCGCCACCCATCCGGACGCGGTCGTGGTGATCGACGAGGCCTATGTCGATTT
CGGCGGTGACAGTGCCATCCCGCTCATTTCCAAATATCCCAACCTGCTTGTCGTTCAGACCTTGTCGAAATCCCGCTCCT
TTGCCGGCCTGCGCGTCGGTTTCGCGCTTGGGCAGCGGGAGCTGATCGAGGCGCTGGTGCGCGTCAAGGACAGCTTCAAT
TCCTATCCGCTCGATCGCCTGGCGCAGGTTGCCGCAACGGCGGCGATCAAGGACGAGGCGTGGTTCGAGGCATGCCGGAC
GAAGCTCATCGCCAGCCGGGACGGTCTCGTCCGGGACCTCGAAGCGCTGGAATTCGAAGTGCTGCCGTCTCAGGCGAATT
TCGTTTTCGCACGGCATGAAAGCCGGTCGGGTGCCGCGCTGCAAGCCGCTCTGCGGGAGCGAGGTGTTCTCGTTCGGCAT
TTCGCCAAGCCGCGCATTTCGGATTTCCTGCGCATCAGCATCGGCACGAACGAGGAGTGCGCCCGTCTGGTTTCCGCTCT
CAAGGAAATACTGGCAGCCTGA

Upstream 100 bases:

>100_bases
GGTCCCAATATCGCTGCCGACTTCGAGGCGCTCGTCGTCGACTATATCGAGAAGCGTTTCGGCCAGCGGACGGCGGCGGA
ATGAAGGTCGGCGAATTCGC

Downstream 100 bases:

>100_bases
GTGACGCTTCAGCTCTTCCGGTCGGCGATGAAATGCGCCGCGGCGATCAGGGTCGAGGCGCGGGCGCCGTAGGGGGCCAG
CAGCGCCTCGGCATCGCGGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSRYWSDIVSKLRPYVAGEQPRIPGLVKLNTNENPYGPSPAALEAIGQAADDRLRLYPDPAATELRETIAARHGLTADEV
FVGNGSDEVLAHAFQALLRHELPLLYPDISYSFYPTYSLLYDIEAIEAPVDDTFQIRLADYDRPCGAIIIPNPNAPTGIG
LPLADIEALVATHPDAVVVIDEAYVDFGGDSAIPLISKYPNLLVVQTLSKSRSFAGLRVGFALGQRELIEALVRVKDSFN
SYPLDRLAQVAATAAIKDEAWFEACRTKLIASRDGLVRDLEALEFEVLPSQANFVFARHESRSGAALQAALRERGVLVRH
FAKPRISDFLRISIGTNEECARLVSALKEILAA

Sequences:

>Translated_353_residues
MSRYWSDIVSKLRPYVAGEQPRIPGLVKLNTNENPYGPSPAALEAIGQAADDRLRLYPDPAATELRETIAARHGLTADEV
FVGNGSDEVLAHAFQALLRHELPLLYPDISYSFYPTYSLLYDIEAIEAPVDDTFQIRLADYDRPCGAIIIPNPNAPTGIG
LPLADIEALVATHPDAVVVIDEAYVDFGGDSAIPLISKYPNLLVVQTLSKSRSFAGLRVGFALGQRELIEALVRVKDSFN
SYPLDRLAQVAATAAIKDEAWFEACRTKLIASRDGLVRDLEALEFEVLPSQANFVFARHESRSGAALQAALRERGVLVRH
FAKPRISDFLRISIGTNEECARLVSALKEILAA
>Mature_352_residues
SRYWSDIVSKLRPYVAGEQPRIPGLVKLNTNENPYGPSPAALEAIGQAADDRLRLYPDPAATELRETIAARHGLTADEVF
VGNGSDEVLAHAFQALLRHELPLLYPDISYSFYPTYSLLYDIEAIEAPVDDTFQIRLADYDRPCGAIIIPNPNAPTGIGL
PLADIEALVATHPDAVVVIDEAYVDFGGDSAIPLISKYPNLLVVQTLSKSRSFAGLRVGFALGQRELIEALVRVKDSFNS
YPLDRLAQVAATAAIKDEAWFEACRTKLIASRDGLVRDLEALEFEVLPSQANFVFARHESRSGAALQAALRERGVLVRHF
AKPRISDFLRISIGTNEECARLVSALKEILAA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=357, Percent_Identity=29.6918767507003, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788722, Length=236, Percent_Identity=31.7796610169492, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=379, Percent_Identity=29.5514511873351, Blast_Score=138, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38683; Mature: 38552

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRYWSDIVSKLRPYVAGEQPRIPGLVKLNTNENPYGPSPAALEAIGQAADDRLRLYPDP
CCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEECCCH
AATELRETIAARHGLTADEVFVGNGSDEVLAHAFQALLRHELPLLYPDISYSFYPTYSLL
HHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHH
YDIEAIEAPVDDTFQIRLADYDRPCGAIIIPNPNAPTGIGLPLADIEALVATHPDAVVVI
EEHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
DEAYVDFGGDSAIPLISKYPNLLVVQTLSKSRSFAGLRVGFALGQRELIEALVRVKDSFN
EEHEEECCCCCCCCHHHCCCCEEEEEEHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHCCC
SYPLDRLAQVAATAAIKDEAWFEACRTKLIASRDGLVRDLEALEFEVLPSQANFVFARHE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEECCCCCCEEEEECC
SRSGAALQAALRERGVLVRHFAKPRISDFLRISIGTNEECARLVSALKEILAA
CCCCHHHHHHHHHCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRYWSDIVSKLRPYVAGEQPRIPGLVKLNTNENPYGPSPAALEAIGQAADDRLRLYPDP
CHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEECCCH
AATELRETIAARHGLTADEVFVGNGSDEVLAHAFQALLRHELPLLYPDISYSFYPTYSLL
HHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHH
YDIEAIEAPVDDTFQIRLADYDRPCGAIIIPNPNAPTGIGLPLADIEALVATHPDAVVVI
EEHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
DEAYVDFGGDSAIPLISKYPNLLVVQTLSKSRSFAGLRVGFALGQRELIEALVRVKDSFN
EEHEEECCCCCCCCHHHCCCCEEEEEEHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHCCC
SYPLDRLAQVAATAAIKDEAWFEACRTKLIASRDGLVRDLEALEFEVLPSQANFVFARHE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEECCCCCCEEEEECC
SRSGAALQAALRERGVLVRHFAKPRISDFLRISIGTNEECARLVSALKEILAA
CCCCHHHHHHHHHCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]