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The map label for this gene is typA [H]

Identifier: 209551282

GI number: 209551282

Start: 3836214

End: 3838034

Strand: Reverse

Name: typA [H]

Synonym: Rleg2_3710

Alternate gene names: 209551282

Gene position: 3838034-3836214 (Counterclockwise)

Preceding gene: 209551283

Following gene: 209551281

Centisome position: 84.58

GC content: 60.24

Gene sequence:

>1821_bases
ATGGCACTTCGCAATATCGCGATCATCGCGCACGTTGACCATGGCAAGACGACCCTGGTGGATGAGCTTCTCAAGCAGTC
CGGCTCGTTCCGCGAAAATCAGCGTGTCGCTGAACGCGTGATGGACTCGAACGATCTCGAAAAAGAACGCGGCATCACCA
TTCTCGCCAAGGCAACCTCGGTCGAGTGGAAGGGTGTGCGTATCAACATCGTCGATACCCCCGGCCACGCCGACTTCGGC
GGCGAAGTCGAGCGCATTCTCTCGATGGTGGACGGCGCGATCGTTCTCGTCGACGCGTCCGAAGGCCCGATGCCGCAGAC
CAAATTCGTCGTCGGCAAGGCGCTGAAGGTCGGCCTTCGCCCGATCGTCGCGATCAACAAGATCGACCGTCCGGACGGCC
GCCACGAAGAAGTCATCAACGAAGTCTTCGACCTTTTCGCCAATCTCGACGCGACCGACGAGCAGCTCGACTTCCCAATC
CTTTACGGTTCCGGTCGCGACGGCTGGATGAACGTCAATCCGGAAGGCCCGAAGGATGAGGGTCTTGCACCTCTGCTCGA
CCTCGTGCTCAAGCATGTGCCGGAGCCGACCGTTCACGAAGGCCCGTTCACGATGATCGGCACGATCCTCGAAGCCAACC
CCTTCCTCGGCCGTATCATCACCGGCCGCATCAATTCCGGTTCCATCAAGCCGAACCAGGCGGTGAAGGTTCTTCACGCC
GACGGCAAGACGATCGAAACCGGCCGCATCTCCAAGATCCTCGCCTTCCGCGGTATCGAGCGCACGGCGATCGACGAAGC
GCATCAAGGCGATATCGTTGCGATCGCCGGCCTTTCCAAGGGCACGGTCGCCGACACCTTCTGCGATCCCTCGGTCACCG
AGCCGCTGCAGGCGCAGCCGATCGATCCGCCGACCGTCACCATGTCCTTCATCGTCAACGATAGCCCGCTGGCGGGCACC
GAAGGCGACAAGGTGACCTCACGCGTTATCCGCGACCGTCTGTTCAAGGAAGCTGAAGGCAACGTCGCCCTGAAAATCGA
AGAAGCCGAAGGCAAGGATTCGTTCTACGTGTCCGGTCGCGGCGAACTTCAGCTCGCCGTTCTCATCGAAACCATGCGTC
GCGAAGGCTTTGAGCTTGCCGTGTCGCGTCCGCGTGTCGTCATGCACAAGGATGAAAGCGGCCAGCTTCTCGAGCCGATC
GAAGAAGTCGTTGTCGACGTCGACGAAGAACATTCCGGTGTCGTCGTCCAAAAGATGTCCGAGCGCAAGGCCGAAATGGT
CGAGCTGCGTCCGTCGGGCGGCAATCGTCTTCGTCTGCGTTTCTACGCACCGACCCGCGGCCTGATCGGCTACCAGTCGG
AACTGCTGACGGATACGCGCGGCACGGCGATCATGAACCGCCTGTTCCACGACTACCAGCCCTACAAGGGTGTGATCGGT
GGCCGCGTCAACGGCGTGCTGCTCGCCAATGCTCCCGGCGAAGCCGTCGCCTATGCGATGTTCAACCTGGAAGACCGCGG
CCCGATGATCATCGAGCCGGGTGAAAAGGTCTATGCCGGCATGATCATCGGCATCCACACGCGCGATAACGATCTCGAAG
TGAATGTCCTGAAGGGCAAGCAGCTGACCAACATCCGCGCCGCCGGCAAGGACGAAGCCGTCAAGCTGACGCCGCCGATC
CGTATGACGCTTGATCGTGCGCTTTCCTGGATCCAGGAAGACGAGCTGATGGAAGTGACGCCGAAGAATATTCGTCTGCG
CAAGATGTATCTCGACGCAAACGATCGCAAGCGTTTCGAAAAGTCCAAAGCGGCTCTCTGA

Upstream 100 bases:

>100_bases
GCGTTCCCCTCTTTCGCAAACGCAAAAAAAACTGTATGGACGCCCCAAACCAATAGGCGCGTCCTCAAGAGCGTGCGCCG
CAGCCTCAGAGATTTCACAT

Downstream 100 bases:

>100_bases
GAGCTTCAAAGCACCTTGGAAACCCCGGCCTTCGTGCCGGGGTTTTTTATTGTGCGCCGCGCTGATTCCGACTTGTGACA
ATCGTTAAAAAAGCGTTAAA

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: Tyrosine phosphorylated protein A [H]

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MALRNIAIIAHVDHGKTTLVDELLKQSGSFRENQRVAERVMDSNDLEKERGITILAKATSVEWKGVRINIVDTPGHADFG
GEVERILSMVDGAIVLVDASEGPMPQTKFVVGKALKVGLRPIVAINKIDRPDGRHEEVINEVFDLFANLDATDEQLDFPI
LYGSGRDGWMNVNPEGPKDEGLAPLLDLVLKHVPEPTVHEGPFTMIGTILEANPFLGRIITGRINSGSIKPNQAVKVLHA
DGKTIETGRISKILAFRGIERTAIDEAHQGDIVAIAGLSKGTVADTFCDPSVTEPLQAQPIDPPTVTMSFIVNDSPLAGT
EGDKVTSRVIRDRLFKEAEGNVALKIEEAEGKDSFYVSGRGELQLAVLIETMRREGFELAVSRPRVVMHKDESGQLLEPI
EEVVVDVDEEHSGVVVQKMSERKAEMVELRPSGGNRLRLRFYAPTRGLIGYQSELLTDTRGTAIMNRLFHDYQPYKGVIG
GRVNGVLLANAPGEAVAYAMFNLEDRGPMIIEPGEKVYAGMIIGIHTRDNDLEVNVLKGKQLTNIRAAGKDEAVKLTPPI
RMTLDRALSWIQEDELMEVTPKNIRLRKMYLDANDRKRFEKSKAAL

Sequences:

>Translated_606_residues
MALRNIAIIAHVDHGKTTLVDELLKQSGSFRENQRVAERVMDSNDLEKERGITILAKATSVEWKGVRINIVDTPGHADFG
GEVERILSMVDGAIVLVDASEGPMPQTKFVVGKALKVGLRPIVAINKIDRPDGRHEEVINEVFDLFANLDATDEQLDFPI
LYGSGRDGWMNVNPEGPKDEGLAPLLDLVLKHVPEPTVHEGPFTMIGTILEANPFLGRIITGRINSGSIKPNQAVKVLHA
DGKTIETGRISKILAFRGIERTAIDEAHQGDIVAIAGLSKGTVADTFCDPSVTEPLQAQPIDPPTVTMSFIVNDSPLAGT
EGDKVTSRVIRDRLFKEAEGNVALKIEEAEGKDSFYVSGRGELQLAVLIETMRREGFELAVSRPRVVMHKDESGQLLEPI
EEVVVDVDEEHSGVVVQKMSERKAEMVELRPSGGNRLRLRFYAPTRGLIGYQSELLTDTRGTAIMNRLFHDYQPYKGVIG
GRVNGVLLANAPGEAVAYAMFNLEDRGPMIIEPGEKVYAGMIIGIHTRDNDLEVNVLKGKQLTNIRAAGKDEAVKLTPPI
RMTLDRALSWIQEDELMEVTPKNIRLRKMYLDANDRKRFEKSKAAL
>Mature_605_residues
ALRNIAIIAHVDHGKTTLVDELLKQSGSFRENQRVAERVMDSNDLEKERGITILAKATSVEWKGVRINIVDTPGHADFGG
EVERILSMVDGAIVLVDASEGPMPQTKFVVGKALKVGLRPIVAINKIDRPDGRHEEVINEVFDLFANLDATDEQLDFPIL
YGSGRDGWMNVNPEGPKDEGLAPLLDLVLKHVPEPTVHEGPFTMIGTILEANPFLGRIITGRINSGSIKPNQAVKVLHAD
GKTIETGRISKILAFRGIERTAIDEAHQGDIVAIAGLSKGTVADTFCDPSVTEPLQAQPIDPPTVTMSFIVNDSPLAGTE
GDKVTSRVIRDRLFKEAEGNVALKIEEAEGKDSFYVSGRGELQLAVLIETMRREGFELAVSRPRVVMHKDESGQLLEPIE
EVVVDVDEEHSGVVVQKMSERKAEMVELRPSGGNRLRLRFYAPTRGLIGYQSELLTDTRGTAIMNRLFHDYQPYKGVIGG
RVNGVLLANAPGEAVAYAMFNLEDRGPMIIEPGEKVYAGMIIGIHTRDNDLEVNVLKGKQLTNIRAAGKDEAVKLTPPIR
MTLDRALSWIQEDELMEVTPKNIRLRKMYLDANDRKRFEKSKAAL

Specific function: Probably interacts with the ribosomes in a GTP dependent manner. GTPase that mediates interactions between enteropathogenic E.coli (EPEC) and epithelial cells [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI94966754, Length=132, Percent_Identity=43.9393939393939, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI157426893, Length=313, Percent_Identity=28.7539936102236, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI18390331, Length=133, Percent_Identity=44.3609022556391, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI19923640, Length=199, Percent_Identity=35.678391959799, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI25306287, Length=199, Percent_Identity=35.678391959799, Blast_Score=106, Evalue=8e-23,
Organism=Homo sapiens, GI25306283, Length=199, Percent_Identity=35.678391959799, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=36.8055555555556, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=40.9090909090909, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=40.9090909090909, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=40.9090909090909, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI34147630, Length=256, Percent_Identity=30.078125, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=35.2941176470588, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=35.2941176470588, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI94966752, Length=128, Percent_Identity=32.8125, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI48994988, Length=602, Percent_Identity=55.3156146179402, Blast_Score=657, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=504, Percent_Identity=25.9920634920635, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1789738, Length=151, Percent_Identity=39.7350993377483, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790412, Length=275, Percent_Identity=29.0909090909091, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789737, Length=275, Percent_Identity=29.0909090909091, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790835, Length=146, Percent_Identity=30.1369863013699, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17556745, Length=142, Percent_Identity=43.6619718309859, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17557151, Length=235, Percent_Identity=32.3404255319149, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17533571, Length=134, Percent_Identity=43.2835820895522, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71988819, Length=128, Percent_Identity=39.0625, Blast_Score=102, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71988811, Length=128, Percent_Identity=39.0625, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17506493, Length=156, Percent_Identity=33.974358974359, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17556456, Length=287, Percent_Identity=28.9198606271777, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17552882, Length=185, Percent_Identity=31.8918918918919, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI25141371, Length=290, Percent_Identity=28.6206896551724, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17552884, Length=270, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17569207, Length=270, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=508, Percent_Identity=27.755905511811, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324707, Length=201, Percent_Identity=34.3283582089552, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=201, Percent_Identity=34.3283582089552, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323098, Length=208, Percent_Identity=34.1346153846154, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322359, Length=148, Percent_Identity=36.4864864864865, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324761, Length=273, Percent_Identity=30.03663003663, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=183, Percent_Identity=36.6120218579235, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6322937, Length=284, Percent_Identity=23.943661971831, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324550, Length=144, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24582462, Length=134, Percent_Identity=45.5223880597015, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI78706572, Length=202, Percent_Identity=34.6534653465347, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585711, Length=148, Percent_Identity=37.8378378378378, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585713, Length=148, Percent_Identity=37.8378378378378, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585709, Length=148, Percent_Identity=37.8378378378378, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574573, Length=137, Percent_Identity=39.4160583941606, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221458488, Length=173, Percent_Identity=38.150289017341, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=37.3134328358209, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281363316, Length=234, Percent_Identity=31.1965811965812, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17864358, Length=234, Percent_Identity=31.1965811965812, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19921738, Length=258, Percent_Identity=30.6201550387597, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66774; Mature: 66642

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALRNIAIIAHVDHGKTTLVDELLKQSGSFRENQRVAERVMDSNDLEKERGITILAKATS
CCCCEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHCCEEEEEEECC
VEWKGVRINIVDTPGHADFGGEVERILSMVDGAIVLVDASEGPMPQTKFVVGKALKVGLR
EEECCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCCC
PIVAINKIDRPDGRHEEVINEVFDLFANLDATDEQLDFPILYGSGRDGWMNVNPEGPKDE
EEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEECCCCCCCCC
GLAPLLDLVLKHVPEPTVHEGPFTMIGTILEANPFLGRIITGRINSGSIKPNQAVKVLHA
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEEEC
DGKTIETGRISKILAFRGIERTAIDEAHQGDIVAIAGLSKGTVADTFCDPSVTEPLQAQP
CCCEEECCCHHHHHHHCCCCHHHHCCCCCCCEEEEECCCCCCEECCCCCCCCCCCCCCCC
IDPPTVTMSFIVNDSPLAGTEGDKVTSRVIRDRLFKEAEGNVALKIEEAEGKDSFYVSGR
CCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECC
GELQLAVLIETMRREGFELAVSRPRVVMHKDESGQLLEPIEEVVVDVDEEHSGVVVQKMS
CCEEEHHHHHHHHCCCCEEEECCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCHHHHHH
ERKAEMVELRPSGGNRLRLRFYAPTRGLIGYQSELLTDTRGTAIMNRLFHDYQPYKGVIG
HCCCEEEEECCCCCCEEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
GRVNGVLLANAPGEAVAYAMFNLEDRGPMIIEPGEKVYAGMIIGIHTRDNDLEVNVLKGK
CCCCEEEEECCCCCEEEEEEEEECCCCCEEECCCCEEEEEEEEEEEECCCCEEEEEECCC
QLTNIRAAGKDEAVKLTPPIRMTLDRALSWIQEDELMEVTPKNIRLRKMYLDANDRKRFE
EEEEEECCCCCCEEEECCCHHHHHHHHHHHHCCCCCEECCCCCEEEEEEEECCCHHHHHH
KSKAAL
HHHCCC
>Mature Secondary Structure 
ALRNIAIIAHVDHGKTTLVDELLKQSGSFRENQRVAERVMDSNDLEKERGITILAKATS
CCCEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHCCEEEEEEECC
VEWKGVRINIVDTPGHADFGGEVERILSMVDGAIVLVDASEGPMPQTKFVVGKALKVGLR
EEECCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCCC
PIVAINKIDRPDGRHEEVINEVFDLFANLDATDEQLDFPILYGSGRDGWMNVNPEGPKDE
EEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEECCCCCCCCC
GLAPLLDLVLKHVPEPTVHEGPFTMIGTILEANPFLGRIITGRINSGSIKPNQAVKVLHA
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEEEC
DGKTIETGRISKILAFRGIERTAIDEAHQGDIVAIAGLSKGTVADTFCDPSVTEPLQAQP
CCCEEECCCHHHHHHHCCCCHHHHCCCCCCCEEEEECCCCCCEECCCCCCCCCCCCCCCC
IDPPTVTMSFIVNDSPLAGTEGDKVTSRVIRDRLFKEAEGNVALKIEEAEGKDSFYVSGR
CCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECC
GELQLAVLIETMRREGFELAVSRPRVVMHKDESGQLLEPIEEVVVDVDEEHSGVVVQKMS
CCEEEHHHHHHHHCCCCEEEECCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCHHHHHH
ERKAEMVELRPSGGNRLRLRFYAPTRGLIGYQSELLTDTRGTAIMNRLFHDYQPYKGVIG
HCCCEEEEECCCCCCEEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
GRVNGVLLANAPGEAVAYAMFNLEDRGPMIIEPGEKVYAGMIIGIHTRDNDLEVNVLKGK
CCCCEEEEECCCCCEEEEEEEEECCCCCEEECCCCEEEEEEEEEEEECCCCEEEEEECCC
QLTNIRAAGKDEAVKLTPPIRMTLDRALSWIQEDELMEVTPKNIRLRKMYLDANDRKRFE
EEEEEECCCCCCEEEECCCHHHHHHHHHHHHCCCCCEECCCCCEEEEEEEECCCHHHHHH
KSKAAL
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9622352 [H]