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The map label for this gene is sdhA [H]

Identifier: 209551262

GI number: 209551262

Start: 3819933

End: 3821774

Strand: Reverse

Name: sdhA [H]

Synonym: Rleg2_3690

Alternate gene names: 209551262

Gene position: 3821774-3819933 (Counterclockwise)

Preceding gene: 209551263

Following gene: 209551261

Centisome position: 84.22

GC content: 65.04

Gene sequence:

>1842_bases
ATGGCACCGACTTCACCCGCCCAGAACGGCAAGGCCTACAAATATGTCGATCACTCCTACGACGTGATCGTCGTCGGCGC
CGGCGGCGCCGGCTTGCGCGCCACGCTGGGCATGGCCGAGCAGGGTTTTCGCACGGCCTGCATCACCAAGGTATTCCCGA
CCCGCTCGCATACGGTTGCGGCGCAGGGCGGCATTGCCGCCTCGCTGCGCAACATGACGCCCGATAGCTGGCAGTGGCAC
CTCTACGACACCGTCAAGGGCTCCGACTGGCTCGGCGACGTCGACGCCATGCAGTACCTGACCATGGAAGCGCCGAAGGC
GGTCTATGAGCTCGAGCATTACGGCGTGCCTTTCTCGCGCAACGAGGAAGGCAAGATCTATCAGCGCCCGTTCGGCGGCC
ATATGCAGAATTACGGTGAAGGCCCGCCGGTGCAGCGCACCTGCGCCGTTGCCGACCGCACCGGCCACGCCATCCTGCAC
ACGCTTTACGGCCAGTCGCTGCGCCACAACGCCGAATTTTTCATCGAGTATTTCGCGCTCGACTTGATCATGTCGGAAGA
TGGCAGCCGCTGCACCGGCGTCGTCGCCTGGTGCCTCGACGACGGCACGATCCATCGCTTCGCCGCCAAGATGGTGGTGC
TGGCGACCGGCGGCTACGGCCGCGCCTATTTCTCGGCGACCTCTGCTCACACCTGCACCGGCGACGGCGGCGGCATGGTG
GCGCGCGCCGGCCTGCCGTTGCAGGACATGGAATTCGTCCAGTTCCACCCGACCGGCATCTACGGTTCGGGCTGTCTGAT
CACCGAAGGCGCGCGCGGCGAAGGCGGTTACCTCGTCAACTCCGAGGGCGAGCGCTTCATGGAGCGTTACGCGCCGTCGG
CCAAGGACCTTGCCTCGCGCGACGTCGTTTCGCGCTGCATGACGCTGGAAATCCGCGAAGGCCGCGGCGTCGGCAAGAAC
AAGGACCACATCTTCCTGCATCTCGACCATCTCGATCCGGCGGTGCTGCACGAGCGGCTGCCGGGGATTTCCGAGAGCGC
CAAGATCTTCGCCGGCGTCGATGTCACGCGCGAGCCGATCCCGGTTCTGCCGACCGTTCATTACAATATGGGCGGCATTC
CGACGAATTATTGGGGCGAAGTGCTGAACGCCGACGGCGCCAATCCGGAACGGATCATCCCCGGGCTGATGGCTGTCGGT
GAAGCCGGCTGCGCCTCGGTGCACGGCGCCAACCGCCTTGGCTCCAACTCGCTGATCGACCTCGTGGTCTTCGGCCGGGC
CGCTGCGATCCGCGCCGGCGAGGTGATCGACCGCGCAGCGCCGATCCCGCATCTCAATGTCTCAGCCTGCGACAAGATCA
TGGACCGCTTCGACGGCCTGCGTCACGCCAGCGGCAGCACGCCGACGGCGGAACTGCGCGAGAAGATGCAGCGGGCCATG
CAGGAAGACGCCGCCGTCTTCCGCACGCAGGAATCGCTGGAATCCGGCTGCCGGCGCATCTCGGCGATCTGGCAGGAAAT
GCGTGATATCAAGGTGACCGACCGCTCGATGATCTGGAACTCGGATCTTGTGGAGACGCTGGAGCTGCAGAACCTGATGG
CCAACGCCATCACGACGATCTACGGCGCCGAGGCCCGCAAGGAGAGCCGCGGTTCGCATGCCCGCGAGGATTATACCGAG
GGCGCATTCGCCGGCCGCGACGACGTCAACTGGCGCAAGCATACGCTTGCCTGGGTCAGCGAGGCAGGCGACGTGAAACT
CGATTACCGGCCCGTTCACACCGACCTCATCGCGGAAGGCATCGACCCGCACAAGATCGAGCCGAAAGCGCGTGTCTATT
AA

Upstream 100 bases:

>100_bases
AAGATCGCTCTCTTAATGCTGAACACCTTCTTTGCGATCCTGATCGCCGGCCTCTGTCTCTTCGCCATTCTGAAAATCGC
ATTCGTAGGATAAGCTCGAT

Downstream 100 bases:

>100_bases
GATGAGAAACGCTGTCTTTCTTTCAATTGTCGCGGTTACCTTGACGGTGTCGTTCTCGGTCTCGGCGGCCGATCGCTACA
AGTTGCGAGCCCCGGGCGGC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MAPTSPAQNGKAYKYVDHSYDVIVVGAGGAGLRATLGMAEQGFRTACITKVFPTRSHTVAAQGGIAASLRNMTPDSWQWH
LYDTVKGSDWLGDVDAMQYLTMEAPKAVYELEHYGVPFSRNEEGKIYQRPFGGHMQNYGEGPPVQRTCAVADRTGHAILH
TLYGQSLRHNAEFFIEYFALDLIMSEDGSRCTGVVAWCLDDGTIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGGMV
ARAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTLEIREGRGVGKN
KDHIFLHLDHLDPAVLHERLPGISESAKIFAGVDVTREPIPVLPTVHYNMGGIPTNYWGEVLNADGANPERIIPGLMAVG
EAGCASVHGANRLGSNSLIDLVVFGRAAAIRAGEVIDRAAPIPHLNVSACDKIMDRFDGLRHASGSTPTAELREKMQRAM
QEDAAVFRTQESLESGCRRISAIWQEMRDIKVTDRSMIWNSDLVETLELQNLMANAITTIYGAEARKESRGSHAREDYTE
GAFAGRDDVNWRKHTLAWVSEAGDVKLDYRPVHTDLIAEGIDPHKIEPKARVY

Sequences:

>Translated_613_residues
MAPTSPAQNGKAYKYVDHSYDVIVVGAGGAGLRATLGMAEQGFRTACITKVFPTRSHTVAAQGGIAASLRNMTPDSWQWH
LYDTVKGSDWLGDVDAMQYLTMEAPKAVYELEHYGVPFSRNEEGKIYQRPFGGHMQNYGEGPPVQRTCAVADRTGHAILH
TLYGQSLRHNAEFFIEYFALDLIMSEDGSRCTGVVAWCLDDGTIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGGMV
ARAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTLEIREGRGVGKN
KDHIFLHLDHLDPAVLHERLPGISESAKIFAGVDVTREPIPVLPTVHYNMGGIPTNYWGEVLNADGANPERIIPGLMAVG
EAGCASVHGANRLGSNSLIDLVVFGRAAAIRAGEVIDRAAPIPHLNVSACDKIMDRFDGLRHASGSTPTAELREKMQRAM
QEDAAVFRTQESLESGCRRISAIWQEMRDIKVTDRSMIWNSDLVETLELQNLMANAITTIYGAEARKESRGSHAREDYTE
GAFAGRDDVNWRKHTLAWVSEAGDVKLDYRPVHTDLIAEGIDPHKIEPKARVY
>Mature_612_residues
APTSPAQNGKAYKYVDHSYDVIVVGAGGAGLRATLGMAEQGFRTACITKVFPTRSHTVAAQGGIAASLRNMTPDSWQWHL
YDTVKGSDWLGDVDAMQYLTMEAPKAVYELEHYGVPFSRNEEGKIYQRPFGGHMQNYGEGPPVQRTCAVADRTGHAILHT
LYGQSLRHNAEFFIEYFALDLIMSEDGSRCTGVVAWCLDDGTIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGGMVA
RAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTLEIREGRGVGKNK
DHIFLHLDHLDPAVLHERLPGISESAKIFAGVDVTREPIPVLPTVHYNMGGIPTNYWGEVLNADGANPERIIPGLMAVGE
AGCASVHGANRLGSNSLIDLVVFGRAAAIRAGEVIDRAAPIPHLNVSACDKIMDRFDGLRHASGSTPTAELREKMQRAMQ
EDAAVFRTQESLESGCRRISAIWQEMRDIKVTDRSMIWNSDLVETLELQNLMANAITTIYGAEARKESRGSHAREDYTEG
AFAGRDDVNWRKHTLAWVSEAGDVKLDYRPVHTDLIAEGIDPHKIEPKARVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=614, Percent_Identity=62.0521172638437, Blast_Score=741, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=558, Percent_Identity=51.0752688172043, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI1790597, Length=587, Percent_Identity=40.8858603066439, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1788928, Length=559, Percent_Identity=32.0214669051878, Blast_Score=216, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17550100, Length=614, Percent_Identity=60.7491856677524, Blast_Score=727, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=618, Percent_Identity=59.2233009708738, Blast_Score=712, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=611, Percent_Identity=63.9934533551555, Blast_Score=772, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=598, Percent_Identity=64.0468227424749, Blast_Score=768, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=488, Percent_Identity=27.4590163934426, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17137288, Length=601, Percent_Identity=64.7254575707155, Blast_Score=769, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=601, Percent_Identity=64.7254575707155, Blast_Score=769, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=601, Percent_Identity=64.7254575707155, Blast_Score=769, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=616, Percent_Identity=55.5194805194805, Blast_Score=688, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 67080; Mature: 66949

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPTSPAQNGKAYKYVDHSYDVIVVGAGGAGLRATLGMAEQGFRTACITKVFPTRSHTVA
CCCCCCCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCEEE
AQGGIAASLRNMTPDSWQWHLYDTVKGSDWLGDVDAMQYLTMEAPKAVYELEHYGVPFSR
ECCCHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCC
NEEGKIYQRPFGGHMQNYGEGPPVQRTCAVADRTGHAILHTLYGQSLRHNAEFFIEYFAL
CCCCCEEECCCCCCHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
DLIMSEDGSRCTGVVAWCLDDGTIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGGMV
HHHCCCCCCCEEEEEEEEECCCHHHHHHEEEEEEEECCCCEEEEECCCCCEEECCCCCEE
ARAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASR
EECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHH
DVVSRCMTLEIREGRGVGKNKDHIFLHLDHLDPAVLHERLPGISESAKIFAGVDVTREPI
HHHHHHHEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCCCCC
PVLPTVHYNMGGIPTNYWGEVLNADGANPERIIPGLMAVGEAGCASVHGANRLGSNSLID
CCCCEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
LVVFGRAAAIRAGEVIDRAAPIPHLNVSACDKIMDRFDGLRHASGSTPTAELREKMQRAM
EEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
QEDAAVFRTQESLESGCRRISAIWQEMRDIKVTDRSMIWNSDLVETLELQNLMANAITTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCHHEEECHHHHHHHHHHHHHHHHHHHH
YGAEARKESRGSHAREDYTEGAFAGRDDVNWRKHTLAWVSEAGDVKLDYRPVHTDLIAEG
HCCHHHHHHCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHCC
IDPHKIEPKARVY
CCCCCCCCCCCCC
>Mature Secondary Structure 
APTSPAQNGKAYKYVDHSYDVIVVGAGGAGLRATLGMAEQGFRTACITKVFPTRSHTVA
CCCCCCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCEEE
AQGGIAASLRNMTPDSWQWHLYDTVKGSDWLGDVDAMQYLTMEAPKAVYELEHYGVPFSR
ECCCHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCC
NEEGKIYQRPFGGHMQNYGEGPPVQRTCAVADRTGHAILHTLYGQSLRHNAEFFIEYFAL
CCCCCEEECCCCCCHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
DLIMSEDGSRCTGVVAWCLDDGTIHRFAAKMVVLATGGYGRAYFSATSAHTCTGDGGGMV
HHHCCCCCCCEEEEEEEEECCCHHHHHHEEEEEEEECCCCEEEEECCCCCEEECCCCCEE
ARAGLPLQDMEFVQFHPTGIYGSGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASR
EECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHH
DVVSRCMTLEIREGRGVGKNKDHIFLHLDHLDPAVLHERLPGISESAKIFAGVDVTREPI
HHHHHHHEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCCCCC
PVLPTVHYNMGGIPTNYWGEVLNADGANPERIIPGLMAVGEAGCASVHGANRLGSNSLID
CCCCEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
LVVFGRAAAIRAGEVIDRAAPIPHLNVSACDKIMDRFDGLRHASGSTPTAELREKMQRAM
EEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
QEDAAVFRTQESLESGCRRISAIWQEMRDIKVTDRSMIWNSDLVETLELQNLMANAITTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCHHEEECHHHHHHHHHHHHHHHHHHHH
YGAEARKESRGSHAREDYTEGAFAGRDDVNWRKHTLAWVSEAGDVKLDYRPVHTDLIAEG
HCCHHHHHHCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHCC
IDPHKIEPKARVY
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA