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The map label for this gene is lpd [H]

Identifier: 209551246

GI number: 209551246

Start: 3804016

End: 3805422

Strand: Reverse

Name: lpd [H]

Synonym: Rleg2_3674

Alternate gene names: 209551246

Gene position: 3805422-3804016 (Counterclockwise)

Preceding gene: 209551247

Following gene: 209551241

Centisome position: 83.86

GC content: 62.97

Gene sequence:

>1407_bases
ATGTCTTACGATGTGATCATTATCGGAACCGGCCCGGGCGGCTATGTCTGCGCCGTCAAGGCAGCCCAGCTCGGCCTCAA
GGTCGCCGTCGTCGAAAAGCGCGCGACCTATGGCGGCACCTGCCTGAACGTCGGCTGCATTCCGTCGAAGGCGCTGCTGC
ATGCCTCCGAAATGTTCCATCAGGCCGGCCATGGCATGAGCGCGCTCGGCATCGACATTGCGGCGCCGACGCTCAATCTC
GGCAATATGATGGCTCACAAGGACGCCACGGTGAAGTCGAATGTCGACGGCGTCGCCTTCCTCTTCAAGAAGAACAAGAT
CGACGCCTTCCAGGGCAGCGGCAAGATCGTCTCGGCCGGCAAGGTCGCGGTCACTGCCGAAGACGGCACGGTGCAGGAGA
TCGACGGCAAGAACATCGTCATCGCCACCGGCTCCGACGTCGCCGGCATCCCCGGCGTGCAGGTTGAGATCGATGAAAAG
ACCATCATCTCCTCCACCGGCGGCATCGCGCTGGAGAAGGTGCCGGAAACGCTGATCGTGGTCGGCGGCGGTGTCATCGG
GCTCGAGCTCGGCTCGGTCTGGTCGCGCCTCGGCGCCAAGGTCACGGTCGTCGAATTTCTCGACACCATCCTCGGCGGCA
TGGACGGCGAAGTCTCCAAGCAGTTCCAGCGCATGCTCGCCAAGCAGGGCATCGATTTCCATCTCGGCGCCAAGGTCACT
GGCGTCGAAAAGGGTGACAAGGGCGCCAAGGTCACGTTCGAGCCGGTCAAGGGCGGCGACAAGGTGACGCTCGATGCCGA
AGTCGTGCTGATCGCTACCGGCCGCAAGCCCTATACGGCGGGGCTCGGCCTCGAGGAGGCTGGTGTTGCGCTCGACAATC
GCGGCCGCGTCGAGATCGACGGTCACTTCAAGACCAATGTCGCCGGCATCTATGCGATCGGCGACGTGGTCAAGGGCCCG
ATGCTGGCGCACAAGGCGGAAGACGAGGGCGTGGCGCTTGCCGAAATCCTCGCCGGCCAGCATGGCCACGTCAATTATGA
CGTCATTCCGAGCGTCGTTTATACCCAGCCGGAGATCGCCTCGGTCGGCAAGACCGAGGAAGAGCTGAAGGCGGCAGGTA
TCGCCTACAAGGTCGGCAAGTTTCCGTTCACGGCGAACGGCCGTGCCCGCGCGATGCTGGCGACCGATGGTTTCGTCAAG
ATCCTTGCGGACAAGGAAACCGACCGGGTGCTCGGCGGCCATATCGTCGGCTTCGGCGCCGGCGAGATGATCCACGAGAT
TACCGTGCTGATGGAGTTCGGCGGTTCGTCGGAAGATCTCGGCCGCACCTGCCATGCTCATCCGACGATGTCGGAAGCGG
TGAAGGAAGCCGCGCTTGCGACCTTCTTCAAGCCGATCCATATGTAA

Upstream 100 bases:

>100_bases
GGTTCAACCGCGTTACCGGAGCGGCGCTCGTCGGCTTCGGCTTCCGCCTCGCGCTGTCGCGCGCGGCCGACTAATTGAAA
AATCCAAAGGGAAAGAAGCA

Downstream 100 bases:

>100_bases
TCTTACATATTCGTAAAAAAGCATTCAGCCGCTTGCCGCGAGGCAGGCGGCTGTTTTGGTTCTATTGCCTGGCGCCCGAC
AAGCTGGCCGCGACAGGCGC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSYDVIIIGTGPGGYVCAVKAAQLGLKVAVVEKRATYGGTCLNVGCIPSKALLHASEMFHQAGHGMSALGIDIAAPTLNL
GNMMAHKDATVKSNVDGVAFLFKKNKIDAFQGSGKIVSAGKVAVTAEDGTVQEIDGKNIVIATGSDVAGIPGVQVEIDEK
TIISSTGGIALEKVPETLIVVGGGVIGLELGSVWSRLGAKVTVVEFLDTILGGMDGEVSKQFQRMLAKQGIDFHLGAKVT
GVEKGDKGAKVTFEPVKGGDKVTLDAEVVLIATGRKPYTAGLGLEEAGVALDNRGRVEIDGHFKTNVAGIYAIGDVVKGP
MLAHKAEDEGVALAEILAGQHGHVNYDVIPSVVYTQPEIASVGKTEEELKAAGIAYKVGKFPFTANGRARAMLATDGFVK
ILADKETDRVLGGHIVGFGAGEMIHEITVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALATFFKPIHM

Sequences:

>Translated_468_residues
MSYDVIIIGTGPGGYVCAVKAAQLGLKVAVVEKRATYGGTCLNVGCIPSKALLHASEMFHQAGHGMSALGIDIAAPTLNL
GNMMAHKDATVKSNVDGVAFLFKKNKIDAFQGSGKIVSAGKVAVTAEDGTVQEIDGKNIVIATGSDVAGIPGVQVEIDEK
TIISSTGGIALEKVPETLIVVGGGVIGLELGSVWSRLGAKVTVVEFLDTILGGMDGEVSKQFQRMLAKQGIDFHLGAKVT
GVEKGDKGAKVTFEPVKGGDKVTLDAEVVLIATGRKPYTAGLGLEEAGVALDNRGRVEIDGHFKTNVAGIYAIGDVVKGP
MLAHKAEDEGVALAEILAGQHGHVNYDVIPSVVYTQPEIASVGKTEEELKAAGIAYKVGKFPFTANGRARAMLATDGFVK
ILADKETDRVLGGHIVGFGAGEMIHEITVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALATFFKPIHM
>Mature_467_residues
SYDVIIIGTGPGGYVCAVKAAQLGLKVAVVEKRATYGGTCLNVGCIPSKALLHASEMFHQAGHGMSALGIDIAAPTLNLG
NMMAHKDATVKSNVDGVAFLFKKNKIDAFQGSGKIVSAGKVAVTAEDGTVQEIDGKNIVIATGSDVAGIPGVQVEIDEKT
IISSTGGIALEKVPETLIVVGGGVIGLELGSVWSRLGAKVTVVEFLDTILGGMDGEVSKQFQRMLAKQGIDFHLGAKVTG
VEKGDKGAKVTFEPVKGGDKVTLDAEVVLIATGRKPYTAGLGLEEAGVALDNRGRVEIDGHFKTNVAGIYAIGDVVKGPM
LAHKAEDEGVALAEILAGQHGHVNYDVIPSVVYTQPEIASVGKTEEELKAAGIAYKVGKFPFTANGRARAMLATDGFVKI
LADKETDRVLGGHIVGFGAGEMIHEITVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALATFFKPIHM

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=463, Percent_Identity=55.5075593952484, Blast_Score=507, Evalue=1e-144,
Organism=Homo sapiens, GI50301238, Length=467, Percent_Identity=30.406852248394, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI22035672, Length=463, Percent_Identity=31.317494600432, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI291045266, Length=476, Percent_Identity=29.6218487394958, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI33519430, Length=474, Percent_Identity=28.0590717299578, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI33519428, Length=474, Percent_Identity=28.0590717299578, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI33519426, Length=474, Percent_Identity=28.0590717299578, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI148277065, Length=474, Percent_Identity=28.0590717299578, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI148277071, Length=474, Percent_Identity=28.0590717299578, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI291045268, Length=468, Percent_Identity=28.6324786324786, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=41.2280701754386, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI87082354, Length=465, Percent_Identity=31.3978494623656, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI87081717, Length=469, Percent_Identity=30.2771855010661, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=30.751708428246, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1789065, Length=186, Percent_Identity=31.7204301075269, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=55.2173913043478, Blast_Score=506, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=29.746835443038, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71983429, Length=456, Percent_Identity=28.5087719298246, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71982272, Length=486, Percent_Identity=25.7201646090535, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71983419, Length=456, Percent_Identity=28.5087719298246, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17559934, Length=264, Percent_Identity=26.8939393939394, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321091, Length=475, Percent_Identity=53.2631578947368, Blast_Score=481, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=32.2784810126582, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6325166, Length=471, Percent_Identity=30.7855626326964, Blast_Score=175, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=54.4871794871795, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24640553, Length=485, Percent_Identity=29.2783505154639, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24640549, Length=485, Percent_Identity=29.2783505154639, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24640551, Length=485, Percent_Identity=29.2783505154639, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17737741, Length=483, Percent_Identity=27.7432712215321, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48671; Mature: 48540

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDVIIIGTGPGGYVCAVKAAQLGLKVAVVEKRATYGGTCLNVGCIPSKALLHASEMFH
CCEEEEEEECCCCCEEEEEEEHHCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
QAGHGMSALGIDIAAPTLNLGNMMAHKDATVKSNVDGVAFLFKKNKIDAFQGSGKIVSAG
HHCCCCEEEEEEEECCCCCCCCCHHCCCCCCCCCCCCEEEEEECCCCCEECCCCCEEECC
KVAVTAEDGTVQEIDGKNIVIATGSDVAGIPGVQVEIDEKTIISSTGGIALEKVPETLIV
EEEEEECCCCEEEECCCEEEEECCCCCCCCCCCEEEECCEEEEECCCCEEEECCCCEEEE
VGGGVIGLELGSVWSRLGAKVTVVEFLDTILGGMDGEVSKQFQRMLAKQGIDFHLGAKVT
ECCCEEEEEHHHHHHHHCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEECCEEE
GVEKGDKGAKVTFEPVKGGDKVTLDAEVVLIATGRKPYTAGLGLEEAGVALDNRGRVEID
ECCCCCCCCEEEEEECCCCCEEEEEEEEEEEEECCCCEECCCCCHHCCEEECCCCEEEEC
GHFKTNVAGIYAIGDVVKGPMLAHKAEDEGVALAEILAGQHGHVNYDVIPSVVYTQPEIA
CCEECCCEEEEEEHHHHCCCHHEECCCCCCCCHHHHHCCCCCCCCCEECCCEEECCCCHH
SVGKTEEELKAAGIAYKVGKFPFTANGRARAMLATDGFVKILADKETDRVLGGHIVGFGA
HCCCCHHHHHHCCEEEEECCCCCCCCCCEEEEEECCCEEEEEECCCCCCEECCEEEEECC
GEMIHEITVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALATFFKPIHM
HHHHHHEEEEEECCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYDVIIIGTGPGGYVCAVKAAQLGLKVAVVEKRATYGGTCLNVGCIPSKALLHASEMFH
CEEEEEEECCCCCEEEEEEEHHCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
QAGHGMSALGIDIAAPTLNLGNMMAHKDATVKSNVDGVAFLFKKNKIDAFQGSGKIVSAG
HHCCCCEEEEEEEECCCCCCCCCHHCCCCCCCCCCCCEEEEEECCCCCEECCCCCEEECC
KVAVTAEDGTVQEIDGKNIVIATGSDVAGIPGVQVEIDEKTIISSTGGIALEKVPETLIV
EEEEEECCCCEEEECCCEEEEECCCCCCCCCCCEEEECCEEEEECCCCEEEECCCCEEEE
VGGGVIGLELGSVWSRLGAKVTVVEFLDTILGGMDGEVSKQFQRMLAKQGIDFHLGAKVT
ECCCEEEEEHHHHHHHHCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEECCEEE
GVEKGDKGAKVTFEPVKGGDKVTLDAEVVLIATGRKPYTAGLGLEEAGVALDNRGRVEID
ECCCCCCCCEEEEEECCCCCEEEEEEEEEEEEECCCCEECCCCCHHCCEEECCCCEEEEC
GHFKTNVAGIYAIGDVVKGPMLAHKAEDEGVALAEILAGQHGHVNYDVIPSVVYTQPEIA
CCEECCCEEEEEEHHHHCCCHHEECCCCCCCCHHHHHCCCCCCCCCEECCCEEECCCCHH
SVGKTEEELKAAGIAYKVGKFPFTANGRARAMLATDGFVKILADKETDRVLGGHIVGFGA
HCCCCHHHHHHCCEEEEECCCCCCCCCCEEEEEECCCEEEEEECCCCCCEECCEEEEECC
GEMIHEITVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALATFFKPIHM
HHHHHHEEEEEECCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9226266 [H]