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The map label for this gene is hisC [H]

Identifier: 209551156

GI number: 209551156

Start: 3707227

End: 3708336

Strand: Reverse

Name: hisC [H]

Synonym: Rleg2_3580

Alternate gene names: 209551156

Gene position: 3708336-3707227 (Counterclockwise)

Preceding gene: 209551157

Following gene: 209551155

Centisome position: 81.72

GC content: 63.42

Gene sequence:

>1110_bases
ATGAGCGTTGAGATGAGCAAGCCCGTTCCGCGTCCCGGTATTCTCGATATCGCATCCTATGTGCCGGGCAAGGAACATGC
GCCGGGGGTTGCCCGCGTCTACAAGCTTTCGTCCAACGAAACGCCGCTCGGCGCCAGCCCGAAGGCGATCGAAGCCTGCA
AGGCGGCCGCCGACCATCTGGGACGTTATCCCGACGGGCAGGCGGTGGAATTGCGCGAGGCGATCGCCGCGGTGCACGGC
CTCAACCCGGCAAACATCCTCTGCGGTAACGGTTCCGACGAGCTACTCGGCCTGCTCTGCCATGTCTATCTCGGCGCCGG
CGACGAGGGCATCATCACCGAGCACGGTTTCCTGGTCTACAAGATCCAGATCCAGGGCGCCGGGGCCACGCCCGTCGTCG
TCAGGGAAAAGGATCATACCGTCGATGTCGATGCGATCCTTGCTGCGGTGACGGAGAAGACGAAGATCGTCTTCATCGCC
AATCCCGGCAATCCGACAGGAACCTATGTCCCGGTCAGCGAGATCCGCCGCCTACAGGCCGGGCTGCCGAAACATGTCGT
CTTGGTTCTCGATGCCGCCTATGCCGAATATGTGCGCCGCAACGATTATGAAGCCGGCATCGAGGTCGTGTCCTCCAATG
CCAATGTGGTGATGACCCGCACCTTCTCGAAGGCCTACGGACTTGCAGCGCTACGCGTCGGCTGGATGTATGCGCCCGCC
GAGATCGTCGACGCGGTGAACCGCGTGCGCGGCCCCTTCAATCTGAACGCGCCGGCAATCGCCGCCGGGGCCGCGGCCAT
CCGCGACCAGGCCTTCGTCCAGCAGGCCGTCTCCTTCAACCAGACGTGGGTAGAAACGCTCACCCAGGCCCTCGAAGCGA
TCGGTCTGAAGGTGACGCCGTCGGTCGCCAATTTCGTCCTCATCCATTTCCCCGAGATTGACGGCAAGCGCGCCGCCGAT
GCCGACGATCTGCTGACGAGCCGGGGCTACATCCTGCGCGCCGTGCGCAGCTACGGCTTTTCCAATGCGCTGCGCATGAG
CATCGGCCCGGAAGAGGCCAATCGCGGCGTCATCGCCGCCCTCACCGAATTCATGGGACATAAGGCATGA

Upstream 100 bases:

>100_bases
GCCGACCACACGCAATCGCTGACGCCGTCCCGGCTCTCGACAAGAACGGCATTCCGCTTTAATGCCACCTGGTCATTTCC
GGCAATTCCAAGGTCGACCC

Downstream 100 bases:

>100_bases
ACGTGCAGTTCGATCGTATCGCGCTGATCGGCATCGGTCTGATCGGCTCTTCGCTTGCCCACGACATCCGGCGGCTCGGC
CTTGCCAGAGAGATCGTCGT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSVEMSKPVPRPGILDIASYVPGKEHAPGVARVYKLSSNETPLGASPKAIEACKAAADHLGRYPDGQAVELREAIAAVHG
LNPANILCGNGSDELLGLLCHVYLGAGDEGIITEHGFLVYKIQIQGAGATPVVVREKDHTVDVDAILAAVTEKTKIVFIA
NPGNPTGTYVPVSEIRRLQAGLPKHVVLVLDAAYAEYVRRNDYEAGIEVVSSNANVVMTRTFSKAYGLAALRVGWMYAPA
EIVDAVNRVRGPFNLNAPAIAAGAAAIRDQAFVQQAVSFNQTWVETLTQALEAIGLKVTPSVANFVLIHFPEIDGKRAAD
ADDLLTSRGYILRAVRSYGFSNALRMSIGPEEANRGVIAALTEFMGHKA

Sequences:

>Translated_369_residues
MSVEMSKPVPRPGILDIASYVPGKEHAPGVARVYKLSSNETPLGASPKAIEACKAAADHLGRYPDGQAVELREAIAAVHG
LNPANILCGNGSDELLGLLCHVYLGAGDEGIITEHGFLVYKIQIQGAGATPVVVREKDHTVDVDAILAAVTEKTKIVFIA
NPGNPTGTYVPVSEIRRLQAGLPKHVVLVLDAAYAEYVRRNDYEAGIEVVSSNANVVMTRTFSKAYGLAALRVGWMYAPA
EIVDAVNRVRGPFNLNAPAIAAGAAAIRDQAFVQQAVSFNQTWVETLTQALEAIGLKVTPSVANFVLIHFPEIDGKRAAD
ADDLLTSRGYILRAVRSYGFSNALRMSIGPEEANRGVIAALTEFMGHKA
>Mature_368_residues
SVEMSKPVPRPGILDIASYVPGKEHAPGVARVYKLSSNETPLGASPKAIEACKAAADHLGRYPDGQAVELREAIAAVHGL
NPANILCGNGSDELLGLLCHVYLGAGDEGIITEHGFLVYKIQIQGAGATPVVVREKDHTVDVDAILAAVTEKTKIVFIAN
PGNPTGTYVPVSEIRRLQAGLPKHVVLVLDAAYAEYVRRNDYEAGIEVVSSNANVVMTRTFSKAYGLAALRVGWMYAPAE
IVDAVNRVRGPFNLNAPAIAAGAAAIRDQAFVQQAVSFNQTWVETLTQALEAIGLKVTPSVANFVLIHFPEIDGKRAADA
DDLLTSRGYILRAVRSYGFSNALRMSIGPEEANRGVIAALTEFMGHKA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=322, Percent_Identity=26.7080745341615, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6322075, Length=396, Percent_Identity=25, Blast_Score=96, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39305; Mature: 39174

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVEMSKPVPRPGILDIASYVPGKEHAPGVARVYKLSSNETPLGASPKAIEACKAAADHL
CCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
GRYPDGQAVELREAIAAVHGLNPANILCGNGSDELLGLLCHVYLGAGDEGIITEHGFLVY
CCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCEEEE
KIQIQGAGATPVVVREKDHTVDVDAILAAVTEKTKIVFIANPGNPTGTYVPVSEIRRLQA
EEEECCCCCCCEEEECCCCCCCHHHHHHHHHCCEEEEEEECCCCCCCCEECHHHHHHHHH
GLPKHVVLVLDAAYAEYVRRNDYEAGIEVVSSNANVVMTRTFSKAYGLAALRVGWMYAPA
CCCCEEEEEEEHHHHHHHHHCCCHHCCEEEECCCCEEEEEEHHHHHCHHHHHHHHEECCH
EIVDAVNRVRGPFNLNAPAIAAGAAAIRDQAFVQQAVSFNQTWVETLTQALEAIGLKVTP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEECC
SVANFVLIHFPEIDGKRAADADDLLTSRGYILRAVRSYGFSNALRMSIGPEEANRGVIAA
CCCCEEEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCHHCCCHHHH
LTEFMGHKA
HHHHHCCCC
>Mature Secondary Structure 
SVEMSKPVPRPGILDIASYVPGKEHAPGVARVYKLSSNETPLGASPKAIEACKAAADHL
CCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
GRYPDGQAVELREAIAAVHGLNPANILCGNGSDELLGLLCHVYLGAGDEGIITEHGFLVY
CCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCEEEE
KIQIQGAGATPVVVREKDHTVDVDAILAAVTEKTKIVFIANPGNPTGTYVPVSEIRRLQA
EEEECCCCCCCEEEECCCCCCCHHHHHHHHHCCEEEEEEECCCCCCCCEECHHHHHHHHH
GLPKHVVLVLDAAYAEYVRRNDYEAGIEVVSSNANVVMTRTFSKAYGLAALRVGWMYAPA
CCCCEEEEEEEHHHHHHHHHCCCHHCCEEEECCCCEEEEEEHHHHHCHHHHHHHHEECCH
EIVDAVNRVRGPFNLNAPAIAAGAAAIRDQAFVQQAVSFNQTWVETLTQALEAIGLKVTP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEECC
SVANFVLIHFPEIDGKRAADADDLLTSRGYILRAVRSYGFSNALRMSIGPEEANRGVIAA
CCCCEEEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCHHCCCHHHH
LTEFMGHKA
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]