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The map label for this gene is cytR [H]

Identifier: 209550986

GI number: 209550986

Start: 3523911

End: 3524942

Strand: Direct

Name: cytR [H]

Synonym: Rleg2_3410

Alternate gene names: 209550986

Gene position: 3523911-3524942 (Clockwise)

Preceding gene: 209550980

Following gene: 209550992

Centisome position: 77.65

GC content: 64.05

Gene sequence:

>1032_bases
GTGTCGAATTCCACGCCCGCAACAATCGAAGACGTCGCCCGGATCGCCGAGGTCTCCATCGCGACGGTGTCCCGGGCGAT
CCATATGCCGGAGAAGGTCGCCAACTCCACCCGGCTCAAGGTCAACCAGGCGATCGCCGTCACCGGCTACACCACCAATG
CCATGGCCCGCAGCCTGAGGCTCGGCCGTTCCAACATGATCCTGGTCGTGGCGCCCGACATCGGCGATCCCAATTTCTCC
AACATCCTCGTCGGGCTGGAAAACGAGGCGCGCGCGCACGGCTACGGCATCCTGATCGGCCACACGCAGAACGACGCCCA
GCGCGGGCTCGAATATCTGAAATTCTTGAATTCCAACCAGGCTGCCGGGCTGATCCTGTTCACCGGCATCCTGCCCTTCG
GGCATCAGACGATGACGGCGCGGCTGCCGCCGAGTGTGGGCGTTTTCGAGCCCGTCTTCAACGGCGGCATTCCCTATGTC
GGCGTCGACGATACCGAAGGCGCCAGGAAAGCCGTGGACCTGCTATTGGCCGAAGGCCATCGCAAGATCGCCTTCATCGG
CGATTCGCGCACCCGGCTTGCCTATATCAGGCGCCGCATGGGCTACGATGCCGGTCTCGATGCCGCCGGCATCCCGCCCG
ATCTGAGGATCGTGCTCGAAGGCGACGGCACGATCGAAAGCGGCCGGCATGCTGTGGAGCAGCTTTTCATGCGCGACACG
CTTCCCACCGCCTTCATGTGCGTGAACGATCAGACGGCGATCGGCGTCATGGTCGGCCTCGGGGCGCGCGGCTACGACAT
TCCGCGTGATTTCTCGGTGACCGGTTTCGACGACGTGCCGCAGGCCGTCTTCATATCACCGCCACTGACGACGATCCGCC
AGCCGCGAACGGCGATCGGCAAACAGGCGATGGCGCTGCTGCTGGAGCTCCTGTCCGATGGCCAGCCGACCGAGACGGAA
ATCCTGCTGCGGCCGGATCTGGTGGTTCGAAACTCCGTCTCCGCACCATCGCGCAACTGGTTGAAGCGCTGA

Upstream 100 bases:

>100_bases
GGTTTACATGGTGGATTAACACAGATCCGTTGAAGCCTGCCTTTGACCTGTCGACAAGTCTGTGTAGTGTCGCGGCGAAG
ACAGCCCAAGGCAGAGCTCA

Downstream 100 bases:

>100_bases
ACAGAGGGATAGCCGGCGACAAAAAATTGCGCCGGCGGCCAATGGCCGCCAGCACGCTTGATCAGACGTAACGGTTGACG
ACGTTTTCGAGCAGTTCCTG

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MSNSTPATIEDVARIAEVSIATVSRAIHMPEKVANSTRLKVNQAIAVTGYTTNAMARSLRLGRSNMILVVAPDIGDPNFS
NILVGLENEARAHGYGILIGHTQNDAQRGLEYLKFLNSNQAAGLILFTGILPFGHQTMTARLPPSVGVFEPVFNGGIPYV
GVDDTEGARKAVDLLLAEGHRKIAFIGDSRTRLAYIRRRMGYDAGLDAAGIPPDLRIVLEGDGTIESGRHAVEQLFMRDT
LPTAFMCVNDQTAIGVMVGLGARGYDIPRDFSVTGFDDVPQAVFISPPLTTIRQPRTAIGKQAMALLLELLSDGQPTETE
ILLRPDLVVRNSVSAPSRNWLKR

Sequences:

>Translated_343_residues
MSNSTPATIEDVARIAEVSIATVSRAIHMPEKVANSTRLKVNQAIAVTGYTTNAMARSLRLGRSNMILVVAPDIGDPNFS
NILVGLENEARAHGYGILIGHTQNDAQRGLEYLKFLNSNQAAGLILFTGILPFGHQTMTARLPPSVGVFEPVFNGGIPYV
GVDDTEGARKAVDLLLAEGHRKIAFIGDSRTRLAYIRRRMGYDAGLDAAGIPPDLRIVLEGDGTIESGRHAVEQLFMRDT
LPTAFMCVNDQTAIGVMVGLGARGYDIPRDFSVTGFDDVPQAVFISPPLTTIRQPRTAIGKQAMALLLELLSDGQPTETE
ILLRPDLVVRNSVSAPSRNWLKR
>Mature_342_residues
SNSTPATIEDVARIAEVSIATVSRAIHMPEKVANSTRLKVNQAIAVTGYTTNAMARSLRLGRSNMILVVAPDIGDPNFSN
ILVGLENEARAHGYGILIGHTQNDAQRGLEYLKFLNSNQAAGLILFTGILPFGHQTMTARLPPSVGVFEPVFNGGIPYVG
VDDTEGARKAVDLLLAEGHRKIAFIGDSRTRLAYIRRRMGYDAGLDAAGIPPDLRIVLEGDGTIESGRHAVEQLFMRDTL
PTAFMCVNDQTAIGVMVGLGARGYDIPRDFSVTGFDDVPQAVFISPPLTTIRQPRTAIGKQAMALLLELLSDGQPTETEI
LLRPDLVVRNSVSAPSRNWLKR

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=336, Percent_Identity=36.9047619047619, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1789202, Length=332, Percent_Identity=31.9277108433735, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1787948, Length=341, Percent_Identity=29.3255131964809, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790194, Length=330, Percent_Identity=30.6060606060606, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1788474, Length=328, Percent_Identity=30.1829268292683, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789068, Length=337, Percent_Identity=28.486646884273, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786540, Length=340, Percent_Identity=29.7058823529412, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI48994940, Length=308, Percent_Identity=27.5974025974026, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787580, Length=343, Percent_Identity=23.3236151603499, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787906, Length=311, Percent_Identity=24.4372990353698, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1789456, Length=328, Percent_Identity=28.0487804878049, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790715, Length=328, Percent_Identity=25.3048780487805, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786268, Length=323, Percent_Identity=23.5294117647059, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790689, Length=305, Percent_Identity=24.9180327868852, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37099; Mature: 36968

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSTPATIEDVARIAEVSIATVSRAIHMPEKVANSTRLKVNQAIAVTGYTTNAMARSLR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEEEEECCCHHHHHHHHH
LGRSNMILVVAPDIGDPNFSNILVGLENEARAHGYGILIGHTQNDAQRGLEYLKFLNSNQ
CCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCC
AAGLILFTGILPFGHQTMTARLPPSVGVFEPVFNGGIPYVGVDDTEGARKAVDLLLAEGH
CCEEEEEECCCCCCCCEEEEECCCCCCCHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCC
RKIAFIGDSRTRLAYIRRRMGYDAGLDAAGIPPDLRIVLEGDGTIESGRHAVEQLFMRDT
CEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHC
LPTAFMCVNDQTAIGVMVGLGARGYDIPRDFSVTGFDDVPQAVFISPPLTTIRQPRTAIG
CCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCHHHHH
KQAMALLLELLSDGQPTETEILLRPDLVVRNSVSAPSRNWLKR
HHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCCHHHHCC
>Mature Secondary Structure 
SNSTPATIEDVARIAEVSIATVSRAIHMPEKVANSTRLKVNQAIAVTGYTTNAMARSLR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEEEEECCCHHHHHHHHH
LGRSNMILVVAPDIGDPNFSNILVGLENEARAHGYGILIGHTQNDAQRGLEYLKFLNSNQ
CCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCC
AAGLILFTGILPFGHQTMTARLPPSVGVFEPVFNGGIPYVGVDDTEGARKAVDLLLAEGH
CCEEEEEECCCCCCCCEEEEECCCCCCCHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCC
RKIAFIGDSRTRLAYIRRRMGYDAGLDAAGIPPDLRIVLEGDGTIESGRHAVEQLFMRDT
CEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHC
LPTAFMCVNDQTAIGVMVGLGARGYDIPRDFSVTGFDDVPQAVFISPPLTTIRQPRTAIG
CCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCHHHHH
KQAMALLLELLSDGQPTETEILLRPDLVVRNSVSAPSRNWLKR
HHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]