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The map label for this gene is ldc [H]

Identifier: 209550966

GI number: 209550966

Start: 3502850

End: 3503983

Strand: Reverse

Name: ldc [H]

Synonym: Rleg2_3390

Alternate gene names: 209550966

Gene position: 3503983-3502850 (Counterclockwise)

Preceding gene: 209550970

Following gene: 209550965

Centisome position: 77.22

GC content: 62.43

Gene sequence:

>1134_bases
ATGACCACCCAGCGCATCCGCGACTTTCTCGCAACCCGACGTCCCGACGGTCCCTGCCTCGTGGTTGACCTCGACGTCAT
CAGCGACAATTTCCACGCCTTCCGTCACGCAATGCCGGACAGCGCCATCTACTACGCCGTCAAGGCCAACCCGGCCCCGG
AAGTGCTGAAGCTGCTTGCAGGCCTCGGCTCCAATTTCGATTGCGCATCCGTTGCCGAAATCGAAATGGCGCTCGAAGCC
GGTGCGACCGCCGCCCGCATCTCCTTTGGCAACACGATCAAGAAGGAACGTGACGTTGCCCGCGCGCATGCGCTCGGCGT
CAGCCTCTTTGCCGTCGACAGCCACGAGGAAGTCGAGAAGATCTCGCGTGCCGCTCCCGGCGCCCGCGTCTTCTGCCGCG
TGCTGACGGATGGCGAAGGCGCCGAATGGCCGCTGTCGCGCAAGTTCGGCTGCGTCCCGCAGATGGCTGTCGATGTTCTC
GTCTACGCCCATCAGCTCGGCCTGCTGTCCTACGGCGTCTCGTTCCATGTCGGTTCTCAGATGACCAAGGTCGATGCCTG
GGATTCGGCGCTTGCCGATGCCAAGCGTGTCTTCGTCTCGCTTGCCAAGCAGGGTATCCACCTGCAGATGGTCAACATGG
GCGGCGGCTTCCCGACCAAGTATCTGCGCGACGTTCCGTCCGCAGAAGCTTACGGCAAGTCGATCTACCAGGCGCTGCGC
ACGCATTTCGGCAACCAGATTCCGCAGACCATCATCGAGCCGGGCCGCGGCATGGTCGGCAATGCCGGCGTTATCAAGGC
TGAAGTCGTGCTGATCTCGAAGAAGTCGGACAATGACGATGCGCGCTGGGTATTCCTCGACATCGGCAAGTTCGGCGGTC
TCGCCGAGACGATGGACGAAGCCATCCGCTATCCGATCCGCACGGAGCACGACGGCGACGAGATGGAGCCCTGCGTCATC
GCCGGCCCGACCTGCGATTCGGCCGACGTGCTCTACGAGAAGAACCTCTATCCGCTGCCGATCTCCCTTTCGATCGGCGA
CGAGGTCCTGATCGAAGGTACCGGCGCCTATACGACGACCTATTCGGCGGTCGCTTTCAACGGTTTCGAGCCGCTGAAGG
CCTACGTCATCTGA

Upstream 100 bases:

>100_bases
ATGGTTCCGGGGTCTCCACCGGCTGGTTCCAATGCGAGTTCTCGTATGCCCTTTGTCCTCCGGTTCATGCCGGAGCTCTG
GAATTGGAAGAGGGAACGAT

Downstream 100 bases:

>100_bases
GGTCGTTTCCGCCGGCCCCGTAGCCAGCCGGGGCGGCAAATTCACAATTTCCTTCATCGCCGCTGATAACGGTATTGGGT
ACGGGAGGCCAAGATGGCCG

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTTQRIRDFLATRRPDGPCLVVDLDVISDNFHAFRHAMPDSAIYYAVKANPAPEVLKLLAGLGSNFDCASVAEIEMALEA
GATAARISFGNTIKKERDVARAHALGVSLFAVDSHEEVEKISRAAPGARVFCRVLTDGEGAEWPLSRKFGCVPQMAVDVL
VYAHQLGLLSYGVSFHVGSQMTKVDAWDSALADAKRVFVSLAKQGIHLQMVNMGGGFPTKYLRDVPSAEAYGKSIYQALR
THFGNQIPQTIIEPGRGMVGNAGVIKAEVVLISKKSDNDDARWVFLDIGKFGGLAETMDEAIRYPIRTEHDGDEMEPCVI
AGPTCDSADVLYEKNLYPLPISLSIGDEVLIEGTGAYTTTYSAVAFNGFEPLKAYVI

Sequences:

>Translated_377_residues
MTTQRIRDFLATRRPDGPCLVVDLDVISDNFHAFRHAMPDSAIYYAVKANPAPEVLKLLAGLGSNFDCASVAEIEMALEA
GATAARISFGNTIKKERDVARAHALGVSLFAVDSHEEVEKISRAAPGARVFCRVLTDGEGAEWPLSRKFGCVPQMAVDVL
VYAHQLGLLSYGVSFHVGSQMTKVDAWDSALADAKRVFVSLAKQGIHLQMVNMGGGFPTKYLRDVPSAEAYGKSIYQALR
THFGNQIPQTIIEPGRGMVGNAGVIKAEVVLISKKSDNDDARWVFLDIGKFGGLAETMDEAIRYPIRTEHDGDEMEPCVI
AGPTCDSADVLYEKNLYPLPISLSIGDEVLIEGTGAYTTTYSAVAFNGFEPLKAYVI
>Mature_376_residues
TTQRIRDFLATRRPDGPCLVVDLDVISDNFHAFRHAMPDSAIYYAVKANPAPEVLKLLAGLGSNFDCASVAEIEMALEAG
ATAARISFGNTIKKERDVARAHALGVSLFAVDSHEEVEKISRAAPGARVFCRVLTDGEGAEWPLSRKFGCVPQMAVDVLV
YAHQLGLLSYGVSFHVGSQMTKVDAWDSALADAKRVFVSLAKQGIHLQMVNMGGGFPTKYLRDVPSAEAYGKSIYQALRT
HFGNQIPQTIIEPGRGMVGNAGVIKAEVVLISKKSDNDDARWVFLDIGKFGGLAETMDEAIRYPIRTEHDGDEMEPCVIA
GPTCDSADVLYEKNLYPLPISLSIGDEVLIEGTGAYTTTYSAVAFNGFEPLKAYVI

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=373, Percent_Identity=32.4396782841823, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI22538418, Length=368, Percent_Identity=26.3586956521739, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI21361583, Length=368, Percent_Identity=26.3586956521739, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI16506287, Length=354, Percent_Identity=29.0960451977401, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1789203, Length=382, Percent_Identity=25.130890052356, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562780, Length=393, Percent_Identity=31.8066157760814, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI25141365, Length=356, Percent_Identity=24.438202247191, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI25141367, Length=199, Percent_Identity=25.6281407035176, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322664, Length=378, Percent_Identity=30.6878306878307, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24586472, Length=380, Percent_Identity=30, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24586474, Length=361, Percent_Identity=29.9168975069252, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 40868; Mature: 40737

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQRIRDFLATRRPDGPCLVVDLDVISDNFHAFRHAMPDSAIYYAVKANPAPEVLKLLA
CCHHHHHHHHHHCCCCCCEEEEEEHHHCCCHHHHHHCCCCCEEEEEEECCCHHHHHHHHH
GLGSNFDCASVAEIEMALEAGATAARISFGNTIKKERDVARAHALGVSLFAVDSHEEVEK
HCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCEEEEEECCHHHHHH
ISRAAPGARVFCRVLTDGEGAEWPLSRKFGCVPQMAVDVLVYAHQLGLLSYGVSFHVGSQ
HHHCCCCHHEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCC
MTKVDAWDSALADAKRVFVSLAKQGIHLQMVNMGGGFPTKYLRDVPSAEAYGKSIYQALR
CEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHH
THFGNQIPQTIIEPGRGMVGNAGVIKAEVVLISKKSDNDDARWVFLDIGKFGGLAETMDE
HHHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHH
AIRYPIRTEHDGDEMEPCVIAGPTCDSADVLYEKNLYPLPISLSIGDEVLIEGTGAYTTT
HHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCCEEEEECCCEEEEECCCCCEEE
YSAVAFNGFEPLKAYVI
EEEEEECCCCCHHEECC
>Mature Secondary Structure 
TTQRIRDFLATRRPDGPCLVVDLDVISDNFHAFRHAMPDSAIYYAVKANPAPEVLKLLA
CHHHHHHHHHHCCCCCCEEEEEEHHHCCCHHHHHHCCCCCEEEEEEECCCHHHHHHHHH
GLGSNFDCASVAEIEMALEAGATAARISFGNTIKKERDVARAHALGVSLFAVDSHEEVEK
HCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCEEEEEECCHHHHHH
ISRAAPGARVFCRVLTDGEGAEWPLSRKFGCVPQMAVDVLVYAHQLGLLSYGVSFHVGSQ
HHHCCCCHHEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCC
MTKVDAWDSALADAKRVFVSLAKQGIHLQMVNMGGGFPTKYLRDVPSAEAYGKSIYQALR
CEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHH
THFGNQIPQTIIEPGRGMVGNAGVIKAEVVLISKKSDNDDARWVFLDIGKFGGLAETMDE
HHHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHH
AIRYPIRTEHDGDEMEPCVIAGPTCDSADVLYEKNLYPLPISLSIGDEVLIEGTGAYTTT
HHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCCEEEEECCCEEEEECCCCCEEE
YSAVAFNGFEPLKAYVI
EEEEEECCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]