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The map label for this gene is yciC [H]

Identifier: 209550960

GI number: 209550960

Start: 3496484

End: 3497566

Strand: Direct

Name: yciC [H]

Synonym: Rleg2_3384

Alternate gene names: 209550960

Gene position: 3496484-3497566 (Clockwise)

Preceding gene: 209550959

Following gene: 209550961

Centisome position: 77.05

GC content: 61.22

Gene sequence:

>1083_bases
ATGACCGACGCGATCTCCACGCAGAAGCCCATTCCCGTCACCGTGCTCACCGGTTATCTCGGCGCCGGCAAGACGACCTT
GCTCAACCGCATCCTTTCCGAAAACCACGGCAAGAAATATGCGGTCATCGTCAATGAGTTCGGCGAAATCGGCATCGACA
ACGACCTGATCGTCGAGTCCGACGAAGAAATCTACGAAATGAACAATGGCTGCGTCTGTTGCACGGTGCGCGGCGACCTG
ATCCGCGTCGTCGAAGGCCTGATGCGCCGTCCCGGCCGTTTCGACGGCATCATCGTGGAAACCACGGGCCTTGCCGATCC
CGTGCCGGTCGCCCAGACCTTCTTCATGGACGATGATGTCCGTGCCAAGACCGAACTCGACGCCGTCATCGCCCTTGTCG
ACGCCAAGCACCTGCCGCTGCGCCTGAAGGACAGCCGCGAGGCCGAAGACCAGATCGCCTTCGCCGACGTCGTCGTCATC
AACAAGAGCGACTTGGTGACCCCGGACGAGCTTGATGTGATCGAAGACATCGTCCGCGCCATCAACCCGGCCGCGCGCGT
CTACAAAACCAGCCGCTCCGGCGTCGACCTCGCCCGTGTGCTCGATCAGGGCGCCTTCAACCTGGAGCGCGCGCTGGAAA
ACGATCCGCATTTCCTGGAGCACGGCCACGACGACCATGTCTGCGGCCCGGATTGCGATCACGACCACCACCATCATGAT
CATGACCATGATCACCACGGGCACGAGCATCATCACCATGGCGCCATGTCGGCGATCCATGATGTGACGGTGCAGTCGGT
ATCGCTGCGCGGCGGTGAGATGAACGCGGAGCGCTTCTTCCCCTGGATCCAGAAGGTCACCCAGACGCAGGGACCGAATA
TTCTGCGCCTCAAGGGCATCATCGCATTCAAGGACGATCCCGAGCGTTATGTCGTCCAGGGCGTGCACATGATCATCGAG
GGCGATCATCAGCGGCCGTGGAAGGAAGACGAGAAGCACGAGAGCCGTCTCGTCTTCATCGGCCGTGATCTCGACCGCGA
AAAGCTCGAAGCCTCCTTCAAGGCCTGCGAGGCAGCCGCCTGA

Upstream 100 bases:

>100_bases
AAAACCCTTTGAACTGCCGCGCCCATGCCATTATATGAGACCAACCGTTCAAGCAGCCGATCCAAACCGCTCGGCCGCAC
GCCTAATCCTAGAGGTTCTC

Downstream 100 bases:

>100_bases
TGCCGACAGTTGCACCGCTTGATCTCGACGGCCACGTTCTGGCCGTCGAATTTTTAGGTGATGTCCCCTTCTTCGCAAAC
GCCAGCGGCACGTTTCACCG

Product: cobalamin synthesis protein P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTDAISTQKPIPVTVLTGYLGAGKTTLLNRILSENHGKKYAVIVNEFGEIGIDNDLIVESDEEIYEMNNGCVCCTVRGDL
IRVVEGLMRRPGRFDGIIVETTGLADPVPVAQTFFMDDDVRAKTELDAVIALVDAKHLPLRLKDSREAEDQIAFADVVVI
NKSDLVTPDELDVIEDIVRAINPAARVYKTSRSGVDLARVLDQGAFNLERALENDPHFLEHGHDDHVCGPDCDHDHHHHD
HDHDHHGHEHHHHGAMSAIHDVTVQSVSLRGGEMNAERFFPWIQKVTQTQGPNILRLKGIIAFKDDPERYVVQGVHMIIE
GDHQRPWKEDEKHESRLVFIGRDLDREKLEASFKACEAAA

Sequences:

>Translated_360_residues
MTDAISTQKPIPVTVLTGYLGAGKTTLLNRILSENHGKKYAVIVNEFGEIGIDNDLIVESDEEIYEMNNGCVCCTVRGDL
IRVVEGLMRRPGRFDGIIVETTGLADPVPVAQTFFMDDDVRAKTELDAVIALVDAKHLPLRLKDSREAEDQIAFADVVVI
NKSDLVTPDELDVIEDIVRAINPAARVYKTSRSGVDLARVLDQGAFNLERALENDPHFLEHGHDDHVCGPDCDHDHHHHD
HDHDHHGHEHHHHGAMSAIHDVTVQSVSLRGGEMNAERFFPWIQKVTQTQGPNILRLKGIIAFKDDPERYVVQGVHMIIE
GDHQRPWKEDEKHESRLVFIGRDLDREKLEASFKACEAAA
>Mature_359_residues
TDAISTQKPIPVTVLTGYLGAGKTTLLNRILSENHGKKYAVIVNEFGEIGIDNDLIVESDEEIYEMNNGCVCCTVRGDLI
RVVEGLMRRPGRFDGIIVETTGLADPVPVAQTFFMDDDVRAKTELDAVIALVDAKHLPLRLKDSREAEDQIAFADVVVIN
KSDLVTPDELDVIEDIVRAINPAARVYKTSRSGVDLARVLDQGAFNLERALENDPHFLEHGHDDHVCGPDCDHDHHHHDH
DHDHHGHEHHHHGAMSAIHDVTVQSVSLRGGEMNAERFFPWIQKVTQTQGPNILRLKGIIAFKDDPERYVVQGVHMIIEG
DHQRPWKEDEKHESRLVFIGRDLDREKLEASFKACEAAA

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=357, Percent_Identity=35.5742296918768, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI146231952, Length=357, Percent_Identity=35.8543417366947, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI33469141, Length=357, Percent_Identity=35.5742296918768, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI148727351, Length=357, Percent_Identity=35.5742296918768, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI223941779, Length=357, Percent_Identity=33.8935574229692, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI223941776, Length=347, Percent_Identity=34.2939481268012, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI119120938, Length=351, Percent_Identity=31.9088319088319, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI87082430, Length=354, Percent_Identity=32.7683615819209, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1788499, Length=169, Percent_Identity=34.3195266272189, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324356, Length=228, Percent_Identity=32.4561403508772, Blast_Score=130, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 40336; Mature: 40205

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAISTQKPIPVTVLTGYLGAGKTTLLNRILSENHGKKYAVIVNEFGEIGIDNDLIVES
CCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEC
DEEIYEMNNGCVCCTVRGDLIRVVEGLMRRPGRFDGIIVETTGLADPVPVAQTFFMDDDV
CHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHEECCCCC
RAKTELDAVIALVDAKHLPLRLKDSREAEDQIAFADVVVINKSDLVTPDELDVIEDIVRA
CHHHHHHHHHHHHCCCCCCEEECCCCCHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHH
INPAARVYKTSRSGVDLARVLDQGAFNLERALENDPHFLEHGHDDHVCGPDCDHDHHHHD
HCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCC
HDHDHHGHEHHHHGAMSAIHDVTVQSVSLRGGEMNAERFFPWIQKVTQTQGPNILRLKGI
CCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEE
IAFKDDPERYVVQGVHMIIEGDHQRPWKEDEKHESRLVFIGRDLDREKLEASFKACEAAA
EEECCCCHHHHHHHEEEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDAISTQKPIPVTVLTGYLGAGKTTLLNRILSENHGKKYAVIVNEFGEIGIDNDLIVES
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEC
DEEIYEMNNGCVCCTVRGDLIRVVEGLMRRPGRFDGIIVETTGLADPVPVAQTFFMDDDV
CHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHEECCCCC
RAKTELDAVIALVDAKHLPLRLKDSREAEDQIAFADVVVINKSDLVTPDELDVIEDIVRA
CHHHHHHHHHHHHCCCCCCEEECCCCCHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHH
INPAARVYKTSRSGVDLARVLDQGAFNLERALENDPHFLEHGHDDHVCGPDCDHDHHHHD
HCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCC
HDHDHHGHEHHHHGAMSAIHDVTVQSVSLRGGEMNAERFFPWIQKVTQTQGPNILRLKGI
CCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEE
IAFKDDPERYVVQGVHMIIEGDHQRPWKEDEKHESRLVFIGRDLDREKLEASFKACEAAA
EEECCCCHHHHHHHEEEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]