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The map label for this gene is emrE [H]

Identifier: 209550584

GI number: 209550584

Start: 3072666

End: 3073007

Strand: Reverse

Name: emrE [H]

Synonym: Rleg2_3008

Alternate gene names: 209550584

Gene position: 3073007-3072666 (Counterclockwise)

Preceding gene: 209550585

Following gene: 209550583

Centisome position: 67.72

GC content: 59.65

Gene sequence:

>342_bases
ATGAGCCAGGCCGCCGTCTACGGGCTGTTGTTTGCCGCCATCGTGCTCGAGGTCATCGGCACGACCGCGCTGCAGCTGTC
GCAGCAGTTCACCCGCATCGGGCCGACGGTGCTCGTCGTCGCCTGTTATGCGGCTGCCTTCTACTGCCTGTCGCTGACGC
TGAAAAGCATCCCTGTCGGCATCGCCTATGCAATTTGGAGCGCTTTGGGAATCGTCCTGATTTCCTCGGTCGGCCTGGTC
TTTTTCAAGCAGCGTCTCGACCTGCCGGCGATCGTCGGGCTCGGGCTGATCATTTCAGGCGTTTTGGTCGTCAATCTCTT
CTCGAAATCGGTTTCCCATTGA

Upstream 100 bases:

>100_bases
CAGATACGCTGGAAAGCCATGATATCGACGGCGTTCTGAGGCGGGATCTCCTCGATCGCCTTGTCGAACTGACCGGGAAA
TAATCCGAAGGAATTTCGCC

Downstream 100 bases:

>100_bases
TATTGCTGTGATATTACCCGCTCAATTTTCGATCTTCCGGCGGTGAATTTTCCCCTTTGTCAAATTCCTGACAAAGGTCT
ATGTGTTGCTGAGACGTGGA

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Efflux-multidrug resistance protein emrE; Ethidium resistance protein; Methyl viologen resistance protein C [H]

Number of amino acids: Translated: 113; Mature: 112

Protein sequence:

>113_residues
MSQAAVYGLLFAAIVLEVIGTTALQLSQQFTRIGPTVLVVACYAAAFYCLSLTLKSIPVGIAYAIWSALGIVLISSVGLV
FFKQRLDLPAIVGLGLIISGVLVVNLFSKSVSH

Sequences:

>Translated_113_residues
MSQAAVYGLLFAAIVLEVIGTTALQLSQQFTRIGPTVLVVACYAAAFYCLSLTLKSIPVGIAYAIWSALGIVLISSVGLV
FFKQRLDLPAIVGLGLIISGVLVVNLFSKSVSH
>Mature_112_residues
SQAAVYGLLFAAIVLEVIGTTALQLSQQFTRIGPTVLVVACYAAAFYCLSLTLKSIPVGIAYAIWSALGIVLISSVGLVF
FKQRLDLPAIVGLGLIISGVLVVNLFSKSVSH

Specific function: Multidrug transporter that expels positively charged hydrophobic drugs across the inner membrane of E.coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. Is involved in the resistanc

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=107, Percent_Identity=56.0747663551402, Blast_Score=117, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11871; Mature: 11740

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQAAVYGLLFAAIVLEVIGTTALQLSQQFTRIGPTVLVVACYAAAFYCLSLTLKSIPVG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYAIWSALGIVLISSVGLVFFKQRLDLPAIVGLGLIISGVLVVNLFSKSVSH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQAAVYGLLFAAIVLEVIGTTALQLSQQFTRIGPTVLVVACYAAAFYCLSLTLKSIPVG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYAIWSALGIVLISSVGLVFFKQRLDLPAIVGLGLIISGVLVVNLFSKSVSH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1936950; 1320256; 9278503; 7896833; 9050242; 9688273 [H]