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The map label for this gene is proC [H]

Identifier: 209550334

GI number: 209550334

Start: 2799256

End: 2800083

Strand: Reverse

Name: proC [H]

Synonym: Rleg2_2755

Alternate gene names: 209550334

Gene position: 2800083-2799256 (Counterclockwise)

Preceding gene: 209550335

Following gene: 209550333

Centisome position: 61.7

GC content: 65.46

Gene sequence:

>828_bases
ATGCCCGCGAACGCTTTCTCCTCGACAAATCCCGTCGTCCTGATCGGCGCCGGAAACATGGGCGGGGCGATGCTCTCCGG
CTGGCTGAAAAGCGGCGTGCCGGGCTCTGCCGTCCTTGTCATCGATCCCGGCCCGTCGCCGGCGATGCTGGCGACGATCA
GCGAGGCCGGCGCGACCCATGTTGTCGCCGCTCCAGCGGATTTGAAGGCAGGCGTGCTTTTTCTCGCGGTCAAGCCACAG
GTGATGGAGACGGTGCTGCCGGCGGTGAGAACTGCCGTCGGGCCGGAAACGGTCGTCGTCTCTGTGGCTGCCGGCAAGAC
GCTTGGCTTTCTCGAGAAACATCTGGGCAAAGCCGCCATGGTGCGGGCTATGCCGAACACGCCGGCCATGGTCGGGCGCG
GCGTCACCGGCGCCTTTGCCAATTCAGCGGTCAGCACTCAGCAGCGCGAGCGTGTCCATTCTCTTCTCAGTGTCTCGGGT
CCTGTGGAATGGGTGCCTGCAGAGGCCGATATCGATGCCGTGACGGCGCTTTCGGGCAGCGGTCCTGCCTATGTGTTCTA
TCTCGTCGAATGCATGGCGGAGGCAGGTCGTAAACTCGGCCTGCAGGCGGACCTCGCCATGCGTCTTGCGCGGGAAACAG
TCGCGGGGGCTGGTGAACTTTTGCACCAGTCCCCCGACGACGCTTCGCGGCTGCGGCAGAATGTGACCTCTCCCGGTGGC
ACGACGGCGGCCGCACTTGCCGTGCTGATGGCCGAAAACGGCATGCAGCCTCTGTTCGACGCAGCACTCGCAGCGGCGCG
CAAGCGGGCCGAAGAACTGGCCGGCTAG

Upstream 100 bases:

>100_bases
GAAGCCTATTTCCAGGCATTCCAGTTCGTCGTCTGGTCCGGCATGGAAGCGACGAAGGCGATGGAAGCCGTGTTGTTCGA
AACCGTCGGCGAGGCATAAG

Downstream 100 bases:

>100_bases
AGCGCCGCGCGTCAAAGACGCGCCAAGGACGCTCTAACATTTTGAATGCGCGTCATTCCTTTGCGAAAATCGAGATCGAT
TTTCGCAAAGGAATGACGCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MPANAFSSTNPVVLIGAGNMGGAMLSGWLKSGVPGSAVLVIDPGPSPAMLATISEAGATHVVAAPADLKAGVLFLAVKPQ
VMETVLPAVRTAVGPETVVVSVAAGKTLGFLEKHLGKAAMVRAMPNTPAMVGRGVTGAFANSAVSTQQRERVHSLLSVSG
PVEWVPAEADIDAVTALSGSGPAYVFYLVECMAEAGRKLGLQADLAMRLARETVAGAGELLHQSPDDASRLRQNVTSPGG
TTAAALAVLMAENGMQPLFDAALAAARKRAEELAG

Sequences:

>Translated_275_residues
MPANAFSSTNPVVLIGAGNMGGAMLSGWLKSGVPGSAVLVIDPGPSPAMLATISEAGATHVVAAPADLKAGVLFLAVKPQ
VMETVLPAVRTAVGPETVVVSVAAGKTLGFLEKHLGKAAMVRAMPNTPAMVGRGVTGAFANSAVSTQQRERVHSLLSVSG
PVEWVPAEADIDAVTALSGSGPAYVFYLVECMAEAGRKLGLQADLAMRLARETVAGAGELLHQSPDDASRLRQNVTSPGG
TTAAALAVLMAENGMQPLFDAALAAARKRAEELAG
>Mature_274_residues
PANAFSSTNPVVLIGAGNMGGAMLSGWLKSGVPGSAVLVIDPGPSPAMLATISEAGATHVVAAPADLKAGVLFLAVKPQV
METVLPAVRTAVGPETVVVSVAAGKTLGFLEKHLGKAAMVRAMPNTPAMVGRGVTGAFANSAVSTQQRERVHSLLSVSGP
VEWVPAEADIDAVTALSGSGPAYVFYLVECMAEAGRKLGLQADLAMRLARETVAGAGELLHQSPDDASRLRQNVTSPGGT
TAAALAVLMAENGMQPLFDAALAAARKRAEELAG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=35.6877323420074, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=35.6877323420074, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=34.2007434944238, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI198041662, Length=263, Percent_Identity=33.0798479087452, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=35.5555555555556, Blast_Score=127, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=36.2595419847328, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17540664, Length=289, Percent_Identity=28.719723183391, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320861, Length=200, Percent_Identity=35, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21358587, Length=273, Percent_Identity=34.4322344322344, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24648116, Length=269, Percent_Identity=31.2267657992565, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24647700, Length=172, Percent_Identity=38.953488372093, Blast_Score=101, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27827; Mature: 27696

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPANAFSSTNPVVLIGAGNMGGAMLSGWLKSGVPGSAVLVIDPGPSPAMLATISEAGATH
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHEEEHHHCCCCE
VVAAPADLKAGVLFLAVKPQVMETVLPAVRTAVGPETVVVSVAAGKTLGFLEKHLGKAAM
EEECCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCHHHH
VRAMPNTPAMVGRGVTGAFANSAVSTQQRERVHSLLSVSGPVEWVPAEADIDAVTALSGS
HHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHEEECCC
GPAYVFYLVECMAEAGRKLGLQADLAMRLARETVAGAGELLHQSPDDASRLRQNVTSPGG
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
TTAAALAVLMAENGMQPLFDAALAAARKRAEELAG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PANAFSSTNPVVLIGAGNMGGAMLSGWLKSGVPGSAVLVIDPGPSPAMLATISEAGATH
CCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHEEEHHHCCCCE
VVAAPADLKAGVLFLAVKPQVMETVLPAVRTAVGPETVVVSVAAGKTLGFLEKHLGKAAM
EEECCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCHHHH
VRAMPNTPAMVGRGVTGAFANSAVSTQQRERVHSLLSVSGPVEWVPAEADIDAVTALSGS
HHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHEEECCC
GPAYVFYLVECMAEAGRKLGLQADLAMRLARETVAGAGELLHQSPDDASRLRQNVTSPGG
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
TTAAALAVLMAENGMQPLFDAALAAARKRAEELAG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]