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The map label for this gene is envZ [H]

Identifier: 209550327

GI number: 209550327

Start: 2793550

End: 2794926

Strand: Reverse

Name: envZ [H]

Synonym: Rleg2_2747

Alternate gene names: 209550327

Gene position: 2794926-2793550 (Counterclockwise)

Preceding gene: 209550328

Following gene: 209550325

Centisome position: 61.59

GC content: 62.89

Gene sequence:

>1377_bases
ATGGTGACGATCGACAGCTTGCGGCGGGAAGACCGCAATTCCGCGCCAGGCTGGCGCTCGGTCGTCCGCTGGCTGCGCCG
GCGGCTGCCGACCGGGCTTTACGCGCGCTCGCTGCTGATCATCATTATTCCGATGGTGCTGCTGCAATCCGTCGTCGCCG
CCGTCTTCATGGAGCGCCACTGGCAGATGGTGACGGAGCGGCTGTCGCTTGCCGTCACCCGCGACATTGCCGCGATCATC
GAGATTATCGAGACCTACCCGCAGAACTCGGACTATAGCGAGATCGTCCGCATCGCTCGCGATCAGCTCAGCCTGCAGAT
CTCGATCGAGCCGGATGGCGACCTGCCGCCGCCGCGCGTCAAGCCGTTCTTCTCGATCCTCGACGGCATCCTCAGCGACG
AGATCACCGACGAGATCCACCGGCCTTTCTGGATCGACACGGTCGGCAACTCGAACCTCGTCGAGATTCGCATCAAGCTC
GACAACAAGATCCTTAGGGTGCTGACCAAGCGCAGCCAGACCTATGCCTCGAACACGCATATCTTCATCGTCTGGATGGT
CGGCACCTCGCTGGTGCTGATCGGCATCTCGATCCTCTTCCTGCGTGGGCAAATCCGGCCGATCCTGACCTTGGCGCGCG
CGGCCGAAAGCTTCGGCAAGGGGCAGAAACCCGATAATTTCTATCCGCGCGGCGCCGACGAGGTCAGGCGCGCCGGCCTT
GCCTTTATCCTGATGCGCGAGCGAATCGAGCGGCAGATCGAGCAGCGAACCGCGATGCTATCCGGCGTCAGCCATGATCT
GCGCACCATCCTCACCCGCTTCAAGCTGCAGCTGGCACTTGCCGGCGACAATCCCGACCTGCATGGGCTGAACGACGACG
TCGACGATATGCAGGCCATGCTGGAGGCCTATACGGCCTTCGCACGCGGCGAGGTCGAAGAGGATGTCGGCGAGCTGAAA
CTCAGCGAGGTCTTCGCAAAGCTGGAATCCGATTTCGCCCTGCACGGCAAGACATTCAGCTATTCGATCGAAGGCGATGA
CGACATATCCGTCAGGCCGAACGCTTTCATGCGTCTCGTCACCAACCTTGCCTCGAATGCGCGGCGTTATGCCGGCAGGC
TCGACATCGAGGCCAAGCACAGTGCCAAATGGTTGACGGTCATCTTCGACGACGACGGGCCGGGCATTCCGGAAAAGAAT
CGCGAGGACGTGTTCAAGCCGTTCTTCCGGCTGGACGCGGCGCGCAACCTCGACGCCTCGGGCACCGGTCTCGGCCTTGC
GATCGCCCGCGACATCGCCCGCAGTCACGGCGGCAACGTCACCCTCGGCGACAGCCCGCTCGGCGGGCTGAGGGCGACGA
TCCGCATTCCGGCCTAA

Upstream 100 bases:

>100_bases
GGCAATGACATGCGGAAAACAAAGACCTAAAGCGCAGGGAGCGAAGCTCAAAGATCGCGACGCGCTTTAGATCTAAGGAT
AGAGGCCAGGACCGGCGCTA

Downstream 100 bases:

>100_bases
ACGCCTGCCACAGTCAGCCTCACGGCCTTGCGCGCATCGAAATCGCCAAGCCGTTCGACGATCCAGCGCCAAAGCGCTGC
GACCTGCATGAGGAGGTCGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MVTIDSLRREDRNSAPGWRSVVRWLRRRLPTGLYARSLLIIIIPMVLLQSVVAAVFMERHWQMVTERLSLAVTRDIAAII
EIIETYPQNSDYSEIVRIARDQLSLQISIEPDGDLPPPRVKPFFSILDGILSDEITDEIHRPFWIDTVGNSNLVEIRIKL
DNKILRVLTKRSQTYASNTHIFIVWMVGTSLVLIGISILFLRGQIRPILTLARAAESFGKGQKPDNFYPRGADEVRRAGL
AFILMRERIERQIEQRTAMLSGVSHDLRTILTRFKLQLALAGDNPDLHGLNDDVDDMQAMLEAYTAFARGEVEEDVGELK
LSEVFAKLESDFALHGKTFSYSIEGDDDISVRPNAFMRLVTNLASNARRYAGRLDIEAKHSAKWLTVIFDDDGPGIPEKN
REDVFKPFFRLDAARNLDASGTGLGLAIARDIARSHGGNVTLGDSPLGGLRATIRIPA

Sequences:

>Translated_458_residues
MVTIDSLRREDRNSAPGWRSVVRWLRRRLPTGLYARSLLIIIIPMVLLQSVVAAVFMERHWQMVTERLSLAVTRDIAAII
EIIETYPQNSDYSEIVRIARDQLSLQISIEPDGDLPPPRVKPFFSILDGILSDEITDEIHRPFWIDTVGNSNLVEIRIKL
DNKILRVLTKRSQTYASNTHIFIVWMVGTSLVLIGISILFLRGQIRPILTLARAAESFGKGQKPDNFYPRGADEVRRAGL
AFILMRERIERQIEQRTAMLSGVSHDLRTILTRFKLQLALAGDNPDLHGLNDDVDDMQAMLEAYTAFARGEVEEDVGELK
LSEVFAKLESDFALHGKTFSYSIEGDDDISVRPNAFMRLVTNLASNARRYAGRLDIEAKHSAKWLTVIFDDDGPGIPEKN
REDVFKPFFRLDAARNLDASGTGLGLAIARDIARSHGGNVTLGDSPLGGLRATIRIPA
>Mature_458_residues
MVTIDSLRREDRNSAPGWRSVVRWLRRRLPTGLYARSLLIIIIPMVLLQSVVAAVFMERHWQMVTERLSLAVTRDIAAII
EIIETYPQNSDYSEIVRIARDQLSLQISIEPDGDLPPPRVKPFFSILDGILSDEITDEIHRPFWIDTVGNSNLVEIRIKL
DNKILRVLTKRSQTYASNTHIFIVWMVGTSLVLIGISILFLRGQIRPILTLARAAESFGKGQKPDNFYPRGADEVRRAGL
AFILMRERIERQIEQRTAMLSGVSHDLRTILTRFKLQLALAGDNPDLHGLNDDVDDMQAMLEAYTAFARGEVEEDVGELK
LSEVFAKLESDFALHGKTFSYSIEGDDDISVRPNAFMRLVTNLASNARRYAGRLDIEAKHSAKWLTVIFDDDGPGIPEKN
REDVFKPFFRLDAARNLDASGTGLGLAIARDIARSHGGNVTLGDSPLGGLRATIRIPA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=278, Percent_Identity=35.6115107913669, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=32.2097378277154, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787894, Length=290, Percent_Identity=31.7241379310345, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=25.3623188405797, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082128, Length=319, Percent_Identity=25.3918495297806, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787374, Length=135, Percent_Identity=31.1111111111111, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=236, Percent_Identity=27.1186440677966, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786600, Length=240, Percent_Identity=23.75, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=25.6637168141593, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790861, Length=295, Percent_Identity=25.7627118644068, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1786783, Length=294, Percent_Identity=22.4489795918367, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51439; Mature: 51439

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTIDSLRREDRNSAPGWRSVVRWLRRRLPTGLYARSLLIIIIPMVLLQSVVAAVFMERH
CCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WQMVTERLSLAVTRDIAAIIEIIETYPQNSDYSEIVRIARDQLSLQISIEPDGDLPPPRV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEEEECCCCCCCCCCC
KPFFSILDGILSDEITDEIHRPFWIDTVGNSNLVEIRIKLDNKILRVLTKRSQTYASNTH
CHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECHHHHHHHHHHHHHHCCCCE
IFIVWMVGTSLVLIGISILFLRGQIRPILTLARAAESFGKGQKPDNFYPRGADEVRRAGL
EEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
AFILMRERIERQIEQRTAMLSGVSHDLRTILTRFKLQLALAGDNPDLHGLNDDVDDMQAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHH
LEAYTAFARGEVEEDVGELKLSEVFAKLESDFALHGKTFSYSIEGDDDISVRPNAFMRLV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEECCCEEEEEECCCCCCCCCHHHHHHHH
TNLASNARRYAGRLDIEAKHSAKWLTVIFDDDGPGIPEKNREDVFKPFFRLDAARNLDAS
HHHHHHHHHHHCCCCEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
GTGLGLAIARDIARSHGGNVTLGDSPLGGLRATIRIPA
CCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECC
>Mature Secondary Structure
MVTIDSLRREDRNSAPGWRSVVRWLRRRLPTGLYARSLLIIIIPMVLLQSVVAAVFMERH
CCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WQMVTERLSLAVTRDIAAIIEIIETYPQNSDYSEIVRIARDQLSLQISIEPDGDLPPPRV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEEEECCCCCCCCCCC
KPFFSILDGILSDEITDEIHRPFWIDTVGNSNLVEIRIKLDNKILRVLTKRSQTYASNTH
CHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECHHHHHHHHHHHHHHCCCCE
IFIVWMVGTSLVLIGISILFLRGQIRPILTLARAAESFGKGQKPDNFYPRGADEVRRAGL
EEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
AFILMRERIERQIEQRTAMLSGVSHDLRTILTRFKLQLALAGDNPDLHGLNDDVDDMQAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHH
LEAYTAFARGEVEEDVGELKLSEVFAKLESDFALHGKTFSYSIEGDDDISVRPNAFMRLV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEECCCEEEEEECCCCCCCCCHHHHHHHH
TNLASNARRYAGRLDIEAKHSAKWLTVIFDDDGPGIPEKNREDVFKPFFRLDAARNLDAS
HHHHHHHHHHHCCCCEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
GTGLGLAIARDIARSHGGNVTLGDSPLGGLRATIRIPA
CCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]