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The map label for this gene is recQ [H]

Identifier: 209550282

GI number: 209550282

Start: 2740886

End: 2742751

Strand: Reverse

Name: recQ [H]

Synonym: Rleg2_2702

Alternate gene names: 209550282

Gene position: 2742751-2740886 (Counterclockwise)

Preceding gene: 209550283

Following gene: 209550281

Centisome position: 60.44

GC content: 64.15

Gene sequence:

>1866_bases
ATGCCGCAGACCGAACGGAACGAACCGGGTTTTTCCGCCTCCGACGCGCTGTTTTCCGCCGGCCGCGCGCCGCTCGATAT
TCTCAAGCAGGTCTATGGCTATTCCTCCTTCCGCGGCAAGCAGCAGCTGGTGGTCGACCATGTGGTATCAGGCGGCGATG
CCGTGGTGCTCTTCCCGACAGGCGCGGGCAAATCGCTGTGCTTCCAAATCCCGGCGCTCTGCCGCGATGGCGTCGGCATT
GTCGTTTCGCCGCTGATTGCCTTGATGCGCGATCAGGTCGAGGCGATGAAGCAGCTCGGCATCCGTGCCGCCGCGCTCAA
TTCGTCGCTGTCGCGCGAAGAATTCGTCGAAGTCCGCCGCGCGCTTTCGGCCGGCCGGCTCGATCTGCTCTACGTCACAC
CCGAGCGCATTCTGACCGATGGTTTCCGCGAGCTGATCGCCAACGAGAAGATTGCGCTGTTTGCCATCGACGAGGCGCAT
TGCGTTTCGCAATGGGGTCATGATTTCCGGCCGGAATATCGCGCGCTCGGCCAGCTTGGCGAACAATATCCCGGCGTGCC
GAGGGTGGCGCTGACGGCGACGGCCGATCCGCATACGCGCGACGACATCATCGAGCGGCTGGGGCTCGACGCTGCCGAGA
TCTTCACCACCAGCTTCGACCGGCCGAACATCGCTTACGAAATCGTCGAGCGCGACCAGCCGCGCCAGCAGCTGTTGCGA
TTCCTGTCCGGCCACAAGGGAAACAGCGGCATCGTCTATTGCCTGTCGCGCGCCAAGGTCGAGGATACGGCGGAGTGGTT
GAACGGGCAGGGCGTGCGCGCGCTTGCCTATCATGCCGGCATGGACCGGGCGGTTCGCGACGCCAATCAGGATGCGTTCC
TGAAAGAGGAAAACCTCTGCCTGGTCGCCACCGTCGCCTTCGGCATGGGCATCGACAAGCCGAATGTGCGGTATGTCGCC
CATCTCGACCTGCCGGGCTCGGTCGAGGCCTATTATCAGGAGACCGGGCGCGCCGGCCGTGACGGACTGCCGTCCGAAGT
CTGGATGGCCTATGGCATGGCCGACGTCATCCAGCGCGGCCGGATGATCGACGAGGGCAGTGCTGCTGCGGAGATCAAGC
GGGTCGAGCGCGCCAAGCTCAATGCATTGCTGGCGATCTGCGAGACCGCCTCCTGCCGCCGCCAGGCGATCCTTGCGCAT
TTCGGCGAGGCGCATGCCGGACAATGCGGCAATTGCGACACCTGCCTGAAGCCGGTCGAAACCTGGGAGGGCACGGAAGC
GGCGATCAAGGCGCTGGCCGCAATCTACCGCACCGGCGAACGTTTCGGCGCCGGCCACGTCATCGACGTGCTTGTCGGCA
ACGTCAACGAAAAGACCGAGCGTTTCGGCCATGTCGATATGCCGGTCTTCGGCGCCGGCAAGGATATTCCATCGCGCACC
TGGCAATCCGTCTACCGCCAGCTGCTTGCCATGGGGCTGATCCGTGTCGATCACGAAGCCTATGGCGCGCTGAAGCTGGA
GCCGGAGGCGCGCGCCGTCTTCAAGCAAGAGCGGCAGGTTTTCTTCCGCAAGGACCGCCCGGCCTCCGAACGGCGCACGA
AGAAGGCTGAACGCAGCGAGCGCAAATCAGGATTGTCAGGCGCCGACGGCACTCTCTTCGACGCGCTGCGGGCCGAGCGC
ATGGCGATCGCCAAATCGCTCGGCGTGCCGCCCTATGTGGTCTTTCCCGATACGACGCTGATCGCTTTTGCCACTGAACG
GCCGCGCAGCCGCAAGGAATTGCTTGCCATATCGGGTGTCGGCCAGGCGAAGCTCGAGCGCTATGGCGATGCGTTCCTGG
AAATCATCCTGGCGCAGGACGGCTGA

Upstream 100 bases:

>100_bases
AGGAAGTGCATTTCGAAGGTGTCCGGCTTGAGAACCAGGAGGCGATCATCGACGGCTTCGGCGTACTCTCCGGTCGCGTC
AAAGGGGCGGCGAACCACTG

Downstream 100 bases:

>100_bases
ACGGGCCGGCCGATGTTCCTGCTGATCTCGGCCCGGCGGTGAAGAAGACAAGCCGGCGGCGATATGCTAACCCGAGTGCT
ATAAAAAACATCAGGAAGGG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MPQTERNEPGFSASDALFSAGRAPLDILKQVYGYSSFRGKQQLVVDHVVSGGDAVVLFPTGAGKSLCFQIPALCRDGVGI
VVSPLIALMRDQVEAMKQLGIRAAALNSSLSREEFVEVRRALSAGRLDLLYVTPERILTDGFRELIANEKIALFAIDEAH
CVSQWGHDFRPEYRALGQLGEQYPGVPRVALTATADPHTRDDIIERLGLDAAEIFTTSFDRPNIAYEIVERDQPRQQLLR
FLSGHKGNSGIVYCLSRAKVEDTAEWLNGQGVRALAYHAGMDRAVRDANQDAFLKEENLCLVATVAFGMGIDKPNVRYVA
HLDLPGSVEAYYQETGRAGRDGLPSEVWMAYGMADVIQRGRMIDEGSAAAEIKRVERAKLNALLAICETASCRRQAILAH
FGEAHAGQCGNCDTCLKPVETWEGTEAAIKALAAIYRTGERFGAGHVIDVLVGNVNEKTERFGHVDMPVFGAGKDIPSRT
WQSVYRQLLAMGLIRVDHEAYGALKLEPEARAVFKQERQVFFRKDRPASERRTKKAERSERKSGLSGADGTLFDALRAER
MAIAKSLGVPPYVVFPDTTLIAFATERPRSRKELLAISGVGQAKLERYGDAFLEIILAQDG

Sequences:

>Translated_621_residues
MPQTERNEPGFSASDALFSAGRAPLDILKQVYGYSSFRGKQQLVVDHVVSGGDAVVLFPTGAGKSLCFQIPALCRDGVGI
VVSPLIALMRDQVEAMKQLGIRAAALNSSLSREEFVEVRRALSAGRLDLLYVTPERILTDGFRELIANEKIALFAIDEAH
CVSQWGHDFRPEYRALGQLGEQYPGVPRVALTATADPHTRDDIIERLGLDAAEIFTTSFDRPNIAYEIVERDQPRQQLLR
FLSGHKGNSGIVYCLSRAKVEDTAEWLNGQGVRALAYHAGMDRAVRDANQDAFLKEENLCLVATVAFGMGIDKPNVRYVA
HLDLPGSVEAYYQETGRAGRDGLPSEVWMAYGMADVIQRGRMIDEGSAAAEIKRVERAKLNALLAICETASCRRQAILAH
FGEAHAGQCGNCDTCLKPVETWEGTEAAIKALAAIYRTGERFGAGHVIDVLVGNVNEKTERFGHVDMPVFGAGKDIPSRT
WQSVYRQLLAMGLIRVDHEAYGALKLEPEARAVFKQERQVFFRKDRPASERRTKKAERSERKSGLSGADGTLFDALRAER
MAIAKSLGVPPYVVFPDTTLIAFATERPRSRKELLAISGVGQAKLERYGDAFLEIILAQDG
>Mature_620_residues
PQTERNEPGFSASDALFSAGRAPLDILKQVYGYSSFRGKQQLVVDHVVSGGDAVVLFPTGAGKSLCFQIPALCRDGVGIV
VSPLIALMRDQVEAMKQLGIRAAALNSSLSREEFVEVRRALSAGRLDLLYVTPERILTDGFRELIANEKIALFAIDEAHC
VSQWGHDFRPEYRALGQLGEQYPGVPRVALTATADPHTRDDIIERLGLDAAEIFTTSFDRPNIAYEIVERDQPRQQLLRF
LSGHKGNSGIVYCLSRAKVEDTAEWLNGQGVRALAYHAGMDRAVRDANQDAFLKEENLCLVATVAFGMGIDKPNVRYVAH
LDLPGSVEAYYQETGRAGRDGLPSEVWMAYGMADVIQRGRMIDEGSAAAEIKRVERAKLNALLAICETASCRRQAILAHF
GEAHAGQCGNCDTCLKPVETWEGTEAAIKALAAIYRTGERFGAGHVIDVLVGNVNEKTERFGHVDMPVFGAGKDIPSRTW
QSVYRQLLAMGLIRVDHEAYGALKLEPEARAVFKQERQVFFRKDRPASERRTKKAERSERKSGLSGADGTLFDALRAERM
AIAKSLGVPPYVVFPDTTLIAFATERPRSRKELLAISGVGQAKLERYGDAFLEIILAQDG

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=645, Percent_Identity=32.093023255814, Blast_Score=323, Evalue=4e-88,
Organism=Homo sapiens, GI14591902, Length=450, Percent_Identity=37.3333333333333, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI14591904, Length=450, Percent_Identity=37.3333333333333, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI110735439, Length=496, Percent_Identity=36.2903225806452, Blast_Score=281, Evalue=2e-75,
Organism=Homo sapiens, GI169218196, Length=496, Percent_Identity=36.2903225806452, Blast_Score=281, Evalue=2e-75,
Organism=Homo sapiens, GI148612816, Length=429, Percent_Identity=40.0932400932401, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI51242943, Length=398, Percent_Identity=40.4522613065327, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI51242947, Length=398, Percent_Identity=40.4522613065327, Blast_Score=261, Evalue=2e-69,
Organism=Homo sapiens, GI284005309, Length=341, Percent_Identity=37.2434017595308, Blast_Score=191, Evalue=2e-48,
Organism=Escherichia coli, GI48994977, Length=593, Percent_Identity=46.2057335581787, Blast_Score=550, Evalue=1e-157,
Organism=Escherichia coli, GI87082221, Length=323, Percent_Identity=24.4582043343653, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1787016, Length=352, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25145561, Length=650, Percent_Identity=34.4615384615385, Blast_Score=342, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI71987993, Length=407, Percent_Identity=39.5577395577396, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI71987997, Length=407, Percent_Identity=39.5577395577396, Blast_Score=303, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI32564293, Length=692, Percent_Identity=30.2023121387283, Blast_Score=301, Evalue=9e-82,
Organism=Caenorhabditis elegans, GI17552866, Length=462, Percent_Identity=35.4978354978355, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17555296, Length=335, Percent_Identity=27.4626865671642, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71995718, Length=344, Percent_Identity=24.4186046511628, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510307, Length=319, Percent_Identity=26.6457680250784, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17510309, Length=319, Percent_Identity=26.6457680250784, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71995514, Length=319, Percent_Identity=26.6457680250784, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323844, Length=544, Percent_Identity=33.6397058823529, Blast_Score=295, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6324778, Length=336, Percent_Identity=24.4047619047619, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323947, Length=339, Percent_Identity=23.8938053097345, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646066, Length=631, Percent_Identity=34.7068145800317, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24664226, Length=449, Percent_Identity=39.4209354120267, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24664230, Length=449, Percent_Identity=39.4209354120267, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI62472181, Length=449, Percent_Identity=39.4209354120267, Blast_Score=277, Evalue=2e-74,
Organism=Drosophila melanogaster, GI21358123, Length=353, Percent_Identity=35.4107648725212, Blast_Score=197, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 68285; Mature: 68153

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQTERNEPGFSASDALFSAGRAPLDILKQVYGYSSFRGKQQLVVDHVVSGGDAVVLFPT
CCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEC
GAGKSLCFQIPALCRDGVGIVVSPLIALMRDQVEAMKQLGIRAAALNSSLSREEFVEVRR
CCCCHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHH
ALSAGRLDLLYVTPERILTDGFRELIANEKIALFAIDEAHCVSQWGHDFRPEYRALGQLG
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCCCCHHHHHHHHHH
EQYPGVPRVALTATADPHTRDDIIERLGLDAAEIFTTSFDRPNIAYEIVERDQPRQQLLR
HHCCCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHCCCHHHHHHH
FLSGHKGNSGIVYCLSRAKVEDTAEWLNGQGVRALAYHAGMDRAVRDANQDAFLKEENLC
HHCCCCCCCCEEEEEECCCHHHHHHHHCCCCCEEHHHHHCHHHHHHCCCCCCCCCCCCEE
LVATVAFGMGIDKPNVRYVAHLDLPGSVEAYYQETGRAGRDGLPSEVWMAYGMADVIQRG
EEEEEHHHCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC
RMIDEGSAAAEIKRVERAKLNALLAICETASCRRQAILAHFGEAHAGQCGNCDTCLKPVE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHH
TWEGTEAAIKALAAIYRTGERFGAGHVIDVLVGNVNEKTERFGHVDMPVFGAGKDIPSRT
HCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCHHHHHCCCCCCCEECCCCCCCHHH
WQSVYRQLLAMGLIRVDHEAYGALKLEPEARAVFKQERQVFFRKDRPASERRTKKAERSE
HHHHHHHHHHHHHHHCCCHHCCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RKSGLSGADGTLFDALRAERMAIAKSLGVPPYVVFPDTTLIAFATERPRSRKELLAISGV
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCCHHHEEEECCC
GQAKLERYGDAFLEIILAQDG
CHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure 
PQTERNEPGFSASDALFSAGRAPLDILKQVYGYSSFRGKQQLVVDHVVSGGDAVVLFPT
CCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEC
GAGKSLCFQIPALCRDGVGIVVSPLIALMRDQVEAMKQLGIRAAALNSSLSREEFVEVRR
CCCCHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHH
ALSAGRLDLLYVTPERILTDGFRELIANEKIALFAIDEAHCVSQWGHDFRPEYRALGQLG
HHCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHCCCCCCHHHHHHHHHH
EQYPGVPRVALTATADPHTRDDIIERLGLDAAEIFTTSFDRPNIAYEIVERDQPRQQLLR
HHCCCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHCCCHHHHHHH
FLSGHKGNSGIVYCLSRAKVEDTAEWLNGQGVRALAYHAGMDRAVRDANQDAFLKEENLC
HHCCCCCCCCEEEEEECCCHHHHHHHHCCCCCEEHHHHHCHHHHHHCCCCCCCCCCCCEE
LVATVAFGMGIDKPNVRYVAHLDLPGSVEAYYQETGRAGRDGLPSEVWMAYGMADVIQRG
EEEEEHHHCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC
RMIDEGSAAAEIKRVERAKLNALLAICETASCRRQAILAHFGEAHAGQCGNCDTCLKPVE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHH
TWEGTEAAIKALAAIYRTGERFGAGHVIDVLVGNVNEKTERFGHVDMPVFGAGKDIPSRT
HCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCHHHHHCCCCCCCEECCCCCCCHHH
WQSVYRQLLAMGLIRVDHEAYGALKLEPEARAVFKQERQVFFRKDRPASERRTKKAERSE
HHHHHHHHHHHHHHHCCCHHCCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RKSGLSGADGTLFDALRAERMAIAKSLGVPPYVVFPDTTLIAFATERPRSRKELLAISGV
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCCHHHEEEECCC
GQAKLERYGDAFLEIILAQDG
CHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]