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The map label for this gene is tdh [H]

Identifier: 209550280

GI number: 209550280

Start: 2738383

End: 2739420

Strand: Reverse

Name: tdh [H]

Synonym: Rleg2_2700

Alternate gene names: 209550280

Gene position: 2739420-2738383 (Counterclockwise)

Preceding gene: 209550281

Following gene: 209550279

Centisome position: 60.37

GC content: 61.46

Gene sequence:

>1038_bases
ATGTCGAACATGATGAAGGCGCTGGTCAAGTCGAAGCCGGAAGTCGGGCTCTGGATGGAGAATGTGCCGGTGCCCGAGGT
TGGGCCGAACGATGTGCTGATCCGGGTTAGGAAGTCGGCGATCTGCGGCACCGACGTCCATATCTGGAACTGGGATCAGT
GGGCGCAGAAGACCATTCCGGTGCCGATGGTCGTCGGCCATGAATTCTCCGGCGAGATCGCCGAGATCGGTTCGGCGGTC
ACCCGCTATCATGTCGGCGAGCGGGTTTCCGGCGAGGGCCATATCGTCTGCGGCAAGTGCCGCAACTGCCGGGCGGGCAG
GGGGCATCTCTGCCGCAACACGCTCGGCGTCGGCGTCAACCGGCCGGGTTCGTTCGGGGAGTTCGTCTGCATTCCCGAAA
GCAATGTCGTGGCGATCCCGGAGGATATTTCCGATGAGATCGCGGCGATCTTCGATCCGTTCGGTAATGCCGTGCACACC
GCACTCTCCTTCGATCTCGTCGGCGAGGACGTTCTCGTGACCGGCGCCGGCCCGATCGGCATCATGGGGGCGCTCGTCGC
CAAACGGTCCGGCGCCCGCAAGGTCGTCATCACCGATATCAATCCGCACCGGCTGGCGTTGGCGCGCAAGCTTGGCATCG
ACCACGTCGTCGACGCTTCGAGCGAAAACCTGGCCGACGTGATGAAATCGATCGGCATGACGGAGGGTTTCGACGTCGGG
CTCGAAATGTCCGGGGCCGCACCCGCCTTCCGCGACATGATCGACAAGATGAACAATGGCGGCAAGATCGCCATTCTCGG
CATCGCGCCGGCGGGTTTCGAGATCGACTGGAACAAGGTGATTTTCAAGATGCTCAATCTGAAGGGCATCTATGGCCGCG
AGATGTTTGAGACCTGGTACAAGATGATCGCCTTCGTCCAGGGCGGCCTTGACCTTGCGCCGATCATCACCCACCGCATA
GGGATCGATGAGTTTCGCGACGGCTTCGAGGCGATGCGGTCGGGCAATTCCGGCAAGGTCGTAATGGATTGGATGTGA

Upstream 100 bases:

>100_bases
ACGGAGAGGTCGCCGCTTGTCTCCTTCGCCCCGCCTGCGGGGAGAAGGTGCCGGCAGGCGGATGAGGGGCCGAAACAGGC
ACTGACCAAGGGATACAGAT

Downstream 100 bases:

>100_bases
GGAGAAAGACATGCTTTATGAGGGAAGCTGCCATTGCGGCAAGGTCGCATTCGAGGTCGAAGGCGAATTTACCGAGGCGC
TGGACTGCAACTGTTCGCTC

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSNMMKALVKSKPEVGLWMENVPVPEVGPNDVLIRVRKSAICGTDVHIWNWDQWAQKTIPVPMVVGHEFSGEIAEIGSAV
TRYHVGERVSGEGHIVCGKCRNCRAGRGHLCRNTLGVGVNRPGSFGEFVCIPESNVVAIPEDISDEIAAIFDPFGNAVHT
ALSFDLVGEDVLVTGAGPIGIMGALVAKRSGARKVVITDINPHRLALARKLGIDHVVDASSENLADVMKSIGMTEGFDVG
LEMSGAAPAFRDMIDKMNNGGKIAILGIAPAGFEIDWNKVIFKMLNLKGIYGREMFETWYKMIAFVQGGLDLAPIITHRI
GIDEFRDGFEAMRSGNSGKVVMDWM

Sequences:

>Translated_345_residues
MSNMMKALVKSKPEVGLWMENVPVPEVGPNDVLIRVRKSAICGTDVHIWNWDQWAQKTIPVPMVVGHEFSGEIAEIGSAV
TRYHVGERVSGEGHIVCGKCRNCRAGRGHLCRNTLGVGVNRPGSFGEFVCIPESNVVAIPEDISDEIAAIFDPFGNAVHT
ALSFDLVGEDVLVTGAGPIGIMGALVAKRSGARKVVITDINPHRLALARKLGIDHVVDASSENLADVMKSIGMTEGFDVG
LEMSGAAPAFRDMIDKMNNGGKIAILGIAPAGFEIDWNKVIFKMLNLKGIYGREMFETWYKMIAFVQGGLDLAPIITHRI
GIDEFRDGFEAMRSGNSGKVVMDWM
>Mature_344_residues
SNMMKALVKSKPEVGLWMENVPVPEVGPNDVLIRVRKSAICGTDVHIWNWDQWAQKTIPVPMVVGHEFSGEIAEIGSAVT
RYHVGERVSGEGHIVCGKCRNCRAGRGHLCRNTLGVGVNRPGSFGEFVCIPESNVVAIPEDISDEIAAIFDPFGNAVHTA
LSFDLVGEDVLVTGAGPIGIMGALVAKRSGARKVVITDINPHRLALARKLGIDHVVDASSENLADVMKSIGMTEGFDVGL
EMSGAAPAFRDMIDKMNNGGKIAILGIAPAGFEIDWNKVIFKMLNLKGIYGREMFETWYKMIAFVQGGLDLAPIITHRIG
IDEFRDGFEAMRSGNSGKVVMDWM

Specific function: Threonine catabolism; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=331, Percent_Identity=28.7009063444109, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI34577061, Length=364, Percent_Identity=25.5494505494505, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI4501929, Length=362, Percent_Identity=25.1381215469613, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI156523966, Length=377, Percent_Identity=24.1379310344828, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI71743840, Length=378, Percent_Identity=24.6031746031746, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI4501939, Length=371, Percent_Identity=24.5283018867925, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI262073058, Length=378, Percent_Identity=24.6031746031746, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4501933, Length=364, Percent_Identity=25, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI71565154, Length=387, Percent_Identity=23.5142118863049, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=70.2941176470588, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI1788075, Length=364, Percent_Identity=31.043956043956, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1788073, Length=338, Percent_Identity=26.9230769230769, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI87082125, Length=362, Percent_Identity=29.5580110497238, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI226510992, Length=335, Percent_Identity=27.1641791044776, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787863, Length=294, Percent_Identity=28.2312925170068, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1788407, Length=355, Percent_Identity=27.0422535211268, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790718, Length=311, Percent_Identity=26.0450160771704, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786825, Length=385, Percent_Identity=28.051948051948, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786552, Length=373, Percent_Identity=26.0053619302949, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87081918, Length=265, Percent_Identity=25.6603773584906, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562876, Length=336, Percent_Identity=32.4404761904762, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17562878, Length=335, Percent_Identity=31.6417910447761, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71988145, Length=195, Percent_Identity=30.7692307692308, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562584, Length=348, Percent_Identity=25.8620689655172, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=295, Percent_Identity=26.1016949152542, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323099, Length=340, Percent_Identity=30.8823529411765, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322619, Length=325, Percent_Identity=27.3846153846154, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319955, Length=325, Percent_Identity=27.0769230769231, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6319258, Length=303, Percent_Identity=28.3828382838284, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=364, Percent_Identity=26.9230769230769, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=249, Percent_Identity=28.1124497991968, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=339, Percent_Identity=28.3185840707965, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=358, Percent_Identity=27.0949720670391, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=338, Percent_Identity=26.0355029585799, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=341, Percent_Identity=25.8064516129032, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=204, Percent_Identity=29.4117647058824, Blast_Score=63, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319949, Length=288, Percent_Identity=27.7777777777778, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17737897, Length=331, Percent_Identity=27.7945619335347, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17137530, Length=330, Percent_Identity=26.6666666666667, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17737895, Length=375, Percent_Identity=24.2666666666667, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221457811, Length=217, Percent_Identity=28.110599078341, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45550770, Length=217, Percent_Identity=28.110599078341, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45551930, Length=217, Percent_Identity=28.110599078341, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37404; Mature: 37273

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNMMKALVKSKPEVGLWMENVPVPEVGPNDVLIRVRKSAICGTDVHIWNWDQWAQKTIP
CCHHHHHHHHCCCCCCEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEECCHHHHHHCCC
VPMVVGHEFSGEIAEIGSAVTRYHVGERVSGEGHIVCGKCRNCRAGRGHLCRNTLGVGVN
CEEEECCCCCCHHHHHHHHHHHHHCCCEECCCCCEEECCCCCCCCCCCCHHHHHHCCCCC
RPGSFGEFVCIPESNVVAIPEDISDEIAAIFDPFGNAVHTALSFDLVGEDVLVTGAGPIG
CCCCCCCEEEECCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHEECCCCEEEECCCHHH
IMGALVAKRSGARKVVITDINPHRLALARKLGIDHVVDASSENLADVMKSIGMTEGFDVG
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCHHHCCCCCCHHHHHHHHCCCCCCCCCC
LEMSGAAPAFRDMIDKMNNGGKIAILGIAPAGFEIDWNKVIFKMLNLKGIYGREMFETWY
EEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHH
KMIAFVQGGLDLAPIITHRIGIDEFRDGFEAMRSGNSGKVVMDWM
HHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure 
SNMMKALVKSKPEVGLWMENVPVPEVGPNDVLIRVRKSAICGTDVHIWNWDQWAQKTIP
CHHHHHHHHCCCCCCEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEECCHHHHHHCCC
VPMVVGHEFSGEIAEIGSAVTRYHVGERVSGEGHIVCGKCRNCRAGRGHLCRNTLGVGVN
CEEEECCCCCCHHHHHHHHHHHHHCCCEECCCCCEEECCCCCCCCCCCCHHHHHHCCCCC
RPGSFGEFVCIPESNVVAIPEDISDEIAAIFDPFGNAVHTALSFDLVGEDVLVTGAGPIG
CCCCCCCEEEECCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHEECCCCEEEECCCHHH
IMGALVAKRSGARKVVITDINPHRLALARKLGIDHVVDASSENLADVMKSIGMTEGFDVG
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCHHHCCCCCCHHHHHHHHCCCCCCCCCC
LEMSGAAPAFRDMIDKMNNGGKIAILGIAPAGFEIDWNKVIFKMLNLKGIYGREMFETWY
EEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHH
KMIAFVQGGLDLAPIITHRIGIDEFRDGFEAMRSGNSGKVVMDWM
HHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA