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The map label for this gene is pepQ [H]

Identifier: 209550152

GI number: 209550152

Start: 2609131

End: 2610966

Strand: Reverse

Name: pepQ [H]

Synonym: Rleg2_2571

Alternate gene names: 209550152

Gene position: 2610966-2609131 (Counterclockwise)

Preceding gene: 209550153

Following gene: 209550149

Centisome position: 57.54

GC content: 63.67

Gene sequence:

>1836_bases
ATGTACCAGTCCTTTGAAGTTACCTCCACGCCCCAATTCGGCAGGGATCGGGTATCGGCGCTGCGCGCTGCTTTCGATTC
GCTCGGGATCGACGCCTTCCTCGTGCCGCGCGCCGACGAGTTCAACGGCGAATATGTTCCCGCATGTTCGGAGCGCCTGG
CATGGCTGACGGGCTTCACCGGCTCTGCAGGCATTGCAATGGTTCTGCGCACGCAGGCGATCGTCTTCGTCGACGGGCGT
TATGTGACGCAGCTTGCCGAACAGGTCGACGGTTCGGTCTTCTCGGGCGGCGATCTCGTCAACGAGCCGCCACATCTCTG
GCTGGCCGCAAACGGCGCCAAGGGCCTTCGGCTCGGCATCGATCCCTGGCTGCATGCCGGTGCCGAGGTGCGCCGTCTGG
AACGAGCGCTTTCGCAGATCGGCGGCACGCTCACCTTCCTGCCCCACAATCCGCTCGACAGGCTCTGGAGCGACCGGCCG
GTCGAGCCGCTCGGCGCGGTCAGCATCCAGAATGTCGCGCAGGCCGGCGTGCTTGCCAGGGATAAAATCGCGACGATCGC
CGCCGACCTTTCGAAGAAGGCTCTGGCGGCAGTGCTGATCGCCGATCCTTCCTCGGTCGCCTGGACCTTCAACATTCGCG
GCGCCGACGTGCCGCATACGCCGCATCCGCTGGCGCGCGCCATCGTCCATGCCGATGGGCGGGCCGATCTTTTCCTCGAC
AAGCGCAAGACCGGCATCGAGCCGGAGGCCTATCTCGCGCAGATCTGCACACAGCTGCCGCCCTCGGCGCTGGAGGAGAG
GCTCACTGCCGTTTCAAGGGATGGCGGCCGTGTGCTGATCGACCCGGATATCGCTTCCTATGCGCTGGCCGAGATTATCC
GCAAGGCGGGCGGCGAAGTGGTAGAGGGGACTGATCCCGCCAAGATGCCGCGCGCGGTGAAGAACGACGTCGAGATCAAC
GGCTCGGCCGCCGCGCATCTGCAGGATGGGGCGGCAATGGTGGAATTCCTCTATTGGCTGTCGCAGACAAAACCCGGCAC
GGTCAGCGAAATTGCTGCCGCCGAGCATCTCGAAGCGGTGCGTGCCCGCGTCGGCCAGAGCATGCAGAACCCGCTGAAGG
ACATTTCCTTCGACACGATTTCAGGCGCCGGCGAACATGCGGCGATCATGCATTACCGCGTGACCACCGAGACCAACCGG
ATGATCGAAGGCGGCGAACTCTTCCTGATCGATTCCGGCGCGCAATATATCAACGGCACTACCGACATTACCCGCACGAT
CGGCATCGGGGCGGTTTCAGAAGAGCATCGCCGCTTCTTCACACTGGTGCTGAAGGGGATGATCCAGATCAGCACGGCGC
GTTTCCCTAAGGGTACGCGCGGCTGCGACCTCGATCCTCTGGCGCGCATCGCGCTGTGGCGGGCAGGGGCCGATTTCGCG
CACGGCACGGGCCACGGTGTCGGCTCCTATCTCTCGGTGCATGAGGGGCCGCAGCGCATCTCCAGGCTTTCGACGCAGGA
ACTGCTGCCCGGCATGATCCTGTCCAACGAGCCGGGCTATTACCGGCCCGGCAGCTTCGGCATCCGCATCGAAAACCTGA
TCTATGTGCGCGCGGCCGAGGAGATCGACGGCGGCGACGCGGCGATGCTCGGCTTCGAAACGCTAACCTTCTGCCCGATC
GATCGCAGCCTCGTCATTCCGGAGCTTCTGACCCATGACGAGCTGCATTGGTTCAACGACTATCACCGCCGCACATGCGA
GGCACTGATGCCGTTGATCCATGATCACGATGTCCGGGCGTGGCTCGAAAACGCGACACTGCCGCTGGAATATTAA

Upstream 100 bases:

>100_bases
TCGACTCGTTTCGTCGCTTTTTCTCCCCATCGATTGAAATTTCGCTAACATGGCCGGCATCCCATTTACCGGATTCGTCT
CAACCATTCGGGTTTCCAGC

Downstream 100 bases:

>100_bases
AGTGATGGCGCTGAACGCCGGCGTTAAACGCCGGCGGTATGGCGCCAGATCATTACGACGATCCAGGCAGCGACCAGCAT
CCATGTATGGGTGAAACGCA

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 611; Mature: 611

Protein sequence:

>611_residues
MYQSFEVTSTPQFGRDRVSALRAAFDSLGIDAFLVPRADEFNGEYVPACSERLAWLTGFTGSAGIAMVLRTQAIVFVDGR
YVTQLAEQVDGSVFSGGDLVNEPPHLWLAANGAKGLRLGIDPWLHAGAEVRRLERALSQIGGTLTFLPHNPLDRLWSDRP
VEPLGAVSIQNVAQAGVLARDKIATIAADLSKKALAAVLIADPSSVAWTFNIRGADVPHTPHPLARAIVHADGRADLFLD
KRKTGIEPEAYLAQICTQLPPSALEERLTAVSRDGGRVLIDPDIASYALAEIIRKAGGEVVEGTDPAKMPRAVKNDVEIN
GSAAAHLQDGAAMVEFLYWLSQTKPGTVSEIAAAEHLEAVRARVGQSMQNPLKDISFDTISGAGEHAAIMHYRVTTETNR
MIEGGELFLIDSGAQYINGTTDITRTIGIGAVSEEHRRFFTLVLKGMIQISTARFPKGTRGCDLDPLARIALWRAGADFA
HGTGHGVGSYLSVHEGPQRISRLSTQELLPGMILSNEPGYYRPGSFGIRIENLIYVRAAEEIDGGDAAMLGFETLTFCPI
DRSLVIPELLTHDELHWFNDYHRRTCEALMPLIHDHDVRAWLENATLPLEY

Sequences:

>Translated_611_residues
MYQSFEVTSTPQFGRDRVSALRAAFDSLGIDAFLVPRADEFNGEYVPACSERLAWLTGFTGSAGIAMVLRTQAIVFVDGR
YVTQLAEQVDGSVFSGGDLVNEPPHLWLAANGAKGLRLGIDPWLHAGAEVRRLERALSQIGGTLTFLPHNPLDRLWSDRP
VEPLGAVSIQNVAQAGVLARDKIATIAADLSKKALAAVLIADPSSVAWTFNIRGADVPHTPHPLARAIVHADGRADLFLD
KRKTGIEPEAYLAQICTQLPPSALEERLTAVSRDGGRVLIDPDIASYALAEIIRKAGGEVVEGTDPAKMPRAVKNDVEIN
GSAAAHLQDGAAMVEFLYWLSQTKPGTVSEIAAAEHLEAVRARVGQSMQNPLKDISFDTISGAGEHAAIMHYRVTTETNR
MIEGGELFLIDSGAQYINGTTDITRTIGIGAVSEEHRRFFTLVLKGMIQISTARFPKGTRGCDLDPLARIALWRAGADFA
HGTGHGVGSYLSVHEGPQRISRLSTQELLPGMILSNEPGYYRPGSFGIRIENLIYVRAAEEIDGGDAAMLGFETLTFCPI
DRSLVIPELLTHDELHWFNDYHRRTCEALMPLIHDHDVRAWLENATLPLEY
>Mature_611_residues
MYQSFEVTSTPQFGRDRVSALRAAFDSLGIDAFLVPRADEFNGEYVPACSERLAWLTGFTGSAGIAMVLRTQAIVFVDGR
YVTQLAEQVDGSVFSGGDLVNEPPHLWLAANGAKGLRLGIDPWLHAGAEVRRLERALSQIGGTLTFLPHNPLDRLWSDRP
VEPLGAVSIQNVAQAGVLARDKIATIAADLSKKALAAVLIADPSSVAWTFNIRGADVPHTPHPLARAIVHADGRADLFLD
KRKTGIEPEAYLAQICTQLPPSALEERLTAVSRDGGRVLIDPDIASYALAEIIRKAGGEVVEGTDPAKMPRAVKNDVEIN
GSAAAHLQDGAAMVEFLYWLSQTKPGTVSEIAAAEHLEAVRARVGQSMQNPLKDISFDTISGAGEHAAIMHYRVTTETNR
MIEGGELFLIDSGAQYINGTTDITRTIGIGAVSEEHRRFFTLVLKGMIQISTARFPKGTRGCDLDPLARIALWRAGADFA
HGTGHGVGSYLSVHEGPQRISRLSTQELLPGMILSNEPGYYRPGSFGIRIENLIYVRAAEEIDGGDAAMLGFETLTFCPI
DRSLVIPELLTHDELHWFNDYHRRTCEALMPLIHDHDVRAWLENATLPLEY

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=583, Percent_Identity=36.5351629502573, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI93141226, Length=605, Percent_Identity=34.2148760330578, Blast_Score=318, Evalue=8e-87,
Organism=Homo sapiens, GI264681565, Length=585, Percent_Identity=34.5299145299145, Blast_Score=307, Evalue=2e-83,
Organism=Escherichia coli, GI1788728, Length=175, Percent_Identity=36.5714285714286, Blast_Score=92, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17509539, Length=617, Percent_Identity=33.54943273906, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI25149105, Length=639, Percent_Identity=28.4820031298905, Blast_Score=241, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6322999, Length=656, Percent_Identity=29.5731707317073, Blast_Score=274, Evalue=3e-74,
Organism=Drosophila melanogaster, GI17137632, Length=619, Percent_Identity=33.2794830371567, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI161078230, Length=583, Percent_Identity=28.3018867924528, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21357287, Length=583, Percent_Identity=28.3018867924528, Blast_Score=217, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 66503; Mature: 66503

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQSFEVTSTPQFGRDRVSALRAAFDSLGIDAFLVPRADEFNGEYVPACSERLAWLTGFT
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCC
GSAGIAMVLRTQAIVFVDGRYVTQLAEQVDGSVFSGGDLVNEPPHLWLAANGAKGLRLGI
CCCCCEEEEEEEEEEEECCHHHHHHHHHHCCCEECCCCCCCCCCCEEEEECCCCCEEECC
DPWLHAGAEVRRLERALSQIGGTLTFLPHNPLDRLWSDRPVEPLGAVSIQNVAQAGVLAR
CHHHHCCHHHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHCCHHH
DKIATIAADLSKKALAAVLIADPSSVAWTFNIRGADVPHTPHPLARAIVHADGRADLFLD
HHHHHHHHHHHHHHEEEEEEECCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCEEEEE
KRKTGIEPEAYLAQICTQLPPSALEERLTAVSRDGGRVLIDPDIASYALAEIIRKAGGEV
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCE
VEGTDPAKMPRAVKNDVEINGSAAAHLQDGAAMVEFLYWLSQTKPGTVSEIAAAEHLEAV
ECCCCHHHCCHHHHCCCEECCCEEEHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RARVGQSMQNPLKDISFDTISGAGEHAAIMHYRVTTETNRMIEGGELFLIDSGAQYINGT
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCEECCCEEEEEECCCHHCCCC
TDITRTIGIGAVSEEHRRFFTLVLKGMIQISTARFPKGTRGCDLDPLARIALWRAGADFA
CHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCC
HGTGHGVGSYLSVHEGPQRISRLSTQELLPGMILSNEPGYYRPGSFGIRIENLIYVRAAE
CCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEEEEEEECC
EIDGGDAAMLGFETLTFCPIDRSLVIPELLTHDELHWFNDYHRRTCEALMPLIHDHDVRA
CCCCCCEEEEEHHEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
WLENATLPLEY
HHHCCCCCCCC
>Mature Secondary Structure
MYQSFEVTSTPQFGRDRVSALRAAFDSLGIDAFLVPRADEFNGEYVPACSERLAWLTGFT
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCC
GSAGIAMVLRTQAIVFVDGRYVTQLAEQVDGSVFSGGDLVNEPPHLWLAANGAKGLRLGI
CCCCCEEEEEEEEEEEECCHHHHHHHHHHCCCEECCCCCCCCCCCEEEEECCCCCEEECC
DPWLHAGAEVRRLERALSQIGGTLTFLPHNPLDRLWSDRPVEPLGAVSIQNVAQAGVLAR
CHHHHCCHHHHHHHHHHHHHCCEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHCCHHH
DKIATIAADLSKKALAAVLIADPSSVAWTFNIRGADVPHTPHPLARAIVHADGRADLFLD
HHHHHHHHHHHHHHEEEEEEECCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCEEEEE
KRKTGIEPEAYLAQICTQLPPSALEERLTAVSRDGGRVLIDPDIASYALAEIIRKAGGEV
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCE
VEGTDPAKMPRAVKNDVEINGSAAAHLQDGAAMVEFLYWLSQTKPGTVSEIAAAEHLEAV
ECCCCHHHCCHHHHCCCEECCCEEEHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RARVGQSMQNPLKDISFDTISGAGEHAAIMHYRVTTETNRMIEGGELFLIDSGAQYINGT
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCEECCCEEEEEECCCHHCCCC
TDITRTIGIGAVSEEHRRFFTLVLKGMIQISTARFPKGTRGCDLDPLARIALWRAGADFA
CHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCC
HGTGHGVGSYLSVHEGPQRISRLSTQELLPGMILSNEPGYYRPGSFGIRIENLIYVRAAE
CCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEEEEEEECC
EIDGGDAAMLGFETLTFCPIDRSLVIPELLTHDELHWFNDYHRRTCEALMPLIHDHDVRA
CCCCCCEEEEEHHEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
WLENATLPLEY
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]