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The map label for this gene is macA [H]

Identifier: 209549848

GI number: 209549848

Start: 2318422

End: 2319648

Strand: Reverse

Name: macA [H]

Synonym: Rleg2_2261

Alternate gene names: 209549848

Gene position: 2319648-2318422 (Counterclockwise)

Preceding gene: 209549849

Following gene: 209549847

Centisome position: 51.12

GC content: 67.32

Gene sequence:

>1227_bases
GTGTTCGAGGTCGCGATTTCTGCCGGGTCGGCGATGTTTGCCGGCATGAACACGACAACAGAACATGACCGAGACCTTGC
CGCCAAGCTCAGATCGCTTTCGATCGAGCCCGGGGCCTTGAAGACCGAGCCGCCGAAGCCTCATTCCCTGCGGCGCCTGA
CCCCTCGCGTAATGCTTGTCCTTGCTGCGGCGGCATCGCTGGCGGCGGCTCTTTTCTATGGACCTGAGACGCTGCAGCGT
ATCGAGACCGCGCTTGCGGGGCTTTCGGGCGGCGACCTTGCGATATCTGCTGATCGGGTGAAGGCACGAGCCAGCGACGG
TGCTGCTGTTGAGGCGGTGCGGACTCCGACCGATGGAGCGAAAAGCGCGGCTGCGCTCCCCCGCGAGGTCACCGGCTCCG
GTTATGTCGTGGCACCCGATATCGCCACCGTCTTTTCCAAATATGAGGGCCGGATCGTGGCGGTAGAGGTTGAGGCGGGC
GACAGCGTCGTCGCGGGGCAGGTGCTGGTGCGGCTTGACGATGCCGGCGCGCGTTTTGCGCTTCGGGGCGCCGAGATAGC
AGGGCGGGCGGCGGCGCTGGCGCTCGAGGCGAGGACGATCGAGCTTGCGCAGGCACGCTCGTCATTTGCGCGCAGCGAGC
GGCTCGCCGGGCGCGATGCCATGTCGGCGCAGGCGCTGGAGGAGGCGAGGACGGCTGTCGACAAGGCCGAGAATGCCGCC
CTGCAGGCACGCCAGGACGTCGAAAAGGCGGAGCTCGAGATCGACAAGGCGCGCGAGCAGGTGGAGGCGCTGATCGTGCG
TGCGCCGATCTCCGGCACCGTCACGCGGCTCGACGCGCATGTCGGCGACACGGTGCTTTCGCGCGAGGACAGTGTGCGGG
AGGATGAGAGCCTGCTCACTATTACCGATACGGCGAGCCTGGTCATCGATGCCGATGTGGCCGAGGCCAATATCGCGCTG
ATGCGGCCGGGCCTGTCGGGCGAGGCGGTGCTCGACGGCTTTCCCGGCCAGCCCTTTGCGATCGCGGTGTCGAAGATCGC
GCCGGTCGTTTCGCGGGAAAAGGGGACGGTGACGCTGCGCCTGTCGCTGACGTCGCCACCGCCCGGAATGCGGCCTGCCA
TGGCTGCGCGCATCCGGCTTTTAGTGGGTGAGGCGGCGGGTGTGGGTGCTCATCACCCGCCCTCGTCCTTCGAGGCTCCG
GCCTTTGGCCTGCGCACCTCAGGATGA

Upstream 100 bases:

>100_bases
AGCCGCACTCTCACTCCGCCCTCATCTTGAGGCGCCCCTCAAGGGCCTCGAAGGGCGAGGGCGGCCACGTACACAATCGC
GATCGAGGACTGCCTGGATC

Downstream 100 bases:

>100_bases
GGCTGATTGTTGTGCGGTGTGGCTGGAAAGCTGATCGCGTGTCGTGCGGCTGGCGGGCTGATCTTGTGACGTGCGGTTTG
GCTTCCTGTGCCGCAGAGCG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MFEVAISAGSAMFAGMNTTTEHDRDLAAKLRSLSIEPGALKTEPPKPHSLRRLTPRVMLVLAAAASLAAALFYGPETLQR
IETALAGLSGGDLAISADRVKARASDGAAVEAVRTPTDGAKSAAALPREVTGSGYVVAPDIATVFSKYEGRIVAVEVEAG
DSVVAGQVLVRLDDAGARFALRGAEIAGRAAALALEARTIELAQARSSFARSERLAGRDAMSAQALEEARTAVDKAENAA
LQARQDVEKAELEIDKAREQVEALIVRAPISGTVTRLDAHVGDTVLSREDSVREDESLLTITDTASLVIDADVAEANIAL
MRPGLSGEAVLDGFPGQPFAIAVSKIAPVVSREKGTVTLRLSLTSPPPGMRPAMAARIRLLVGEAAGVGAHHPPSSFEAP
AFGLRTSG

Sequences:

>Translated_408_residues
MFEVAISAGSAMFAGMNTTTEHDRDLAAKLRSLSIEPGALKTEPPKPHSLRRLTPRVMLVLAAAASLAAALFYGPETLQR
IETALAGLSGGDLAISADRVKARASDGAAVEAVRTPTDGAKSAAALPREVTGSGYVVAPDIATVFSKYEGRIVAVEVEAG
DSVVAGQVLVRLDDAGARFALRGAEIAGRAAALALEARTIELAQARSSFARSERLAGRDAMSAQALEEARTAVDKAENAA
LQARQDVEKAELEIDKAREQVEALIVRAPISGTVTRLDAHVGDTVLSREDSVREDESLLTITDTASLVIDADVAEANIAL
MRPGLSGEAVLDGFPGQPFAIAVSKIAPVVSREKGTVTLRLSLTSPPPGMRPAMAARIRLLVGEAAGVGAHHPPSSFEAP
AFGLRTSG
>Mature_408_residues
MFEVAISAGSAMFAGMNTTTEHDRDLAAKLRSLSIEPGALKTEPPKPHSLRRLTPRVMLVLAAAASLAAALFYGPETLQR
IETALAGLSGGDLAISADRVKARASDGAAVEAVRTPTDGAKSAAALPREVTGSGYVVAPDIATVFSKYEGRIVAVEVEAG
DSVVAGQVLVRLDDAGARFALRGAEIAGRAAALALEARTIELAQARSSFARSERLAGRDAMSAQALEEARTAVDKAENAA
LQARQDVEKAELEIDKAREQVEALIVRAPISGTVTRLDAHVGDTVLSREDSVREDESLLTITDTASLVIDADVAEANIAL
MRPGLSGEAVLDGFPGQPFAIAVSKIAPVVSREKGTVTLRLSLTSPPPGMRPAMAARIRLLVGEAAGVGAHHPPSSFEAP
AFGLRTSG

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=270, Percent_Identity=24.0740740740741, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082036, Length=195, Percent_Identity=28.2051282051282, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42377; Mature: 42377

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEVAISAGSAMFAGMNTTTEHDRDLAAKLRSLSIEPGALKTEPPKPHSLRRLTPRVMLV
CEEEEEECCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LAAAASLAAALFYGPETLQRIETALAGLSGGDLAISADRVKARASDGAAVEAVRTPTDGA
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHCCCCCCEEEEEECCCCCC
KSAAALPREVTGSGYVVAPDIATVFSKYEGRIVAVEVEAGDSVVAGQVLVRLDDAGARFA
HHHHCCCCCCCCCCEEECCHHHHHHHHHCCEEEEEEECCCCCEEEEEEEEEEECCCCEEE
LRGAEIAGRAAALALEARTIELAQARSSFARSERLAGRDAMSAQALEEARTAVDKAENAA
EECCHHCCCHHEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LQARQDVEKAELEIDKAREQVEALIVRAPISGTVTRLDAHVGDTVLSREDSVREDESLLT
HHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEHHHHHCCHHHCCCCCCCCCCCEEE
ITDTASLVIDADVAEANIALMRPGLSGEAVLDGFPGQPFAIAVSKIAPVVSREKGTVTLR
EECCCEEEEECCCCCCCEEEECCCCCCCEEECCCCCCCCEEEHHHHHHHHCCCCCEEEEE
LSLTSPPPGMRPAMAARIRLLVGEAAGVGAHHPPSSFEAPAFGLRTSG
EEECCCCCCCCHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFEVAISAGSAMFAGMNTTTEHDRDLAAKLRSLSIEPGALKTEPPKPHSLRRLTPRVMLV
CEEEEEECCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LAAAASLAAALFYGPETLQRIETALAGLSGGDLAISADRVKARASDGAAVEAVRTPTDGA
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHCCCCCCEEEEEECCCCCC
KSAAALPREVTGSGYVVAPDIATVFSKYEGRIVAVEVEAGDSVVAGQVLVRLDDAGARFA
HHHHCCCCCCCCCCEEECCHHHHHHHHHCCEEEEEEECCCCCEEEEEEEEEEECCCCEEE
LRGAEIAGRAAALALEARTIELAQARSSFARSERLAGRDAMSAQALEEARTAVDKAENAA
EECCHHCCCHHEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LQARQDVEKAELEIDKAREQVEALIVRAPISGTVTRLDAHVGDTVLSREDSVREDESLLT
HHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEHHHHHCCHHHCCCCCCCCCCCEEE
ITDTASLVIDADVAEANIALMRPGLSGEAVLDGFPGQPFAIAVSKIAPVVSREKGTVTLR
EECCCEEEEECCCCCCCEEEECCCCCCCEEECCCCCCCCEEEHHHHHHHHCCCCCEEEEE
LSLTSPPPGMRPAMAARIRLLVGEAAGVGAHHPPSSFEAPAFGLRTSG
EEECCCCCCCCHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]