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The map label for this gene is hhoB [H]

Identifier: 209549799

GI number: 209549799

Start: 2269780

End: 2270739

Strand: Reverse

Name: hhoB [H]

Synonym: Rleg2_2210

Alternate gene names: 209549799

Gene position: 2270739-2269780 (Counterclockwise)

Preceding gene: 209549804

Following gene: 209549792

Centisome position: 50.04

GC content: 63.75

Gene sequence:

>960_bases
ATGGGTTACATGGACAAGGCGGTAGCGCCTCAAAATGACGGGGCGCTGATCGATGCCTATTCACAATCGATCGCAGCAGC
AGTCGACACGGTCGGGCCGGCCGTCAGCCGGATCGAGAGGGTTGGTGGCCGGCAGGGGCATGGTTCGGGCTTCGCCGTCT
CGCCAGACGGCCTGATCATCACCAACAGTCATGTCGTCGACGACGCCAAAGTCGTTCGCATTACCACGCCCGACGGCTTC
GTTACGGAAGGCCGGGTGTTGGGTCGCGATGTCGATACCGATATCGCCCTCATTCGCGCCAATACAAGCACCGGCGCTTG
GGCGAGGCTCGGAGATTCCCAGCGCTTGCGCCGAGGCCATATCGCTATCGCGATCGGAAACCCGCTCGGTTTCGAATGGA
CGGTTACTGCCGGCATCGTCTCGGCGCTCGGCCGGTCGATGCGGGCAGCCAGCGGCCGCCTGATGGAGGATGTCATCCAG
ACAGATGCGGCGCTCAATCCCGGCAACTCAGGTGGACCGCTGGTGTCTTCCAGCGGCGAGGTCATCGGCGTCAATACCGC
CGTCATCCAGGGCGCGCAGAGCATCGCTTTTGCCGTAGCGTCGAATACCGCCAATTTCGTCGTTTCGGAAATACTCCGCT
ACGGCCAGGTCAGGCGCGCCTTCATCGGTATCGCGGGCGATACGATCGTGCTGCCGCGCCGGGTGGCGCTTGCGGCGGGG
ACGGTGCAGACGACCTCCGTTCGCATCCGACGCGTCGAGCCCGACGGGCCGGCGGCAAAGGGAGGGCTGCAGGAGGGCGA
TTACATCCTCGCCATCGACGGCAGTCCGGTCGGCGGTGTCGACGATATCGTCAGGCTGATGGATGGCAGCAGGATCGACA
GGGATACGGAGATACTGGTGTTCTCGGTGGCGGGTCGGATCGAAAAGAAGACCTTGCTGCCGATGGCGCGGACGTCCTGA

Upstream 100 bases:

>100_bases
GCCCAACCATCTAATCCTCAACAACAGTATGATGGCGAACCGTCGCAACCAAGACCGCTTGGGCCGCGGACGACGGCTAT
TCCCGCCTGAGGATCAAATC

Downstream 100 bases:

>100_bases
CAAAGACGTCACGTCCCGTCAGGCGCTGACCGCCTGCTGCTCCGTCCCCGAAAAATCCACAGCCGCAAAGGCTGCCGCCA
ATACTTCCGGCCCGGCACCG

Product: peptidase S1 and S6 chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MGYMDKAVAPQNDGALIDAYSQSIAAAVDTVGPAVSRIERVGGRQGHGSGFAVSPDGLIITNSHVVDDAKVVRITTPDGF
VTEGRVLGRDVDTDIALIRANTSTGAWARLGDSQRLRRGHIAIAIGNPLGFEWTVTAGIVSALGRSMRAASGRLMEDVIQ
TDAALNPGNSGGPLVSSSGEVIGVNTAVIQGAQSIAFAVASNTANFVVSEILRYGQVRRAFIGIAGDTIVLPRRVALAAG
TVQTTSVRIRRVEPDGPAAKGGLQEGDYILAIDGSPVGGVDDIVRLMDGSRIDRDTEILVFSVAGRIEKKTLLPMARTS

Sequences:

>Translated_319_residues
MGYMDKAVAPQNDGALIDAYSQSIAAAVDTVGPAVSRIERVGGRQGHGSGFAVSPDGLIITNSHVVDDAKVVRITTPDGF
VTEGRVLGRDVDTDIALIRANTSTGAWARLGDSQRLRRGHIAIAIGNPLGFEWTVTAGIVSALGRSMRAASGRLMEDVIQ
TDAALNPGNSGGPLVSSSGEVIGVNTAVIQGAQSIAFAVASNTANFVVSEILRYGQVRRAFIGIAGDTIVLPRRVALAAG
TVQTTSVRIRRVEPDGPAAKGGLQEGDYILAIDGSPVGGVDDIVRLMDGSRIDRDTEILVFSVAGRIEKKTLLPMARTS
>Mature_318_residues
GYMDKAVAPQNDGALIDAYSQSIAAAVDTVGPAVSRIERVGGRQGHGSGFAVSPDGLIITNSHVVDDAKVVRITTPDGFV
TEGRVLGRDVDTDIALIRANTSTGAWARLGDSQRLRRGHIAIAIGNPLGFEWTVTAGIVSALGRSMRAASGRLMEDVIQT
DAALNPGNSGGPLVSSSGEVIGVNTAVIQGAQSIAFAVASNTANFVVSEILRYGQVRRAFIGIAGDTIVLPRRVALAAGT
VQTTSVRIRRVEPDGPAAKGGLQEGDYILAIDGSPVGGVDDIVRLMDGSRIDRDTEILVFSVAGRIEKKTLLPMARTS

Specific function: A putative protease, its function overlaps that of the related putative proteases HtrA and HhoA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=300, Percent_Identity=34.6666666666667, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI22129776, Length=276, Percent_Identity=35.1449275362319, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI24308541, Length=285, Percent_Identity=32.280701754386, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI7019477, Length=288, Percent_Identity=35.4166666666667, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1786356, Length=235, Percent_Identity=41.7021276595745, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789629, Length=238, Percent_Identity=36.9747899159664, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1789630, Length=289, Percent_Identity=34.6020761245675, Blast_Score=140, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646839, Length=266, Percent_Identity=30.8270676691729, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 33182; Mature: 33051

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYMDKAVAPQNDGALIDAYSQSIAAAVDTVGPAVSRIERVGGRQGHGSGFAVSPDGLII
CCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEE
TNSHVVDDAKVVRITTPDGFVTEGRVLGRDVDTDIALIRANTSTGAWARLGDSQRLRRGH
ECCEEECCCEEEEEECCCCCEECCEEECCCCCCCEEEEEECCCCCCEEECCCHHHHCCCC
IAIAIGNPLGFEWTVTAGIVSALGRSMRAASGRLMEDVIQTDAALNPGNSGGPLVSSSGE
EEEEECCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECCCC
VIGVNTAVIQGAQSIAFAVASNTANFVVSEILRYGQVRRAFIGIAGDTIVLPRRVALAAG
EEEEHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCEEEECCCEEEECC
TVQTTSVRIRRVEPDGPAAKGGLQEGDYILAIDGSPVGGVDDIVRLMDGSRIDRDTEILV
CEEEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCEEEE
FSVAGRIEKKTLLPMARTS
EEECCCCCHHHCCCCCCCC
>Mature Secondary Structure 
GYMDKAVAPQNDGALIDAYSQSIAAAVDTVGPAVSRIERVGGRQGHGSGFAVSPDGLII
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEE
TNSHVVDDAKVVRITTPDGFVTEGRVLGRDVDTDIALIRANTSTGAWARLGDSQRLRRGH
ECCEEECCCEEEEEECCCCCEECCEEECCCCCCCEEEEEECCCCCCEEECCCHHHHCCCC
IAIAIGNPLGFEWTVTAGIVSALGRSMRAASGRLMEDVIQTDAALNPGNSGGPLVSSSGE
EEEEECCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECCCC
VIGVNTAVIQGAQSIAFAVASNTANFVVSEILRYGQVRRAFIGIAGDTIVLPRRVALAAG
EEEEHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCEEEECCCEEEECC
TVQTTSVRIRRVEPDGPAAKGGLQEGDYILAIDGSPVGGVDDIVRLMDGSRIDRDTEILV
CEEEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCEEEE
FSVAGRIEKKTLLPMARTS
EEECCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]