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The map label for this gene is fabF [H]

Identifier: 209549707

GI number: 209549707

Start: 2173664

End: 2174950

Strand: Reverse

Name: fabF [H]

Synonym: Rleg2_2114

Alternate gene names: 209549707

Gene position: 2174950-2173664 (Counterclockwise)

Preceding gene: 209549708

Following gene: 209549706

Centisome position: 47.93

GC content: 65.97

Gene sequence:

>1287_bases
ATGACAGCTTCCGCTTACAGGGATCACCTCGGCCGTCCGATCGTGGCCGTGACCGGCATGGGTATCATCACCTCGCTCGG
TCAGGGCCTCAGCGACAACTGGGCAGCGCTTTCGTCAGGCACGTCGGGCATTCACGAGATCAACCGTTTCCCGACCGAAG
GATTGTCGACGCGGATCGCCGGCACCGTCGATTTCATCGGTATCCCGGCCCCGAATGCCGTCGAGCGCTCCTACGCCTTC
GCCCGCGAAACAACGATCGAGGCGTTGGCCGATGCCGGCCTTTCCGGTGATTTCAATGGCCCGCTGTTTCTCGCTGCCCC
GCCGATCGAGCCGGAATGGAGCGCCCGTTTCGAGCTTGCCGACCGTTCGCCGGCCTCCGAGCATCCTGGTGATGCTTATG
AACGTTTCCTGACGGCGCTGCGCCAGCGGCCGGATCCGGCCTTCCATGAGGCGGCCCTGTTCGGGGCGATTTCCGAGCGG
CTTGCCGACCGGTTCGGCACGCGCGGCCTTCCCGTCACGCTGTCGACGGCCTGCGCCTCCGGCGTCACTGCGATCCAGCT
CGGCATCGAGGCGATCCGCCAGGGCCGCACCGATCGCGCCCTGACGGTTGCGACCGACGGCTCTCTCAGCGCCGAAGCGC
TGATCCGCTTCTCGCTCCTGTCGGCCCTTTCGACGCAGAACGATCCGCCGACCAAGGCATCCAAGCCGTTCAGCAAGGAT
CGCGACGGGTTCGTCATCGCCGAAGGTGCGGCGACGCTGGTGCTGGAATCGCTTGAGGCGGCGGTCGCCCGCGGCGCCAA
GGTGCTCGGCATCATGAAAGGCGCCGGCGACAAGGCCGACAGCTTCCACCGCACGCGCTCCTCGCCGGACGGCGGCCCGG
CGATCGCGACGATCCGCGCCGCCCTTGCCGATGCCGGCATCGACGAAAGCGGCATCGGCTACATCAACGCGCACGGCACC
TCGACGCCGGAGAACGACAAGATGGAATATGGGGCGATGTCGGCCGTCTTCGGCGAGCGGCTCGTCGGCATTCCGGTGTC
CTCGAACAAGTCGATGATCGGCCATACGTTGACGGCGGCGGGCGCCGTCGAGGCGGTGTTCTCGCTGCAGACGATGCTGA
CCGGCACGTTGCCGCCGACGATCAACTATACCAATCCCGATCCGTCGATCGTTCTCGATGTCGTGCCGAACAAGAAGCGG
GAAGCGCAGGTTTCCGCCGTGCTTTCCAACTCCTTCGGCTTCGGCGGGCAGAATGCCAGCCTTGTCATGGCGCTCGAACC
GGCTTAA

Upstream 100 bases:

>100_bases
GATGCGGGCAGGCGCCGCGGCCGCCGTCGTCACCGCGGTCGGACACCAGCGCGGCGAGGGCGTTGCCGTCCTTTCCGCAA
ATGCGTGAGGAGTGAAAGAT

Downstream 100 bases:

>100_bases
GCGGTTTCCGACACATTTTTGAGATGAGATGACGCCTACAGCATCGGCCCGAAAATCGGGCGATTTTCGGAAAGCCTGAT
GCGTAGATTTAAAGAGTTAG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTASAYRDHLGRPIVAVTGMGIITSLGQGLSDNWAALSSGTSGIHEINRFPTEGLSTRIAGTVDFIGIPAPNAVERSYAF
ARETTIEALADAGLSGDFNGPLFLAAPPIEPEWSARFELADRSPASEHPGDAYERFLTALRQRPDPAFHEAALFGAISER
LADRFGTRGLPVTLSTACASGVTAIQLGIEAIRQGRTDRALTVATDGSLSAEALIRFSLLSALSTQNDPPTKASKPFSKD
RDGFVIAEGAATLVLESLEAAVARGAKVLGIMKGAGDKADSFHRTRSSPDGGPAIATIRAALADAGIDESGIGYINAHGT
STPENDKMEYGAMSAVFGERLVGIPVSSNKSMIGHTLTAAGAVEAVFSLQTMLTGTLPPTINYTNPDPSIVLDVVPNKKR
EAQVSAVLSNSFGFGGQNASLVMALEPA

Sequences:

>Translated_428_residues
MTASAYRDHLGRPIVAVTGMGIITSLGQGLSDNWAALSSGTSGIHEINRFPTEGLSTRIAGTVDFIGIPAPNAVERSYAF
ARETTIEALADAGLSGDFNGPLFLAAPPIEPEWSARFELADRSPASEHPGDAYERFLTALRQRPDPAFHEAALFGAISER
LADRFGTRGLPVTLSTACASGVTAIQLGIEAIRQGRTDRALTVATDGSLSAEALIRFSLLSALSTQNDPPTKASKPFSKD
RDGFVIAEGAATLVLESLEAAVARGAKVLGIMKGAGDKADSFHRTRSSPDGGPAIATIRAALADAGIDESGIGYINAHGT
STPENDKMEYGAMSAVFGERLVGIPVSSNKSMIGHTLTAAGAVEAVFSLQTMLTGTLPPTINYTNPDPSIVLDVVPNKKR
EAQVSAVLSNSFGFGGQNASLVMALEPA
>Mature_427_residues
TASAYRDHLGRPIVAVTGMGIITSLGQGLSDNWAALSSGTSGIHEINRFPTEGLSTRIAGTVDFIGIPAPNAVERSYAFA
RETTIEALADAGLSGDFNGPLFLAAPPIEPEWSARFELADRSPASEHPGDAYERFLTALRQRPDPAFHEAALFGAISERL
ADRFGTRGLPVTLSTACASGVTAIQLGIEAIRQGRTDRALTVATDGSLSAEALIRFSLLSALSTQNDPPTKASKPFSKDR
DGFVIAEGAATLVLESLEAAVARGAKVLGIMKGAGDKADSFHRTRSSPDGGPAIATIRAALADAGIDESGIGYINAHGTS
TPENDKMEYGAMSAVFGERLVGIPVSSNKSMIGHTLTAAGAVEAVFSLQTMLTGTLPPTINYTNPDPSIVLDVVPNKKRE
AQVSAVLSNSFGFGGQNASLVMALEPA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=428, Percent_Identity=34.1121495327103, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=43.2432432432432, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI41872631, Length=274, Percent_Identity=28.4671532846715, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1787337, Length=418, Percent_Identity=35.4066985645933, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI1788663, Length=421, Percent_Identity=33.9667458432304, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71983541, Length=302, Percent_Identity=35.4304635761589, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=37.9310344827586, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI212642053, Length=277, Percent_Identity=27.7978339350181, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=267, Percent_Identity=27.7153558052434, Blast_Score=81, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=453, Percent_Identity=30.6843267108168, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24644341, Length=423, Percent_Identity=34.2789598108747, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI221330659, Length=279, Percent_Identity=26.5232974910394, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920632, Length=279, Percent_Identity=26.5232974910394, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24581345, Length=278, Percent_Identity=26.6187050359712, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44539; Mature: 44407

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00098 THIOLASE_1 ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASAYRDHLGRPIVAVTGMGIITSLGQGLSDNWAALSSGTSGIHEINRFPTEGLSTRIA
CCCCHHHHHHCCCEEEEECHHHHHHHCCCCCCCCHHHCCCCCHHHHHHCCCCCCCCCCCC
GTVDFIGIPAPNAVERSYAFARETTIEALADAGLSGDFNGPLFLAAPPIEPEWSARFELA
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEEEEC
DRSPASEHPGDAYERFLTALRQRPDPAFHEAALFGAISERLADRFGTRGLPVTLSTACAS
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHC
GVTAIQLGIEAIRQGRTDRALTVATDGSLSAEALIRFSLLSALSTQNDPPTKASKPFSKD
CHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RDGFVIAEGAATLVLESLEAAVARGAKVLGIMKGAGDKADSFHRTRSSPDGGPAIATIRA
CCCEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHH
ALADAGIDESGIGYINAHGTSTPENDKMEYGAMSAVFGERLVGIPVSSNKSMIGHTLTAA
HHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHH
GAVEAVFSLQTMLTGTLPPTINYTNPDPSIVLDVVPNKKREAQVSAVLSNSFGFGGQNAS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCE
LVMALEPA
EEEEECCC
>Mature Secondary Structure 
TASAYRDHLGRPIVAVTGMGIITSLGQGLSDNWAALSSGTSGIHEINRFPTEGLSTRIA
CCCHHHHHHCCCEEEEECHHHHHHHCCCCCCCCHHHCCCCCHHHHHHCCCCCCCCCCCC
GTVDFIGIPAPNAVERSYAFARETTIEALADAGLSGDFNGPLFLAAPPIEPEWSARFELA
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEEEEC
DRSPASEHPGDAYERFLTALRQRPDPAFHEAALFGAISERLADRFGTRGLPVTLSTACAS
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHC
GVTAIQLGIEAIRQGRTDRALTVATDGSLSAEALIRFSLLSALSTQNDPPTKASKPFSKD
CHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RDGFVIAEGAATLVLESLEAAVARGAKVLGIMKGAGDKADSFHRTRSSPDGGPAIATIRA
CCCEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHH
ALADAGIDESGIGYINAHGTSTPENDKMEYGAMSAVFGERLVGIPVSSNKSMIGHTLTAA
HHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHH
GAVEAVFSLQTMLTGTLPPTINYTNPDPSIVLDVVPNKKREAQVSAVLSNSFGFGGQNAS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCE
LVMALEPA
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]