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The map label for this gene is yqjI [H]

Identifier: 209549700

GI number: 209549700

Start: 2167223

End: 2168653

Strand: Reverse

Name: yqjI [H]

Synonym: Rleg2_2107

Alternate gene names: 209549700

Gene position: 2168653-2167223 (Counterclockwise)

Preceding gene: 209549704

Following gene: 209549699

Centisome position: 47.79

GC content: 62.26

Gene sequence:

>1431_bases
GTGGAAAAGGCAGAAATCGGACTGATCGGTCTTGCGGTCATGGGCTCCAACCTGGCGCTCAACATCGCGGAGAAAGGCAA
TAAAATTGCGGTCTTCAACCGTACGCCTGAGAAAACCGACGAATTCTACGAAAGCGCCGGCGATCTGAAAAAGCAGATTA
TTCCCTGCAAGACGATCGAAGAGTTCGTCGATGCGATCCGGCCGCCGCGCCCGATCATCATCATGATCAAGGCGGGTGAT
GCCGTCGATCAGCAGATGGAGGCGTTGCGCCCGCATCTGTCCAAGGGCGACATCATGATCGATGCCGGCAACGCCAATTT
CCGCGACACCGTCGCGCGCTTCGACCGCCTCAAGGATACCGATCTCACCTTCATCGGCATGGGTGTTTCCGGCGGCGAAG
AAGGTGCGCGCCATGGCCCGTCGATCATGGTCGGCGGCACGGAAGACTCCTGGAAGCGCGTCGAGAAGGTGCTGACCTCG
ATTGCCGCCCGCTACAACGACGAGCCCTGCGTCGCCTGGCTCGGCAATGACGGCGCCGGCCATTTTGTCAAGACCATCCA
TAACGGCATTGAATATGCCGATATGCAGATGATTGCCGAAATCTACGGCATCCTGCGCGACGGCCTCGGCATGAGCGCCT
CCGACATCTCCGGCATCTTCGGCGAATGGAACAAGGGCCGGTTGAACTCCTATCTGATCGAGATTTCCGAGAAGGTGCTT
GCCGCGACCGATCCGGTCTCCGGCGGCCCGATGGTCGACATGATCCTCGACAAGGCCGGCCAGAAGGGCACCGGCAAATG
GTCGGCGATCGAGGCGCAGAACATGGGCATTCCGGCAACGGCGATCGAAGCCGCGGTTGCCGCCCGCAGCCTCTCCTCGA
TGAAATCGCAGCGCGAAGCCGCCGAAAAGATCTTCGGCACGCAGGCCGTATCCTTCCCGATCGCTTACGGTCCCGAACTC
AACAAGGATCTCGAGCTGGCGCTGTTTGCCGCCAAGATCGGCGCCTATGCGCAGGGCTTCGCGGTGATGGCGGAAGCCTC
GCGCGAGTTCAACTGGTCGCTGCCGATGCCGACCATTGCCAGGATCTGGCGCGCCGGCTGCATCATCCGCTCGCAGTTCC
TCGACGAGATCACCTCGGCCTTCACCAAGGCGCCGGATGCCGCAAACCTGATCGTCACGCCGGCCTTCTCCGACATGGTC
AAGGAATCGATCCCGGCGTTGCGCCGCGTCGTCGCCGCGGCAATTTCCGCCGGCCTGCCGGTGCCGGCGCTGACTTCGGC
GCTCACCTATTTCGACGCCTACCGCCAGGGCAGGGGAACGGCAAACCTCATCCAGGCGCAGCGCGACTTCTTCGGCGCCC
ACGGCTTCGACCGCCTGGATGGCAAAGATTTCCACCACGGCCCCTGGGGCAGCGGTGCGGCGAGCTTCTGA

Upstream 100 bases:

>100_bases
ATTTCATTGCTTTTGCGAACCGATTAGACCCTTGCGAGACTTGCCGTTTGACCGAGACAGTGCCACAACACCGGTCCAAA
TGACACATCGGAGGTTTGTC

Downstream 100 bases:

>100_bases
GGCTTGCCGAGAAGAGATCGAGGAAAGCCCGGCCGTCGCGCCGGGCTTTTTCGTGGCTTCGGCCGCTCAGGCGGTGAGGC
GTTCGAAAGGGAGATCGACG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MEKAEIGLIGLAVMGSNLALNIAEKGNKIAVFNRTPEKTDEFYESAGDLKKQIIPCKTIEEFVDAIRPPRPIIIMIKAGD
AVDQQMEALRPHLSKGDIMIDAGNANFRDTVARFDRLKDTDLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTS
IAARYNDEPCVAWLGNDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLGMSASDISGIFGEWNKGRLNSYLIEISEKVL
AATDPVSGGPMVDMILDKAGQKGTGKWSAIEAQNMGIPATAIEAAVAARSLSSMKSQREAAEKIFGTQAVSFPIAYGPEL
NKDLELALFAAKIGAYAQGFAVMAEASREFNWSLPMPTIARIWRAGCIIRSQFLDEITSAFTKAPDAANLIVTPAFSDMV
KESIPALRRVVAAAISAGLPVPALTSALTYFDAYRQGRGTANLIQAQRDFFGAHGFDRLDGKDFHHGPWGSGAASF

Sequences:

>Translated_476_residues
MEKAEIGLIGLAVMGSNLALNIAEKGNKIAVFNRTPEKTDEFYESAGDLKKQIIPCKTIEEFVDAIRPPRPIIIMIKAGD
AVDQQMEALRPHLSKGDIMIDAGNANFRDTVARFDRLKDTDLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTS
IAARYNDEPCVAWLGNDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLGMSASDISGIFGEWNKGRLNSYLIEISEKVL
AATDPVSGGPMVDMILDKAGQKGTGKWSAIEAQNMGIPATAIEAAVAARSLSSMKSQREAAEKIFGTQAVSFPIAYGPEL
NKDLELALFAAKIGAYAQGFAVMAEASREFNWSLPMPTIARIWRAGCIIRSQFLDEITSAFTKAPDAANLIVTPAFSDMV
KESIPALRRVVAAAISAGLPVPALTSALTYFDAYRQGRGTANLIQAQRDFFGAHGFDRLDGKDFHHGPWGSGAASF
>Mature_476_residues
MEKAEIGLIGLAVMGSNLALNIAEKGNKIAVFNRTPEKTDEFYESAGDLKKQIIPCKTIEEFVDAIRPPRPIIIMIKAGD
AVDQQMEALRPHLSKGDIMIDAGNANFRDTVARFDRLKDTDLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTS
IAARYNDEPCVAWLGNDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLGMSASDISGIFGEWNKGRLNSYLIEISEKVL
AATDPVSGGPMVDMILDKAGQKGTGKWSAIEAQNMGIPATAIEAAVAARSLSSMKSQREAAEKIFGTQAVSFPIAYGPEL
NKDLELALFAAKIGAYAQGFAVMAEASREFNWSLPMPTIARIWRAGCIIRSQFLDEITSAFTKAPDAANLIVTPAFSDMV
KESIPALRRVVAAAISAGLPVPALTSALTYFDAYRQGRGTANLIQAQRDFFGAHGFDRLDGKDFHHGPWGSGAASF

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=45.1271186440678, Blast_Score=395, Evalue=1e-110,
Organism=Escherichia coli, GI1788341, Length=471, Percent_Identity=47.3460721868365, Blast_Score=449, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17542558, Length=461, Percent_Identity=45.119305856833, Blast_Score=409, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321695, Length=461, Percent_Identity=47.5054229934924, Blast_Score=430, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321977, Length=459, Percent_Identity=46.4052287581699, Blast_Score=409, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24639279, Length=473, Percent_Identity=45.877378435518, Blast_Score=403, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51256; Mature: 51256

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00936 RIBOSOMAL_L35 ; PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKAEIGLIGLAVMGSNLALNIAEKGNKIAVFNRTPEKTDEFYESAGDLKKQIIPCKTIE
CCCCCEEEEEHEEECCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
EFVDAIRPPRPIIIMIKAGDAVDQQMEALRPHLSKGDIMIDAGNANFRDTVARFDRLKDT
HHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCC
DLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTSIAARYNDEPCVAWLGNDGAG
CEEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
HFVKTIHNGIEYADMQMIAEIYGILRDGLGMSASDISGIFGEWNKGRLNSYLIEISEKVL
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AATDPVSGGPMVDMILDKAGQKGTGKWSAIEAQNMGIPATAIEAAVAARSLSSMKSQREA
HCCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AEKIFGTQAVSFPIAYGPELNKDLELALFAAKIGAYAQGFAVMAEASREFNWSLPMPTIA
HHHHHCCHHEECCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
RIWRAGCIIRSQFLDEITSAFTKAPDAANLIVTPAFSDMVKESIPALRRVVAAAISAGLP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
VPALTSALTYFDAYRQGRGTANLIQAQRDFFGAHGFDRLDGKDFHHGPWGSGAASF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEKAEIGLIGLAVMGSNLALNIAEKGNKIAVFNRTPEKTDEFYESAGDLKKQIIPCKTIE
CCCCCEEEEEHEEECCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
EFVDAIRPPRPIIIMIKAGDAVDQQMEALRPHLSKGDIMIDAGNANFRDTVARFDRLKDT
HHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCC
DLTFIGMGVSGGEEGARHGPSIMVGGTEDSWKRVEKVLTSIAARYNDEPCVAWLGNDGAG
CEEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
HFVKTIHNGIEYADMQMIAEIYGILRDGLGMSASDISGIFGEWNKGRLNSYLIEISEKVL
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AATDPVSGGPMVDMILDKAGQKGTGKWSAIEAQNMGIPATAIEAAVAARSLSSMKSQREA
HCCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AEKIFGTQAVSFPIAYGPELNKDLELALFAAKIGAYAQGFAVMAEASREFNWSLPMPTIA
HHHHHCCHHEECCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
RIWRAGCIIRSQFLDEITSAFTKAPDAANLIVTPAFSDMVKESIPALRRVVAAAISAGLP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
VPALTSALTYFDAYRQGRGTANLIQAQRDFFGAHGFDRLDGKDFHHGPWGSGAASF
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]