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The map label for this gene is gor [H]

Identifier: 209549602

GI number: 209549602

Start: 2069548

End: 2070933

Strand: Reverse

Name: gor [H]

Synonym: Rleg2_2009

Alternate gene names: 209549602

Gene position: 2070933-2069548 (Counterclockwise)

Preceding gene: 209549604

Following gene: 209549600

Centisome position: 45.64

GC content: 62.63

Gene sequence:

>1386_bases
ATGTCTTCCTACGACTACGACCTTTTCGTCATTGGTGGCGGTTCCGGAGGCGTGCGTGGCGCGCGTGTCGCCGCCTCGCT
CGGCAAAAAGGTGGCGATCGCCGAGGAATACCGCTACGGCGGCACATGCGTCATCCGCGGCTGCGTGCCGAAGAAACTGT
TCGTCTATGCCTCGCAGTTCCATGAGCATTTCGAGGATGCAGCCGGCTTCGGCTGGACGGTCGGCGAAAGCAGCTTCGAC
TGGAAGAAGCTGGTGGCGGCCAAGGACGTCGAAATTGCCCGGCTGGAAGGCCTTTACAAGAAGGGACTTGCCGGCGCCAA
TGCCGAGATCCTGGAAACGCGCGCCGAGCTCGTCGACGCCCATACGGTGCGGCTTGTGAAAACAGGCCAGACGGTGACGG
CAAAGACGATCGTGATCGCCACCGGCGGAAGGCCGAACCCGCATGCGGCCCTTCCCGGCTACGAGTTGTGCATCTCCTCC
AACGAGGCCTTTCATCTCGAAGAGCTGCCGAAATCGATCGTCATATCAGGCGGCGGTTATATAGCCGTCGAGTTCGCCAA
TATCTTCCATGGCCTCGGCGTCGAGACGACGCTGATCTATCGCGGCGCCGAGATCCTGTCGCGCTTCGACGAGGATCTGA
GGCGCGGGCTGCACGAGGCAATGGTCGCCAAGGGCATCCGCATCCTCTGCCACGACACACTGCAGAAGGTTTCCAAAGGC
GAGGGCGGGCTCATTCTGGAGACGCTGAACAGCGGCACGCTGCAGGCTGACGTCGTCATGCTAGCGCTGGGGCGCGACCC
GAACACCGAAGGCCTCGGCCTCGAGGCGGCTGGCGTCGCGGTCGACGAGCGCGGCGCAATTATCGTCGACGACTATTCCC
GCACCAATGTCGAGAACATCTACGCGCTCGGCGATGTCACCAACCGGGTACAGCTGACGCCGGTGGCGATCCATGAGGCG
ATGTGCTTCATCGAAACCGAATACAAGAACAATCCGACCCGGCCGGACTACGAGCTGATCCCGACAGCCGTCTTCTCGCA
GCCGGAGATCGGCACTGTCGGTCTTTCGGAAGAAGAGGCGGGCAAGCGTTACGGTGAGCTCGAGGTGTATCGGGCTCAGT
TCCGGCCGCTGAAGGCGACACTTTCCGGCCGCGCCGAGCGGATGATCATGAAGCTGATCGTCGATGCGGCAAGCCGCAAG
GTGGTGGGCGCCCATATCCTCGGTCACGATGCCGGCGAAATGGCACAGCTGCTCGGCGTTACGCTCAAGGCCGGCTGCAC
CAAGGACGATTTCGACCAGACCATGGCGCTGCACCCGACGGCGGCCGAAGAGCTCGTCACCATGTATGCGCCGAGCTATA
GGGTCCGTGACGGGCAGCGCGTCTGA

Upstream 100 bases:

>100_bases
GGCGAGGGGAACGGGATGATGCAGGAGCGGGCTTTTGTTTTGAGGGCGATCGCCCCTATATCAGGGACATCCTTCCTGCG
ATTCCCTTCCGGAGCTCCTC

Downstream 100 bases:

>100_bases
GCGCCCCTTGGGCGCTTAGCTGGTAATGCGCGGCGCGCGGATGGCTTTGAGGAAGAGAGCCTTCATCGCATCGGCGATAC
CTTCGGTCGGCGTCACCTCG

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSSYDYDLFVIGGGSGGVRGARVAASLGKKVAIAEEYRYGGTCVIRGCVPKKLFVYASQFHEHFEDAAGFGWTVGESSFD
WKKLVAAKDVEIARLEGLYKKGLAGANAEILETRAELVDAHTVRLVKTGQTVTAKTIVIATGGRPNPHAALPGYELCISS
NEAFHLEELPKSIVISGGGYIAVEFANIFHGLGVETTLIYRGAEILSRFDEDLRRGLHEAMVAKGIRILCHDTLQKVSKG
EGGLILETLNSGTLQADVVMLALGRDPNTEGLGLEAAGVAVDERGAIIVDDYSRTNVENIYALGDVTNRVQLTPVAIHEA
MCFIETEYKNNPTRPDYELIPTAVFSQPEIGTVGLSEEEAGKRYGELEVYRAQFRPLKATLSGRAERMIMKLIVDAASRK
VVGAHILGHDAGEMAQLLGVTLKAGCTKDDFDQTMALHPTAAEELVTMYAPSYRVRDGQRV

Sequences:

>Translated_461_residues
MSSYDYDLFVIGGGSGGVRGARVAASLGKKVAIAEEYRYGGTCVIRGCVPKKLFVYASQFHEHFEDAAGFGWTVGESSFD
WKKLVAAKDVEIARLEGLYKKGLAGANAEILETRAELVDAHTVRLVKTGQTVTAKTIVIATGGRPNPHAALPGYELCISS
NEAFHLEELPKSIVISGGGYIAVEFANIFHGLGVETTLIYRGAEILSRFDEDLRRGLHEAMVAKGIRILCHDTLQKVSKG
EGGLILETLNSGTLQADVVMLALGRDPNTEGLGLEAAGVAVDERGAIIVDDYSRTNVENIYALGDVTNRVQLTPVAIHEA
MCFIETEYKNNPTRPDYELIPTAVFSQPEIGTVGLSEEEAGKRYGELEVYRAQFRPLKATLSGRAERMIMKLIVDAASRK
VVGAHILGHDAGEMAQLLGVTLKAGCTKDDFDQTMALHPTAAEELVTMYAPSYRVRDGQRV
>Mature_460_residues
SSYDYDLFVIGGGSGGVRGARVAASLGKKVAIAEEYRYGGTCVIRGCVPKKLFVYASQFHEHFEDAAGFGWTVGESSFDW
KKLVAAKDVEIARLEGLYKKGLAGANAEILETRAELVDAHTVRLVKTGQTVTAKTIVIATGGRPNPHAALPGYELCISSN
EAFHLEELPKSIVISGGGYIAVEFANIFHGLGVETTLIYRGAEILSRFDEDLRRGLHEAMVAKGIRILCHDTLQKVSKGE
GGLILETLNSGTLQADVVMLALGRDPNTEGLGLEAAGVAVDERGAIIVDDYSRTNVENIYALGDVTNRVQLTPVAIHEAM
CFIETEYKNNPTRPDYELIPTAVFSQPEIGTVGLSEEEAGKRYGELEVYRAQFRPLKATLSGRAERMIMKLIVDAASRKV
VGAHILGHDAGEMAQLLGVTLKAGCTKDDFDQTMALHPTAAEELVTMYAPSYRVRDGQRV

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=39.7408207343413, Blast_Score=305, Evalue=8e-83,
Organism=Homo sapiens, GI33519430, Length=475, Percent_Identity=35.3684210526316, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI33519428, Length=475, Percent_Identity=35.3684210526316, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI33519426, Length=475, Percent_Identity=35.3684210526316, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI148277065, Length=476, Percent_Identity=35.2941176470588, Blast_Score=245, Evalue=8e-65,
Organism=Homo sapiens, GI148277071, Length=475, Percent_Identity=35.3684210526316, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI22035672, Length=470, Percent_Identity=35.531914893617, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI291045266, Length=474, Percent_Identity=34.3881856540084, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI291045268, Length=472, Percent_Identity=31.9915254237288, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI91199540, Length=467, Percent_Identity=28.6937901498929, Blast_Score=168, Evalue=8e-42,
Organism=Escherichia coli, GI1789915, Length=430, Percent_Identity=40.4651162790698, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI1786307, Length=447, Percent_Identity=27.9642058165548, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI87082354, Length=456, Percent_Identity=28.0701754385965, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=27.6315789473684, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71983419, Length=454, Percent_Identity=40.7488986784141, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI71983429, Length=454, Percent_Identity=40.7488986784141, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=30.5907172995781, Blast_Score=224, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI71982272, Length=484, Percent_Identity=31.198347107438, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32565766, Length=457, Percent_Identity=28.0087527352298, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17559934, Length=238, Percent_Identity=27.3109243697479, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=462, Percent_Identity=37.4458874458874, Blast_Score=280, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6321091, Length=462, Percent_Identity=28.1385281385281, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=27.6595744680851, Blast_Score=140, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=35.031847133758, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=35.031847133758, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=35.031847133758, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI17737741, Length=481, Percent_Identity=32.2245322245322, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=29.4871794871795, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49881; Mature: 49749

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSYDYDLFVIGGGSGGVRGARVAASLGKKVAIAEEYRYGGTCVIRGCVPKKLFVYASQF
CCCCCEEEEEEECCCCCCCHHHHHHHHCCEEEEEHHHCCCCEEEEECCCCHHHHHHHHHH
HEHFEDAAGFGWTVGESSFDWKKLVAAKDVEIARLEGLYKKGLAGANAEILETRAELVDA
HHHHHHHCCCCEECCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
HTVRLVKTGQTVTAKTIVIATGGRPNPHAALPGYELCISSNEAFHLEELPKSIVISGGGY
HEEEEEECCCEEEEEEEEEEECCCCCCCCCCCCEEEEECCCCCEEHHHCCCEEEEECCCE
IAVEFANIFHGLGVETTLIYRGAEILSRFDEDLRRGLHEAMVAKGIRILCHDTLQKVSKG
EEEEHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHCC
EGGLILETLNSGTLQADVVMLALGRDPNTEGLGLEAAGVAVDERGAIIVDDYSRTNVENI
CCCEEEEECCCCCEEEEEEEEEECCCCCCCCCCEEECCEEEECCCEEEEECCCCCCCCCE
YALGDVTNRVQLTPVAIHEAMCFIETEYKNNPTRPDYELIPTAVFSQPEIGTVGLSEEEA
EEECCCCCEEEEEHHHHHHEEEEEEEECCCCCCCCCHHCCCHHHCCCCCCCEECCCHHHH
GKRYGELEVYRAQFRPLKATLSGRAERMIMKLIVDAASRKVVGAHILGHDAGEMAQLLGV
CCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHH
TLKAGCTKDDFDQTMALHPTAAEELVTMYAPSYRVRDGQRV
HHCCCCCCCCCCCEEEECCCHHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure 
SSYDYDLFVIGGGSGGVRGARVAASLGKKVAIAEEYRYGGTCVIRGCVPKKLFVYASQF
CCCCEEEEEEECCCCCCCHHHHHHHHCCEEEEEHHHCCCCEEEEECCCCHHHHHHHHHH
HEHFEDAAGFGWTVGESSFDWKKLVAAKDVEIARLEGLYKKGLAGANAEILETRAELVDA
HHHHHHHCCCCEECCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
HTVRLVKTGQTVTAKTIVIATGGRPNPHAALPGYELCISSNEAFHLEELPKSIVISGGGY
HEEEEEECCCEEEEEEEEEEECCCCCCCCCCCCEEEEECCCCCEEHHHCCCEEEEECCCE
IAVEFANIFHGLGVETTLIYRGAEILSRFDEDLRRGLHEAMVAKGIRILCHDTLQKVSKG
EEEEHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHCC
EGGLILETLNSGTLQADVVMLALGRDPNTEGLGLEAAGVAVDERGAIIVDDYSRTNVENI
CCCEEEEECCCCCEEEEEEEEEECCCCCCCCCCEEECCEEEECCCEEEEECCCCCCCCCE
YALGDVTNRVQLTPVAIHEAMCFIETEYKNNPTRPDYELIPTAVFSQPEIGTVGLSEEEA
EEECCCCCEEEEEHHHHHHEEEEEEEECCCCCCCCCHHCCCHHHCCCCCCCEECCCHHHH
GKRYGELEVYRAQFRPLKATLSGRAERMIMKLIVDAASRKVVGAHILGHDAGEMAQLLGV
CCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHH
TLKAGCTKDDFDQTMALHPTAAEELVTMYAPSYRVRDGQRV
HHCCCCCCCCCCCEEEECCCHHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]