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The map label for this gene is purC1 [H]

Identifier: 209549520

GI number: 209549520

Start: 1972694

End: 1973458

Strand: Direct

Name: purC1 [H]

Synonym: Rleg2_1926

Alternate gene names: 209549520

Gene position: 1972694-1973458 (Clockwise)

Preceding gene: 209549519

Following gene: 209549521

Centisome position: 43.47

GC content: 58.82

Gene sequence:

>765_bases
ATGAACCGTCGCCGCCGTATCTACGAGGGCAAGGCAAAGATTCTGTATGAGGGCCCGGAACCGGGCACTTTGATCCAGTT
CTTCAAGGACGATGCCACTGCCTTCAACAAGAAGAAACACGAAGTCATCGACGGCAAGGGCGTCCTCAACAACCGCATTT
CCGAATATATCTTCAGCCATCTGAACAAGATCGGCATCCCCACCCATTTCATCCGCCGGCTCAACATGCGCGAGCAGCTG
ATCAAGGAAGTGGAGATGATCCCGCTGGAGATCGTCGTGCGCAACGTTGCCGCCGGTTCGCTCGCCAAGCGTCTGGGGAT
CGACGAAGGCGTGGTGCTGCCGCGCTCGATCATCGAATTCTACTACAAGTCAGACGCGCTCGACGATCCGATGGTCTCCG
AAGAGCACATCACCGCCTTCGGCTGGGCCAATCCCGCCGAGCTCGACGACATCATGGCGCTCGCCATCCGCGTCAACGAC
TTCATGACCGGCCTCTTCCTCGGCGTCGGCATCCAGCTCGTCGACTTCAAGATCGAATGCGGCCGCCTCTTCGAAGGCGA
TCTGATGCGCATCATCCTCGCCGACGAAATCTCACCGGACAGCTGCCGGCTCTGGGATATCGAGACCCACGAGAAGATGG
ACAAGGATCGTTTCCGCCGCGATCTCGGCGGGTTGCTCGAAGCCTATTCCGAAGTTGCGCGCCGTCTCGGCATCATCAAT
GAAAACGAGCCTGTGCGCGGCACCGGCCCGGTTCTGGTCAAGTAA

Upstream 100 bases:

>100_bases
ACAGGCGGATTGTGAAACTTACTCTTTTCCTTTAAGGGGACGCCACGAGATCGATCCACTCGCGCTATCCCAAGAGCGCC
AACAACAGAGAATGACCACG

Downstream 100 bases:

>100_bases
GGCAGGAAAGACAAAGTGATCAAGGCTCGTGTCACCGTCACGCTGAAAAACGGCGTTCTCGATCCGCAGGGCAAGGCTAT
CGAAGGCGCGCTCGGCGCCC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase 1 [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVIDGKGVLNNRISEYIFSHLNKIGIPTHFIRRLNMREQL
IKEVEMIPLEIVVRNVAAGSLAKRLGIDEGVVLPRSIIEFYYKSDALDDPMVSEEHITAFGWANPAELDDIMALAIRVND
FMTGLFLGVGIQLVDFKIECGRLFEGDLMRIILADEISPDSCRLWDIETHEKMDKDRFRRDLGGLLEAYSEVARRLGIIN
ENEPVRGTGPVLVK

Sequences:

>Translated_254_residues
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVIDGKGVLNNRISEYIFSHLNKIGIPTHFIRRLNMREQL
IKEVEMIPLEIVVRNVAAGSLAKRLGIDEGVVLPRSIIEFYYKSDALDDPMVSEEHITAFGWANPAELDDIMALAIRVND
FMTGLFLGVGIQLVDFKIECGRLFEGDLMRIILADEISPDSCRLWDIETHEKMDKDRFRRDLGGLLEAYSEVARRLGIIN
ENEPVRGTGPVLVK
>Mature_254_residues
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVIDGKGVLNNRISEYIFSHLNKIGIPTHFIRRLNMREQL
IKEVEMIPLEIVVRNVAAGSLAKRLGIDEGVVLPRSIIEFYYKSDALDDPMVSEEHITAFGWANPAELDDIMALAIRVND
FMTGLFLGVGIQLVDFKIECGRLFEGDLMRIILADEISPDSCRLWDIETHEKMDKDRFRRDLGGLLEAYSEVARRLGIIN
ENEPVRGTGPVLVK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=228, Percent_Identity=34.2105263157895, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI5453539, Length=228, Percent_Identity=34.2105263157895, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI119220559, Length=235, Percent_Identity=32.7659574468085, Blast_Score=100, Evalue=9e-22,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=46.6386554621849, Blast_Score=218, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17531275, Length=228, Percent_Identity=32.4561403508772, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI18860083, Length=237, Percent_Identity=29.957805907173, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24583917, Length=250, Percent_Identity=24.8, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 28988; Mature: 28988

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS01057 SAICAR_SYNTHETASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVIDGKGVLNNRISEYIFSH
CCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHH
LNKIGIPTHFIRRLNMREQLIKEVEMIPLEIVVRNVAAGSLAKRLGIDEGVVLPRSIIEF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
YYKSDALDDPMVSEEHITAFGWANPAELDDIMALAIRVNDFMTGLFLGVGIQLVDFKIEC
HHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
GRLFEGDLMRIILADEISPDSCRLWDIETHEKMDKDRFRRDLGGLLEAYSEVARRLGIIN
CCCCCCCCEEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ENEPVRGTGPVLVK
CCCCCCCCCCEEEC
>Mature Secondary Structure
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVIDGKGVLNNRISEYIFSH
CCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHH
LNKIGIPTHFIRRLNMREQLIKEVEMIPLEIVVRNVAAGSLAKRLGIDEGVVLPRSIIEF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
YYKSDALDDPMVSEEHITAFGWANPAELDDIMALAIRVNDFMTGLFLGVGIQLVDFKIEC
HHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
GRLFEGDLMRIILADEISPDSCRLWDIETHEKMDKDRFRRDLGGLLEAYSEVARRLGIIN
CCCCCCCCEEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ENEPVRGTGPVLVK
CCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]