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The map label for this gene is 209549450

Identifier: 209549450

GI number: 209549450

Start: 1903369

End: 1904337

Strand: Direct

Name: 209549450

Synonym: Rleg2_1856

Alternate gene names: NA

Gene position: 1903369-1904337 (Clockwise)

Preceding gene: 209549449

Following gene: 209549451

Centisome position: 41.94

GC content: 63.16

Gene sequence:

>969_bases
ATGTCGGCTCTCTATCCGGAAATCGAACCCTATGATCATGGCCTGCTCGACACGGGCGACGGCAACCTGATCTATTGGGA
GGCCTGCGGCAATCCGGCTGGCCGGCCGGCGCTGGTGCTGCATGGCGGGCCGGGCTCCGGCTGTTCGACGACGGCGCGGC
GCCATTTCGATCCGGACGCCTACCGAATCATTCTGTTCGATCAGCGCAATTGCGGCCGCAGTCTGCCGAGCGCTGCCGAT
CCCGAAACCGATCTCTCCCGCAACACCACCTGGCATCTCGTTGCCGATATCGAACGGCTGCGGGTCTTCTTCGGCATCGA
CACCTGGCTGGTTTTCGGCAACTCCTGGGGATCGACGCTGGCGCTCACGTATGCCGAAACCCATCCGCAGCGCGTCGCCG
CGATCGTCATATCAGGCGTGACCACCACAAGGCGCTCGGAAATCGACTGGCTCTATCGCGGCATGGCGCCGCTTTTCCCG
GAAGAATGGCACCGTTTCCGCCGGGCGGCGTGCTGCCAGGAGCAAGACCTGGACATGGTTGCCACCTATCATCATCTCCT
CAATCATCCCGACTCAGAGACGCGCCTGAAGGCGGCGCGCGACTGGCATGACTGGGAAGCGGCTTCCATCCTGCTCGCCG
ATCCCAAAGGCCTGCCGCGCCGCTGGGCCGATCCGGCTTATTTGCTGACGCGCGCCCGCATCATCACCCACTATTTTGCC
AATGGCGCCTGGCTGGAGGACGGCCAGCTTTTGAACAATGCCGACCGGCTGGCAGGCATTCCGGCGATCCTGCTGCAGGG
GCGGTTCGATATCGAGGCGCCGCTGGTCACTGCCTGGGAACTGGCCCGCGCCTGGCCGCAAAGCGAGCTGCAGATTCTTC
CGCATGCTGCCCATTCCACCGCAAATCCCAATATGAGCGCCGCGATCGTCGCCGCCACCGATCGATTTCGCCATCTCCAT
CAAAAATAA

Upstream 100 bases:

>100_bases
GAATTAGGCTTCGGAAAGCCGGAGCGAAATCCTGTCGCAAGTCGTTCCTACCATTCAGCCATAGATATTATGAGTAGAAC
AACCTGCGACAGGCAGAACG

Downstream 100 bases:

>100_bases
TTTTGCCGCCCAAATCCGGAATCCGAGCGACAGCCAGCTTTCGAGCGCGTCGAATCCGCCGATTCCAGCGGCATTGCCGG
CCCGCTCCGCGCCGCCGGAC

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSALYPEIEPYDHGLLDTGDGNLIYWEACGNPAGRPALVLHGGPGSGCSTTARRHFDPDAYRIILFDQRNCGRSLPSAAD
PETDLSRNTTWHLVADIERLRVFFGIDTWLVFGNSWGSTLALTYAETHPQRVAAIVISGVTTTRRSEIDWLYRGMAPLFP
EEWHRFRRAACCQEQDLDMVATYHHLLNHPDSETRLKAARDWHDWEAASILLADPKGLPRRWADPAYLLTRARIITHYFA
NGAWLEDGQLLNNADRLAGIPAILLQGRFDIEAPLVTAWELARAWPQSELQILPHAAHSTANPNMSAAIVAATDRFRHLH
QK

Sequences:

>Translated_322_residues
MSALYPEIEPYDHGLLDTGDGNLIYWEACGNPAGRPALVLHGGPGSGCSTTARRHFDPDAYRIILFDQRNCGRSLPSAAD
PETDLSRNTTWHLVADIERLRVFFGIDTWLVFGNSWGSTLALTYAETHPQRVAAIVISGVTTTRRSEIDWLYRGMAPLFP
EEWHRFRRAACCQEQDLDMVATYHHLLNHPDSETRLKAARDWHDWEAASILLADPKGLPRRWADPAYLLTRARIITHYFA
NGAWLEDGQLLNNADRLAGIPAILLQGRFDIEAPLVTAWELARAWPQSELQILPHAAHSTANPNMSAAIVAATDRFRHLH
QK
>Mature_321_residues
SALYPEIEPYDHGLLDTGDGNLIYWEACGNPAGRPALVLHGGPGSGCSTTARRHFDPDAYRIILFDQRNCGRSLPSAADP
ETDLSRNTTWHLVADIERLRVFFGIDTWLVFGNSWGSTLALTYAETHPQRVAAIVISGVTTTRRSEIDWLYRGMAPLFPE
EWHRFRRAACCQEQDLDMVATYHHLLNHPDSETRLKAARDWHDWEAASILLADPKGLPRRWADPAYLLTRARIITHYFAN
GAWLEDGQLLNNADRLAGIPAILLQGRFDIEAPLVTAWELARAWPQSELQILPHAAHSTANPNMSAAIVAATDRFRHLHQ
K

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 36213; Mature: 36082

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALYPEIEPYDHGLLDTGDGNLIYWEACGNPAGRPALVLHGGPGSGCSTTARRHFDPDA
CCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCHHHHCCCCCE
YRIILFDQRNCGRSLPSAADPETDLSRNTTWHLVADIERLRVFFGIDTWLVFGNSWGSTL
EEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHEECCEEEEEEECCCCCEE
ALTYAETHPQRVAAIVISGVTTTRRSEIDWLYRGMAPLFPEEWHRFRRAACCQEQDLDMV
EEEEECCCHHHEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHH
ATYHHLLNHPDSETRLKAARDWHDWEAASILLADPKGLPRRWADPAYLLTRARIITHYFA
HHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHC
NGAWLEDGQLLNNADRLAGIPAILLQGRFDIEAPLVTAWELARAWPQSELQILPHAAHST
CCCEECCCHHHCCCHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCHHEECCCCCCCC
ANPNMSAAIVAATDRFRHLHQK
CCCCCCEEEEEEHHHHHHHHCC
>Mature Secondary Structure 
SALYPEIEPYDHGLLDTGDGNLIYWEACGNPAGRPALVLHGGPGSGCSTTARRHFDPDA
CCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCHHHHCCCCCE
YRIILFDQRNCGRSLPSAADPETDLSRNTTWHLVADIERLRVFFGIDTWLVFGNSWGSTL
EEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHEECCEEEEEEECCCCCEE
ALTYAETHPQRVAAIVISGVTTTRRSEIDWLYRGMAPLFPEEWHRFRRAACCQEQDLDMV
EEEEECCCHHHEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHH
ATYHHLLNHPDSETRLKAARDWHDWEAASILLADPKGLPRRWADPAYLLTRARIITHYFA
HHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHC
NGAWLEDGQLLNNADRLAGIPAILLQGRFDIEAPLVTAWELARAWPQSELQILPHAAHST
CCCEECCCHHHCCCHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCHHEECCCCCCCC
ANPNMSAAIVAATDRFRHLHQK
CCCCCCEEEEEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]