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The map label for this gene is lpxD [H]

Identifier: 209549190

GI number: 209549190

Start: 1617020

End: 1618084

Strand: Direct

Name: lpxD [H]

Synonym: Rleg2_1591

Alternate gene names: 209549190

Gene position: 1617020-1618084 (Clockwise)

Preceding gene: 209549189

Following gene: 209549191

Centisome position: 35.63

GC content: 61.88

Gene sequence:

>1065_bases
ATGGAGCAAAACGTTTTTTTTCTGCCCCATGAAGGTCTGAAGCTCGCTGAGCTGGCAGAGTTTCTTGGGGCGGAACTCGC
CAATTCCGACCATGCCGATATCGTCGTCCGATCCGTGGCCCCGATCAACCGGGCGCGCGCCGGTGATGTCTGTTATATCC
TGTCGCGTCGCAACCGCGACGAACTGGCGACATGCGAAGCCTCGGCGGTGATCTGCGACAAGGCGCTCGCGGATCTCGTC
CCCCCGCATATCCCCATCATCCTGTCGTCCAATCCGCACGCCGCCTTCGCGATGGCGGGCGGCCTGTTTTATCCCGCCGC
ATTGCGTCCTGTGGTCTTTTCGGGTGAAGGCGAGATCGCGCCGAGCGCGGTGATCGATCCGAGCGCCAGGCTTGAAAAGG
GCGTGATCGTCGAGCCGTTGGCCGTCATCGGCGCGCATGCCGAGATCGGCGAGGGCACCCGCATCGGCGCACATAGCCTC
ATCGGTCCAGGCGTCAAGATCGGCCGCGATTGTTCGATCGCAGCCGGCGCCAGCATTCTCTGCGCGCTGATCGGCAACGG
CGTCATCATCCATAACGGCGTTCGCATTGGCCAGGATGGTTTCGGTTATGCGCCGGGTCCGCGCGGCATGATCAAGATCG
TCCAGATCGGCCGGGTGATCATCCAGGATAAGGTCGAGATCGGCGCCAACACCACGATCGACCGCGGCGCCATGGACGAT
ACGGTCATCGGTGAAGGCACCAAGATCGACAACCAGGTACAGATCGGCCACAACGTTCAGATCGGACGCCATTGCGCCAT
CGTCGCGCAGGTCGGCATCGCCGGCAGCACGAAGATCGGCAACGGCGTGCAGATCGGTGGCCAGGTCGGCATCAAGGGAC
ATGTGACGATCGGTGACGGCGTGCAGATCGCTGCCAAAAGCGGTATCATGACCGATCTTGCCGCCGGCGGGCAATATGGC
GGCGTACCGGCCCGTCCGCTAAAAGACTATCTGAGAGAGGCCGCACAACAAGTGTCGAAGTCAAAGTTGCGCGGTCGGAA
CCCTGGAGGCAAGGAAAATGACTGA

Upstream 100 bases:

>100_bases
ACTTCGACAAGACGCAGAACTTCAAGTTTGGCATCAACAACCAATTCTGATATCGGCAGTCCGGAACTGTAAGACTCAAT
TCCGTTCTGGAGCATTGCCG

Downstream 100 bases:

>100_bases
AGAAGCCACGACAACGCTTTCTTCGGCGGACATCATCGAGATCATGAAGCTGCTACCGCATCGTTACCCCTTCCTCATGG
TCGACAAGATCATCGAGATC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MEQNVFFLPHEGLKLAELAEFLGAELANSDHADIVVRSVAPINRARAGDVCYILSRRNRDELATCEASAVICDKALADLV
PPHIPIILSSNPHAAFAMAGGLFYPAALRPVVFSGEGEIAPSAVIDPSARLEKGVIVEPLAVIGAHAEIGEGTRIGAHSL
IGPGVKIGRDCSIAAGASILCALIGNGVIIHNGVRIGQDGFGYAPGPRGMIKIVQIGRVIIQDKVEIGANTTIDRGAMDD
TVIGEGTKIDNQVQIGHNVQIGRHCAIVAQVGIAGSTKIGNGVQIGGQVGIKGHVTIGDGVQIAAKSGIMTDLAAGGQYG
GVPARPLKDYLREAAQQVSKSKLRGRNPGGKEND

Sequences:

>Translated_354_residues
MEQNVFFLPHEGLKLAELAEFLGAELANSDHADIVVRSVAPINRARAGDVCYILSRRNRDELATCEASAVICDKALADLV
PPHIPIILSSNPHAAFAMAGGLFYPAALRPVVFSGEGEIAPSAVIDPSARLEKGVIVEPLAVIGAHAEIGEGTRIGAHSL
IGPGVKIGRDCSIAAGASILCALIGNGVIIHNGVRIGQDGFGYAPGPRGMIKIVQIGRVIIQDKVEIGANTTIDRGAMDD
TVIGEGTKIDNQVQIGHNVQIGRHCAIVAQVGIAGSTKIGNGVQIGGQVGIKGHVTIGDGVQIAAKSGIMTDLAAGGQYG
GVPARPLKDYLREAAQQVSKSKLRGRNPGGKEND
>Mature_354_residues
MEQNVFFLPHEGLKLAELAEFLGAELANSDHADIVVRSVAPINRARAGDVCYILSRRNRDELATCEASAVICDKALADLV
PPHIPIILSSNPHAAFAMAGGLFYPAALRPVVFSGEGEIAPSAVIDPSARLEKGVIVEPLAVIGAHAEIGEGTRIGAHSL
IGPGVKIGRDCSIAAGASILCALIGNGVIIHNGVRIGQDGFGYAPGPRGMIKIVQIGRVIIQDKVEIGANTTIDRGAMDD
TVIGEGTKIDNQVQIGHNVQIGRHCAIVAQVGIAGSTKIGNGVQIGGQVGIKGHVTIGDGVQIAAKSGIMTDLAAGGQYG
GVPARPLKDYLREAAQQVSKSKLRGRNPGGKEND

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=336, Percent_Identity=38.6904761904762, Blast_Score=191, Evalue=5e-50,
Organism=Escherichia coli, GI1786378, Length=198, Percent_Identity=26.7676767676768, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36613; Mature: 36613

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQNVFFLPHEGLKLAELAEFLGAELANSDHADIVVRSVAPINRARAGDVCYILSRRNRD
CCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCC
ELATCEASAVICDKALADLVPPHIPIILSSNPHAAFAMAGGLFYPAALRPVVFSGEGEIA
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCEECCHHCCCEEECCCCCCC
PSAVIDPSARLEKGVIVEPLAVIGAHAEIGEGTRIGAHSLIGPGVKIGRDCSIAAGASIL
CCEEECCHHHHCCCCEECCHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHH
CALIGNGVIIHNGVRIGQDGFGYAPGPRGMIKIVQIGRVIIQDKVEIGANTTIDRGAMDD
HHHHCCCEEEECCEEECCCCCCCCCCCCCHHHHHHHHHHHEEHHHHCCCCCCCCCCCCCC
TVIGEGTKIDNQVQIGHNVQIGRHCAIVAQVGIAGSTKIGNGVQIGGQVGIKGHVTIGDG
CEECCCCCCCCEEEECCCEEECCEEEEEEEECCCCCCCCCCCEEECCEECEEEEEEECCC
VQIAAKSGIMTDLAAGGQYGGVPARPLKDYLREAAQQVSKSKLRGRNPGGKEND
EEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEQNVFFLPHEGLKLAELAEFLGAELANSDHADIVVRSVAPINRARAGDVCYILSRRNRD
CCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCC
ELATCEASAVICDKALADLVPPHIPIILSSNPHAAFAMAGGLFYPAALRPVVFSGEGEIA
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCEECCHHCCCEEECCCCCCC
PSAVIDPSARLEKGVIVEPLAVIGAHAEIGEGTRIGAHSLIGPGVKIGRDCSIAAGASIL
CCEEECCHHHHCCCCEECCHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHH
CALIGNGVIIHNGVRIGQDGFGYAPGPRGMIKIVQIGRVIIQDKVEIGANTTIDRGAMDD
HHHHCCCEEEECCEEECCCCCCCCCCCCCHHHHHHHHHHHEEHHHHCCCCCCCCCCCCCC
TVIGEGTKIDNQVQIGHNVQIGRHCAIVAQVGIAGSTKIGNGVQIGGQVGIKGHVTIGDG
CEECCCCCCCCEEEECCCEEECCEEEEEEEECCCCCCCCCCCEEECCEECEEEEEEECCC
VQIAAKSGIMTDLAAGGQYGGVPARPLKDYLREAAQQVSKSKLRGRNPGGKEND
EEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA