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The map label for this gene is uppS [H]

Identifier: 209549186

GI number: 209549186

Start: 1611697

End: 1612440

Strand: Direct

Name: uppS [H]

Synonym: Rleg2_1587

Alternate gene names: 209549186

Gene position: 1611697-1612440 (Clockwise)

Preceding gene: 209549185

Following gene: 209549187

Centisome position: 35.52

GC content: 63.17

Gene sequence:

>744_bases
ATGTCGGAATCTGTATTTGTGACTGTGCCAGAGCATGTTGCCATCATCATGGACGGCAATGGCCGTTGGGCCAAGCAGCG
CGGCCTGCCGCGCACGATGGGCCATCGCAAGGGCGTCGAGGCGGTCCGCGAGACAGTGCGCGCCGCCGGCGCGGCCGGCA
TAAAATATCTGACCCTCTTTGCCTTCTCCTCGGAGAACTGGCGCAGGCCGGAGGCCGAGGTCTCCGACCTGCTTGGTCTT
CTCAAGGCTTTCATCCGGCGTGACCTTGCCGAGCTTCATCGCCAGAATGTGCGGATCAAGGTGATCGGTGACCGCCACAG
CCTGCGCAACGACATTCTCGGCCTGCTGCTCGAGGCGGAGGAAACGACCAAGGACAATACGGCGCTGACGCTGGTCATCG
CTTTCAACTACGGCTCACGCGACGAGATCTCGCGGGCTGTGGTGAGCCTGGCGAGGGACGTCGAGGCCGGCCGCCTGAGG
GCGCAGGATATCACGCCATCGCTGATCAACGCCCGTCTCGATACAGCCGGTATTCCCGATCCGGACCTCATCATCCGCAC
CAGCGGCGAGGAGCGGCTTTCCAATTTCCTCCTCTGGCAGGCCGCCTATTCGGAATTCATCTTCGTTCCGGAATATTGGC
CGGATTTCAGCCCCGAGATCTTCCGCTCGGCGCTGGAGAAATTCGCCTCCCGCGACCGACGCTTCGGCGGCCTGTCGTCG
CAGGCAGCCGCGGTCGGCACCTGA

Upstream 100 bases:

>100_bases
GAGACGATTTCCGAAATCGACCGCTTGCTTGGCGAGAAGGAAAAGGAAATCATGCAGGTCTAGTGGATCTGTGCCTTTGC
CTGGAAAGACCGGACGGGAA

Downstream 100 bases:

>100_bases
TGCAGCAGGAATTGAAGCTCCGCATCGTTTCAGGCCTGATTCTTGCGGTGATCGTTCTTGCCGCCACCTGGTATGGCGGA
TTTGCCTTCCGCATCCTGGC

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MSESVFVTVPEHVAIIMDGNGRWAKQRGLPRTMGHRKGVEAVRETVRAAGAAGIKYLTLFAFSSENWRRPEAEVSDLLGL
LKAFIRRDLAELHRQNVRIKVIGDRHSLRNDILGLLLEAEETTKDNTALTLVIAFNYGSRDEISRAVVSLARDVEAGRLR
AQDITPSLINARLDTAGIPDPDLIIRTSGEERLSNFLLWQAAYSEFIFVPEYWPDFSPEIFRSALEKFASRDRRFGGLSS
QAAAVGT

Sequences:

>Translated_247_residues
MSESVFVTVPEHVAIIMDGNGRWAKQRGLPRTMGHRKGVEAVRETVRAAGAAGIKYLTLFAFSSENWRRPEAEVSDLLGL
LKAFIRRDLAELHRQNVRIKVIGDRHSLRNDILGLLLEAEETTKDNTALTLVIAFNYGSRDEISRAVVSLARDVEAGRLR
AQDITPSLINARLDTAGIPDPDLIIRTSGEERLSNFLLWQAAYSEFIFVPEYWPDFSPEIFRSALEKFASRDRRFGGLSS
QAAAVGT
>Mature_246_residues
SESVFVTVPEHVAIIMDGNGRWAKQRGLPRTMGHRKGVEAVRETVRAAGAAGIKYLTLFAFSSENWRRPEAEVSDLLGLL
KAFIRRDLAELHRQNVRIKVIGDRHSLRNDILGLLLEAEETTKDNTALTLVIAFNYGSRDEISRAVVSLARDVEAGRLRA
QDITPSLINARLDTAGIPDPDLIIRTSGEERLSNFLLWQAAYSEFIFVPEYWPDFSPEIFRSALEKFASRDRRFGGLSSQ
AAAVGT

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=212, Percent_Identity=41.9811320754717, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI45580738, Length=212, Percent_Identity=41.9811320754717, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1786371, Length=237, Percent_Identity=45.9915611814346, Blast_Score=212, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71993029, Length=213, Percent_Identity=36.150234741784, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=37.962962962963, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=223, Percent_Identity=34.5291479820628, Blast_Score=109, Evalue=4e-25,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=37.280701754386, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27583; Mature: 27452

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESVFVTVPEHVAIIMDGNGRWAKQRGLPRTMGHRKGVEAVRETVRAAGAAGIKYLTLF
CCCCEEEEECCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
AFSSENWRRPEAEVSDLLGLLKAFIRRDLAELHRQNVRIKVIGDRHSLRNDILGLLLEAE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCC
ETTKDNTALTLVIAFNYGSRDEISRAVVSLARDVEAGRLRAQDITPSLINARLDTAGIPD
CCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCEECCCCCHHHHHHHCCCCCCCC
PDLIIRTSGEERLSNFLLWQAAYSEFIFVPEYWPDFSPEIFRSALEKFASRDRRFGGLSS
CCEEEECCCHHHHHHHHHHHHHHHCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
QAAAVGT
CCCCCCC
>Mature Secondary Structure 
SESVFVTVPEHVAIIMDGNGRWAKQRGLPRTMGHRKGVEAVRETVRAAGAAGIKYLTLF
CCCEEEEECCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
AFSSENWRRPEAEVSDLLGLLKAFIRRDLAELHRQNVRIKVIGDRHSLRNDILGLLLEAE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHCCC
ETTKDNTALTLVIAFNYGSRDEISRAVVSLARDVEAGRLRAQDITPSLINARLDTAGIPD
CCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCEECCCCCHHHHHHHCCCCCCCC
PDLIIRTSGEERLSNFLLWQAAYSEFIFVPEYWPDFSPEIFRSALEKFASRDRRFGGLSS
CCEEEECCCHHHHHHHHHHHHHHHCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
QAAAVGT
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]