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The map label for this gene is metC [H]

Identifier: 209549163

GI number: 209549163

Start: 1589519

End: 1590709

Strand: Direct

Name: metC [H]

Synonym: Rleg2_1564

Alternate gene names: 209549163

Gene position: 1589519-1590709 (Clockwise)

Preceding gene: 209549158

Following gene: 209549166

Centisome position: 35.03

GC content: 61.88

Gene sequence:

>1191_bases
ATGAAAGAAAAAGACAGCTTGCTGCAGAACGCTGGCATCAACACCCGCCTGACGCATATCGGCAACGACCCTTTCGACTA
TCACGGCTTCGTCAATCCGCCGGTCGTGCATGCCTCGACGGTGCTGTTTCCGAATGCGCGCACGATGGAGACGCGCTCGC
AGAAATACACCTATGGAACGCGCGGCACGCCGACGACGGATGCGCTCTGCGAGGCAATCGACGCACTCGAAGGCTCGGCC
GGCACGATCCTCGTCCCGTCCGGCCTTGCGGCCGTCACCATTCCGTTCCTGGGTTTCGTCGCCGCCGGCGACCATGCGCT
TGTCGTCGATTCGGTCTATGGCCCGACGCGCCATTTCTGCGACACGATGTTGAAGCGGCTTGGCGTCGAGGTCGAATATT
ACGACCCGTCGATCGGCGCCGGCATCGAGACGCTGTTCCGGCCGAACACCAAGATCGTCCACACCGAGGCGCCCGGCTCC
AACACCTTCGAGATGCAGGATATCCCGGCGATCTCGGCGGTGGCGCACCGCCACGGCGCCGTTGTCATGATGGACAATAC
TTGGGCGACGCCGCTCTATTTCAAACCGCTCGATCACGGCGTCGATATCTCGATCCACGCATCGACGAAATATCCGTCCG
GCCATTCCGATATTCTGCTTGGAACGGTGTCGGCCAATGCCGAGCACTGGGAGCGGCTGAAGGAAGCAAACGGTGTGCTC
GGCATCTGCGGCGCACCCGATGACGCTTACCAGATCCTGCGCGGATTGCGCACCATGGGCCTGCGCCTCGAGCGGCATTA
TGAAAGCGCGCTTGGTATCGCGCAATGGCTGGAGGGCAGGGAGGACGTCGCCCGCGTGCTGCATCCGGCCCTGCGGAGTT
TTCCCTCTCACCATCTCTGGAAGCGCGATTTCAAAGGCGCCAGCGGCATCTTTTCCTTCGTGCTCGCCGCTGATGGCCCG
GAAAAATCCAGGGCAAAGGCGCATGCCTTCCTCGATGCGCTCCGGATTTTCGGTCTCGGCTATTCCTGGGGCGGCTTTGA
AAGCCTCGCATTGCACGCCTATCTCAACGACCGCACCGTCGCCAAGGCGCCGACGGATGGTGCTGTCATCCGCCTGCAGA
TCGGCATCGAGGATGTGGTTGACCTCAAGGCCGATATCGAACGGGGATTTGCCGCCGCAAGCGCCGTCTGA

Upstream 100 bases:

>100_bases
GTCCAAGCGTTGTCGCCAACCCATCATCAAGGGGTTGACCGGAAACGGCGGGGCGTCCAAAAGTCTGTTTTCCAGCCCCT
CGCCAAAGGCTATTTCCGAC

Downstream 100 bases:

>100_bases
CACGCCGTGTTTTATGGCAGATGCAGGGCCCGGTAGCCGTAGATCCAGTCGAGGTCCGCCGCGAGGCTTTGCGGCGGCTT
GAGGCCAAGCACGAGATCGC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKEKDSLLQNAGINTRLTHIGNDPFDYHGFVNPPVVHASTVLFPNARTMETRSQKYTYGTRGTPTTDALCEAIDALEGSA
GTILVPSGLAAVTIPFLGFVAAGDHALVVDSVYGPTRHFCDTMLKRLGVEVEYYDPSIGAGIETLFRPNTKIVHTEAPGS
NTFEMQDIPAISAVAHRHGAVVMMDNTWATPLYFKPLDHGVDISIHASTKYPSGHSDILLGTVSANAEHWERLKEANGVL
GICGAPDDAYQILRGLRTMGLRLERHYESALGIAQWLEGREDVARVLHPALRSFPSHHLWKRDFKGASGIFSFVLAADGP
EKSRAKAHAFLDALRIFGLGYSWGGFESLALHAYLNDRTVAKAPTDGAVIRLQIGIEDVVDLKADIERGFAAASAV

Sequences:

>Translated_396_residues
MKEKDSLLQNAGINTRLTHIGNDPFDYHGFVNPPVVHASTVLFPNARTMETRSQKYTYGTRGTPTTDALCEAIDALEGSA
GTILVPSGLAAVTIPFLGFVAAGDHALVVDSVYGPTRHFCDTMLKRLGVEVEYYDPSIGAGIETLFRPNTKIVHTEAPGS
NTFEMQDIPAISAVAHRHGAVVMMDNTWATPLYFKPLDHGVDISIHASTKYPSGHSDILLGTVSANAEHWERLKEANGVL
GICGAPDDAYQILRGLRTMGLRLERHYESALGIAQWLEGREDVARVLHPALRSFPSHHLWKRDFKGASGIFSFVLAADGP
EKSRAKAHAFLDALRIFGLGYSWGGFESLALHAYLNDRTVAKAPTDGAVIRLQIGIEDVVDLKADIERGFAAASAV
>Mature_396_residues
MKEKDSLLQNAGINTRLTHIGNDPFDYHGFVNPPVVHASTVLFPNARTMETRSQKYTYGTRGTPTTDALCEAIDALEGSA
GTILVPSGLAAVTIPFLGFVAAGDHALVVDSVYGPTRHFCDTMLKRLGVEVEYYDPSIGAGIETLFRPNTKIVHTEAPGS
NTFEMQDIPAISAVAHRHGAVVMMDNTWATPLYFKPLDHGVDISIHASTKYPSGHSDILLGTVSANAEHWERLKEANGVL
GICGAPDDAYQILRGLRTMGLRLERHYESALGIAQWLEGREDVARVLHPALRSFPSHHLWKRDFKGASGIFSFVLAADGP
EKSRAKAHAFLDALRIFGLGYSWGGFESLALHAYLNDRTVAKAPTDGAVIRLQIGIEDVVDLKADIERGFAAASAV

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=388, Percent_Identity=33.2474226804124, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI299473759, Length=388, Percent_Identity=30.4123711340206, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI25453487, Length=387, Percent_Identity=29.9741602067183, Blast_Score=160, Evalue=1e-39,
Organism=Escherichia coli, GI1789383, Length=396, Percent_Identity=43.4343434343434, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1790375, Length=380, Percent_Identity=32.8947368421053, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17560056, Length=375, Percent_Identity=35.2, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71980708, Length=392, Percent_Identity=30.8673469387755, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17538055, Length=375, Percent_Identity=33.6, Blast_Score=193, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321170, Length=338, Percent_Identity=45.8579881656805, Blast_Score=321, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6319307, Length=394, Percent_Identity=29.1878172588832, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6323333, Length=391, Percent_Identity=28.3887468030691, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321254, Length=400, Percent_Identity=25.25, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321904, Length=391, Percent_Identity=25.0639386189258, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922554, Length=399, Percent_Identity=34.8370927318296, Blast_Score=217, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42969; Mature: 42969

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKDSLLQNAGINTRLTHIGNDPFDYHGFVNPPVVHASTVLFPNARTMETRSQKYTYGT
CCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCHHCCCCCEECCC
RGTPTTDALCEAIDALEGSAGTILVPSGLAAVTIPFLGFVAAGDHALVVDSVYGPTRHFC
CCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHH
DTMLKRLGVEVEYYDPSIGAGIETLFRPNTKIVHTEAPGSNTFEMQDIPAISAVAHRHGA
HHHHHHHCCEEEEECCCCCCCHHHHCCCCCEEEEECCCCCCCEEECCCCHHHHHHHHCCE
VVMMDNTWATPLYFKPLDHGVDISIHASTKYPSGHSDILLGTVSANAEHWERLKEANGVL
EEEECCCCCCCEEECCCCCCCEEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHCCCEE
GICGAPDDAYQILRGLRTMGLRLERHYESALGIAQWLEGREDVARVLHPALRSFPSHHLW
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHH
KRDFKGASGIFSFVLAADGPEKSRAKAHAFLDALRIFGLGYSWGGFESLALHAYLNDRTV
HHHCCCHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEE
AKAPTDGAVIRLQIGIEDVVDLKADIERGFAAASAV
ECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKEKDSLLQNAGINTRLTHIGNDPFDYHGFVNPPVVHASTVLFPNARTMETRSQKYTYGT
CCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCHHCCCCCEECCC
RGTPTTDALCEAIDALEGSAGTILVPSGLAAVTIPFLGFVAAGDHALVVDSVYGPTRHFC
CCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHH
DTMLKRLGVEVEYYDPSIGAGIETLFRPNTKIVHTEAPGSNTFEMQDIPAISAVAHRHGA
HHHHHHHCCEEEEECCCCCCCHHHHCCCCCEEEEECCCCCCCEEECCCCHHHHHHHHCCE
VVMMDNTWATPLYFKPLDHGVDISIHASTKYPSGHSDILLGTVSANAEHWERLKEANGVL
EEEECCCCCCCEEECCCCCCCEEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHCCCEE
GICGAPDDAYQILRGLRTMGLRLERHYESALGIAQWLEGREDVARVLHPALRSFPSHHLW
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHH
KRDFKGASGIFSFVLAADGPEKSRAKAHAFLDALRIFGLGYSWGGFESLALHAYLNDRTV
HHHCCCHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEE
AKAPTDGAVIRLQIGIEDVVDLKADIERGFAAASAV
ECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]