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The map label for this gene is accC [H]

Identifier: 209549135

GI number: 209549135

Start: 1559925

End: 1561274

Strand: Reverse

Name: accC [H]

Synonym: Rleg2_1536

Alternate gene names: 209549135

Gene position: 1561274-1559925 (Counterclockwise)

Preceding gene: 209549136

Following gene: 209549134

Centisome position: 34.4

GC content: 61.78

Gene sequence:

>1350_bases
ATGATTTCGAAAATCCTCATCGCCAATCGCGGGGAAATCGCCCTTCGCGTGCTCCGGGCCTGCAAGGAGCTCGGCATCGC
CTGTGTTGTGGTTCATTCCACCGCCGACGCCGATGCCATGCATGTGCGCCTTGCCGACGAAAGCGTCTGCATCGGTCCGC
CCTCCTCGCGCGAGAGCTATCTCAATATCCACCAGATCGTCGCCGCCTGCGAGATCACCGGGGCCGATGCAGTGCATCCG
GGCTACGGCTTTCTGTCGGAGAATGCCAAGTTCGCCGATATTCTCGAAGCCCACGGCATCACCTTCATCGGGCCGACGGC
GGACCATATCCGCATCATGGGTGACAAGATCACCGCCAAGACGACGGCGCTGGAGCTCGGCATTCCCGTCGTTCCGGGCT
CGGACGGCGAGGTGAAGACCGAAGAGGATGCGCTGAAGACAGCCGCCGAAATTGGCTATCCCGTGCTGATCAAGGCAACG
GCCGGCGGTGGCGGACGCGGCATGAAGGTTGCCAAGAGCGAGGCCGACCTGATCGAGGCCTGGTCGACGGCGCGCACGGA
AGCGGCAGCCGCCTTCGGCAACGATGCCGTCTATATGGAAAAATATCTCGGCAAGCCGCGTCACATCGAAATCCAGGTAT
TCGGCGACGGTGAAGGCAACGCCATCCATCTCGGCGAACGCGACTGCTCGCTGCAGCGCCGCCACCAGAAGGTCTGGGAA
GAGGCGAATTCGCCGGCGCTCAACGTCGAGCAGCGCATGAAGATCGGCCAGGTCTGCGCCGACGCCATGAAGAAGCTGAA
ATATCGCGGCGCCGGCACGATCGAATTCCTCTACGAGAACGGCGAGTTCTATTTCATCGAAATGAACACCCGCCTGCAGG
TGGAGCATCCGATCACGGAAGCCATCACCGGCATCGATCTCGTGCACGAGCAGATCCGCGTCGCCTCCGGCGGCGGTCTC
TCGGTGACGCAGGATGAAGTGCATTTTTCCGGTCATGCCATCGAATGCCGCATCAATGCCGAGCACCCGCGCACTTTCGT
GCCCTCGCCCGGCACGATCACGCATTTCCACGCACCGGGCGGTCTCGGCGTGCGCATCGATTCCGGCGCCTATCAGGGCT
ACAAGATCCCGCCCTATTACGACAGCCTCATCGGCAAGCTGATCGTGCATGGCCGTACCCGCGTCGAATGCATGATGCGG
CTGCGCCGGGCGCTCGACGAATTCGTCGTTGACGGCATCAATACGACGCTGCCGCTGTTCCAGGATCTCGTCTCCAACCA
GGATATCGCCAACGGCGATTACGACATCCACTGGCTGGAACACTACCTCGCCAACGAACCGGCGGCATAG

Upstream 100 bases:

>100_bases
CCGTCGCCGAAGTCGGGCAAGGTAACCGAGATCCTCGTCGATGACGGACATCCCGTTGAATACGGCCAAGCCCTCGTCGT
CATCGAATAGGCCGATGCCC

Downstream 100 bases:

>100_bases
GGCAGGAATGGCAGGATCGCGCAGGAAGTCACCAGGCATTACCCCTGAAATTCTCCTGCGCGCCTATTCCATCGGCCTCT
TCCCGATGGCTGAATCCGCC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MISKILIANRGEIALRVLRACKELGIACVVVHSTADADAMHVRLADESVCIGPPSSRESYLNIHQIVAACEITGADAVHP
GYGFLSENAKFADILEAHGITFIGPTADHIRIMGDKITAKTTALELGIPVVPGSDGEVKTEEDALKTAAEIGYPVLIKAT
AGGGGRGMKVAKSEADLIEAWSTARTEAAAAFGNDAVYMEKYLGKPRHIEIQVFGDGEGNAIHLGERDCSLQRRHQKVWE
EANSPALNVEQRMKIGQVCADAMKKLKYRGAGTIEFLYENGEFYFIEMNTRLQVEHPITEAITGIDLVHEQIRVASGGGL
SVTQDEVHFSGHAIECRINAEHPRTFVPSPGTITHFHAPGGLGVRIDSGAYQGYKIPPYYDSLIGKLIVHGRTRVECMMR
LRRALDEFVVDGINTTLPLFQDLVSNQDIANGDYDIHWLEHYLANEPAA

Sequences:

>Translated_449_residues
MISKILIANRGEIALRVLRACKELGIACVVVHSTADADAMHVRLADESVCIGPPSSRESYLNIHQIVAACEITGADAVHP
GYGFLSENAKFADILEAHGITFIGPTADHIRIMGDKITAKTTALELGIPVVPGSDGEVKTEEDALKTAAEIGYPVLIKAT
AGGGGRGMKVAKSEADLIEAWSTARTEAAAAFGNDAVYMEKYLGKPRHIEIQVFGDGEGNAIHLGERDCSLQRRHQKVWE
EANSPALNVEQRMKIGQVCADAMKKLKYRGAGTIEFLYENGEFYFIEMNTRLQVEHPITEAITGIDLVHEQIRVASGGGL
SVTQDEVHFSGHAIECRINAEHPRTFVPSPGTITHFHAPGGLGVRIDSGAYQGYKIPPYYDSLIGKLIVHGRTRVECMMR
LRRALDEFVVDGINTTLPLFQDLVSNQDIANGDYDIHWLEHYLANEPAA
>Mature_449_residues
MISKILIANRGEIALRVLRACKELGIACVVVHSTADADAMHVRLADESVCIGPPSSRESYLNIHQIVAACEITGADAVHP
GYGFLSENAKFADILEAHGITFIGPTADHIRIMGDKITAKTTALELGIPVVPGSDGEVKTEEDALKTAAEIGYPVLIKAT
AGGGGRGMKVAKSEADLIEAWSTARTEAAAAFGNDAVYMEKYLGKPRHIEIQVFGDGEGNAIHLGERDCSLQRRHQKVWE
EANSPALNVEQRMKIGQVCADAMKKLKYRGAGTIEFLYENGEFYFIEMNTRLQVEHPITEAITGIDLVHEQIRVASGGGL
SVTQDEVHFSGHAIECRINAEHPRTFVPSPGTITHFHAPGGLGVRIDSGAYQGYKIPPYYDSLIGKLIVHGRTRVECMMR
LRRALDEFVVDGINTTLPLFQDLVSNQDIANGDYDIHWLEHYLANEPAA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=440, Percent_Identity=48.6363636363636, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI189095269, Length=440, Percent_Identity=48.6363636363636, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI295821183, Length=440, Percent_Identity=48.6363636363636, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI116805327, Length=435, Percent_Identity=45.2873563218391, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=44.8430493273543, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=44.8430493273543, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=44.8430493273543, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI134142062, Length=514, Percent_Identity=29.9610894941634, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI38679974, Length=517, Percent_Identity=29.5938104448743, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI38679960, Length=517, Percent_Identity=29.5938104448743, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI38679977, Length=517, Percent_Identity=29.5938104448743, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI38679967, Length=517, Percent_Identity=29.5938104448743, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI38679971, Length=517, Percent_Identity=29.5938104448743, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=60.1351351351351, Blast_Score=537, Evalue=1e-154,
Organism=Escherichia coli, GI1786216, Length=251, Percent_Identity=28.2868525896414, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17567343, Length=440, Percent_Identity=47.9545454545455, Blast_Score=403, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=435, Percent_Identity=45.7471264367816, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17562816, Length=453, Percent_Identity=41.9426048565121, Blast_Score=348, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=28.8617886178862, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71997168, Length=513, Percent_Identity=27.4853801169591, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=513, Percent_Identity=27.4853801169591, Blast_Score=189, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6319685, Length=452, Percent_Identity=41.5929203539823, Blast_Score=355, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6319695, Length=444, Percent_Identity=43.6936936936937, Blast_Score=333, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6321376, Length=441, Percent_Identity=43.9909297052154, Blast_Score=326, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6324343, Length=526, Percent_Identity=29.8479087452471, Blast_Score=216, Evalue=7e-57,
Organism=Saccharomyces cerevisiae, GI6323863, Length=476, Percent_Identity=31.0924369747899, Blast_Score=207, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24652212, Length=450, Percent_Identity=47.3333333333333, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652210, Length=450, Percent_Identity=47.3333333333333, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652214, Length=450, Percent_Identity=47.3333333333333, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI19921944, Length=450, Percent_Identity=47.3333333333333, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652216, Length=450, Percent_Identity=47.3333333333333, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI281363050, Length=450, Percent_Identity=47.3333333333333, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652224, Length=450, Percent_Identity=47.3333333333333, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652222, Length=450, Percent_Identity=47.3333333333333, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652220, Length=450, Percent_Identity=47.3333333333333, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652218, Length=450, Percent_Identity=47.3333333333333, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24651757, Length=432, Percent_Identity=44.6759259259259, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=390, Percent_Identity=44.1025641025641, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=29.6222664015905, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=29.6222664015905, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=29.6222664015905, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=29.6222664015905, Blast_Score=203, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48919; Mature: 48919

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISKILIANRGEIALRVLRACKELGIACVVVHSTADADAMHVRLADESVCIGPPSSRESY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEEECCEEEECCCCCCHHH
LNIHQIVAACEITGADAVHPGYGFLSENAKFADILEAHGITFIGPTADHIRIMGDKITAK
HHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCEEEEE
TTALELGIPVVPGSDGEVKTEEDALKTAAEIGYPVLIKATAGGGGRGMKVAKSEADLIEA
EEEEEECCEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCHHHHHHH
WSTARTEAAAAFGNDAVYMEKYLGKPRHIEIQVFGDGEGNAIHLGERDCSLQRRHQKVWE
HHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EANSPALNVEQRMKIGQVCADAMKKLKYRGAGTIEFLYENGEFYFIEMNTRLQVEHPITE
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AITGIDLVHEQIRVASGGGLSVTQDEVHFSGHAIECRINAEHPRTFVPSPGTITHFHAPG
HHHHHHHHHHHHEEECCCCCEEECCCEEECCEEEEEEEECCCCEEECCCCCCEEEEECCC
GLGVRIDSGAYQGYKIPPYYDSLIGKLIVHGRTRVECMMRLRRALDEFVVDGINTTLPLF
CEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QDLVSNQDIANGDYDIHWLEHYLANEPAA
HHHHCCCCCCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MISKILIANRGEIALRVLRACKELGIACVVVHSTADADAMHVRLADESVCIGPPSSRESY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEEECCEEEECCCCCCHHH
LNIHQIVAACEITGADAVHPGYGFLSENAKFADILEAHGITFIGPTADHIRIMGDKITAK
HHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCEEEEE
TTALELGIPVVPGSDGEVKTEEDALKTAAEIGYPVLIKATAGGGGRGMKVAKSEADLIEA
EEEEEECCEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCHHHHHHH
WSTARTEAAAAFGNDAVYMEKYLGKPRHIEIQVFGDGEGNAIHLGERDCSLQRRHQKVWE
HHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EANSPALNVEQRMKIGQVCADAMKKLKYRGAGTIEFLYENGEFYFIEMNTRLQVEHPITE
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AITGIDLVHEQIRVASGGGLSVTQDEVHFSGHAIECRINAEHPRTFVPSPGTITHFHAPG
HHHHHHHHHHHHEEECCCCCEEECCCEEECCEEEEEEEECCCCEEECCCCCCEEEEECCC
GLGVRIDSGAYQGYKIPPYYDSLIGKLIVHGRTRVECMMRLRRALDEFVVDGINTTLPLF
CEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QDLVSNQDIANGDYDIHWLEHYLANEPAA
HHHHCCCCCCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]