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The map label for this gene is cbs [H]

Identifier: 209549041

GI number: 209549041

Start: 1461912

End: 1462949

Strand: Reverse

Name: cbs [H]

Synonym: Rleg2_1438

Alternate gene names: 209549041

Gene position: 1462949-1461912 (Counterclockwise)

Preceding gene: 209549044

Following gene: 209549040

Centisome position: 32.24

GC content: 62.72

Gene sequence:

>1038_bases
ATGACCTTCCATCCTTCCGTTCTCGAAGCCATCGGCAATACGCCCCTGATCAAACTGAAGGGCGCGTCGGCGGCGACCGG
CTGCACCATTCTCGGCAAGGCGGAGTTCCTGAACCCCGGCCAGTCGGTGAAGGACCGTGCCGCGCTCTACATCATCCGCG
ACGCGGAACGGAAAGGGTTGCTTCGGCCCGGCGGCGTCATCGTCGAAGGCACGGCCGGCAATACCGGCATCGGGCTGACG
CTGGTCGCCAAGGCGCTCGGCTACCGCACCGTCATCGTCATTCCGGAAACGCAGAGCCAGGAAAAGAAGGACGCGTTGAA
ACTGCTCGGCGCCGAACTCGTCGAAGTGCCGGCCGTTCCCTACAAGAACCCCAACAACTACGTGAAGGTCTCGGGGCGGC
TCGCCGAGCAACTGGCGAAGACAGAGCCGAACGGGGCGATCTGGGCGAACCAGTTCGACAACGTCGCCAACCGCCAGGCG
CATATCGAAACCACCGCTCGGGAAATCTGGAACGATACCGACGGCAAGGTCGACGGCTTCATCTGCTCCGTCGGTTCCGG
CGGCACGCTGGCCGGCGTCGCTGCCGGCCTGAAGGCATTCAATGCGAACGTCAAGATCGGAATCGCCGATCCCGAAGGTG
CTGCTCTTTATGAGTTTTACCAGAACGGCACGCTGAAATCCGAGGGTTCCTCGATCACCGAGGGCATCGGCCAGGGCCGC
GTCACCGCCAATCTCGAAGGCTTCACGCCTGATTTCTCCTATCGGGTCTCCGATGCCGAAGCGCTGCCCTATCTCTTCGA
CCTCGTCGAAAACGAAGGCCTGTGCCTCGGCGGCTCGACGGCGATCAACATTGCCGGCGCGGTCAAGCTCGCCCGGGATC
TCGGACCCGGCCACACGGTGGTGACGATCCTCTGCGACTACGGCAACCGCTATCAGTCGAAGCTCTTCAATCCGGATTTC
CTGACCTCGAAGGGACTGCCCGTTCCGGGCTGGATGGCCAAGTCGCCCGAGATAGACGTTCCCTACGAACCCGCGTGA

Upstream 100 bases:

>100_bases
TCGTGCCCGACAGGGGCGTGGAATAGCATTTCTTGCCAACTCAGCCTTGTGAAGGGAAAAGACCGTTCCTAAAGTAAGAG
TTCGAATAGAGGCAGATTCC

Downstream 100 bases:

>100_bases
GACCCCATGCCCGTCAATGCCCTCTATCGTGACGACTTTTATCTCTCGACATGCGAGGCGGTCGTCACCGCCGTCCACGA
AGACGGGGGCATCGAACTCG

Product: cysteine synthase A

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTFHPSVLEAIGNTPLIKLKGASAATGCTILGKAEFLNPGQSVKDRAALYIIRDAERKGLLRPGGVIVEGTAGNTGIGLT
LVAKALGYRTVIVIPETQSQEKKDALKLLGAELVEVPAVPYKNPNNYVKVSGRLAEQLAKTEPNGAIWANQFDNVANRQA
HIETTAREIWNDTDGKVDGFICSVGSGGTLAGVAAGLKAFNANVKIGIADPEGAALYEFYQNGTLKSEGSSITEGIGQGR
VTANLEGFTPDFSYRVSDAEALPYLFDLVENEGLCLGGSTAINIAGAVKLARDLGPGHTVVTILCDYGNRYQSKLFNPDF
LTSKGLPVPGWMAKSPEIDVPYEPA

Sequences:

>Translated_345_residues
MTFHPSVLEAIGNTPLIKLKGASAATGCTILGKAEFLNPGQSVKDRAALYIIRDAERKGLLRPGGVIVEGTAGNTGIGLT
LVAKALGYRTVIVIPETQSQEKKDALKLLGAELVEVPAVPYKNPNNYVKVSGRLAEQLAKTEPNGAIWANQFDNVANRQA
HIETTAREIWNDTDGKVDGFICSVGSGGTLAGVAAGLKAFNANVKIGIADPEGAALYEFYQNGTLKSEGSSITEGIGQGR
VTANLEGFTPDFSYRVSDAEALPYLFDLVENEGLCLGGSTAINIAGAVKLARDLGPGHTVVTILCDYGNRYQSKLFNPDF
LTSKGLPVPGWMAKSPEIDVPYEPA
>Mature_344_residues
TFHPSVLEAIGNTPLIKLKGASAATGCTILGKAEFLNPGQSVKDRAALYIIRDAERKGLLRPGGVIVEGTAGNTGIGLTL
VAKALGYRTVIVIPETQSQEKKDALKLLGAELVEVPAVPYKNPNNYVKVSGRLAEQLAKTEPNGAIWANQFDNVANRQAH
IETTAREIWNDTDGKVDGFICSVGSGGTLAGVAAGLKAFNANVKIGIADPEGAALYEFYQNGTLKSEGSSITEGIGQGRV
TANLEGFTPDFSYRVSDAEALPYLFDLVENEGLCLGGSTAINIAGAVKLARDLGPGHTVVTILCDYGNRYQSKLFNPDFL
TSKGLPVPGWMAKSPEIDVPYEPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=325, Percent_Identity=39.6923076923077, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI295821200, Length=325, Percent_Identity=39.6923076923077, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4557415, Length=325, Percent_Identity=39.6923076923077, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI11345492, Length=211, Percent_Identity=29.8578199052133, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI2367138, Length=312, Percent_Identity=35.5769230769231, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=37.3040752351097, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=37.1335504885993, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17562970, Length=318, Percent_Identity=35.8490566037736, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32566674, Length=306, Percent_Identity=36.2745098039216, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17534315, Length=339, Percent_Identity=33.9233038348083, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI25147552, Length=335, Percent_Identity=31.3432835820896, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI115535073, Length=315, Percent_Identity=34.9206349206349, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17561720, Length=324, Percent_Identity=33.0246913580247, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32566672, Length=232, Percent_Identity=32.3275862068966, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71996324, Length=325, Percent_Identity=25.8461538461538, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=40.9090909090909, Blast_Score=192, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6321594, Length=333, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24643623, Length=350, Percent_Identity=34.5714285714286, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI20129101, Length=350, Percent_Identity=34.5714285714286, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 36438; Mature: 36307

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFHPSVLEAIGNTPLIKLKGASAATGCTILGKAEFLNPGQSVKDRAALYIIRDAERKGL
CCCCHHHHHHHCCCCEEEEECCCCCCCEEEEECHHHCCCCCCCCCCEEEEEEEECCCCCC
LRPGGVIVEGTAGNTGIGLTLVAKALGYRTVIVIPETQSQEKKDALKLLGAELVEVPAVP
CCCCCEEEECCCCCCCCHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCC
YKNPNNYVKVSGRLAEQLAKTEPNGAIWANQFDNVANRQAHIETTAREIWNDTDGKVDGF
CCCCCCEEEECHHHHHHHHHCCCCCCEECCHHHHHHCCHHHHHHHHHHHHCCCCCCCCEE
ICSVGSGGTLAGVAAGLKAFNANVKIGIADPEGAALYEFYQNGTLKSEGSSITEGIGQGR
EEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHCCCCE
VTANLEGFTPDFSYRVSDAEALPYLFDLVENEGLCLGGSTAINIAGAVKLARDLGPGHTV
EEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCEEECCCCEEEHHHHHHHHHHCCCCCEE
VTILCDYGNRYQSKLFNPDFLTSKGLPVPGWMAKSPEIDVPYEPA
EEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TFHPSVLEAIGNTPLIKLKGASAATGCTILGKAEFLNPGQSVKDRAALYIIRDAERKGL
CCCHHHHHHHCCCCEEEEECCCCCCCEEEEECHHHCCCCCCCCCCEEEEEEEECCCCCC
LRPGGVIVEGTAGNTGIGLTLVAKALGYRTVIVIPETQSQEKKDALKLLGAELVEVPAVP
CCCCCEEEECCCCCCCCHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCC
YKNPNNYVKVSGRLAEQLAKTEPNGAIWANQFDNVANRQAHIETTAREIWNDTDGKVDGF
CCCCCCEEEECHHHHHHHHHCCCCCCEECCHHHHHHCCHHHHHHHHHHHHCCCCCCCCEE
ICSVGSGGTLAGVAAGLKAFNANVKIGIADPEGAALYEFYQNGTLKSEGSSITEGIGQGR
EEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHCCCCE
VTANLEGFTPDFSYRVSDAEALPYLFDLVENEGLCLGGSTAINIAGAVKLARDLGPGHTV
EEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCEEECCCCEEEHHHHHHHHHHCCCCCEE
VTILCDYGNRYQSKLFNPDFLTSKGLPVPGWMAKSPEIDVPYEPA
EEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]