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The map label for this gene is phhA [H]

Identifier: 209549006

GI number: 209549006

Start: 1424165

End: 1424956

Strand: Reverse

Name: phhA [H]

Synonym: Rleg2_1403

Alternate gene names: 209549006

Gene position: 1424956-1424165 (Counterclockwise)

Preceding gene: 209549008

Following gene: 209548998

Centisome position: 31.4

GC content: 60.73

Gene sequence:

>792_bases
ATGACCAAGGAAAGCAGCTACACCGCCAAATTGCCCGGCCCGGACCGCCTTTATGACTACACAGCCGAGGAAGATGCGAT
CTGGGGCGAACTCTACCGGCGCCAGATGAAGATGCTGGCCGATACCGCCTGCCGCGAATATCTGGACGGCGTCACGCTGC
TGGGGCTCAAGCCGGAGAAAGTGCCGCAGCTTCTCGATGTGAACAGACGCCTGAACGAGACCACCGGCTTCGGCGTCGAA
GGCGTGCCGGCGCTCATTCCGCCCTCGCGCTTTTACGAGCTTCTGTCGCAAGGCAAATTCCCGCTGGCAACCTTCCTGCG
CCGCCGCGAGCATATCGACTATATCGAGGAACCGGACCTGTTCCACGAGGTGTTCGGCCACTGCCCGCTGCTGACCAACC
AGAGCTATGCCAATTTCGTCCGGCATTTCGGCGAAACTGCCGTCCGCCTCGGCAAAGGTTACTCCTGGCATCTGTTCCGG
ATCTTCTGGTTCACCGTCGAATTCGGGCTGATCAACACGCCGCAGGGGCGCCGCTGCTTCGGCGCGGGCATCGTCTCATC
ACCAAGCGAAGCGAAGGCGGCAACCGAAGGCACGGCCTGCGAGTTTCGGCCGTTCGATCTGCTGAGCGTGCTGAGGACGC
CCTACCGCATCGATATTCTCCAGCCGATCTACTACGTCATCGACAGCTTCGCCGATCTGGAGGCGATCGTGGAGCAGGAT
ATCGAGGGCACGATCCTCAAGGCGAAATCGCTCGGTGATTTCGCTCCCGCTTTCGAAGCCAAGGCTTCGTAA

Upstream 100 bases:

>100_bases
TTGCCACCATTATCGCAAGATCCAAGATGAAAGAAAAGAAAATCCGCAAATGCTGGAGGATAATGACAGCCATGTCGTCA
TGTTCCGGGAGGATCAGCCT

Downstream 100 bases:

>100_bases
ACGCCGACGGAGCGAACGAGGGTGGGGATTGACGATCTCTTCCCTCTCACTTCGGAGCGGCAGAACTTCGATCGACGAAA
TCCACCAGGACGCCCGGCTT

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MTKESSYTAKLPGPDRLYDYTAEEDAIWGELYRRQMKMLADTACREYLDGVTLLGLKPEKVPQLLDVNRRLNETTGFGVE
GVPALIPPSRFYELLSQGKFPLATFLRRREHIDYIEEPDLFHEVFGHCPLLTNQSYANFVRHFGETAVRLGKGYSWHLFR
IFWFTVEFGLINTPQGRRCFGAGIVSSPSEAKAATEGTACEFRPFDLLSVLRTPYRIDILQPIYYVIDSFADLEAIVEQD
IEGTILKAKSLGDFAPAFEAKAS

Sequences:

>Translated_263_residues
MTKESSYTAKLPGPDRLYDYTAEEDAIWGELYRRQMKMLADTACREYLDGVTLLGLKPEKVPQLLDVNRRLNETTGFGVE
GVPALIPPSRFYELLSQGKFPLATFLRRREHIDYIEEPDLFHEVFGHCPLLTNQSYANFVRHFGETAVRLGKGYSWHLFR
IFWFTVEFGLINTPQGRRCFGAGIVSSPSEAKAATEGTACEFRPFDLLSVLRTPYRIDILQPIYYVIDSFADLEAIVEQD
IEGTILKAKSLGDFAPAFEAKAS
>Mature_262_residues
TKESSYTAKLPGPDRLYDYTAEEDAIWGELYRRQMKMLADTACREYLDGVTLLGLKPEKVPQLLDVNRRLNETTGFGVEG
VPALIPPSRFYELLSQGKFPLATFLRRREHIDYIEEPDLFHEVFGHCPLLTNQSYANFVRHFGETAVRLGKGYSWHLFRI
FWFTVEFGLINTPQGRRCFGAGIVSSPSEAKAATEGTACEFRPFDLLSVLRTPYRIDILQPIYYVIDSFADLEAIVEQDI
EGTILKAKSLGDFAPAFEAKAS

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4759248, Length=218, Percent_Identity=35.3211009174312, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI88900503, Length=218, Percent_Identity=33.4862385321101, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI88900505, Length=218, Percent_Identity=33.4862385321101, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI88900501, Length=218, Percent_Identity=33.4862385321101, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI31795563, Length=218, Percent_Identity=33.9449541284404, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI4557819, Length=223, Percent_Identity=31.390134529148, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17531391, Length=216, Percent_Identity=31.4814814814815, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71980736, Length=218, Percent_Identity=30.2752293577982, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI115532103, Length=233, Percent_Identity=27.4678111587983, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI115533973, Length=233, Percent_Identity=27.8969957081545, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71980731, Length=149, Percent_Identity=27.5167785234899, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24660393, Length=229, Percent_Identity=33.1877729257642, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI62472054, Length=229, Percent_Identity=33.1877729257642, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17136776, Length=235, Percent_Identity=30.2127659574468, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17136774, Length=235, Percent_Identity=30.2127659574468, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24654994, Length=218, Percent_Identity=31.1926605504587, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 29851; Mature: 29720

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKESSYTAKLPGPDRLYDYTAEEDAIWGELYRRQMKMLADTACREYLDGVTLLGLKPEK
CCCCCCCEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHH
VPQLLDVNRRLNETTGFGVEGVPALIPPSRFYELLSQGKFPLATFLRRREHIDYIEEPDL
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHH
FHEVFGHCPLLTNQSYANFVRHFGETAVRLGKGYSWHLFRIFWFTVEFGLINTPQGRRCF
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEE
GAGIVSSPSEAKAATEGTACEFRPFDLLSVLRTPYRIDILQPIYYVIDSFADLEAIVEQD
CCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IEGTILKAKSLGDFAPAFEAKAS
CCCEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TKESSYTAKLPGPDRLYDYTAEEDAIWGELYRRQMKMLADTACREYLDGVTLLGLKPEK
CCCCCCEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHH
VPQLLDVNRRLNETTGFGVEGVPALIPPSRFYELLSQGKFPLATFLRRREHIDYIEEPDL
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHH
FHEVFGHCPLLTNQSYANFVRHFGETAVRLGKGYSWHLFRIFWFTVEFGLINTPQGRRCF
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEE
GAGIVSSPSEAKAATEGTACEFRPFDLLSVLRTPYRIDILQPIYYVIDSFADLEAIVEQD
CCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IEGTILKAKSLGDFAPAFEAKAS
CCCEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]