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The map label for this gene is degS [H]

Identifier: 209548993

GI number: 209548993

Start: 1412434

End: 1413822

Strand: Reverse

Name: degS [H]

Synonym: Rleg2_1390

Alternate gene names: 209548993

Gene position: 1413822-1412434 (Counterclockwise)

Preceding gene: 209548994

Following gene: 209548992

Centisome position: 31.16

GC content: 60.4

Gene sequence:

>1389_bases
ATGAATTGGCTTCGCCGCTGGAATGCCCGCTCACTCGCCTCGCAGTTCTTCATCGCGGGTGGTTTGATCTCGATTGCCGC
CATGTTCCTGGTGGGCCTTCTCGTCACCCATCTCATCGAGGAGGCAGTCATCTACAATTCCGGTGCCGCGACGGCACTCT
ATGTCGACAGCGTTGTCGCGCCGCTGCTTCCCGACATGCAAACGGCATCATTCCTGGACGAAGGCAGCGCCCAGGCTCTG
GACGAAACGCTTGGTCAGGGCGCGCTCGGCAGGCGGCTTGTTTCGTTCAAGCTGTGGCGAAGCGACGGCACCGTTCTCTA
CTCGAACGAAAAGGAACTTGTGGGAAAGACGTTTGCGGTCAACGACAAGCTTCGAAAAGCCTTCGCAGGCTCTCTCGTTG
CGCGCTACGAAATCGCCGACGATCCGGAAAGCGAAAAGGAGCGTGCGCTCGGCAAGCCGCTGATGGAAATCTACAACCCT
GTGCTCCAACCATGGTCCGGACAGGCCGTCGCCGTCATTGAATTCTACGAGACCGCGCAAGGACTAGGCGACAGTTTGAC
CAATGCCAGGCTCCGGAGCTGGGCCGCAGTCGCCGCTCTGACGGCAATCTTTTTCCTTATTCTCGCCGTCCTGGTGTTTC
GGGTCAGCCGCACGATCGAGGCGCAACGGAAGGATCTCAAGGAACGGGTCAACGACCTGTCTGCGCTGCTGGCGGAAAAC
CGCGGGCTGCAGCGGCGGCTGCAGCGCGCCTCCCAGCGCGTAGCGGCGCTGAACGAAACATATCTGCGCAGCATCGGCGC
CGATCTGCACGACGGTCCGGCCCAGCACATTGCCTATGCCTCACTGCGGCTGGACAGCGATATGTTGATCAATGCGTCGA
CCCCCCCCGAAGCACGCGAAAAGGAGCTCGCGTGGATACGTTCGAGCCTTGCCGAGGCGATGACCGAGATCCGTAACATC
TGCAGCGGGCTGGTGCTCCCGCAGATCGAGAAGTCCTCGATCACCGAGATCGTCGCCCGTGTGGTCGAAGCGCATCAGCA
CAAGACCGAAACCCGTGTCGAAACAATTATCGACGACGATGGACCCGAACCCGCGCCTGCCGTAAAGATCTGTATCTATC
GCTTCGTTCAGGAAGCCTTGAACAATGCCTATCGCCATGGCGGCGGTATTCAGCAGACCGTAAGCGCCGTCTCGCACAAC
GGACATGTTCATGTCGAGGTCAGCGACCGCGGCGATGGCTTCGACCCGATGGAGGTGAGGCCGACAAGCCTCGGCCTGGT
GGGGCTGCGCGAACGGATCGACAGTCTGGGAGGATCCTTCGACGTGAAGACGGGCGAAGGAGGGACGACGGTGACCATGA
CCTTCGAGCCTATGGAAGTGGGAGATTAG

Upstream 100 bases:

>100_bases
AGGCGCCGAAATCTTCGATACCAGGGATGTCCCCTGACGCCGTCTGGAAAAATTTCGAGGAAGCGATAGGTTAGTCGGCA
AGTCTCTTACCGGTATCACA

Downstream 100 bases:

>100_bases
ACATGACATCCATCACGATCGGCGTCGTGGACGACCATCCGCTTTTTCGCGAGGGCGTAACCCGGAGCCTCTCCGAGATC
AGCGACTTTGCCGTCGTTGG

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MNWLRRWNARSLASQFFIAGGLISIAAMFLVGLLVTHLIEEAVIYNSGAATALYVDSVVAPLLPDMQTASFLDEGSAQAL
DETLGQGALGRRLVSFKLWRSDGTVLYSNEKELVGKTFAVNDKLRKAFAGSLVARYEIADDPESEKERALGKPLMEIYNP
VLQPWSGQAVAVIEFYETAQGLGDSLTNARLRSWAAVAALTAIFFLILAVLVFRVSRTIEAQRKDLKERVNDLSALLAEN
RGLQRRLQRASQRVAALNETYLRSIGADLHDGPAQHIAYASLRLDSDMLINASTPPEAREKELAWIRSSLAEAMTEIRNI
CSGLVLPQIEKSSITEIVARVVEAHQHKTETRVETIIDDDGPEPAPAVKICIYRFVQEALNNAYRHGGGIQQTVSAVSHN
GHVHVEVSDRGDGFDPMEVRPTSLGLVGLRERIDSLGGSFDVKTGEGGTTVTMTFEPMEVGD

Sequences:

>Translated_462_residues
MNWLRRWNARSLASQFFIAGGLISIAAMFLVGLLVTHLIEEAVIYNSGAATALYVDSVVAPLLPDMQTASFLDEGSAQAL
DETLGQGALGRRLVSFKLWRSDGTVLYSNEKELVGKTFAVNDKLRKAFAGSLVARYEIADDPESEKERALGKPLMEIYNP
VLQPWSGQAVAVIEFYETAQGLGDSLTNARLRSWAAVAALTAIFFLILAVLVFRVSRTIEAQRKDLKERVNDLSALLAEN
RGLQRRLQRASQRVAALNETYLRSIGADLHDGPAQHIAYASLRLDSDMLINASTPPEAREKELAWIRSSLAEAMTEIRNI
CSGLVLPQIEKSSITEIVARVVEAHQHKTETRVETIIDDDGPEPAPAVKICIYRFVQEALNNAYRHGGGIQQTVSAVSHN
GHVHVEVSDRGDGFDPMEVRPTSLGLVGLRERIDSLGGSFDVKTGEGGTTVTMTFEPMEVGD
>Mature_462_residues
MNWLRRWNARSLASQFFIAGGLISIAAMFLVGLLVTHLIEEAVIYNSGAATALYVDSVVAPLLPDMQTASFLDEGSAQAL
DETLGQGALGRRLVSFKLWRSDGTVLYSNEKELVGKTFAVNDKLRKAFAGSLVARYEIADDPESEKERALGKPLMEIYNP
VLQPWSGQAVAVIEFYETAQGLGDSLTNARLRSWAAVAALTAIFFLILAVLVFRVSRTIEAQRKDLKERVNDLSALLAEN
RGLQRRLQRASQRVAALNETYLRSIGADLHDGPAQHIAYASLRLDSDMLINASTPPEAREKELAWIRSSLAEAMTEIRNI
CSGLVLPQIEKSSITEIVARVVEAHQHKTETRVETIIDDDGPEPAPAVKICIYRFVQEALNNAYRHGGGIQQTVSAVSHN
GHVHVEVSDRGDGFDPMEVRPTSLGLVGLRERIDSLGGSFDVKTGEGGTTVTMTFEPMEVGD

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=231, Percent_Identity=25.974025974026, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50587; Mature: 50587

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWLRRWNARSLASQFFIAGGLISIAAMFLVGLLVTHLIEEAVIYNSGAATALYVDSVVA
CCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
PLLPDMQTASFLDEGSAQALDETLGQGALGRRLVSFKLWRSDGTVLYSNEKELVGKTFAV
HHCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHEEEECCCCEEECCCHHHHCCHHHH
NDKLRKAFAGSLVARYEIADDPESEKERALGKPLMEIYNPVLQPWSGQAVAVIEFYETAQ
HHHHHHHHHHHHHHEEECCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEEHHHHHH
GLGDSLTNARLRSWAAVAALTAIFFLILAVLVFRVSRTIEAQRKDLKERVNDLSALLAEN
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RGLQRRLQRASQRVAALNETYLRSIGADLHDGPAQHIAYASLRLDSDMLINASTPPEARE
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEECCCEEEECCCCCHHHH
KELAWIRSSLAEAMTEIRNICSGLVLPQIEKSSITEIVARVVEAHQHKTETRVETIIDDD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPEPAPAVKICIYRFVQEALNNAYRHGGGIQQTVSAVSHNGHVHVEVSDRGDGFDPMEVR
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
PTSLGLVGLRERIDSLGGSFDVKTGEGGTTVTMTFEPMEVGD
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MNWLRRWNARSLASQFFIAGGLISIAAMFLVGLLVTHLIEEAVIYNSGAATALYVDSVVA
CCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
PLLPDMQTASFLDEGSAQALDETLGQGALGRRLVSFKLWRSDGTVLYSNEKELVGKTFAV
HHCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHEEEECCCCEEECCCHHHHCCHHHH
NDKLRKAFAGSLVARYEIADDPESEKERALGKPLMEIYNPVLQPWSGQAVAVIEFYETAQ
HHHHHHHHHHHHHHEEECCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEEHHHHHH
GLGDSLTNARLRSWAAVAALTAIFFLILAVLVFRVSRTIEAQRKDLKERVNDLSALLAEN
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RGLQRRLQRASQRVAALNETYLRSIGADLHDGPAQHIAYASLRLDSDMLINASTPPEARE
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEECCCEEEECCCCCHHHH
KELAWIRSSLAEAMTEIRNICSGLVLPQIEKSSITEIVARVVEAHQHKTETRVETIIDDD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPEPAPAVKICIYRFVQEALNNAYRHGGGIQQTVSAVSHNGHVHVEVSDRGDGFDPMEVR
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
PTSLGLVGLRERIDSLGGSFDVKTGEGGTTVTMTFEPMEVGD
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]