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The map label for this gene is ilvD [H]

Identifier: 209548964

GI number: 209548964

Start: 1379692

End: 1381530

Strand: Direct

Name: ilvD [H]

Synonym: Rleg2_1361

Alternate gene names: 209548964

Gene position: 1379692-1381530 (Clockwise)

Preceding gene: 209548961

Following gene: 209548967

Centisome position: 30.4

GC content: 63.95

Gene sequence:

>1839_bases
ATGCCAGCCTACCGTTCCAGAACCACGACCCACGGCCGCAACATGGCAGGCGCGCGCGGCCTTTGGCGCGCCACGGGCAT
GAAGGATTCGGATTTCGGCAAGCCGATTATCGCGGTGGTGAATTCTTTCACCCAGTTCGTACCCGGCCACGTGCACCTGA
AGGACCTCGGCCAGCTCGTTGCCCGCGAAATCGAGGCGGCCGGCGGTGTCGCCAAGGAATTCAACACGATCGCCGTCGAC
GACGGCATCGCCATGGGCCATGACGGCATGCTCTATTCGCTGCCCTCGCGCGAACTCATCGCCGACAGCGTCGAATACAT
GGTCAATGCCCATTGCGCCGACGCCATGGTCTGCATCTCCAATTGCGACAAGATCACCCCCGGCATGCTGATGGCGTCGT
TGCGCCTCAACATACCCACAGTCTTCGTCTCGGGCGGCCCGATGGAAGCGGGCAAGGTGGTGCTGCACGGCAAGACGCAT
GCACTCGACCTCGTCGATGCCATGGTCGCCGCAGCCGATGAAAAGATCAGTGACGAGGACGTTCAGACCATCGAGCGCTC
GGCCTGTCCGACCTGCGGCTCCTGCTCCGGCATGTTTACCGCCAATTCGATGAACTGCCTGACCGAGGCGCTCGGCCTGT
CGCTGCCCGGCAACGGTTCGACGCTCGCAACCCACGCCGACCGCAAGCGCCTCTTCGTCGAGGCCGGTCATCTGATCGTC
GATCTCGCCCGCCGTTACTACGAGCAGGACGATATCAAGGCGCTGCCGCGCACCATCGCCTCCAAGCAGGCCTTCGAGAA
TGCCATGGCGCTCGATATCGCCATGGGCGGCTCGACCAATACGGTCCTGCACATCCTTGCTGCTGCCCATGAAGGCGAAA
TCGATTTCACCATGGCCGATATCGACGCGCTCTCGCGCCGAGTGCCCTGCCTGTCGAAGGTCGCACCCGCCAAGAGCGAT
GTTCATATGGAAGACGTGCACCGCGCCGGCGGCATCATGTCGATCCTCGGAGAGCTCGATAAGGGCGGTCTCTTGAACCG
CAATTGCCCGACAGTGCATGCCGAGACGCTGGGCGATGCGATCGACCGCTGGGATATCACCCGCACCACCAGCGAAACGG
TCCGCAACTTCTATCGTGCCGCACCCGGCGGCATCCCGACCCAGGTTGCCTTCAGCCAGGAGGCCCGCTGGGACGAACTC
GACACCGACCGCCAGAATGGCGTCATCCGCTCGGTCGAACATCCTTTCTCTAGGGATGGCGGCCTTGCCGTGCTCAAGGG
CAATCTCGCGGTCGACGGATGCATCGTCAAGACGGCCGGCGTCGATGAATCGATCCTGAAATTTTCAGGCCCGGCCCGTG
TCTTCGAAAGCCAGGATGCCTCCGTGAAGGCGATCCTCGCCAACGAAGTGAAGGCCGGCGACGTCGTCGTCATTCGCTAC
GAAGGCCCGAAGGGCGGCCCCGGCATGCAGGAAATGCTCTATCCGACGAGCTATCTGAAGTCGAAGGGCCTCGGCAAGGC
GTGCGCGCTGATCACCGACGGCCGCTTCTCCGGCGGTACCTCCGGCCTCTCGATCGGCCACGCCTCGCCGGAAGCGGCCA
ATGGCGGTACGATCGGCCTGGTGCGCGAAGGCGACATGATCGACATCGACATCCCGAACCGCACGATCAGCCTGCGCGTG
GATGAGGCCGAACTCGCCGCCCGCCGCGCCGATCAGGACGCCAAGGGCTGGCATCCCGCAGAAGTGCGCAAGCGCAACGT
CACGACGGCGCTGAAGGCTTATGCTGCCTTTGCGACGAGCGCGGACCGCGGCGCCGTGCGCGATCTGAACGCCCGCTGA

Upstream 100 bases:

>100_bases
GATTGGATTAGGACAATTCCAAACAGCAGCGTTGCCCGGCCGCAGGCTCAATGCCGCCCCGTTTCGCCTGATGATCTCCG
ACACGTCGAGGAAGATACCG

Downstream 100 bases:

>100_bases
CGCGCGTCAATCGATAGTCTTTTCGACCGGTCGCTTTCAAAGCGGCCGGTTGATGTTTTTATAGCTCTCGCCGAGTTGCT
TCAGCCGCTCGTCATAGGCA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPTVFVSGGPMEAGKVVLHGKTH
ALDLVDAMVAAADEKISDEDVQTIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
DLARRYYEQDDIKALPRTIASKQAFENAMALDIAMGGSTNTVLHILAAAHEGEIDFTMADIDALSRRVPCLSKVAPAKSD
VHMEDVHRAGGIMSILGELDKGGLLNRNCPTVHAETLGDAIDRWDITRTTSETVRNFYRAAPGGIPTQVAFSQEARWDEL
DTDRQNGVIRSVEHPFSRDGGLAVLKGNLAVDGCIVKTAGVDESILKFSGPARVFESQDASVKAILANEVKAGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAANGGTIGLVREGDMIDIDIPNRTISLRV
DEAELAARRADQDAKGWHPAEVRKRNVTTALKAYAAFATSADRGAVRDLNAR

Sequences:

>Translated_612_residues
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPTVFVSGGPMEAGKVVLHGKTH
ALDLVDAMVAAADEKISDEDVQTIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
DLARRYYEQDDIKALPRTIASKQAFENAMALDIAMGGSTNTVLHILAAAHEGEIDFTMADIDALSRRVPCLSKVAPAKSD
VHMEDVHRAGGIMSILGELDKGGLLNRNCPTVHAETLGDAIDRWDITRTTSETVRNFYRAAPGGIPTQVAFSQEARWDEL
DTDRQNGVIRSVEHPFSRDGGLAVLKGNLAVDGCIVKTAGVDESILKFSGPARVFESQDASVKAILANEVKAGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAANGGTIGLVREGDMIDIDIPNRTISLRV
DEAELAARRADQDAKGWHPAEVRKRNVTTALKAYAAFATSADRGAVRDLNAR
>Mature_611_residues
PAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPTVFVSGGPMEAGKVVLHGKTHA
LDLVDAMVAAADEKISDEDVQTIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIVD
LARRYYEQDDIKALPRTIASKQAFENAMALDIAMGGSTNTVLHILAAAHEGEIDFTMADIDALSRRVPCLSKVAPAKSDV
HMEDVHRAGGIMSILGELDKGGLLNRNCPTVHAETLGDAIDRWDITRTTSETVRNFYRAAPGGIPTQVAFSQEARWDELD
TDRQNGVIRSVEHPFSRDGGLAVLKGNLAVDGCIVKTAGVDESILKFSGPARVFESQDASVKAILANEVKAGDVVVIRYE
GPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAANGGTIGLVREGDMIDIDIPNRTISLRVD
EAELAARRADQDAKGWHPAEVRKRNVTTALKAYAAFATSADRGAVRDLNAR

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=611, Percent_Identity=75.1227495908347, Blast_Score=947, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=538, Percent_Identity=30.4832713754647, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI1786464, Length=535, Percent_Identity=31.0280373831776, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI2367371, Length=566, Percent_Identity=29.5053003533569, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322476, Length=610, Percent_Identity=36.7213114754098, Blast_Score=343, Evalue=3e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65216; Mature: 65085

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPTVFVSGGPMEAGKVVLHGKTHALDLVDAMVAAADEKISDED
CCCCCCHHHHHHHHEECCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHH
VQTIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
DLARRYYEQDDIKALPRTIASKQAFENAMALDIAMGGSTNTVLHILAAAHEGEIDFTMAD
HHHHHHHCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHEEEHHCCCCCEEEEEHH
IDALSRRVPCLSKVAPAKSDVHMEDVHRAGGIMSILGELDKGGLLNRNCPTVHAETLGDA
HHHHHHCCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHCCCCCCCCCCCCCEEEHHHHHHH
IDRWDITRTTSETVRNFYRAAPGGIPTQVAFSQEARWDELDTDRQNGVIRSVEHPFSRDG
HHHCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHCCCEEECCCCCCCCC
GLAVLKGNLAVDGCIVKTAGVDESILKFSGPARVFESQDASVKAILANEVKAGDVVVIRY
CEEEEECCEEECEEEEEECCCCHHHHHCCCCHHHHCCCCCCEEEEEECCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAANGGTIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEE
VREGDMIDIDIPNRTISLRVDEAELAARRADQDAKGWHPAEVRKRNVTTALKAYAAFATS
EECCCEEEEECCCCEEEEEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
ADRGAVRDLNAR
CCCCCCCCCCCC
>Mature Secondary Structure 
PAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPTVFVSGGPMEAGKVVLHGKTHALDLVDAMVAAADEKISDED
CCCCCCHHHHHHHHEECCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHH
VQTIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
DLARRYYEQDDIKALPRTIASKQAFENAMALDIAMGGSTNTVLHILAAAHEGEIDFTMAD
HHHHHHHCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHEEEHHCCCCCEEEEEHH
IDALSRRVPCLSKVAPAKSDVHMEDVHRAGGIMSILGELDKGGLLNRNCPTVHAETLGDA
HHHHHHCCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHCCCCCCCCCCCCCEEEHHHHHHH
IDRWDITRTTSETVRNFYRAAPGGIPTQVAFSQEARWDELDTDRQNGVIRSVEHPFSRDG
HHHCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHCCCEEECCCCCCCCC
GLAVLKGNLAVDGCIVKTAGVDESILKFSGPARVFESQDASVKAILANEVKAGDVVVIRY
CEEEEECCEEECEEEEEECCCCHHHHHCCCCHHHHCCCCCCEEEEEECCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHASPEAANGGTIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEE
VREGDMIDIDIPNRTISLRVDEAELAARRADQDAKGWHPAEVRKRNVTTALKAYAAFATS
EECCCEEEEECCCCEEEEEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
ADRGAVRDLNAR
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA