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The map label for this gene is adk [H]

Identifier: 209548956

GI number: 209548956

Start: 1373577

End: 1374227

Strand: Direct

Name: adk [H]

Synonym: Rleg2_1353

Alternate gene names: 209548956

Gene position: 1373577-1374227 (Clockwise)

Preceding gene: 209548955

Following gene: 209548957

Centisome position: 30.27

GC content: 61.14

Gene sequence:

>651_bases
ATGAGACTTATCCTTTTAGGGCCGCCGGGCGCGGGTAAGGGAACCCAGGCCCAGCGGATCGTGGAAAAGCACGGCATTCC
GCAGCTTTCCACGGGGGACATGCTGCGCGCAGCGGTAAACGCCGGCACGGATGTCGGCAAGCGCGCCAAGGCGGTGATGG
ATGCCGGCAAACTTGTCTCGGATGAGATCGTTATTGCCATCGTCTCCGAGCGAATCGATCAACCCGATTGCGCCAACGGC
TTCATTCTCGACGGTTTCCCCCGGACGCTCGTCCAGGCGGACGCCACCGAAGCGATGCTGAGGGCGAAGGGTCTCGGCCT
CTCCGTCGTCATCGAATTCCGTGTCGACGATGACGAACTGGTCCGCCGTGTCGCCGGCCGCTACTCCTGCGCCCAGTGCG
GCAGCGTCTATCACGATACCGATAAGGTTCCGGCCGCCGAAGGCGTCTGCGACAAGTGCGGTTCCACGCACTTCAAGCGC
CGTCCCGACGACAATCCGGAGACCATGACGGCTCGGCTGCAGGTCTATTACAAGGAAACCTCGCCGCTGATCGGCTATTA
CCATGCCAAGGGCAAACTCAGGTCCGTGGACGGCATGGCGGAAATCGATCAGGTGACGGCCGAGGTCGAAAACATTCTTT
CCAAGCTTTAA

Upstream 100 bases:

>100_bases
TAACTCTTGATACGGTTGCACAGATCCAGGGTCACCTGATCGCGCAGCAATACGAAGGCCTGATCAAGAAATCGAAGTTG
CGTGGAGGAAAGAGGGGGCG

Downstream 100 bases:

>100_bases
GGCTTTGAAAATAAACTTGGCGGAACGGTTGCTTTTCAGCAGTGATTCCGCTAAACACCGCGCCAACTCGCGACATTCCA
TGCGATCGGCGCGGATTTCC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MRLILLGPPGAGKGTQAQRIVEKHGIPQLSTGDMLRAAVNAGTDVGKRAKAVMDAGKLVSDEIVIAIVSERIDQPDCANG
FILDGFPRTLVQADATEAMLRAKGLGLSVVIEFRVDDDELVRRVAGRYSCAQCGSVYHDTDKVPAAEGVCDKCGSTHFKR
RPDDNPETMTARLQVYYKETSPLIGYYHAKGKLRSVDGMAEIDQVTAEVENILSKL

Sequences:

>Translated_216_residues
MRLILLGPPGAGKGTQAQRIVEKHGIPQLSTGDMLRAAVNAGTDVGKRAKAVMDAGKLVSDEIVIAIVSERIDQPDCANG
FILDGFPRTLVQADATEAMLRAKGLGLSVVIEFRVDDDELVRRVAGRYSCAQCGSVYHDTDKVPAAEGVCDKCGSTHFKR
RPDDNPETMTARLQVYYKETSPLIGYYHAKGKLRSVDGMAEIDQVTAEVENILSKL
>Mature_216_residues
MRLILLGPPGAGKGTQAQRIVEKHGIPQLSTGDMLRAAVNAGTDVGKRAKAVMDAGKLVSDEIVIAIVSERIDQPDCANG
FILDGFPRTLVQADATEAMLRAKGLGLSVVIEFRVDDDELVRRVAGRYSCAQCGSVYHDTDKVPAAEGVCDKCGSTHFKR
RPDDNPETMTARLQVYYKETSPLIGYYHAKGKLRSVDGMAEIDQVTAEVENILSKL

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=43.7209302325581, Blast_Score=187, Evalue=7e-48,
Organism=Homo sapiens, GI4502013, Length=215, Percent_Identity=43.7209302325581, Blast_Score=187, Evalue=9e-48,
Organism=Homo sapiens, GI19923437, Length=213, Percent_Identity=32.8638497652582, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI310110345, Length=214, Percent_Identity=31.7757009345794, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI53832003, Length=214, Percent_Identity=31.7757009345794, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI8051579, Length=214, Percent_Identity=31.7757009345794, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI53832001, Length=214, Percent_Identity=31.7757009345794, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI4502011, Length=208, Percent_Identity=31.25, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI7706497, Length=218, Percent_Identity=31.1926605504587, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI28144899, Length=200, Percent_Identity=28, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI28144897, Length=200, Percent_Identity=28, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI22749187, Length=187, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=52.7522935779816, Blast_Score=213, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI17552384, Length=216, Percent_Identity=42.5925925925926, Blast_Score=177, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17567503, Length=215, Percent_Identity=31.6279069767442, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17537943, Length=201, Percent_Identity=29.8507462686567, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17550688, Length=213, Percent_Identity=26.7605633802817, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=216, Percent_Identity=40.2777777777778, Blast_Score=169, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321018, Length=200, Percent_Identity=33, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322828, Length=215, Percent_Identity=27.906976744186, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=43.8679245283019, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=36.1809045226131, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=36.1809045226131, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17647141, Length=208, Percent_Identity=31.7307692307692, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24663208, Length=208, Percent_Identity=31.7307692307692, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221459597, Length=212, Percent_Identity=27.8301886792453, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356893, Length=212, Percent_Identity=27.8301886792453, Blast_Score=88, Evalue=4e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23375; Mature: 23375

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGPPGAGKGTQAQRIVEKHGIPQLSTGDMLRAAVNAGTDVGKRAKAVMDAGKLVS
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHC
DEIVIAIVSERIDQPDCANGFILDGFPRTLVQADATEAMLRAKGLGLSVVIEFRVDDDEL
HHHHEEEHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEECHHHH
VRRVAGRYSCAQCGSVYHDTDKVPAAEGVCDKCGSTHFKRRPDDNPETMTARLQVYYKET
HHHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHEEEEEEEEEECC
SPLIGYYHAKGKLRSVDGMAEIDQVTAEVENILSKL
CCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGPPGAGKGTQAQRIVEKHGIPQLSTGDMLRAAVNAGTDVGKRAKAVMDAGKLVS
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCHHC
DEIVIAIVSERIDQPDCANGFILDGFPRTLVQADATEAMLRAKGLGLSVVIEFRVDDDEL
HHHHEEEHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEECHHHH
VRRVAGRYSCAQCGSVYHDTDKVPAAEGVCDKCGSTHFKRRPDDNPETMTARLQVYYKET
HHHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHEEEEEEEEEECC
SPLIGYYHAKGKLRSVDGMAEIDQVTAEVENILSKL
CCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA