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The map label for this gene is pyrC [H]

Identifier: 209548901

GI number: 209548901

Start: 1321032

End: 1322336

Strand: Reverse

Name: pyrC [H]

Synonym: Rleg2_1298

Alternate gene names: 209548901

Gene position: 1322336-1321032 (Counterclockwise)

Preceding gene: 209548902

Following gene: 209548900

Centisome position: 29.14

GC content: 64.9

Gene sequence:

>1305_bases
ATGAGCAACCCGATCGTCCTCCAGAACGTCCGCATCGTCGATCCCTCGCGCAATCTCGACGAGGTGGGCACGATCATCGC
CGCAAACGGCGTGATCCTTGCTGCCGGAAGCGCCGCGCAGAACCAGGGCGCACCCGAAGGTGCCGATATCCGCGACTGCA
CCGGCCTTGTCGCCACACCGGGCCTCGTCGATGCGCGCGTCCATATCGGCGAACCCGGCGGCGAGCACCGCGAGACGATC
GCCTCGGCAAGCCGGGCAGCGGCCGCCGGCGGCGTCACCTCGATCATCATGATGCCGGACACAGATCCCGTGATCGACGA
CATCGCCCTCGTCGAATTCGTCAAGAAGACGGCGCGCGATACCGCCGCCGTCAACGTCTATCCGGCCGCCGCCCTCACCA
AGGGACTTTCCGGCGAGGAAATGACCGAGATCGGCCTGCTGATGCAGGCAGGCGCCGTCGCCTTCACCGATGCCCATTCC
AGCGTCCACGATACGCAGGTGCTGCGCCGGATCATGACCTATGCGCGCGAATTCGGCGCCGTCATCTGCTGCGAAACCCG
CGACAAATATCTCGGCGCCAACGGCGTCATGCATGAGGGGCTTTTCGCCAGCTGGCTCGGGCTCTCCGGCATTCCAAGAG
AAGCCGAGCTCATCCCGCTCGAACGCGATCTCAGGATCGCAGAGCTGACACGCGGGCGTTATCATGCCGCGATGATCTCG
GTGCCGCAATCGGTCGAGGCGATCGAACGCGCCCGCAGCCGTGGCGCCAAAGTGACCTCGGGCATCTCGATCAACAATCT
GGCGCTCAACGAAAACGACATCGGCGAATATCGCACCTTCTTCAAGCTCTATCCGCCGCTGCGCCCGGAAGACGACCGGG
TCGCCATGGTCGAGGCGCTGGCAAGCGGCGCGATCGATATCATCGTCTCCTCGCACGACCCGCAGGACGTCGATACGAAG
CGCCTGCCCTTCGGCGAGGCTGAAGACGGCGCGGTCGGCCTCGAAACCATGCTGGCGGCGGCTCTCAGGCTTCACCATGG
CGGCCAGGTGAGCCTGATGCGCCTGATCGACGCCATGTCCACCCGCCCGGCCGAGATTTTCGGCCTCCCCGCCGGCACGC
TGAAGCCGGGGGCTGCGGCCGATATCGCGCTGATCGATCTCGATGAGCCTTGGCTTGTCGCCAAAGACATGCTTCTCTCC
CGCTCGAAGAACACGCCGTTCGAAGATGCGCGCTTCAGCGGGCGGGCAATCGCGACATACGTCTCGGGAAGCTTGTCCAT
GCACTCTAGGACGCGGCTGGACTGA

Upstream 100 bases:

>100_bases
TCGCCGAACAGGTGGAAATGGGGGTCGCGGTGCGCATGGCGGTGATGGAGACGCTGCTCGTCTCGCAGAACCAGGGCCCC
CGAACCGATGGATTGAAGGC

Downstream 100 bases:

>100_bases
GAATAGGCCACGGAGGGCTGAGGCGGCATATGTTATCCAATCTCATGTCATGGCAGATCACGCTGCCGGTCGCGCTTGCC
GCCGCCGTCATCGGCTATCT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSNPIVLQNVRIVDPSRNLDEVGTIIAANGVILAAGSAAQNQGAPEGADIRDCTGLVATPGLVDARVHIGEPGGEHRETI
ASASRAAAAGGVTSIIMMPDTDPVIDDIALVEFVKKTARDTAAVNVYPAAALTKGLSGEEMTEIGLLMQAGAVAFTDAHS
SVHDTQVLRRIMTYAREFGAVICCETRDKYLGANGVMHEGLFASWLGLSGIPREAELIPLERDLRIAELTRGRYHAAMIS
VPQSVEAIERARSRGAKVTSGISINNLALNENDIGEYRTFFKLYPPLRPEDDRVAMVEALASGAIDIIVSSHDPQDVDTK
RLPFGEAEDGAVGLETMLAAALRLHHGGQVSLMRLIDAMSTRPAEIFGLPAGTLKPGAAADIALIDLDEPWLVAKDMLLS
RSKNTPFEDARFSGRAIATYVSGSLSMHSRTRLD

Sequences:

>Translated_434_residues
MSNPIVLQNVRIVDPSRNLDEVGTIIAANGVILAAGSAAQNQGAPEGADIRDCTGLVATPGLVDARVHIGEPGGEHRETI
ASASRAAAAGGVTSIIMMPDTDPVIDDIALVEFVKKTARDTAAVNVYPAAALTKGLSGEEMTEIGLLMQAGAVAFTDAHS
SVHDTQVLRRIMTYAREFGAVICCETRDKYLGANGVMHEGLFASWLGLSGIPREAELIPLERDLRIAELTRGRYHAAMIS
VPQSVEAIERARSRGAKVTSGISINNLALNENDIGEYRTFFKLYPPLRPEDDRVAMVEALASGAIDIIVSSHDPQDVDTK
RLPFGEAEDGAVGLETMLAAALRLHHGGQVSLMRLIDAMSTRPAEIFGLPAGTLKPGAAADIALIDLDEPWLVAKDMLLS
RSKNTPFEDARFSGRAIATYVSGSLSMHSRTRLD
>Mature_433_residues
SNPIVLQNVRIVDPSRNLDEVGTIIAANGVILAAGSAAQNQGAPEGADIRDCTGLVATPGLVDARVHIGEPGGEHRETIA
SASRAAAAGGVTSIIMMPDTDPVIDDIALVEFVKKTARDTAAVNVYPAAALTKGLSGEEMTEIGLLMQAGAVAFTDAHSS
VHDTQVLRRIMTYAREFGAVICCETRDKYLGANGVMHEGLFASWLGLSGIPREAELIPLERDLRIAELTRGRYHAAMISV
PQSVEAIERARSRGAKVTSGISINNLALNENDIGEYRTFFKLYPPLRPEDDRVAMVEALASGAIDIIVSSHDPQDVDTKR
LPFGEAEDGAVGLETMLAAALRLHHGGQVSLMRLIDAMSTRPAEIFGLPAGTLKPGAAADIALIDLDEPWLVAKDMLLSR
SKNTPFEDARFSGRAIATYVSGSLSMHSRTRLD

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=376, Percent_Identity=28.4574468085106, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786722, Length=450, Percent_Identity=27.5555555555556, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193204318, Length=401, Percent_Identity=25.6857855361596, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI86575075, Length=443, Percent_Identity=23.2505643340858, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322218, Length=399, Percent_Identity=24.3107769423559, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24642586, Length=399, Percent_Identity=25.062656641604, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18859883, Length=409, Percent_Identity=25.6723716381418, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46210; Mature: 46079

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPIVLQNVRIVDPSRNLDEVGTIIAANGVILAAGSAAQNQGAPEGADIRDCTGLVATP
CCCCEEEEEEEEECCCCCHHHHHHEEEECCEEEEECCCCCCCCCCCCCCHHHCCCCCCCC
GLVDARVHIGEPGGEHRETIASASRAAAAGGVTSIIMMPDTDPVIDDIALVEFVKKTARD
CEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCC
TAAVNVYPAAALTKGLSGEEMTEIGLLMQAGAVAFTDAHSSVHDTQVLRRIMTYAREFGA
CEEEEEECHHHHHCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHCC
VICCETRDKYLGANGVMHEGLFASWLGLSGIPREAELIPLERDLRIAELTRGRYHAAMIS
EEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHCCCCEEEEEE
VPQSVEAIERARSRGAKVTSGISINNLALNENDIGEYRTFFKLYPPLRPEDDRVAMVEAL
CCHHHHHHHHHHHCCCEEECCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
ASGAIDIIVSSHDPQDVDTKRLPFGEAEDGAVGLETMLAAALRLHHGGQVSLMRLIDAMS
HCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHC
TRPAEIFGLPAGTLKPGAAADIALIDLDEPWLVAKDMLLSRSKNTPFEDARFSGRAIATY
CCCCCEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
VSGSLSMHSRTRLD
ECCCCCCCCCCCCC
>Mature Secondary Structure 
SNPIVLQNVRIVDPSRNLDEVGTIIAANGVILAAGSAAQNQGAPEGADIRDCTGLVATP
CCCEEEEEEEEECCCCCHHHHHHEEEECCEEEEECCCCCCCCCCCCCCHHHCCCCCCCC
GLVDARVHIGEPGGEHRETIASASRAAAAGGVTSIIMMPDTDPVIDDIALVEFVKKTARD
CEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCC
TAAVNVYPAAALTKGLSGEEMTEIGLLMQAGAVAFTDAHSSVHDTQVLRRIMTYAREFGA
CEEEEEECHHHHHCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHCC
VICCETRDKYLGANGVMHEGLFASWLGLSGIPREAELIPLERDLRIAELTRGRYHAAMIS
EEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHCCCCEEEEEE
VPQSVEAIERARSRGAKVTSGISINNLALNENDIGEYRTFFKLYPPLRPEDDRVAMVEAL
CCHHHHHHHHHHHCCCEEECCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
ASGAIDIIVSSHDPQDVDTKRLPFGEAEDGAVGLETMLAAALRLHHGGQVSLMRLIDAMS
HCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHC
TRPAEIFGLPAGTLKPGAAADIALIDLDEPWLVAKDMLLSRSKNTPFEDARFSGRAIATY
CCCCCEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
VSGSLSMHSRTRLD
ECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA