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The map label for this gene is rnr [H]

Identifier: 209548897

GI number: 209548897

Start: 1314040

End: 1316412

Strand: Reverse

Name: rnr [H]

Synonym: Rleg2_1294

Alternate gene names: 209548897

Gene position: 1316412-1314040 (Counterclockwise)

Preceding gene: 209548898

Following gene: 209548896

Centisome position: 29.01

GC content: 66.08

Gene sequence:

>2373_bases
GTGAGCAGAATACCGCGCGACAGAACGAACCCTGCGGGCAAGCGCCCGGGCAAGATCGGCCGTGCCGGCAAGGATGCTCC
CGCCGTCGAGCCGCTGAACATCGTCCACGGCGCGCTGCCGTCGCGGGAGGTGATCCTGCGCTTCATCGCCGATCATCCGC
AGAAAGCGTCCAAGCGGGAACTCGCCAAGGCTTTCGGCCTGAAGGGCGACAGCCGCGTCGAGCTCAAGCACCTGCTGCAG
GAGCTCGAGCAGGAAGGCATGCTGCAGAAGAACCGCAAATCGCTGATCCGCCCCGGCGCGCTGCCGCCGGTCACCGTTCT
CGATATCACCACGCGTGACAAGGATGGCGACCTGATCGGCCGGCCGGCGGAATGGCCCGAGGATCAGGGTGTCGCGCCCG
CCGTCGCCATCCGCCAGCAATCGCCCGCAGGCCGCCAGGGCAAAGGCAAGGCACCGGTCGCCGGCCTCGGCGACCGCATT
CTGGCGAAGATCTTCCCGGCCGTCGATCGTGCCGGGCCGGCCTATACGGCGCGGATCATCAAGGTGATCGACAAGCGCCG
CGGCGCCTCGATGGGCGTTTTCCGCACGACGCCTGGCGGCGGCGGCCGGCTGCTGCCGATCGAGCGACGCGGCGAGGAGA
TGGTCATCGATCCAGACTTCACCGGCGGCGCCAAAGACGGCGACCTGGTCGAGATCGAAGTCGCCCGTCTCGGGCGCTTC
GGCCTGCCGCGCGCCAAGGTGCTTTCGGTCGTTGGCTCCGTCGGCTCGGAAAAGGCGATCTCGATGATTGCCATCCATGC
GCACGGCATTCCGCATGTCTTCCCACCCGCCGTTATCGCTGAGGCCGAGGATGCAAAACCCGCGACGATGTCGCATCGCG
AGGACTGGCGCGACGTGCCGCTGATCACCATCGATCCGGCCGATGCCAAGGACCATGACGACGCCGTCTATGCCGAACTC
GACCCCTCGCCCGACAATCCCGGCGGCGTCATCGTCACCGTGGCGATTGCCGACGTCTCCTGGTATGTCCGCCCGAAGTC
GCCGCTCGACCGCGAGGCGCTGAAGCGCGGCAACTCGGTCTATTTCCCGGATCGCGTCGTACCGATGCTGCCGGAGCGCA
TTTCCAACGATCTCTGCTCGCTGAAGGAAGGCGTCGACCGCCCGGCGCTTGCCGTGCGCATGAGCTTTTCCGGGGAAGGC
CGCAAGATCGGCCACACGTTTCATCGCGTCATGATGAAGAGCGCGGCCAAACTCTCCTACCAGCAGGCGCAGGCGGCGAT
CGACGGCGCGCCGGACGATAGGACCGGACCGATGCTCGAGCCGATCCTGAAGCCGCTCTGGCACGCCTATGCGGTGATGA
AGCGCGGACGCGATCGGCGCCAGCCGCTGGAACTCGACATGCCGGAGCGCAAGATCCTGCTGAAGCCCGACGGCACCGTC
GACCGGGTCCACGTGCCGCCGCGGCTCGACGCTCACAAGCTGATCGAAGAGATGATGATCCAGGCGAACGTCTCGGCCGC
CGAGACGCTGGAAAAGAAACGCCAGCCGCTGATCTACCGCATCCATGACGGCCCGACGCTTGCCAAGCAGGAAATCCTGC
GCGAGTTCCTGGCGACGCTCGGCATCCCGCTTGCCAAGGGCGGCAATATGCGCGCCAACAACTTCAACGGCATTCTGGCG
AAGGCGGACGGCACGCCGCACCAGACCATGGTCAACGAGATGGTGCTGCGCTCGCAGAGCCAGGCGATCTACGGCCCGGA
AAATATCGGCCATTTCGGCCTCAACCTGATGAAATACGCGCATTTCACCTCGCCGATCCGCCGTTACGCCGATCTCATCG
TGCATCGCGCCCTCGTCGGCTCGCTCGGCTTCGGCGAAGGCGGCATCACGACAGAGGAAGAGGCAGGCCTCGACGATATC
GCCGCGGAAATTTCGACCTTCGAGCGACGGGCCATGGCGGCCGAGCGTGAGACGGTCGACCGGCTGATCGCGCATCATCT
GAGCGGCCGCGTCGGCGAGGAATTTGCCGGGCGGGTCTCGGGTGTTACGAAATCCGGGCTGTTTGTCGCCCTGCCGGAGT
ATGGTGCCGATGGTTTCGTCCCCATATCGACGCTCGGCAGCGACTATTTCATCTATGACGAGGCGCATCAGGCGCTCTCG
GGTGAACGGACGGGGCTCGGCTATCGCCTTGGCGACAACGTCACGGTGAAGCTTGCCGAATCAATCCCGCTTGCCGGCGC
GCTGCGCTTCGAGATGGTCAGCGAAGGGCGCGAGATGCCGACGGCGGTGCGCTCCTTCCACAAAGCCGGCCGCCGCGACC
GGGGCCAGGTTCGCAAGAAGCCGGGAACGAGGCCACCGCGCGGGCGGCATTGA

Upstream 100 bases:

>100_bases
AAGCCGAAGGCGGCCGCCGCCGAAGCCAAGACCACCAAGACGGCGGCCAAGCCGAAGGCAACGAAGGCGAAAGCGCCCGC
GAAATCGAAAAAGAGCTGAC

Downstream 100 bases:

>100_bases
AATGTTCCAGCTGTCCGAAAGCGGCATTGGGCGAGATTCACGAGCCTATGCGGCCTGAAGAGGAAGATGCGATGAGCACA
CCGACCGAACCGGTCGTCCG

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; Protein vacB [H]

Number of amino acids: Translated: 790; Mature: 789

Protein sequence:

>790_residues
MSRIPRDRTNPAGKRPGKIGRAGKDAPAVEPLNIVHGALPSREVILRFIADHPQKASKRELAKAFGLKGDSRVELKHLLQ
ELEQEGMLQKNRKSLIRPGALPPVTVLDITTRDKDGDLIGRPAEWPEDQGVAPAVAIRQQSPAGRQGKGKAPVAGLGDRI
LAKIFPAVDRAGPAYTARIIKVIDKRRGASMGVFRTTPGGGGRLLPIERRGEEMVIDPDFTGGAKDGDLVEIEVARLGRF
GLPRAKVLSVVGSVGSEKAISMIAIHAHGIPHVFPPAVIAEAEDAKPATMSHREDWRDVPLITIDPADAKDHDDAVYAEL
DPSPDNPGGVIVTVAIADVSWYVRPKSPLDREALKRGNSVYFPDRVVPMLPERISNDLCSLKEGVDRPALAVRMSFSGEG
RKIGHTFHRVMMKSAAKLSYQQAQAAIDGAPDDRTGPMLEPILKPLWHAYAVMKRGRDRRQPLELDMPERKILLKPDGTV
DRVHVPPRLDAHKLIEEMMIQANVSAAETLEKKRQPLIYRIHDGPTLAKQEILREFLATLGIPLAKGGNMRANNFNGILA
KADGTPHQTMVNEMVLRSQSQAIYGPENIGHFGLNLMKYAHFTSPIRRYADLIVHRALVGSLGFGEGGITTEEEAGLDDI
AAEISTFERRAMAAERETVDRLIAHHLSGRVGEEFAGRVSGVTKSGLFVALPEYGADGFVPISTLGSDYFIYDEAHQALS
GERTGLGYRLGDNVTVKLAESIPLAGALRFEMVSEGREMPTAVRSFHKAGRRDRGQVRKKPGTRPPRGRH

Sequences:

>Translated_790_residues
MSRIPRDRTNPAGKRPGKIGRAGKDAPAVEPLNIVHGALPSREVILRFIADHPQKASKRELAKAFGLKGDSRVELKHLLQ
ELEQEGMLQKNRKSLIRPGALPPVTVLDITTRDKDGDLIGRPAEWPEDQGVAPAVAIRQQSPAGRQGKGKAPVAGLGDRI
LAKIFPAVDRAGPAYTARIIKVIDKRRGASMGVFRTTPGGGGRLLPIERRGEEMVIDPDFTGGAKDGDLVEIEVARLGRF
GLPRAKVLSVVGSVGSEKAISMIAIHAHGIPHVFPPAVIAEAEDAKPATMSHREDWRDVPLITIDPADAKDHDDAVYAEL
DPSPDNPGGVIVTVAIADVSWYVRPKSPLDREALKRGNSVYFPDRVVPMLPERISNDLCSLKEGVDRPALAVRMSFSGEG
RKIGHTFHRVMMKSAAKLSYQQAQAAIDGAPDDRTGPMLEPILKPLWHAYAVMKRGRDRRQPLELDMPERKILLKPDGTV
DRVHVPPRLDAHKLIEEMMIQANVSAAETLEKKRQPLIYRIHDGPTLAKQEILREFLATLGIPLAKGGNMRANNFNGILA
KADGTPHQTMVNEMVLRSQSQAIYGPENIGHFGLNLMKYAHFTSPIRRYADLIVHRALVGSLGFGEGGITTEEEAGLDDI
AAEISTFERRAMAAERETVDRLIAHHLSGRVGEEFAGRVSGVTKSGLFVALPEYGADGFVPISTLGSDYFIYDEAHQALS
GERTGLGYRLGDNVTVKLAESIPLAGALRFEMVSEGREMPTAVRSFHKAGRRDRGQVRKKPGTRPPRGRH
>Mature_789_residues
SRIPRDRTNPAGKRPGKIGRAGKDAPAVEPLNIVHGALPSREVILRFIADHPQKASKRELAKAFGLKGDSRVELKHLLQE
LEQEGMLQKNRKSLIRPGALPPVTVLDITTRDKDGDLIGRPAEWPEDQGVAPAVAIRQQSPAGRQGKGKAPVAGLGDRIL
AKIFPAVDRAGPAYTARIIKVIDKRRGASMGVFRTTPGGGGRLLPIERRGEEMVIDPDFTGGAKDGDLVEIEVARLGRFG
LPRAKVLSVVGSVGSEKAISMIAIHAHGIPHVFPPAVIAEAEDAKPATMSHREDWRDVPLITIDPADAKDHDDAVYAELD
PSPDNPGGVIVTVAIADVSWYVRPKSPLDREALKRGNSVYFPDRVVPMLPERISNDLCSLKEGVDRPALAVRMSFSGEGR
KIGHTFHRVMMKSAAKLSYQQAQAAIDGAPDDRTGPMLEPILKPLWHAYAVMKRGRDRRQPLELDMPERKILLKPDGTVD
RVHVPPRLDAHKLIEEMMIQANVSAAETLEKKRQPLIYRIHDGPTLAKQEILREFLATLGIPLAKGGNMRANNFNGILAK
ADGTPHQTMVNEMVLRSQSQAIYGPENIGHFGLNLMKYAHFTSPIRRYADLIVHRALVGSLGFGEGGITTEEEAGLDDIA
AEISTFERRAMAAERETVDRLIAHHLSGRVGEEFAGRVSGVTKSGLFVALPEYGADGFVPISTLGSDYFIYDEAHQALSG
ERTGLGYRLGDNVTVKLAESIPLAGALRFEMVSEGREMPTAVRSFHKAGRRDRGQVRKKPGTRPPRGRH

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs. Required for the expression of virulence genes in enteroinvasive strains of E.coli [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=527, Percent_Identity=29.4117647058824, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI190014625, Length=527, Percent_Identity=29.4117647058824, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI134288890, Length=490, Percent_Identity=28.5714285714286, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI19115966, Length=505, Percent_Identity=26.5346534653465, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI219521928, Length=505, Percent_Identity=26.5346534653465, Blast_Score=135, Evalue=2e-31,
Organism=Escherichia coli, GI87082383, Length=736, Percent_Identity=36.4130434782609, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1787542, Length=458, Percent_Identity=31.2227074235808, Blast_Score=166, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI212645896, Length=479, Percent_Identity=29.2275574112735, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17553506, Length=501, Percent_Identity=28.7425149700599, Blast_Score=164, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324552, Length=436, Percent_Identity=30.7339449541284, Blast_Score=180, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24649634, Length=472, Percent_Identity=28.3898305084746, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI19922976, Length=362, Percent_Identity=28.1767955801105, Blast_Score=124, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24654597, Length=362, Percent_Identity=28.1767955801105, Blast_Score=124, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24654592, Length=361, Percent_Identity=28.2548476454294, Blast_Score=123, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 86276; Mature: 86145

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIPRDRTNPAGKRPGKIGRAGKDAPAVEPLNIVHGALPSREVILRFIADHPQKASKRE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCHHHHHH
LAKAFGLKGDSRVELKHLLQELEQEGMLQKNRKSLIRPGALPPVTVLDITTRDKDGDLIG
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCC
RPAEWPEDQGVAPAVAIRQQSPAGRQGKGKAPVAGLGDRILAKIFPAVDRAGPAYTARII
CCCCCCCCCCCCCHHEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
KVIDKRRGASMGVFRTTPGGGGRLLPIERRGEEMVIDPDFTGGAKDGDLVEIEVARLGRF
HHHHHHCCCCCCEEEECCCCCCEEEEEECCCCEEEECCCCCCCCCCCCEEEEEHHHCCCC
GLPRAKVLSVVGSVGSEKAISMIAIHAHGIPHVFPPAVIAEAEDAKPATMSHREDWRDVP
CCCHHHHHHHHHCCCCCHHEEEEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCC
LITIDPADAKDHDDAVYAELDPSPDNPGGVIVTVAIADVSWYVRPKSPLDREALKRGNSV
EEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECEEEEECCCCCCCHHHHHCCCCE
YFPDRVVPMLPERISNDLCSLKEGVDRPALAVRMSFSGEGRKIGHTFHRVMMKSAAKLSY
ECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
QQAQAAIDGAPDDRTGPMLEPILKPLWHAYAVMKRGRDRRQPLELDMPERKILLKPDGTV
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCE
DRVHVPPRLDAHKLIEEMMIQANVSAAETLEKKRQPLIYRIHDGPTLAKQEILREFLATL
EEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
GIPLAKGGNMRANNFNGILAKADGTPHQTMVNEMVLRSQSQAIYGPENIGHFGLNLMKYA
CCEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHH
HFTSPIRRYADLIVHRALVGSLGFGEGGITTEEEAGLDDIAAEISTFERRAMAAERETVD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHH
RLIAHHLSGRVGEEFAGRVSGVTKSGLFVALPEYGADGFVPISTLGSDYFIYDEAHQALS
HHHHHHHCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCEEHHHCCCCEEEEHHHHHHHC
GERTGLGYRLGDNVTVKLAESIPLAGALRFEMVSEGREMPTAVRSFHKAGRRDRGQVRKK
CCCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHCC
PGTRPPRGRH
CCCCCCCCCC
>Mature Secondary Structure 
SRIPRDRTNPAGKRPGKIGRAGKDAPAVEPLNIVHGALPSREVILRFIADHPQKASKRE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCHHHHHH
LAKAFGLKGDSRVELKHLLQELEQEGMLQKNRKSLIRPGALPPVTVLDITTRDKDGDLIG
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCC
RPAEWPEDQGVAPAVAIRQQSPAGRQGKGKAPVAGLGDRILAKIFPAVDRAGPAYTARII
CCCCCCCCCCCCCHHEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
KVIDKRRGASMGVFRTTPGGGGRLLPIERRGEEMVIDPDFTGGAKDGDLVEIEVARLGRF
HHHHHHCCCCCCEEEECCCCCCEEEEEECCCCEEEECCCCCCCCCCCCEEEEEHHHCCCC
GLPRAKVLSVVGSVGSEKAISMIAIHAHGIPHVFPPAVIAEAEDAKPATMSHREDWRDVP
CCCHHHHHHHHHCCCCCHHEEEEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCC
LITIDPADAKDHDDAVYAELDPSPDNPGGVIVTVAIADVSWYVRPKSPLDREALKRGNSV
EEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECEEEEECCCCCCCHHHHHCCCCE
YFPDRVVPMLPERISNDLCSLKEGVDRPALAVRMSFSGEGRKIGHTFHRVMMKSAAKLSY
ECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
QQAQAAIDGAPDDRTGPMLEPILKPLWHAYAVMKRGRDRRQPLELDMPERKILLKPDGTV
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCE
DRVHVPPRLDAHKLIEEMMIQANVSAAETLEKKRQPLIYRIHDGPTLAKQEILREFLATL
EEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
GIPLAKGGNMRANNFNGILAKADGTPHQTMVNEMVLRSQSQAIYGPENIGHFGLNLMKYA
CCEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHH
HFTSPIRRYADLIVHRALVGSLGFGEGGITTEEEAGLDDIAAEISTFERRAMAAERETVD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHH
RLIAHHLSGRVGEEFAGRVSGVTKSGLFVALPEYGADGFVPISTLGSDYFIYDEAHQALS
HHHHHHHCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCEEHHHCCCCEEEEHHHHHHHC
GERTGLGYRLGDNVTVKLAESIPLAGALRFEMVSEGREMPTAVRSFHKAGRRDRGQVRKK
CCCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHCC
PGTRPPRGRH
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 3058695; 1400189; 9603904 [H]