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The map label for this gene is lon [H]

Identifier: 209548852

GI number: 209548852

Start: 1264683

End: 1267100

Strand: Direct

Name: lon [H]

Synonym: Rleg2_1249

Alternate gene names: 209548852

Gene position: 1264683-1267100 (Clockwise)

Preceding gene: 209548851

Following gene: 209548853

Centisome position: 27.87

GC content: 60.67

Gene sequence:

>2418_bases
ATGACGAAGAAAACGTCTGTAGCGAGCAGTACTGCCTACCCTGTTCTGCCTTTGCGCGACATCGTGGTTTTCCCGCATAT
GATCGTGCCGCTGTTCGTCGGACGGGAAAAGTCGATCCGTGCGCTCGAAGAGGTCATGGGTTCCGACAAGCAGATCATGC
TGGTGACGCAGATCAACGCCAGTGACGACGATCCGGATCCCTCCGCGATCCACAAGGTCGGCACCGTGGCGAACGTATTG
CAGCTGTTGAAGCTGCCTGACGGCACCGTCAAGGTTCTGGTCGAAGGCCGCGCCCGCGCCGAAATCGATACCTATACCAG
CCGCGAAGATTTCTATGAGGCGCTCGGCCACGTGCTTGAGGAGCCGCATGACGATCCGGTCGAGCTGGAAGCCTTGTCGC
GTTCGGTCGTCTCCGAATTCGAAAGCTATGTGAAGCTCAACAAGAAGATTTCGCCTGAGGTGGTGGGTGCCGCCAGCCAG
ATCGACGACTATTCAAAGCTCGCTGATACGGTTGCTTCGCATCTGTCGATCAAGATCACCGAGAAGCAGGAGATGCTGGA
AACCACCAGCGTCAAGGCCCGCCTCGAAAAGGCCCTCGGCTTCATGGAAGGCGAGATTTCGGTCCTGCAGGTCGAAAAGC
GCATCCGCTCGCGCGTCAAGCGCCAGATGGAAAAGACCCAGCGCGAATACTACCTGAACGAACAGATGAAGGCGATCCAG
AAGGAGCTCGGCGACGGCGAGGAAGGCCGAGACGAGATGAGCGAACTGGAAGAGCGCATTGCCAAGACCAAGCTCTCCAA
GGAGGCCCGTGAAAAGGCCGATGCGGAGCTGAAGAAGCTGCGTCAGATGAGCCCGATGTCGGCTGAAGCCACCGTCGTGC
GCAATTATCTGGACTGGCTGCTCGGCATTCCGTGGGGCAAGAAGTCGAAGATCAAGGCCGATCTCAACAATGCCGAGAAG
ATCCTCGAAGCCGATCACTTCGGTCTCGACAAGGTCAAGGAACGCATCGTCGAATATCTGGCCGTGCAGGCCCGCGCCAC
CAAGATCAAGGGCCCGATCCTGTGCCTCGTCGGCCCTCCGGGCGTCGGCAAGACCTCGCTCGCCCAGTCGATCGCCAAGG
CGACCGGCCGTGAGTATGTCCGCATGGCGCTTGGCGGCGTTCGCGACGAAGCCGAAATCCGCGGTCACCGCCGCACCTAT
ATCGGCTCGATGCCCGGCAAGGTCATCCAGTCGATGAAGAAGGCCAAGAAGTCGAACCCGCTCTTCCTGCTCGACGAAAT
CGACAAGCTCGGCCAGGACTATCGCGGCGATCCGTCTTCGGCCCTGCTCGAGGTGCTCGACCCGGCGCAGAACTCGACCT
TCATGGACCATTACCTGGAAGTCGAATACGACCTGTCGGACGTGATGTTCATCACGACGGCGAATACGCTGAACATCCCG
GCGCCGCTGATGGATCGCATGGAGATCATCCGTATCGCCGGCTACACCGAAGACGAAAAGCGCGAGATCGCCAAGCGGCA
TCTGCTGCCGAAGGCCATCAAGGAACATGCGTTGCAGCCGGAAGAATTCTCGGTCAGTGACGACGCCCTGATGGCGATCA
GCCAGCAGTATACCCGGGAAGCCGGGGTGCGCAGCTTCGAACGTGAACTGATGAAGCTCGCCCGCAAGGCGGTCACCGAG
ATCATCAAGGGCAAGACGAAGTCCGTGCATGTGACGGCCGCCAACATCTCCGACTATCTGGGCGTCCCGCGCTTCCGCCA
TGGCGAAGCCGAGGGCGAGGATCAGGTCGGCGTTGTCACCGGTCTTGCCTGGACGGAAGTCGGCGGTGAACTGCTGACCA
TCGAAGGCGTGATGATGCCGGGCAAGGGCCGTATGACGGTCACCGGCAATCTGAAGGAAGTCATGAAGGAATCGATCTCG
GCGGCGGCCTCCTATGTCCGCTCGCGCGCTGTCGATTTCGGCATCGAGCCGCCGCGCTTCGACAAGAGCGACATCCACGT
GCACGTGCCGGAAGGCGCGACGCCCAAGGATGGCCCCTCGGCCGGCGTCGCCATGGCGACTGCCATCGTCTCGATCATGA
CCGGTATCCCGGTGAACAGGCACGTGGCCATGACCGGTGAAATCACCCTTCGCGGCCGTGTGCTGCCGATCGGCGGTCTG
AAGGAAAAGCTGCTCGCAGCGCTTCGCGGCGGCATCAAGAAGGTGCTGATTCCGGAGGAAAACGCCAAGGACCTGGCGGA
GATTCCGGACAACGTGAAGAACAGCATGGAGATCATCCCGGTGTCCCGCATGGGCGAGGTGATCAAACATGCGCTGATCC
GGCGGCCGGAGCCGATCGAATGGGATGGCACGGTGGAAACGCCTGTCATCACCTCGGTCGAAGGCCTGGACGAGACGGGC
GCGACCATAGCGCATTGA

Upstream 100 bases:

>100_bases
GTAGTCAGAACCTCCACTTGTAGCAACAAGTGAGAGTGCCGGCCGGTCCCAAGCGGCCGTGCAGAGAGCCCGGTAACGGG
ACGATGGAAAGGACTTAAAA

Downstream 100 bases:

>100_bases
GTGGGCTAGGCCACATTTATGCCCCATTGGCTGAAAAGACGGAAAAAGGCTGGCGAAAACGCCAGCCTTTTTTGTGAAAA
CGTCATGTAGACGCTTGCTT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 805; Mature: 804

Protein sequence:

>805_residues
MTKKTSVASSTAYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGSDKQIMLVTQINASDDDPDPSAIHKVGTVANVL
QLLKLPDGTVKVLVEGRARAEIDTYTSREDFYEALGHVLEEPHDDPVELEALSRSVVSEFESYVKLNKKISPEVVGAASQ
IDDYSKLADTVASHLSIKITEKQEMLETTSVKARLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQ
KELGDGEEGRDEMSELEERIAKTKLSKEAREKADAELKKLRQMSPMSAEATVVRNYLDWLLGIPWGKKSKIKADLNNAEK
ILEADHFGLDKVKERIVEYLAVQARATKIKGPILCLVGPPGVGKTSLAQSIAKATGREYVRMALGGVRDEAEIRGHRRTY
IGSMPGKVIQSMKKAKKSNPLFLLDEIDKLGQDYRGDPSSALLEVLDPAQNSTFMDHYLEVEYDLSDVMFITTANTLNIP
APLMDRMEIIRIAGYTEDEKREIAKRHLLPKAIKEHALQPEEFSVSDDALMAISQQYTREAGVRSFERELMKLARKAVTE
IIKGKTKSVHVTAANISDYLGVPRFRHGEAEGEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKEVMKESIS
AAASYVRSRAVDFGIEPPRFDKSDIHVHVPEGATPKDGPSAGVAMATAIVSIMTGIPVNRHVAMTGEITLRGRVLPIGGL
KEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNSMEIIPVSRMGEVIKHALIRRPEPIEWDGTVETPVITSVEGLDETG
ATIAH

Sequences:

>Translated_805_residues
MTKKTSVASSTAYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGSDKQIMLVTQINASDDDPDPSAIHKVGTVANVL
QLLKLPDGTVKVLVEGRARAEIDTYTSREDFYEALGHVLEEPHDDPVELEALSRSVVSEFESYVKLNKKISPEVVGAASQ
IDDYSKLADTVASHLSIKITEKQEMLETTSVKARLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQ
KELGDGEEGRDEMSELEERIAKTKLSKEAREKADAELKKLRQMSPMSAEATVVRNYLDWLLGIPWGKKSKIKADLNNAEK
ILEADHFGLDKVKERIVEYLAVQARATKIKGPILCLVGPPGVGKTSLAQSIAKATGREYVRMALGGVRDEAEIRGHRRTY
IGSMPGKVIQSMKKAKKSNPLFLLDEIDKLGQDYRGDPSSALLEVLDPAQNSTFMDHYLEVEYDLSDVMFITTANTLNIP
APLMDRMEIIRIAGYTEDEKREIAKRHLLPKAIKEHALQPEEFSVSDDALMAISQQYTREAGVRSFERELMKLARKAVTE
IIKGKTKSVHVTAANISDYLGVPRFRHGEAEGEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKEVMKESIS
AAASYVRSRAVDFGIEPPRFDKSDIHVHVPEGATPKDGPSAGVAMATAIVSIMTGIPVNRHVAMTGEITLRGRVLPIGGL
KEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNSMEIIPVSRMGEVIKHALIRRPEPIEWDGTVETPVITSVEGLDETG
ATIAH
>Mature_804_residues
TKKTSVASSTAYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGSDKQIMLVTQINASDDDPDPSAIHKVGTVANVLQ
LLKLPDGTVKVLVEGRARAEIDTYTSREDFYEALGHVLEEPHDDPVELEALSRSVVSEFESYVKLNKKISPEVVGAASQI
DDYSKLADTVASHLSIKITEKQEMLETTSVKARLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQK
ELGDGEEGRDEMSELEERIAKTKLSKEAREKADAELKKLRQMSPMSAEATVVRNYLDWLLGIPWGKKSKIKADLNNAEKI
LEADHFGLDKVKERIVEYLAVQARATKIKGPILCLVGPPGVGKTSLAQSIAKATGREYVRMALGGVRDEAEIRGHRRTYI
GSMPGKVIQSMKKAKKSNPLFLLDEIDKLGQDYRGDPSSALLEVLDPAQNSTFMDHYLEVEYDLSDVMFITTANTLNIPA
PLMDRMEIIRIAGYTEDEKREIAKRHLLPKAIKEHALQPEEFSVSDDALMAISQQYTREAGVRSFERELMKLARKAVTEI
IKGKTKSVHVTAANISDYLGVPRFRHGEAEGEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKEVMKESISA
AASYVRSRAVDFGIEPPRFDKSDIHVHVPEGATPKDGPSAGVAMATAIVSIMTGIPVNRHVAMTGEITLRGRVLPIGGLK
EKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNSMEIIPVSRMGEVIKHALIRRPEPIEWDGTVETPVITSVEGLDETGA
TIAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=660, Percent_Identity=42.5757575757576, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI31377667, Length=777, Percent_Identity=37.1943371943372, Blast_Score=502, Evalue=1e-142,
Organism=Escherichia coli, GI1786643, Length=764, Percent_Identity=64.1361256544503, Blast_Score=988, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=704, Percent_Identity=39.6306818181818, Blast_Score=494, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17556486, Length=651, Percent_Identity=35.6374807987711, Blast_Score=424, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319449, Length=843, Percent_Identity=36.2989323843416, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI221513036, Length=664, Percent_Identity=41.566265060241, Blast_Score=513, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24666867, Length=664, Percent_Identity=41.566265060241, Blast_Score=513, Evalue=1e-145,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88958; Mature: 88827

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKTSVASSTAYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGSDKQIMLVTQINA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEECC
SDDDPDPSAIHKVGTVANVLQLLKLPDGTVKVLVEGRARAEIDTYTSREDFYEALGHVLE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHCCCCHHHHHHHHHHHHC
EPHDDPVELEALSRSVVSEFESYVKLNKKISPEVVGAASQIDDYSKLADTVASHLSIKIT
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHEEEEE
EKQEMLETTSVKARLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQ
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGDGEEGRDEMSELEERIAKTKLSKEAREKADAELKKLRQMSPMSAEATVVRNYLDWL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LGIPWGKKSKIKADLNNAEKILEADHFGLDKVKERIVEYLAVQARATKIKGPILCLVGPP
HCCCCCCCCCCHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
GVGKTSLAQSIAKATGREYVRMALGGVRDEAEIRGHRRTYIGSMPGKVIQSMKKAKKSNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCC
LFLLDEIDKLGQDYRGDPSSALLEVLDPAQNSTFMDHYLEVEYDLSDVMFITTANTLNIP
EEEEHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHEEEEECCCCEEEEEECCCCCCC
APLMDRMEIIRIAGYTEDEKREIAKRHLLPKAIKEHALQPEEFSVSDDALMAISQQYTRE
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AGVRSFERELMKLARKAVTEIIKGKTKSVHVTAANISDYLGVPRFRHGEAEGEDQVGVVT
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHCCCCCCCCCCCCCCCCEEEE
GLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKEVMKESISAAASYVRSRAVDFGIEPPRF
CCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DKSDIHVHVPEGATPKDGPSAGVAMATAIVSIMTGIPVNRHVAMTGEITLRGRVLPIGGL
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEEEECCCH
KEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNSMEIIPVSRMGEVIKHALIRRPEPIE
HHHHHHHHHCCCEEEECCCCCCHHHHHCCHHHHCCEEEEEHHHHHHHHHHHHHCCCCCCC
WDGTVETPVITSVEGLDETGATIAH
CCCCCCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TKKTSVASSTAYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGSDKQIMLVTQINA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEECC
SDDDPDPSAIHKVGTVANVLQLLKLPDGTVKVLVEGRARAEIDTYTSREDFYEALGHVLE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHCCCCHHHHHHHHHHHHC
EPHDDPVELEALSRSVVSEFESYVKLNKKISPEVVGAASQIDDYSKLADTVASHLSIKIT
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHEEEEE
EKQEMLETTSVKARLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQ
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGDGEEGRDEMSELEERIAKTKLSKEAREKADAELKKLRQMSPMSAEATVVRNYLDWL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LGIPWGKKSKIKADLNNAEKILEADHFGLDKVKERIVEYLAVQARATKIKGPILCLVGPP
HCCCCCCCCCCHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
GVGKTSLAQSIAKATGREYVRMALGGVRDEAEIRGHRRTYIGSMPGKVIQSMKKAKKSNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCC
LFLLDEIDKLGQDYRGDPSSALLEVLDPAQNSTFMDHYLEVEYDLSDVMFITTANTLNIP
EEEEHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHEEEEECCCCEEEEEECCCCCCC
APLMDRMEIIRIAGYTEDEKREIAKRHLLPKAIKEHALQPEEFSVSDDALMAISQQYTRE
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AGVRSFERELMKLARKAVTEIIKGKTKSVHVTAANISDYLGVPRFRHGEAEGEDQVGVVT
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHCCCCCCCCCCCCCCCCEEEE
GLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKEVMKESISAAASYVRSRAVDFGIEPPRF
CCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DKSDIHVHVPEGATPKDGPSAGVAMATAIVSIMTGIPVNRHVAMTGEITLRGRVLPIGGL
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEEEECCCH
KEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNSMEIIPVSRMGEVIKHALIRRPEPIE
HHHHHHHHHCCCEEEECCCCCCHHHHHCCHHHHCCEEEEEHHHHHHHHHHHHHCCCCCCC
WDGTVETPVITSVEGLDETGATIAH
CCCCCCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10762258; 11481430 [H]