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The map label for this gene is parC [H]

Identifier: 209548711

GI number: 209548711

Start: 1132624

End: 1134879

Strand: Direct

Name: parC [H]

Synonym: Rleg2_1108

Alternate gene names: 209548711

Gene position: 1132624-1134879 (Clockwise)

Preceding gene: 209548709

Following gene: 209548712

Centisome position: 24.96

GC content: 62.9

Gene sequence:

>2256_bases
ATGGGACAAGAGATTTTGCCGCCTTCCGGCGGAGACGACGATTACATCCAACCGGTCGACCTCAAGGCGGCGCTCGAGCA
GCGCTATCTCGCCTATGCGCTGTCGACCATCATGCACCGTGCTTTGCCTGACGTGCGCGACGGGCTGAAGCCTGTGCATC
GCCGCATCGTCTATGCGATGAACGAGATGGGTCTGCGCCCGACCTCGGCCTTCAGGAAATGCGCCAAGATCGTCGGCGAG
GTGATGGGTAACTACCATCCGCACGGCGACCAGTCGATCTATGATGCGCTTGCCCGTCTCGCCCAGGACTTCTCGCAACG
CTACACGCTGGTCAACGGCCAGGGCAATTTCGGCAATATCGATGGCGACAGCCCCGCCGCCATGCGTTACACCGAATCGA
AGATGACGGCGGTCTCCGAACTGCTGCTTGAAGGCATCGATCAGGATGCCGTCGATTTCCGCGACACCTACGACGAATCG
AATTCCGAGCCGACCGTCCTTCCCGGCGCCTTCCCGAACCTGCTCGCCAACGGCTCCTCCGGCATCGCCGTCGGCATGGC
GACCTCGATCCCGTCGCACAATGCCCACGAGCTTTGCGACGCCGCGCTGCATCTGATCAAGCATCCGGATGCGACCGTCG
AAAAGCTCGTCGAATTCATTCCCGGCCCGGATTTTCCCACGGGCGGCATCATCATCGACAGCCGCGACAGCATCATCGAG
AGCTATCGCACCGGCCGCGGTGGCTTCCGCGTGCGGGCGAAGTGGCAAACCGAGGATCTCGGCCGCGGCGGCTACCAGAT
CGTAATAACCGAAATTCCCTTCCAGGTGCAGAAGTCGCGGCTGATCGAGAAGATCGCCGAGCTGCTGATCGCCCGCAAAC
TGCCGCTCCTGGAGGACATCCGCGATGAGTCGGCCGAGGACATCCGTGTCGTCCTGGTGCCGAAGACCCGCAGCGTCGAT
CCGACGATCCTGATGGAATCGATGTTCAAGCTGACGGAGCTCGAAAGCCGCTTTCCGCTCAACATGAACGTGCTGTCCAT
GGGCCGCATCCCGCGGGTCATGGCGCTGAACGAAGTGCTGAAGGAGTGGCTGGATCACCGCCGCGAGGTGCTGCAGCGCC
GCTCGCGCTTCCGACTGGCCGCGATCGACAGGCGTCTCGAAATCCTCGGCGGCCTTCTGATCGCCTATCTCAACATCGAC
GAGGTGATCAGGATCATCCGCGAGGAGGATGAGCCGAAGCCTGTGATGATGGCGCGCTGGGATCTCACCGACATTCAGGT
CGAAGCGATCCTCAACATGCGGCTGCGCGCCTTGCGCAAGCTGGAAGAGTTCGAGATCCGCAAGGAATTCGACGAACTCA
CCAAGGAAAAGGGCGAGATCGAAGCGCTGCTTGCCTCCGACGACAAGCAGTGGCAGACGGTCGCCTGGGAAATCGGCGAA
GTGAAGAAGAAATTCGCCAAGGCGACCGAGGTCGGCCGCCGCCGCACCCAGTTTGCCGACGCACCCGAGGCCGACGAGGA
AGCAATCCAGCAGGCGATGATCGAGAAAGAACCGATCACCGTCGTCATATCCGAAAAGGGCTGGATCCGAGCGCTGAAGG
GCCATATCGCCGATACGGCGACGCTGACCTTCAAGGAGGGCGACGGCCTGAAGATAGCCTTCCCGGCGCAGACGACGGAC
AAGATCCTGATCGTCACGACAGGCGGCAAGGCCTTCACCCTTGGCGGCGACAAGCTGCCGGGCGGTCGCGGCCATGGCGA
GCCGCTGCGCATCATGGTCGACATGGACAACGACCAGGCGGTGCTGACGGCTTTCGTCCACGATCCGTCGCGCAAGCAGC
TGATCGTCTCGACAGCCGGCAACGGCTTCGTCGTTCCGGAGGCCGAGCTGGTCGCCAATACGCGCAAGGGCAAGCAGATC
ATGAACGTCGCGCTGCCCGAGGAGACGCAGCTGCTCGTGCCCGTCAGCGGCGACCATGTCGCCGTCGTCGGCGAAAACCG
CAAGCTGCTGGTGTTCCCGCTGGCACAGGTGCCGGAAATGTCGCGCGGCAAGGGCGTGCGCCTGCAGCGTTACAAGGATG
GCGGCATTTCCGACGTCCGCTGCTTCGCAATATCGGGCGGCCTCGTCTGGGAAGACAGCGCCGGCCGCACCTTCACGAAG
AACAAGGACGAGCTTGCCGAATGGCTGGCCGACCGCGCCACCGCCGGCCGCACCGTGCCGAAGGGTTTTCCGCGCAGCGG
CAAATTCGCCGGTTAA

Upstream 100 bases:

>100_bases
ACGTTTGTCTCATCCTTTGATGTCGGTGCCAAGACTTCATCCACAGCTGCAATGGCCTGGATTCCTTGCCCGCCAGCCTC
TTCTGGGCTAGTCAGAACCT

Downstream 100 bases:

>100_bases
TGCGTGATGCCGAAAAGTGTGAGCGGTTTTCGGGCGACATCATGCTCTAACTTTGTCGCCCGCAAGCGCGCAGCGGTTCC
GGGCTAGCGATATAAAAATT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 751; Mature: 750

Protein sequence:

>751_residues
MGQEILPPSGGDDDYIQPVDLKAALEQRYLAYALSTIMHRALPDVRDGLKPVHRRIVYAMNEMGLRPTSAFRKCAKIVGE
VMGNYHPHGDQSIYDALARLAQDFSQRYTLVNGQGNFGNIDGDSPAAMRYTESKMTAVSELLLEGIDQDAVDFRDTYDES
NSEPTVLPGAFPNLLANGSSGIAVGMATSIPSHNAHELCDAALHLIKHPDATVEKLVEFIPGPDFPTGGIIIDSRDSIIE
SYRTGRGGFRVRAKWQTEDLGRGGYQIVITEIPFQVQKSRLIEKIAELLIARKLPLLEDIRDESAEDIRVVLVPKTRSVD
PTILMESMFKLTELESRFPLNMNVLSMGRIPRVMALNEVLKEWLDHRREVLQRRSRFRLAAIDRRLEILGGLLIAYLNID
EVIRIIREEDEPKPVMMARWDLTDIQVEAILNMRLRALRKLEEFEIRKEFDELTKEKGEIEALLASDDKQWQTVAWEIGE
VKKKFAKATEVGRRRTQFADAPEADEEAIQQAMIEKEPITVVISEKGWIRALKGHIADTATLTFKEGDGLKIAFPAQTTD
KILIVTTGGKAFTLGGDKLPGGRGHGEPLRIMVDMDNDQAVLTAFVHDPSRKQLIVSTAGNGFVVPEAELVANTRKGKQI
MNVALPEETQLLVPVSGDHVAVVGENRKLLVFPLAQVPEMSRGKGVRLQRYKDGGISDVRCFAISGGLVWEDSAGRTFTK
NKDELAEWLADRATAGRTVPKGFPRSGKFAG

Sequences:

>Translated_751_residues
MGQEILPPSGGDDDYIQPVDLKAALEQRYLAYALSTIMHRALPDVRDGLKPVHRRIVYAMNEMGLRPTSAFRKCAKIVGE
VMGNYHPHGDQSIYDALARLAQDFSQRYTLVNGQGNFGNIDGDSPAAMRYTESKMTAVSELLLEGIDQDAVDFRDTYDES
NSEPTVLPGAFPNLLANGSSGIAVGMATSIPSHNAHELCDAALHLIKHPDATVEKLVEFIPGPDFPTGGIIIDSRDSIIE
SYRTGRGGFRVRAKWQTEDLGRGGYQIVITEIPFQVQKSRLIEKIAELLIARKLPLLEDIRDESAEDIRVVLVPKTRSVD
PTILMESMFKLTELESRFPLNMNVLSMGRIPRVMALNEVLKEWLDHRREVLQRRSRFRLAAIDRRLEILGGLLIAYLNID
EVIRIIREEDEPKPVMMARWDLTDIQVEAILNMRLRALRKLEEFEIRKEFDELTKEKGEIEALLASDDKQWQTVAWEIGE
VKKKFAKATEVGRRRTQFADAPEADEEAIQQAMIEKEPITVVISEKGWIRALKGHIADTATLTFKEGDGLKIAFPAQTTD
KILIVTTGGKAFTLGGDKLPGGRGHGEPLRIMVDMDNDQAVLTAFVHDPSRKQLIVSTAGNGFVVPEAELVANTRKGKQI
MNVALPEETQLLVPVSGDHVAVVGENRKLLVFPLAQVPEMSRGKGVRLQRYKDGGISDVRCFAISGGLVWEDSAGRTFTK
NKDELAEWLADRATAGRTVPKGFPRSGKFAG
>Mature_750_residues
GQEILPPSGGDDDYIQPVDLKAALEQRYLAYALSTIMHRALPDVRDGLKPVHRRIVYAMNEMGLRPTSAFRKCAKIVGEV
MGNYHPHGDQSIYDALARLAQDFSQRYTLVNGQGNFGNIDGDSPAAMRYTESKMTAVSELLLEGIDQDAVDFRDTYDESN
SEPTVLPGAFPNLLANGSSGIAVGMATSIPSHNAHELCDAALHLIKHPDATVEKLVEFIPGPDFPTGGIIIDSRDSIIES
YRTGRGGFRVRAKWQTEDLGRGGYQIVITEIPFQVQKSRLIEKIAELLIARKLPLLEDIRDESAEDIRVVLVPKTRSVDP
TILMESMFKLTELESRFPLNMNVLSMGRIPRVMALNEVLKEWLDHRREVLQRRSRFRLAAIDRRLEILGGLLIAYLNIDE
VIRIIREEDEPKPVMMARWDLTDIQVEAILNMRLRALRKLEEFEIRKEFDELTKEKGEIEALLASDDKQWQTVAWEIGEV
KKKFAKATEVGRRRTQFADAPEADEEAIQQAMIEKEPITVVISEKGWIRALKGHIADTATLTFKEGDGLKIAFPAQTTDK
ILIVTTGGKAFTLGGDKLPGGRGHGEPLRIMVDMDNDQAVLTAFVHDPSRKQLIVSTAGNGFVVPEAELVANTRKGKQIM
NVALPEETQLLVPVSGDHVAVVGENRKLLVFPLAQVPEMSRGKGVRLQRYKDGGISDVRCFAISGGLVWEDSAGRTFTKN
KDELAEWLADRATAGRTVPKGFPRSGKFAG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=380, Percent_Identity=23.6842105263158, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1789396, Length=682, Percent_Identity=41.2023460410557, Blast_Score=529, Evalue=1e-151,
Organism=Escherichia coli, GI1788562, Length=638, Percent_Identity=37.7742946708464, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17535065, Length=483, Percent_Identity=24.223602484472, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI212645845, Length=363, Percent_Identity=23.9669421487603, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=483, Percent_Identity=24.223602484472, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=347, Percent_Identity=26.8011527377522, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17136538, Length=180, Percent_Identity=28.3333333333333, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83559; Mature: 83428

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQEILPPSGGDDDYIQPVDLKAALEQRYLAYALSTIMHRALPDVRDGLKPVHRRIVYAM
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
NEMGLRPTSAFRKCAKIVGEVMGNYHPHGDQSIYDALARLAQDFSQRYTLVNGQGNFGNI
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCEEEECCCCCCCCC
DGDSPAAMRYTESKMTAVSELLLEGIDQDAVDFRDTYDESNSEPTVLPGAFPNLLANGSS
CCCCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCC
GIAVGMATSIPSHNAHELCDAALHLIKHPDATVEKLVEFIPGPDFPTGGIIIDSRDSIIE
CEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEECCHHHHHH
SYRTGRGGFRVRAKWQTEDLGRGGYQIVITEIPFQVQKSRLIEKIAELLIARKLPLLEDI
HHHCCCCCEEEEEEECHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
RDESAEDIRVVLVPKTRSVDPTILMESMFKLTELESRFPLNMNVLSMGRIPRVMALNEVL
HCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHH
KEWLDHRREVLQRRSRFRLAAIDRRLEILGGLLIAYLNIDEVIRIIREEDEPKPVMMARW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEEC
DLTDIQVEAILNMRLRALRKLEEFEIRKEFDELTKEKGEIEALLASDDKQWQTVAWEIGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
VKKKFAKATEVGRRRTQFADAPEADEEAIQQAMIEKEPITVVISEKGWIRALKGHIADTA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCE
TLTFKEGDGLKIAFPAQTTDKILIVTTGGKAFTLGGDKLPGGRGHGEPLRIMVDMDNDQA
EEEEECCCCEEEEECCCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCEEEEEECCCCCE
VLTAFVHDPSRKQLIVSTAGNGFVVPEAELVANTRKGKQIMNVALPEETQLLVPVSGDHV
EEEEEEECCCCCEEEEEECCCCEECCCHHHHHCCCCCHHHHEEECCCCCEEEEEECCCEE
AVVGENRKLLVFPLAQVPEMSRGKGVRLQRYKDGGISDVRCFAISGGLVWEDSAGRTFTK
EEEECCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCEEEECCCCCCCCC
NKDELAEWLADRATAGRTVPKGFPRSGKFAG
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GQEILPPSGGDDDYIQPVDLKAALEQRYLAYALSTIMHRALPDVRDGLKPVHRRIVYAM
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
NEMGLRPTSAFRKCAKIVGEVMGNYHPHGDQSIYDALARLAQDFSQRYTLVNGQGNFGNI
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCEEEECCCCCCCCC
DGDSPAAMRYTESKMTAVSELLLEGIDQDAVDFRDTYDESNSEPTVLPGAFPNLLANGSS
CCCCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCC
GIAVGMATSIPSHNAHELCDAALHLIKHPDATVEKLVEFIPGPDFPTGGIIIDSRDSIIE
CEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEECCHHHHHH
SYRTGRGGFRVRAKWQTEDLGRGGYQIVITEIPFQVQKSRLIEKIAELLIARKLPLLEDI
HHHCCCCCEEEEEEECHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
RDESAEDIRVVLVPKTRSVDPTILMESMFKLTELESRFPLNMNVLSMGRIPRVMALNEVL
HCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHH
KEWLDHRREVLQRRSRFRLAAIDRRLEILGGLLIAYLNIDEVIRIIREEDEPKPVMMARW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEEEC
DLTDIQVEAILNMRLRALRKLEEFEIRKEFDELTKEKGEIEALLASDDKQWQTVAWEIGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
VKKKFAKATEVGRRRTQFADAPEADEEAIQQAMIEKEPITVVISEKGWIRALKGHIADTA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCE
TLTFKEGDGLKIAFPAQTTDKILIVTTGGKAFTLGGDKLPGGRGHGEPLRIMVDMDNDQA
EEEEECCCCEEEEECCCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCEEEEEECCCCCE
VLTAFVHDPSRKQLIVSTAGNGFVVPEAELVANTRKGKQIMNVALPEETQLLVPVSGDHV
EEEEEEECCCCCEEEEEECCCCEECCCHHHHHCCCCCHHHHEEECCCCCEEEEEECCCEE
AVVGENRKLLVFPLAQVPEMSRGKGVRLQRYKDGGISDVRCFAISGGLVWEDSAGRTFTK
EEEECCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCEEEECCCCCCCCC
NKDELAEWLADRATAGRTVPKGFPRSGKFAG
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]