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The map label for this gene is purM [H]

Identifier: 209548698

GI number: 209548698

Start: 1114597

End: 1115670

Strand: Reverse

Name: purM [H]

Synonym: Rleg2_1095

Alternate gene names: 209548698

Gene position: 1115670-1114597 (Counterclockwise)

Preceding gene: 209548703

Following gene: 209548697

Centisome position: 24.59

GC content: 66.48

Gene sequence:

>1074_bases
ATGAGCCAGTCTGGGAAAAACGGCCTGACCTACAGCGACGCGGGCGTCGACATCGATGCCGGCAACCTCCTCGTCGAGAA
GATCAAACCGGCGGTGCGCTCGACCCGCCGCCCCGGCGCTGACGGCGAGATCGGCGGCTTCGGCGGGCTTTTCGATCTCA
AGGCCGCCGGCTTTAACGACCCGGTTCTCGTTGCCGCCAATGACGGCGTCGGCACCAAGCTGAAGATCGCCATCGATGCC
GATTATCACGACACCGTCGGCATCGACCTCGTCGCCATGTGCGTCAACGATCTCGTGGTGCAGGGCGCCGAGCCGCTGTT
TTTCCTCGATTATTTCGCCACCGGCAAGCTCGACCCCGACCAGGGTGCTGCGATCGTCGGCGGCATCGCCGCCGGCTGCC
GGCAGGCCGGCTGCGCGCTGATCGGCGGCGAGACGGCCGAAATGCCCGGCATGTATTCCTCCGGCGACTATGATCTCGCC
GGTTTTGCCGTCGGCGCTGCCGAACGCGGCAAGCTGCTGCCCTCGGGCGATATCGCCGAGGGCGATGTGATCCTCGGCCT
CGCCTCCTCCGGCGTGCATTCCAACGGTTTCTCGCTGGTGCGCAAGATCGTCGAACTCTCCGGCCTCGGCTGGGATGCGC
CGGCGCCATTTGCCAGCGATAAGAAGCTCGGCGAGGCCCTGCTCGAGCCGACGCGCATCTATGTGAAGCCGCTTCTGAAG
GCGATCCGCGAGACCGGCGCCATCAAGGCGCTGGCCCACATCACCGGCGGCGGCTTCCCGGAAAACATCCCGCGCGTGCT
GCCGAAGCATCTGGCGGCCGAGATCGATCTTGCCGCCGTCAAGGCTCCGCCGGTGTTTTCGTGGCTCGCCAGGACGGGCG
GCGTCGAAACCAAGGAGATGCTGCGCACCTTCAACTGCGGCGTCGGCATGATCGCCGTCGTCGCTAGCGAGAATGTCGCG
GCGGTTTCCGCCGCACTCGAGGCCGAGGGCGAAACCGTCGTCACGCTCGGCCGCATGATCGCCCGAGACGAGGGTGCAGC
CGGCACGGTCTATCAGGGCACGCTTGCCCTATGA

Upstream 100 bases:

>100_bases
CTTTTGCCATGCGGCGCTTGCATAAAGGCCCCTGTCATGCAATTGCGACCGGCAGATGACGCGGCGCGTCTGCCGCCTGA
AATAGCCATCGGAGACCAGC

Downstream 100 bases:

>100_bases
GCGCGAAGCGCAAACGCGTCGTTGTCCTCATATCCGGCAGCGGCTCCAACATGATGGCGCTGGTTGCGGCGGCCAAGGCT
GCCGACTATCCAGCCGAAAT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSQSGKNGLTYSDAGVDIDAGNLLVEKIKPAVRSTRRPGADGEIGGFGGLFDLKAAGFNDPVLVAANDGVGTKLKIAIDA
DYHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPDQGAAIVGGIAAGCRQAGCALIGGETAEMPGMYSSGDYDLA
GFAVGAAERGKLLPSGDIAEGDVILGLASSGVHSNGFSLVRKIVELSGLGWDAPAPFASDKKLGEALLEPTRIYVKPLLK
AIRETGAIKALAHITGGGFPENIPRVLPKHLAAEIDLAAVKAPPVFSWLARTGGVETKEMLRTFNCGVGMIAVVASENVA
AVSAALEAEGETVVTLGRMIARDEGAAGTVYQGTLAL

Sequences:

>Translated_357_residues
MSQSGKNGLTYSDAGVDIDAGNLLVEKIKPAVRSTRRPGADGEIGGFGGLFDLKAAGFNDPVLVAANDGVGTKLKIAIDA
DYHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPDQGAAIVGGIAAGCRQAGCALIGGETAEMPGMYSSGDYDLA
GFAVGAAERGKLLPSGDIAEGDVILGLASSGVHSNGFSLVRKIVELSGLGWDAPAPFASDKKLGEALLEPTRIYVKPLLK
AIRETGAIKALAHITGGGFPENIPRVLPKHLAAEIDLAAVKAPPVFSWLARTGGVETKEMLRTFNCGVGMIAVVASENVA
AVSAALEAEGETVVTLGRMIARDEGAAGTVYQGTLAL
>Mature_356_residues
SQSGKNGLTYSDAGVDIDAGNLLVEKIKPAVRSTRRPGADGEIGGFGGLFDLKAAGFNDPVLVAANDGVGTKLKIAIDAD
YHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPDQGAAIVGGIAAGCRQAGCALIGGETAEMPGMYSSGDYDLAG
FAVGAAERGKLLPSGDIAEGDVILGLASSGVHSNGFSLVRKIVELSGLGWDAPAPFASDKKLGEALLEPTRIYVKPLLKA
IRETGAIKALAHITGGGFPENIPRVLPKHLAAEIDLAAVKAPPVFSWLARTGGVETKEMLRTFNCGVGMIAVVASENVAA
VSAALEAEGETVVTLGRMIARDEGAAGTVYQGTLAL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=342, Percent_Identity=57.0175438596491, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI209869995, Length=342, Percent_Identity=57.0175438596491, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI209869993, Length=342, Percent_Identity=57.0175438596491, Blast_Score=389, Evalue=1e-108,
Organism=Escherichia coli, GI1788845, Length=340, Percent_Identity=55.5882352941177, Blast_Score=368, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17567511, Length=348, Percent_Identity=47.7011494252874, Blast_Score=306, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6321203, Length=356, Percent_Identity=58.7078651685393, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24582400, Length=295, Percent_Identity=48.8135593220339, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36581; Mature: 36450

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSGKNGLTYSDAGVDIDAGNLLVEKIKPAVRSTRRPGADGEIGGFGGLFDLKAAGFND
CCCCCCCCCEECCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCC
PVLVAANDGVGTKLKIAIDADYHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPD
CEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCC
QGAAIVGGIAAGCRQAGCALIGGETAEMPGMYSSGDYDLAGFAVGAAERGKLLPSGDIAE
CCCEEEHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCEEEEECCHHCCCCCCCCCCCC
GDVILGLASSGVHSNGFSLVRKIVELSGLGWDAPAPFASDKKLGEALLEPTRIYVKPLLK
CCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHH
AIRETGAIKALAHITGGGFPENIPRVLPKHLAAEIDLAAVKAPPVFSWLARTGGVETKEM
HHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCHHHH
LRTFNCGVGMIAVVASENVAAVSAALEAEGETVVTLGRMIARDEGAAGTVYQGTLAL
HHHHCCCCCEEEEEECCCHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCEECCEECC
>Mature Secondary Structure 
SQSGKNGLTYSDAGVDIDAGNLLVEKIKPAVRSTRRPGADGEIGGFGGLFDLKAAGFND
CCCCCCCCEECCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCC
PVLVAANDGVGTKLKIAIDADYHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPD
CEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCC
QGAAIVGGIAAGCRQAGCALIGGETAEMPGMYSSGDYDLAGFAVGAAERGKLLPSGDIAE
CCCEEEHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCEEEEECCHHCCCCCCCCCCCC
GDVILGLASSGVHSNGFSLVRKIVELSGLGWDAPAPFASDKKLGEALLEPTRIYVKPLLK
CCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHH
AIRETGAIKALAHITGGGFPENIPRVLPKHLAAEIDLAAVKAPPVFSWLARTGGVETKEM
HHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCHHHH
LRTFNCGVGMIAVVASENVAAVSAALEAEGETVVTLGRMIARDEGAAGTVYQGTLAL
HHHHCCCCCEEEEEECCCHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA